LOCUS       NM_177371               5777 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Mus musculus tumor necrosis factor (ligand) superfamily, member 15
            (Tnfsf15), mRNA.
ACCESSION   NM_177371
VERSION     NM_177371.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5777)
  AUTHORS   Liu,X., Zhang,J., Zhang,D., Pan,Y., Zeng,R., Xu,C., Shi,S., Xu,J.,
            Qi,Q., Dong,X., Wang,J., Liu,T. and Dong,L.
  TITLE     Necroptosis plays a role in TL1A-induced airway inflammation and
            barrier damage in asthma
  JOURNAL   Respir Res 25 (1), 271 (2024)
   PUBMED   38987753
  REMARK    GeneRIF: Necroptosis plays a role in TL1A-induced airway
            inflammation and barrier damage in asthma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5777)
  AUTHORS   Schmitt,P., Duval,A., Camus,M., Lefrancais,E., Roga,S., Dedieu,C.,
            Ortega,N., Bellard,E., Mirey,E., Mouton-Barbosa,E.,
            Burlet-Schiltz,O., Gonzalez-de-Peredo,A., Cayrol,C. and Girard,J.P.
  TITLE     TL1A is an epithelial alarmin that cooperates with IL-33 for
            initiation of allergic airway inflammation
  JOURNAL   J Exp Med 221 (6) (2024)
   PUBMED   38597952
  REMARK    GeneRIF: TL1A is an epithelial alarmin that cooperates with IL-33
            for initiation of allergic airway inflammation.
REFERENCE   3  (bases 1 to 5777)
  AUTHORS   Wang,S., Kozai,M., Hiraishi,M., Rubel,M.Z.U., Ichii,O., Inaba,M.,
            Matsuo,K. and Takada,K.
  TITLE     Roles of tumor necrosis factor-like ligand 1A in gammadeltaT-cell
            activation and psoriasis pathogenesis
  JOURNAL   Front Immunol 15, 1340467 (2024)
   PUBMED   38348035
  REMARK    GeneRIF: Roles of tumor necrosis factor-like ligand 1A in
            gammadeltaT-cell activation and psoriasis pathogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5777)
  AUTHORS   Gu,X., Zhu,Y., Zhao,C., Cao,Y., Wang,J., Zhang,Q. and Li,L.
  TITLE     TNFSF15 facilitates the differentiation of CD11b+ myeloid cells
            into vascular pericytes in tumors
  JOURNAL   Cancer Biol Med 20 (11), 869-884 (2023)
   PUBMED   37921408
  REMARK    GeneRIF: TNFSF15 facilitates the differentiation of CD11b[+]
            myeloid cells into vascular pericytes in tumors.
REFERENCE   5  (bases 1 to 5777)
  AUTHORS   Wu,B., Wu,B., Benkaci,S., Shi,L., Lu,P., Park,T., Morrow,B.E.,
            Wang,Y. and Zhou,B.
  TITLE     Crk and Crkl Are Required in the Endocardial Lineage for Heart
            Valve Development
  JOURNAL   J Am Heart Assoc 12 (18), e029683 (2023)
   PUBMED   37702066
REFERENCE   6  (bases 1 to 5777)
  AUTHORS   Kim,M.Y., Toellner,K.M., White,A., McConnell,F.M., Gaspal,F.M.,
            Parnell,S.M., Jenkinson,E., Anderson,G. and Lane,P.J.
  TITLE     Neonatal and adult CD4+ CD3- cells share similar gene expression
            profile, and neonatal cells up-regulate OX40 ligand in response to
            TL1A (TNFSF15)
  JOURNAL   J Immunol 177 (5), 3074-3081 (2006)
   PUBMED   16920944
  REMARK    GeneRIF: neonatal CD4+ CD3- cells up-regulate both CD30L and OX40L
            after adoptive transfer into an adult recipient
REFERENCE   7  (bases 1 to 5777)
  AUTHORS   Bamias,G., Mishina,M., Nyce,M., Ross,W.G., Kollias,G.,
            Rivera-Nieves,J., Pizarro,T.T. and Cominelli,F.
