LOCUS       NM_019418               1907 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Mus musculus tumor necrosis factor (ligand) superfamily, member 14
            (Tnfsf14), mRNA.
ACCESSION   NM_019418
VERSION     NM_019418.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1907)
  AUTHORS   Oranger,A., Colaianni,G., Ingravallo,G., Scarcella,V.S.,
            Faienza,M.F., Grano,M., Colucci,S. and Brunetti,G.
  TITLE     LIGHT/TNFSF14 Affects Adipose Tissue Phenotype
  JOURNAL   Int J Mol Sci 25 (2), 716 (2024)
   PUBMED   38255789
  REMARK    GeneRIF: LIGHT/TNFSF14 Affects Adipose Tissue Phenotype.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1907)
  AUTHORS   Zhang,N., Liu,X., Qin,J., Sun,Y., Xiong,H., Lin,B., Liu,K., Tan,B.,
            Zhang,C., Huang,C., Ren,S., Liu,M. and Du,B.
  TITLE     LIGHT/TNFSF14 promotes CAR-T cell trafficking and cytotoxicity
            through reversing immunosuppressive tumor microenvironment
  JOURNAL   Mol Ther 31 (9), 2575-2590 (2023)
   PUBMED   37408308
  REMARK    GeneRIF: LIGHT/TNFSF14 promotes CAR-T cell trafficking and
            cytotoxicity through reversing immunosuppressive tumor
            microenvironment.
REFERENCE   3  (bases 1 to 1907)
  AUTHORS   Hsu,C.Y., Huang,C.Y., Shih,C.M., Lin,Y.W., Huang,P.H., Lin,S.J.,
            Liu,C.W., Lin,C.Y. and Lin,F.Y.
  TITLE     Tumor Necrosis Factor Superfamily 14 (LIGHT) Restricts
            Neovascularization by Decreasing Circulating Endothelial Progenitor
            Cells and Function
  JOURNAL   Int J Mol Sci 24 (8), 6997 (2023)
   PUBMED   37108160
  REMARK    GeneRIF: Tumor Necrosis Factor Superfamily 14 (LIGHT) Restricts
            Neovascularization by Decreasing Circulating Endothelial Progenitor
            Cells and Function.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1907)
  AUTHORS   Lai,D., Lv,Z., Lu,X., Shang,P., Geng,Y. and Wang,P.
  TITLE     LIGHT Amplification by NF-kappaB Contributes to TLR3 Signaling
            Pathway-Induced Acute Hepatitis
  JOURNAL   Mediators Inflamm 2023, 3732315 (2023)
   PUBMED   36654880
  REMARK    GeneRIF: LIGHT Amplification by NF-kappaB Contributes to TLR3
            Signaling Pathway-Induced Acute Hepatitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1907)
  AUTHORS   Shi,L.N., Zhou,Y., Wu,C., Huang,W., Yuan,F., Chen,J., Wu,Z., Tu,W.,
            Chen,H., Chen,Q., Zhu,M., Peng,H., Yang,Y. and Tang,H.
  TITLE     LIGHT of pulmonary NKT cells annihilates tissue protective alveolar
            macrophages in augmenting severe influenza pneumonia
  JOURNAL   Sci Bull (Beijing) 66 (20), 2124-2134 (2021)
   PUBMED   36654270
  REMARK    GeneRIF: LIGHT of pulmonary NKT cells annihilates tissue protective
            alveolar macrophages in augmenting severe influenza pneumonia.
REFERENCE   6  (bases 1 to 1907)
  AUTHORS   Shaikh,R.B., Santee,S., Granger,S.W., Butrovich,K., Cheung,T.,
            Kronenberg,M., Cheroutre,H. and Ware,C.F.
  TITLE     Constitutive expression of LIGHT on T cells leads to lymphocyte
            activation, inflammation, and tissue destruction
  JOURNAL   J Immunol 167 (11), 6330-6337 (2001)
   PUBMED   11714797
REFERENCE   7  (bases 1 to 1907)
  AUTHORS   Locksley,R.M., Killeen,N. and Lenardo,M.J.
