LOCUS       NM_183391               3113 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus tumor necrosis factor (ligand) superfamily, member 18
            (Tnfsf18), mRNA.
ACCESSION   NM_183391
VERSION     NM_183391.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3113)
  AUTHORS   Gan,Y., Zhou,H., Guo,Y., Huang,B., Liu,H., Wang,Z., Li,Z., Zhao,X.,
            Zhu,H., Han,Q., Ye,H., He,J., Wang,Q., Li,Z. and Sun,X.
  TITLE     A GITRL-mTORC1-GM-CSF Positive Loop Promotes Pathogenic Th17
            Response in Primary Sjogren Syndrome
  JOURNAL   Arthritis Rheumatol 76 (9), 1419-1430 (2024)
   PUBMED   38589318
  REMARK    GeneRIF: A GITRL-mTORC1-GM-CSF Positive Loop Promotes Pathogenic
            Th17 Response in Primary Sjogren Syndrome.
REFERENCE   2  (bases 1 to 3113)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3113)
  AUTHORS   Li,L., He,Y., Liu,K., Liu,L., Shan,S., Liu,H., Ren,J., Sun,S.,
            Wang,M., Jia,J. and Wang,P.
  TITLE     GITRL impairs hepatocyte repopulation by liver progenitor cells to
            aggravate inflammation and fibrosis by GITR+CD8+ T lymphocytes in
            CDE Mice
  JOURNAL   Cell Death Dis 15 (2), 114 (2024)
   PUBMED   38321001
  REMARK    GeneRIF: GITRL impairs hepatocyte repopulation by liver progenitor
            cells to aggravate inflammation and fibrosis by GITR[+]CD8[+] T
            lymphocytes in CDE Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3113)
  AUTHORS   Tian,J., Zhang,B., Yuan,Q., Sun,X., Peng,N., Zhu,B., Liu,C.,
            Wang,X., Han,M., Cao,M., Xiao,F., Wang,S., Rui,K. and Lu,L.
  TITLE     GITRL impairs the immunosuppressive function of MDSCs via
            PTEN-mediated signaling pathway in experimental Sjogren syndrome
  JOURNAL   Inflamm Res 71 (12), 1577-1588 (2022)
   PUBMED   36301339
  REMARK    GeneRIF: GITRL impairs the immunosuppressive function of MDSCs via
            PTEN-mediated signaling pathway in experimental Sjogren syndrome.
REFERENCE   5  (bases 1 to 3113)
  AUTHORS   Wang,Y., Liu,B., Niu,C., Zou,W., Yang,L., Wang,T., Tian,D., Luo,Z.,
            Dai,J., Li,Q., Liu,E., Gong,C., Fu,Z. and Ding,F.
  TITLE     Blockade of GITRL/GITR signaling pathway attenuates house dust
            mite-induced allergic asthma in mice through inhibition of MAPKs
            and NF-kappaB signaling
  JOURNAL   Mol Immunol 137, 238-246 (2021)
   PUBMED   34293591
  REMARK    GeneRIF: Blockade of GITRL/GITR signaling pathway attenuates house
            dust mite-induced allergic asthma in mice through inhibition of
            MAPKs and NF-kappaB signaling.
REFERENCE   6  (bases 1 to 3113)
  AUTHORS   Stephens,G.L., McHugh,R.S., Whitters,M.J., Young,D.A.,
            Luxenberg,D., Carreno,B.M., Collins,M. and Shevach,E.M.
  TITLE     Engagement of glucocorticoid-induced TNFR family-related receptor
            on effector T cells by its ligand mediates resistance to
            suppression by CD4+CD25+ T cells
  JOURNAL   J Immunol 173 (8), 5008-5020 (2004)
   PUBMED   15470044
  REMARK    GeneRIF: GITR-L provides an important signal for CD25- T cells,
            rendering them resistant to CD25+ -mediated regulation at the
            initiation of the immune response.
REFERENCE   7  (bases 1 to 3113)
  AUTHORS   Ji,H.B., Liao,G., Faubion,W.A., Abadia-Molina,A.C., Cozzo,C.,
            Laroux,F.S., Caton,A. and Terhorst,C.
  TITLE     Cutting edge: the natural ligand for glucocorticoid-induced TNF
            receptor-related protein abrogates regulatory T cell suppression
  JOURNAL   J Immunol 172 (10), 5823-5827 (2004)
   PUBMED   15128759
  REMARK    GeneRIF: A soluble form of mouse GITR ligand (sGITR-L) induces
            GITR-dependent NF-kappa B activation and blocks in vitro
            suppression mediated by both resting and preactivated polyclonal
            and antigen-specific regulatory T (Treg) cells.