  TITLE     Role of TL1A and its receptor DR3 in two models of chronic murine
            ileitis
  JOURNAL   Proc Natl Acad Sci U S A 103 (22), 8441-8446 (2006)
   PUBMED   16698931
  REMARK    GeneRIF: induction of intestinal inflammation is associated with
            significant up-regulation of TL1A and tm DR3 in the inflamed mucosa
REFERENCE   8  (bases 1 to 5777)
  AUTHORS   Xiao,Q., Hsu,C.Y., Chen,H., Ma,X., Xu,J. and Lee,J.M.
  TITLE     Characterization of cis-regulatory elements of the vascular
            endothelial growth inhibitor gene promoter
  JOURNAL   Biochem J 388 (Pt 3), 913-920 (2005)
   PUBMED   15702971
  REMARK    GeneRIF: findings suggest that the transcription factor NF-kappaB
            plays an important role in the regulation of VEGI expression
REFERENCE   9  (bases 1 to 5777)
  AUTHORS   Collette,Y., Gilles,A., Pontarotti,P. and Olive,D.
  TITLE     A co-evolution perspective of the TNFSF and TNFRSF families in the
            immune system
  JOURNAL   Trends Immunol 24 (7), 387-394 (2003)
   PUBMED   12860530
  REMARK    Review article
REFERENCE   10 (bases 1 to 5777)
  AUTHORS   Migone,T.S., Zhang,J., Luo,X., Zhuang,L., Chen,C., Hu,B.,
            Hong,J.S., Perry,J.W., Chen,S.F., Zhou,J.X., Cho,Y.H., Ullrich,S.,
            Kanakaraj,P., Carrell,J., Boyd,E., Olsen,H.S., Hu,G., Pukac,L.,
            Liu,D., Ni,J., Kim,S., Gentz,R., Feng,P., Moore,P.A., Ruben,S.M.
            and Wei,P.
  TITLE     TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T
            cell costimulator
  JOURNAL   Immunity 16 (3), 479-492 (2002)
   PUBMED   11911831
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL691468.12.
            
            On Mar 20, 2019 this sequence version replaced NM_177371.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus. The use of an alternative upstream start codon, which
            appears to be rodent-specific, would result in a protein that is 18
            aa longer at the N-terminal.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096494.1, CF905061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               AL691468.12        109522-109772       c
            252-294             AL691468.12        98967-99009         c
            295-333             AL691468.12        98041-98079         c
            334-5777            AL691468.12        89313-94756         c
FEATURES             Location/Qualifiers
     source          1..5777
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 34.06 cM"
     gene            1..5777
                     /gene="Tnfsf15"
                     /gene_synonym="Tl1; Tl1a; Tnlg1b; Vegi"
                     /note="tumor necrosis factor (ligand) superfamily, member
                     15"
                     /db_xref="GeneID:326623"
                     /db_xref="MGI:MGI:2180140"
     exon            1..251
                     /gene="Tnfsf15"
                     /gene_synonym="Tl1; Tl1a; Tnlg1b; Vegi"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..788