  TITLE     The TNF and TNF receptor superfamilies: integrating mammalian
            biology
  JOURNAL   Cell 104 (4), 487-501 (2001)
   PUBMED   11239407
  REMARK    Review article
REFERENCE   8  (bases 1 to 1907)
  AUTHORS   Tamada,K., Shimozaki,K., Chapoval,A.I., Zhu,G., Sica,G., Flies,D.,
            Boone,T., Hsu,H., Fu,Y.X., Nagata,S., Ni,J. and Chen,L.
  TITLE     Modulation of T-cell-mediated immunity in tumor and
            graft-versus-host disease models through the LIGHT co-stimulatory
            pathway
  JOURNAL   Nat Med 6 (3), 283-289 (2000)
   PUBMED   10700230
REFERENCE   9  (bases 1 to 1907)
  AUTHORS   Misawa,K., Nosaka,T., Kojima,T., Hirai,M. and Kitamura,T.
  TITLE     Molecular cloning and characterization of a mouse homolog of human
            TNFSF14, a member of the TNF superfamily
  JOURNAL   Cytogenet Cell Genet 89 (1-2), 89-91 (2000)
   PUBMED   10894944
REFERENCE   10 (bases 1 to 1907)
  AUTHORS   Matsumoto,M.
  TITLE     Role of TNF ligand and receptor family in the lymphoid
            organogenesis defined by gene targeting
  JOURNAL   J Med Invest 46 (3-4), 141-150 (1999)
   PUBMED   10687308
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025692.15.
            
            On Oct 17, 2022 this sequence version replaced NM_019418.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB029155.1, BC125479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               CT025692.15        77062-77387         c
            327-363             CT025692.15        76108-76144         c
            364-405             CT025692.15        75764-75805         c
            406-1907            CT025692.15        72642-74143         c
FEATURES             Location/Qualifiers
     source          1..1907
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.71 cM"
     gene            1..1907
                     /gene="Tnfsf14"
                     /gene_synonym="HVEM-L; HVEML; LIGHT; LTg; Ly113; Tnlg1d"
                     /note="tumor necrosis factor (ligand) superfamily, member
                     14"
                     /db_xref="GeneID:50930"
                     /db_xref="MGI:MGI:1355317"
     exon            1..326
                     /gene="Tnfsf14"
                     /gene_synonym="HVEM-L; HVEML; LIGHT; LTg; Ly113; Tnlg1d"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..833
                     /gene="Tnfsf14"
                     /gene_synonym="HVEM-L; HVEML; LIGHT; LTg; Ly113; Tnlg1d"
                     /note="tumor necrosis factor ligand 1d"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     14"
                     /protein_id="NP_062291.1"
                     /db_xref="CCDS:CCDS28928.1"
                     /db_xref="GeneID:50930"
                     /db_xref="MGI:MGI:1355317"
                     /translation="MESVVQPSVFVVDGQTDIPFRRLEQNHRRRRCGTVQVSLALVLL
                     LGAGLATQGWFLLRLHQRLGDIVAHLPDGGKGSWEKLIQDQRSHQANPAAHLTGANAS
                     LIGIGGPLLWETRLGLAFLRGLTYHDGALVTMEPGYYYVYSKVQLSGVGCPQGLANGL
                     PITHGLYKRTSRYPKELELLVSRRSPCGRANSSRVWWDSSFLGGVVHLEAGEEVVVRV
                     PGNRLVRPRDGTRSYFGAFMV"
     exon            327..363
                     /gene="Tnfsf14"
                     /gene_synonym="HVEM-L; HVEML; LIGHT; LTg; Ly113; Tnlg1d"
                     /inference="alignment:Splign:2.1.0"
     exon            364..405
                     /gene="Tnfsf14"
                     /gene_synonym="HVEM-L; HVEML; LIGHT; LTg; Ly113; Tnlg1d"
                     /inference="alignment:Splign:2.1.0"
     exon            406..1907
                     /gene="Tnfsf14"