REFERENCE   8  (bases 1 to 3113)
  AUTHORS   Tone,M., Tone,Y., Adams,E., Yates,S.F., Frewin,M.R., Cobbold,S.P.
            and Waldmann,H.
  TITLE     Mouse glucocorticoid-induced tumor necrosis factor receptor ligand
            is costimulatory for T cells
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 15059-15064 (2003)
   PUBMED   14608036
  REMARK    GeneRIF: glucocorticoid-induced tumor necrosis factor receptor
            ligand is costimulatory for T cells
REFERENCE   9  (bases 1 to 3113)
  AUTHORS   Kim,J.D., Choi,B.K., Bae,J.S., Lee,U.H., Han,I.S., Lee,H.W.,
            Youn,B.S., Vinay,D.S. and Kwon,B.S.
  TITLE     Cloning and characterization of GITR ligand
  JOURNAL   Genes Immun 4 (8), 564-569 (2003)
   PUBMED   14647196
REFERENCE   10 (bases 1 to 3113)
  AUTHORS   Yu,K.Y., Kim,H.S., Song,S.Y., Min,S.S., Jeong,J.J. and Youn,B.S.
  TITLE     Identification of a ligand for glucocorticoid-induced tumor
            necrosis factor receptor constitutively expressed in dendritic
            cells
  JOURNAL   Biochem Biophys Res Commun 310 (2), 433-438 (2003)
   PUBMED   14521928
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163268.4.
            
            On Dec 20, 2021 this sequence version replaced NM_183391.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ577579.1, SRR11927932.2113863.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AC163268.4         91395-91590         c
            197-230             AC163268.4         85738-85771         c
            231-3113            AC163268.4         79908-82790         c
FEATURES             Location/Qualifiers
     source          1..3113
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 69.75 cM"
     gene            1..3113
                     /gene="Tnfsf18"
                     /gene_synonym="Gitrl; Tnlg2a"
                     /note="tumor necrosis factor (ligand) superfamily, member
                     18"
                     /db_xref="GeneID:240873"
                     /db_xref="MGI:MGI:2673064"
     exon            1..196
                     /gene="Tnfsf18"
                     /gene_synonym="Gitrl; Tnlg2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..583
                     /gene="Tnfsf18"
                     /gene_synonym="Gitrl; Tnlg2a"
                     /note="GITR ligand; glucocorticoid-induced-tumor necrosis
                     factor receptor ligand; glucocorticoid-induced TNF-related
                     ligand; tumor necrosis factor ligand 2a"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     18"
                     /protein_id="NP_899247.3"
                     /db_xref="CCDS:CCDS15417.1"
                     /db_xref="GeneID:240873"
                     /db_xref="MGI:MGI:2673064"
                     /translation="MEEMPLRESSPQRAERCKKSWLLCIVALLLMLLCSLGTLIYTSL
                     KPTAIESCMVKFELSSSKWHMTSPKPHCVNTTSDGKLKILQSGTYLIYGQVIPVDKKY
                     IKDNAPFVVQIYKKNDVLQTLMNDFQILPIGGVYELHAGDNIYLKFNSKDHIQKTNTY
                     WGIILMPDLPFIS"
     exon            197..230
                     /gene="Tnfsf18"
                     /gene_synonym="Gitrl; Tnlg2a"
                     /inference="alignment:Splign:2.1.0"
     exon            231..3113
                     /gene="Tnfsf18"
                     /gene_synonym="Gitrl; Tnlg2a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3089..3094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfsf18"
                     /gene_synonym="Gitrl; Tnlg2a"
                     /note="hexamer: AATAAA"
     polyA_site      3113
                     /gene="Tnfsf18"
                     /gene_synonym="Gitrl; Tnlg2a"
                     /note="major polyA site"
ORIGIN      
        1 atcacttgtg ggtatctgct ttccccagtt ctcattccat cagagaacga gttctagcct