                     /gene="Tnfsf15"
                     /gene_synonym="Tl1; Tl1a; Tnlg1b; Vegi"
                     /note="vascular endothelial growth inhibitor; bM20K13.3
                     (tumor necrosis factor (ligand) superfamily, member 15);
                     tumor necrosis factor ligand 1b; TNF ligand-related
                     molecule 1; vascular endothelial cell growth inhibitor"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     15"
                     /protein_id="NP_796345.4"
                     /db_xref="CCDS:CCDS18263.2"
                     /db_xref="GeneID:326623"
                     /db_xref="MGI:MGI:2180140"
                     /translation="MAEELGLGFGEGVPVEVLPEGCRHRPEARAGLAARSKACLALTC
                     CLLSFPILAGLSTLLMAGQLRVPGKDCMLRAITEERSEPSPQQVYSPPRGKPRAHLTI
                     KKQTPAPHLKNQLSALHWEHDLGMAFTKNGMKYINKSLVIPESGDYFIYSQITFRGTT
                     SVCGDISRGRRPNKPDSITMVITKVADSYPEPARLLTGSKSVCEISNNWFQSLYLGAT
                     FSLEEGDRLMVNVSDISLVDYTKEDKTFFGAFLL"
     exon            252..294
                     /gene="Tnfsf15"
                     /gene_synonym="Tl1; Tl1a; Tnlg1b; Vegi"
                     /inference="alignment:Splign:2.1.0"
     exon            295..333
                     /gene="Tnfsf15"
                     /gene_synonym="Tl1; Tl1a; Tnlg1b; Vegi"
                     /inference="alignment:Splign:2.1.0"
     exon            334..5777
                     /gene="Tnfsf15"
                     /gene_synonym="Tl1; Tl1a; Tnlg1b; Vegi"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcagaagtc tctccaagac agcagaagga tggcagagga gctggggttg ggcttcggag
       61 aaggagtccc agtggaagtg ctgccggaag gctgtagaca caggccagag gccagggccg
      121 ggctagctgc caggagcaaa gcctgcctgg ctctcacctg ctgcctgttg tcatttccca
      181 tcctcgcagg acttagcacc ctcctaatgg ctggccagct ccgggtcccc ggaaaagact
      241 gtatgcttcg ggccataaca gaagagagat ctgagccttc accacagcaa gtttactcac
      301 ctcccagagg caagccgaga gcacacctga caattaagaa acaaacccca gcaccacatc
      361 tgaaaaatca gctctctgct ctacactggg aacatgacct agggatggcc ttcaccaaga
      421 acgggatgaa gtacatcaac aaatccctgg tgatcccaga gtcaggagac tatttcatct
      481 actcccagat cacattccga gggaccacat ctgtgtgtgg tgacatcagt cgggggagac
      541 gaccaaacaa gccagactcc atcaccatgg ttatcaccaa ggtagcagac agctaccctg
      601 agcctgcccg cctactaaca gggtccaagt ctgtgtgtga aataagcaac aactggttcc
      661 agtccctcta ccttggggcc acgttctcct tggaagaagg agacagacta atggtaaacg
      721 tcagtgacat ctccttggtg gattacacaa aagaagataa aactttcttt ggagctttct
      781 tgctataagg aggagaaaac catcattcca aggggctccc ctgcctccta ctttccaatt
      841 tccttttctc atatggatct ataaacaggg gctttagagg gatcagggaa ggggacagtg
      901 gtttagctat ataatttagg aacccaatat tgatccgtat atgccttatg gactaaaata
      961 gtaaatggaa aacccagtac agctcatgtt tgatagagac ctgctgggtt ttaaaaattg
     1021 aaacacgcct catccaatgg cacaatctac tgatttcagg acagaacctt tccacagtgc
