LOCUS       NM_009452               1609 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus tumor necrosis factor (ligand) superfamily, member 4
            (Tnfsf4), mRNA.
ACCESSION   NM_009452
VERSION     NM_009452.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1609)
  AUTHORS   Zhao,L., Zhang,W., Liu,M., Jia,R., Wang,J., Wang,F. and Xu,Y.
  TITLE     OX40L enhances the immunogenicity of dendritic cells and inhibits
            tumor metastasis in mice
  JOURNAL   Microbiol Immunol 67 (2), 79-89 (2023)
   PUBMED   36345699
  REMARK    GeneRIF: OX40L enhances the immunogenicity of dendritic cells and
            inhibits tumor metastasis in mice.
REFERENCE   2  (bases 1 to 1609)
  AUTHORS   Sato,A., Azuma,M., Nagai,H., Imai,W., Kawaguchi,K., Morita,M.,
            Okuyama,Y., Ishii,N. and So,T.
  TITLE     OX40 Ligand-Mannose-Binding Lectin Fusion Protein Induces Potent
            OX40 Cosignaling in CD4+ T Cells
  JOURNAL   Biol Pharm Bull 45 (12), 1798-1804 (2022)
   PUBMED   36450532
  REMARK    GeneRIF: OX40 Ligand-Mannose-Binding Lectin Fusion Protein Induces
            Potent OX40 Cosignaling in CD4[+] T Cells.
REFERENCE   3  (bases 1 to 1609)
  AUTHORS   Liu,L., Zhao,J., Li,A., Yang,X., Sprangers,B. and Li,S.
  TITLE     Prolongation of allograft survival by artemisinin treatment is
            associated with blockade of OX40-OX40L
  JOURNAL   Immunopharmacol Immunotoxicol 43 (3), 291-298 (2021)
   PUBMED   33757384
  REMARK    GeneRIF: Prolongation of allograft survival by artemisinin
            treatment is associated with blockade of OX40-OX40L.
REFERENCE   4  (bases 1 to 1609)
  AUTHORS   Li,Q., Li,X., Quan,H., Wang,Y., Qu,G., Shen,Z. and He,C.
  TITLE     IL-10-/- Enhances DCs Immunity Against Chlamydia psittaci Infection
            via OX40L/NLRP3 and IDO/Treg Pathways
  JOURNAL   Front Immunol 12, 645653 (2021)
   PUBMED   34093535
  REMARK    GeneRIF: IL-10(-/-) Enhances DCs Immunity Against Chlamydia
            psittaci Infection via OX40L/NLRP3 and IDO/Treg Pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1609)
  AUTHORS   Bassani,B., Tripodo,C., Portararo,P., Gulino,A., Botti,L.,
            Chiodoni,C., Jachetti,E., Bolli,N., Ciciarello,M., Joehrens,K.,
            Anagnostopoulos,I., Na,I.K., Curti,A., Colombo,M.P. and
            Sangaletti,S.
  TITLE     CD40 Activity on Mesenchymal Cells Negatively Regulates OX40L to
            Maintain Bone Marrow Immune Homeostasis Under Stress Conditions
  JOURNAL   Front Immunol 12, 662048 (2021)
   PUBMED   34084166
  REMARK    GeneRIF: CD40 Activity on Mesenchymal Cells Negatively Regulates
            OX40L to Maintain Bone Marrow Immune Homeostasis Under Stress
            Conditions.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1609)
  AUTHORS   Hwa,J.J., Zollman,S., Warden,C.H., Taylor,B.A., Edwards,P.A.,
            Fogelman,A.M. and Lusis,A.J.
  TITLE     Genetic and dietary interactions in the regulation of HMG-CoA
            reductase gene expression
  JOURNAL   J Lipid Res 33 (5), 711-725 (1992)
   PUBMED   1352323
REFERENCE   7  (bases 1 to 1609)
  AUTHORS   Ishida,B.Y., Blanche,P.J., Nichols,A.V., Yashar,M. and Paigen,B.
  TITLE     Effects of atherogenic diet consumption on lipoproteins in mouse
            strains C57BL/6 and C3H
  JOURNAL   J Lipid Res 32 (4), 559-568 (1991)
   PUBMED   1856605
REFERENCE   8  (bases 1 to 1609)
  AUTHORS   Paigen,B., Nesbitt,M.N., Mitchell,D., Albee,D. and LeBoeuf,R.C.
  TITLE     Ath-2, a second gene determining atherosclerosis susceptibility and
            high density lipoprotein levels in mice
  JOURNAL   Genetics 122 (1), 163-168 (1989)
   PUBMED   2499515
REFERENCE   9  (bases 1 to 1609)
  AUTHORS   Paigen,B., Mitchell,D., Holmes,P.A. and Albee,D.
  TITLE     Genetic analysis of strains C57BL/6J and BALB/cJ for Ath-1, a gene
            determining atherosclerosis susceptibility in mice
  JOURNAL   Biochem Genet 25 (11-12), 881-892 (1987)
   PUBMED   3450276
REFERENCE   10 (bases 1 to 1609)
  AUTHORS   Paigen,B., Albee,D., Holmes,P.A. and Mitchell,D.
  TITLE     Genetic analysis of murine strains C57BL/6J and C3H/HeJ to confirm
            the map position of Ath-1, a gene determining atherosclerosis
            susceptibility
  JOURNAL   Biochem Genet 25 (7-8), 501-511 (1987)
   PUBMED   3128974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY208852.1, FJ176943.1 and AC163268.4.