       61 catggaggaa atgcctttga gagaatcaag tcctcaaagg gcagagaggt gcaagaagtc
      121 atggctcttg tgcatagtgg ctctgttact gatgttgctc tgttctttgg gtacactgat
      181 ctatacttca ctcaagccaa ctgccatcga gtcctgcatg gttaagtttg aactatcatc
      241 ctcaaaatgg cacatgacat ctcccaaacc tcactgtgtg aatacgacat ctgatgggaa
      301 gctgaagata ctgcagagtg gcacatattt aatctacggc caagtgattc ctgtggataa
      361 gaaatacata aaagacaatg cccccttcgt agtacagata tataaaaaga atgatgtcct
      421 acaaactcta atgaatgatt ttcaaatctt gcctatagga ggggtttatg aactgcatgc
      481 tggagataac atatatctga agttcaactc taaagaccat attcagaaaa ctaacacata
      541 ctgggggatc atcttaatgc ctgatctacc attcatctct tagagattgg gtttggtctc
      601 ctcatcttct tctttgtatc ccgagatgct ggtgggtggg ttggaggggg atgattgatg
      661 gcaatgcaca cagtttgtga gggcttacaa attgacacaa tcagagcctc ttggcatata
      721 aaattttagc cctcatatct gtctgaagag gactcagcaa atgggccaat ccctaatgtt
      781 gggtctgcaa atggacttgt acaatccatg ataaaaagga gtatgggcca cagaagacag
      841 aaactcttcc aaagaatgtc tttctaacct tgatccctgg gtagaatgag atcctgtttc
      901 catgggagtc ttacttggct tgcaaaaaag ggtgtagggc agtagcttgg ccttttttcc
      961 atcataattt ccttgagctg ttttacctta atccctccaa actctcacct tctgagagcc
     1021 tcctaatgaa acattgttag actggtgggg tggccaagac atgccaacaa cacccttctt
     1081 tagaggtggt gtttttagag gacagagaac attatgaagc ctagagcagc agaggtcaag
     1141 atgccacgaa atggaattga tctgggaatt tttttttttt ttcattctca ggatgcaggt
     1201 tcattctgaa ctttccccta ggccttcatt gcttttgtgt gtatgtgtgc ataaattctg
     1261 caaatagaaa aatgagagtt tgcaccagta ctcactagat ttaacaccag aaagtggtac
     1321 ttttctggct gtattatgcc atgatagcac attttctgtt ggtgttccct aactgacaag
     1381 tataacagtt ttcctaaacc acacaacaat gctatgatgt taatggggta gatatttttg
     1441 gaaaaaaatt gcacagtgag aacatgggta gatgaaccct aagactctta cctcaattca
     1501 gaactcgcaa ggagttaagt gagtggggtc ttcattagac cattcacatg gtctctgctt
     1561 tgaaactggc gttgctactg tctcattata catcactaaa atggaattaa ctcaactttg
     1621 aaatggatgc atcgacttta ccccaaggtg tccagaatga agctacaaga cttttaccag
     1681 cagtcatttt ccttttgcct ggagcaagaa gatccaggat actgttggaa gagttcatct
     1741 cactcaacca tgctgacttt ccaaagtaat aatgaacatt tgtgttcaaa ttttggattc
     1801 tgttaaattt agccagcttg tgagttcttg tcgaaaagta ttttaaacca atttacacta
     1861 tttatgggta tttgtgaaaa gctatatagt gatattttat atataactaa tttaaaatat
     1921 ttttatttta tgtaacaaaa atactatagg ctaagctatt tcttcttatt tttttatgaa
     1981 tacttgctga attgccatag ggcacaaaga ctcttctgtt tgcatatctt ctcaggaaat
     2041 taaaattgta tcacatgtat ttataagaat ctgttagtgt tgttatttgt tgtgttgtaa
     2101 gcaccactgt tgggataggc taccactact tcataggaac caattactta atttttagga
     2161 attttgtagt ttgagaattt ttatactatg gagattggca aacattacaa accagaacat
     2221 ttctttcgga aaactggctc actaggacac cattcttcgt aaaagttcct ctccctctcc
     2281 ctttccctct ccctctctcc ctgtccctgt ccctgtcccc gtccccgtcc acatccacgt
     2341 ccccgtcccc gtccccctcc ccctctccct ccccctccct ctcctccctc tcctccctct
     2401 cccttcctct ccctcccccc tccccctccc tattcctctc cctctccctc cctcccctcc
     2461 ctcctcctcc caccctctct gtgtatgtgt tatgttgttt gtatgtattg catgcaatta
     2521 tttaggtgtg cacatgtatg tgttgtgcga gagcctgtgc aagtgtgtat gtgcttgtgg
     2581 gtgtggcact gagtgtcttc cttagttcct ctacccctta atctttgaga cgtggtgatc
     2641 tctccctgaa cccagagttc atctatttgg cttggcctgc ccaccatttg gctctaagga
     2701 tctagctatt gctgctcacc agccacagtt ctcagattac aggtgtgtgc cgctatgcct
     2761 ggatatcaca tggattttgg agatctaaac ttaggtcctt atacttacat agcaggcatg
     2821 ctatccacag agttatttct ggaacttaat gatgtcattc tgtccctgtc ttattcttag
     2881 gacaatcaag gcagatagaa aacgaaaaaa atgatattgc cacataccca gcaaaggccc
     2941 aacagaattg tgattttttt ttaagtacca gtgggattca gacagaggga tagctagcaa
     3001 catatagcat ctgaatttct tccaatgtta tcatttcagc ttttgcgttc aatgtatact
     3061 caactctttt tctctatttt aaaactacaa taaaatatgt atttataatt gta
//