     1081 cctctgtcca agtcctttct gaattcagca gttcagttag agctgaattc gacaatgaac
     1141 ttactccaga tcaagagcta aagacagaat ccaaagaaag actgagaaaa tgatgttatt
     1201 tctccaagag gcaatgcatt tccacattct tttgtgccta acctaaaaaa taagaaagaa
     1261 gaaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa
     1321 ggaaggaagg aagggacaag aaaagacaag acaagacaag aaaaaagaaa aaatggtatt
     1381 tctcgtgaat attccctaaa aggaattggt tttctgctgt gaaggagaaa cctcaccttt
     1441 cttctgattg catcctttag tatccaaaca tacaagtggg aattccaaat gcacatggaa
     1501 catagaacac ttttattatt gtgagaacat gtttattgag tacctactat gctctgggca
     1561 ctcagcccac aggaccatga agagaaagtc aaattttctt aaaaactaaa tgaatcctca
     1621 atacatactt cctgatcaac taccactcaa aatgtataac ttccaaagta taacttcaag
     1681 tcagccatct aggtggtttc ttgggtaaag gtgcttgtca ttaagcctga cacctgggtt
     1741 tgacctccca gaacccaaaa gctggaagga gagaattggt tcccacaaat tatcctcaaa
     1801 cccccataca aatgatgtgg catgcacaca tgtaactaaa taaataagtg taaaacaaaa
     1861 acaaaaacaa aattttaaag aaaaatttca agtcctgaaa gacagcattc ctgagaatgt
     1921 tgtctccatc gttgtccagt ataggctaac cagctgatag agacactgaa ggaatttaaa
     1981 gacagacatc aagtgaaatg gagcactgta gaaacacttg attcatgcca ggagtcaatg
     2041 tactatgaag accaacaaca aagtgtcagt catcaaatcc agaggtgttt atctagatct
     2101 gctttcaagt ttggtttgca gcctttatat agtctctatt acaaatgctc gtgtcatggt
     2161 agatgccaca aggagtcaga gggtaaactt agccccaaac cactgctgag ccatcttcta
     2221 ggaaaccttc gaagcagagc tgggcagcgt gactcccaca caatgactgg gaaagtagta
     2281 gctgatcaaa atttgttgag taataatttg ttagaaaatt catctccact gcctactaaa
     2341 cctaagttgt atactatcta gcttctgcta agccaactta cattggccac tttttctgtc
     2401 ttcaacttct tgaagtatca caggtctcag tgagaacaca gggaaaggtg aggtcgcctt
     2461 cccctggttc ttcatagggg aaaccacacc tgaaagaaga tgagcagcct gaggtgacct
     2521 ggaggaaggg ctgtctcaga agaaggactt attttttggc ttaggtctaa aaccttgaga
     2581 gtaatgctca ctggtcaatt gaggatgctt tatcaatgac tccagtctga ctccaaggtc
     2641 agaaaggaga gtgagatgct ctctctgcct gcatatatct tcatggaaca tgagaatatt
     2701 gagcaacata gacttatagg aaaacacttg cccaaaagta gccagagtga cctggtcatc
     2761 ccctctacta aacccaagct ttgtgtcaag ggccttcaaa gctgcccaga agtgatctgg
     2821 atggcttggg aatttatcca agacaggaat ttcctgacag ccaaagatgc ttgagtcctt
     2881 gtgcctgaca tgcatttatt ttgcccctgt ttattgaaga ctgtaactgt tgatttgtgg
     2941 gtatacatac atacatacat acatacatac atacatacat acatatgctg tcatgaaggc
     3001 agcatcaaac attactaatt ggactcaaac cagcatttct gtttccaaga tactaagtat
     3061 tcccatgcaa acaggagcat gctatttttc taaagcaaaa tgaaaaaaat agttttgaaa
     3121 gtatatatat gatggagtca agtgtaatgg catacatctg taaacccagc acatgggatg
     3181 ctgagccagg aggattgccg tgagtttgag gagaacaggg gctaaatagt aattttcagg
     3241 aaagccttgc ctatataaca agaccttgtc tcaaatgaaa aaaaaaaaaa aaatagaccc
     3301 caggctggtc cttggagata aggtaatata ttcattgggt gagggggtgt gtgttttgga
     3361 aaatagttaa tttagtgaga aatgcttttc ggtcaaatgc atctcaaagg ctgctgaatt