                     /gene_synonym="HVEM-L; HVEML; LIGHT; LTg; Ly113; Tnlg1d"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1850..1855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfsf14"
                     /gene_synonym="HVEM-L; HVEML; LIGHT; LTg; Ly113; Tnlg1d"
                     /note="hexamer: AATAAA"
     regulatory      1854..1859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfsf14"
                     /gene_synonym="HVEM-L; HVEML; LIGHT; LTg; Ly113; Tnlg1d"
                     /note="hexamer: AATAAA"
     polyA_site      1872
                     /gene="Tnfsf14"
                     /gene_synonym="HVEM-L; HVEML; LIGHT; LTg; Ly113; Tnlg1d"
                     /note="major polyA site"
     regulatory      1875..1880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfsf14"
                     /gene_synonym="HVEM-L; HVEML; LIGHT; LTg; Ly113; Tnlg1d"
                     /note="hexamer: AATAAT"
     polyA_site      1876
                     /gene="Tnfsf14"
                     /gene_synonym="HVEM-L; HVEML; LIGHT; LTg; Ly113; Tnlg1d"
                     /note="major polyA site"
     polyA_site      1907
                     /gene="Tnfsf14"
                     /gene_synonym="HVEM-L; HVEML; LIGHT; LTg; Ly113; Tnlg1d"
ORIGIN      
        1 cttttgcagt ttgcacagcc cgagcgtgtt gggcaattgt ggtttcctcc ggagaggagg
       61 aactcaggct tgccaaccct ttccctgggc ttcggagcct cagctgctct ggcatggaga
      121 gtgtggtaca gccttcagtg tttgtggtgg atggacagac ggacatccca ttcaggcggc
      181 tggaacagaa ccaccggaga cggcgctgtg gcactgtcca ggtcagcctg gccctggtgc
      241 tgctgctagg tgctgggctg gccactcagg gctggtttct cctgagactg catcaacgtc
      301 ttggagacat agtagctcat ctgccagatg gaggcaaagg ctcctgggag aagctgatac
      361 aagatcaacg atctcaccag gccaacccag cagcacatct tacaggagcc aacgccagct
      421 tgataggtat tggtggacct ctgttatggg agacacgact tggcctggcc ttcttgaggg
      481 gcttgacgta tcatgatggg gccctggtga ccatggagcc cggttactac tatgtgtact
      541 ccaaagtgca gctgagcggc gtgggctgcc cccaggggct ggccaatggc ctccccatca
      601 cccatggact atacaagcgc acatcccgct acccgaagga gttagaactg ctggtcagtc
      661 ggcggtcacc ctgtggccgg gccaacagct cccgagtctg gtgggacagc agcttcctgg
      721 gcggcgtggt acatctggag gctggggaag aggtggtggt ccgcgtgcct ggaaaccgcc
      781 tggtcagacc acgtgacggc accaggtcct atttcggagc tttcatggtc tgaaggctgc
      841 ggtgacaatg tattttgtgg agggacctct ccaggactca cctcaaaccc agcaataggg
      901 tttgaagtcc tccctttaag gagccctgaa ctctgcagtg ctcggggcgg tgtagactgc
      961 tgacctgctt tgggcaatct tcaaatcaga gacctggaga cttggggcgt ggagcccagg
     1021 agcgaggggt cagctcattt gcctgatatt caggaagaaa gaatcaagct ggggtattta
     1081 tgcttctgat gcaaacactg agatttcggc tttctgggtt ttgagctgga ggcaagaaac
     1141 cttcccagag tgtcatcagg accatgttgg caggacttgg ggctccagac ttgccaccac
     1201 actctggcct ctcccatcca tccgctgcat tggtttccag ccaccaaaac agcactggcc
     1261 ccctggctgc aactggccag gtacgagctt ctgagcacct acattcctca gggacatctt
     1321 gatgagatct cagtactcag tccaatgcgc agcagcgaca gacatgccag gaatggttgg
     1381 tcagaaggga agggaggaaa gggaggaaag aagggaatgc agaagagaag gggggaaaac
     1441 aagaccaaaa caaaacagca acaacaaagc ggcagggagg aggtgacacc cttggggata
     1501 ctttagtcaa cacacttaga acagattgtg ccaggcctgt tggattcctg gagttgatgg
     1561 gatcgtggga aggcacaatg gggagcaagt gggcttgggt tatggctcag tgggtaaagt
     1621 gcaattatgg ggatctgagt ttgaatccct ggtacccata taaagacaca gatgcggtga
     1681 tgggcacttg tgacaatgag atcatcaata gggaatggag acaggaggga cctctggggt
     1741 tcactggcca ggcagtctag ctgaatcaaa gagctccaag ttcagtcgat agctcctgaa
     1801 gatgacaact gaggctattc tccaaacccc acacgcagga cacatgcgta ataaataaaa
     1861 ttttaaaaat attaaataat agtgtttgag aggcacttta tatgttc
//