            
            On May 1, 2009 this sequence version replaced NM_009452.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U12763.1, LN874397.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               BY208852.1         31-194
            165-741             FJ176943.1         21-597
            742-1609            AC163268.4         168034-168901       c
FEATURES             Location/Qualifiers
     source          1..1609
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 69.75 cM"
     gene            1..1609
                     /gene="Tnfsf4"
                     /gene_synonym="Ath-1; Ath1; CD134L; gp34; OX-40L; Ox40l;
                     Tnlg2b; TXGP1; Txgp1l"
                     /note="tumor necrosis factor (ligand) superfamily, member
                     4"
                     /db_xref="GeneID:22164"
                     /db_xref="MGI:MGI:104511"
     exon            1..306
                     /gene="Tnfsf4"
                     /gene_synonym="Ath-1; Ath1; CD134L; gp34; OX-40L; Ox40l;
                     Tnlg2b; TXGP1; Txgp1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..741
                     /gene="Tnfsf4"
                     /gene_synonym="Ath-1; Ath1; CD134L; gp34; OX-40L; Ox40l;
                     Tnlg2b; TXGP1; Txgp1l"
                     /note="tax-transcriptionally activated glycoprotein 1
                     ligand; atherosclerosis 1; OX40 ligand; tumor necrosis
                     factor ligand 2b"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     4"
                     /protein_id="NP_033478.1"
                     /db_xref="CCDS:CCDS15416.1"
                     /db_xref="GeneID:22164"
                     /db_xref="MGI:MGI:104511"
                     /translation="MEGEGVQPLDENLENGSRPRFKWKKTLRLVVSGIKGAGMLLCFI
                     YVCLQLSSSPAKDPPIQRLRGAVTRCEDGQLFISSYKNEYQTMEVQNNSVVIKCDGLY
                     IIYLKGSFFQEVKIDLHFREDHNPISIPMLNDGRRIVFTVVASLAFKDKVYLTVNAPD
                     TLCEHLQINDGELIVVQLTPGYCAPEGSYHSTVNQVPL"
     exon            307..349
                     /gene="Tnfsf4"
                     /gene_synonym="Ath-1; Ath1; CD134L; gp34; OX-40L; Ox40l;
                     Tnlg2b; TXGP1; Txgp1l"
                     /inference="alignment:Splign:2.1.0"
     exon            350..1609
                     /gene="Tnfsf4"
                     /gene_synonym="Ath-1; Ath1; CD134L; gp34; OX-40L; Ox40l;
                     Tnlg2b; TXGP1; Txgp1l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgcttttt gtctcctgtt ctgggacctt tatcttctga cccgcaggct tgactttgcc
       61 cttattggct cctttgtggt gaagagcagt cttcccccag gttccccgcc acagctgtat
      121 ctcctctgca ccccgactgc agagatggaa ggggaagggg ttcaacccct ggatgagaat
      181 ctggaaaacg gatcaaggcc aagattcaag tggaagaaga cgctaaggct ggtggtctct
      241 gggatcaagg gagcagggat gcttctgtgc ttcatctatg tctgcctgca actctcttcc
      301 tctccggcaa aggaccctcc aatccaaaga ctcagaggag cagttaccag atgtgaggat
      361 gggcaactat tcatcagctc atacaagaat gagtatcaaa ctatggaggt gcagaacaat
      421 tcggttgtca tcaagtgcga tgggctttat atcatctacc tgaagggctc ctttttccag
      481 gaggtcaaga ttgaccttca tttccgggag gatcataatc ccatctctat tccaatgctg
      541 aacgatggtc gaaggattgt cttcactgtg gtggcctctt tggctttcaa agataaagtt
      601 tacctgactg taaatgctcc tgatactctc tgcgaacacc tccagataaa tgatggggag
      661 ctgattgttg tccagctaac gcctggatac tgtgctcctg aaggatctta ccacagcact
      721 gtgaaccaag taccactgtg aattccactc tgagggtgga cgggacacag gttctttctc
      781 gagagagatg agtgcatcct gctcatgaga tgtgactgaa tgcagagcct accctacttc
      841 ctcactcagg gatatttaaa tcatgtctta cataacagtt gacctctcat tcccaggatt
      901 gccttgagcc tgctaagagc tgttctggga atgaaaaaaa aaataaatgt ctcttcaaga
      961 cacattgctt ctgtcggtca gaagctcatc gtaataaaca tctgccactg aaaatggcgc
     1021 ttgattgcta tcttctagaa ttttgatgtt gtcaaaagaa agcaaaacat ggaaagggtg
     1081 gtgtccaccg gccagtagga gctggagtgc tctcttcaag gttaaggtga tagaagttta
     1141 catgttgcct aaaactgtct ctcatctcat ggggggcttg gaaagaagat taccccgtgg
     1201 aaagcaggac ttgaagatga ctgtttaagc aacaaggtgc actcttttcc tggcccctga
     1261 atacacataa aagacaactt ccttcaaaga actacctagg gactatgata cccaccaaag
     1321 aaccacgtca gcgatgcaaa gaaaaccagg agagctttgt ttattttgca gagtatacga
     1381 gagattttac cctgagggct atttttatta tacaggatga gagtgaactg gatgtctcag
     1441 gataaaggcc aagaaggatt tttcacagtc tgagcaagac tgtttttgta ggttctctct
     1501 ccaaaacttt taggtaaatt tttgataatt ttaaaatttt tagttatatt tttggaccat
     1561 tttcaataga agattgaaac atttccagat ggtttcatat ccccacaag
//