     3421 caaatcgggt ctgtaaatgc ttacctagtg cttgcttgcc ctggggacag agacataaat
     3481 tactttagtc tcagatccac tcgttctaac agattggcat ctccatcgtc tgtggagctt
     3541 ttaatcactc tgtttgtatt agctaattaa ttagctaact tgagacacac tgatattttc
     3601 ttattataaa catgggtgcc atttgataaa agacaatcat taacaaaatg gttcgaattt
     3661 ccgcttaagt gatcttcttt tttccttttc atttttttta actagctaat caaaggtagt
     3721 ttcccaaaaa taaatgcaaa gggagtataa agaaaaaatt ccctgtggtg ggagctagta
     3781 ttgaaacaac agtatcaaag aggctgttac ctactggcct caaattttgg caggaacgcc
     3841 tttgaaaatg ttagaacttt acggacagcc tagaggtgct ttgaaaagtc tctgttgcca
     3901 acaaaagcca ttaatcagca tgcggcacag gttactcaaa ttttgacctt gactgttttt
     3961 tagatctgtt acacagaaca caacttctgg gctgtaatct ctgatgtgga tttggtgatt
     4021 tactaaggta ccgtgggaaa caaggaaagt gtacttgtac cacatcgttt ctcagtgcat
     4081 gtcagagtct actcaacagc agggcatgcc agagccttgg atacattccg ggacaaacta
     4141 tgtcactcct aaggaaattc caagtgtgtg cctgtcaagc actctggatc atagaagccc
     4201 acgagttcac tgtgcacaag gcacagccat ggccagcact ctcttgcatg gtatttctct
     4261 taagctctta ctcaatcacg gtcccatgat tgtgacattg gggattaatt gcttgagcag
     4321 gtttatttac agtctgttcc ttgcaaaata catgcagata tgtctggcct caaaatcccc
     4381 tgattgtttt agggcttaga gaatactggg gatgtttttg ctgttttcag atgtacttta
     4441 tttaagcttg cagaattacc ctgaatatta acagtgttct aagatattgc ctgctagctt
     4501 ctggctaatt tactagtggt gacagtatca gatcagagta tctatattta tgtcttgcta
     4561 ttatagttaa aacttcctga tctctgtaac acactcaccc ctacctcatc tatctaccca
     4621 tcttgtggat gtagctgtga gaagactcac aagcccgagt tgcagttact tttctgaagc
     4681 aacatagtat gttaatggaa tggccagaac tctactcttg gcacatggca ctgaatttga
     4741 tgccactaaa agaaaaattg aaggcagaaa tattttttac tatgcatggg acaacgtaga
     4801 agagcaagga gactgcttac acatggtggt cacatctctg gcttcatccc taaaccaatt
     4861 ttctgacccc aagtcgattt tttttcatgt agttattgtt cattttctgg aaagagtcaa
     4921 gcaaaaagag agttttatag aaaccattgc atcatggagg tcaggggagg gattaagcca
     4981 aagaattcct tctccaaatc tatagccata tggccaccct ttggtgtact tctatttgat
     5041 catgacaaac ctgagagccc tgcccagagt tcagtggatc ctaatgaact ccaagagtaa
     5101 ttcattccct caccaactct aggggcttgg ccagtgcaga aaatgtcatg ggattttaaa
     5161 gttaacatga gctgctatcc aaacttatgt ctctttaaga atggagagac acaggccagg
     5221 agaggtaaca tatgaagcct ggtattgggc agtagcttga tggagtattg aggctaaaag
     5281 tagacttcct gcccctgacc atacacaaca ccctttcagt ttgatccatg gtggtcttat
     5341 tctactttat tttgagcacc tgtcacacct agttactgtc atgccaagaa ggtccataac
     5401 aggcaaatcc tactctgctg tgtgcacaca agaggaagga ggctcacagt agcaagtaaa
     5461 cagataagca aacgtacacg attttcgtct taaagtcatt aagacacacg cgtacccctc
     5521 ttttgtttca gagggtatac aggctgaaca gatgtcagtg ttcacctatt cttattgata
     5581 agccccatgt gctttcattg gttgaatgtt ttatgttaaa acgtcatatt gccatcgtaa
     5641 aatgcatatt gtatgttgtt gggtatataa ttaactaata tgcatcgcat gtatgaattc
     5701 taatctctgt aaatgaaaac ttatatatgt taacatatgt aatagttata atttaataaa
     5761 ctgacactgg agactac
//
