LOCUS       NM_033622               1699 bp    mRNA    linear   ROD 09-OCT-2023
DEFINITION  Mus musculus tumor necrosis factor (ligand) superfamily, member 13b
            (Tnfsf13b), transcript variant 1, mRNA.
ACCESSION   NM_033622
VERSION     NM_033622.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1699)
  AUTHORS   Doll JR, Moreno-Fernandez ME, Stankiewicz TE, Wayland JL, Wilburn
            A, Weinhaus B, Chougnet CA, Giordano D, Cappelletti M, Presicce P,
            Kallapur SG, Salomonis N, Tilburgs T and Divanovic S.
  TITLE     BAFF and APRIL counterregulate susceptibility to
            inflammation-induced preterm birth
  JOURNAL   Cell Rep 42 (4), 112352 (2023)
   PUBMED   37027297
  REMARK    GeneRIF: BAFF and APRIL counterregulate susceptibility to
            inflammation-induced preterm birth.
REFERENCE   2  (bases 1 to 1699)
  AUTHORS   Giordano D, Kuley R, Draves KE, Elkon KB, Giltiay NV and Clark EA.
  TITLE     B cell-activating factor (BAFF) from dendritic cells, monocytes and
            neutrophils is required for B cell maturation and autoantibody
            production in SLE-like autoimmune disease
  JOURNAL   Front Immunol 14, 1050528 (2023)
   PUBMED   36923413
  REMARK    GeneRIF: B cell-activating factor (BAFF) from dendritic cells,
            monocytes and neutrophils is required for B cell maturation and
            autoantibody production in SLE-like autoimmune disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1699)
  AUTHORS   Kanemitsu-Okada K, Abe M, Nakamura Y, Miyake T, Watanabe T, Yoshida
            O, Koizumi Y, Hirooka M, Tokumoto Y, Matsuura B, Koizumi M and
            Hiasa Y.
  TITLE     Role of B Cell-Activating Factor in Fibrosis Progression in a
            Murine Model of Non-Alcoholic Steatohepatitis
  JOURNAL   Int J Mol Sci 24 (3), 2509 (2023)
   PUBMED   36768854
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1699)
  AUTHORS   Stohl W, Yu N and Wu Y.
  TITLE     B Cell and T Cell Dissimilarities in BAFF-Deficient versus
            BR3-Deficient C57BL/6 Mice
  JOURNAL   J Immunol 209 (11), 2133-2140 (2022)
   PUBMED   36426969
  REMARK    GeneRIF: B Cell and T Cell Dissimilarities in BAFF-Deficient versus
            BR3-Deficient C57BL/6 Mice.
REFERENCE   5  (bases 1 to 1699)
  AUTHORS   Liu W, Stachura P, Xu HC, Varaljai R, Shinde P, Ganesh NU, Mack M,
            Van Lierop A, Huang A, Sundaram B, Lang KS, Picard D, Fischer U,
            Remke M, Homey B, Roesch A, Haussinger D, Lang PA, Borkhardt A and
            Pandyra AA.
  TITLE     BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor
            Microenvironment
  JOURNAL   Cancer Res 82 (2), 264-277 (2022)
   PUBMED   34810198
  REMARK    GeneRIF: BAFF Attenuates Immunosuppressive Monocytes in the
            Melanoma Tumor Microenvironment.
REFERENCE   6  (bases 1 to 1699)
  AUTHORS   Yu G, Boone T, Delaney J, Hawkins N, Kelley M, Ramakrishnan M,
            McCabe S, Qiu WR, Kornuc M, Xia XZ, Guo J, Stolina M, Boyle WJ,
            Sarosi I, Hsu H, Senaldi G and Theill LE.
  TITLE     APRIL and TALL-I and receptors BCMA and TACI: system for regulating
            humoral immunity
  JOURNAL   Nat Immunol 1 (3), 252-256 (2000)
   PUBMED   10973284
REFERENCE   7  (bases 1 to 1699)
  AUTHORS   Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill
            LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K,
            Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY,
            Boyle WJ and Hsu H.
  TITLE     TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis
            factor family member involved in B cell regulation
  JOURNAL   J Exp Med 192 (1), 137-143 (2000)
   PUBMED   10880535
REFERENCE   8  (bases 1 to 1699)
  AUTHORS   Gross JA, Johnston J, Mudri S, Enselman R, Dillon SR, Madden K, Xu
            W, Parrish-Novak J, Foster D, Lofton-Day C, Moore M, Littau A,
            Grossman A, Haugen H, Foley K, Blumberg H, Harrison K, Kindsvogel W
            and Clegg CH.
  TITLE     TACI and BCMA are receptors for a TNF homologue implicated in
            B-cell autoimmune disease
  JOURNAL   Nature 404 (6781), 995-999 (2000)
   PUBMED   10801128
REFERENCE   9  (bases 1 to 1699)
  AUTHORS   Mackay F, Woodcock SA, Lawton P, Ambrose C, Baetscher M, Schneider
            P, Tschopp J and Browning JL.
  TITLE     Mice transgenic for BAFF develop lymphocytic disorders along with
            autoimmune manifestations
  JOURNAL   J Exp Med 190 (11), 1697-1710 (1999)
   PUBMED   10587360
REFERENCE   10 (bases 1 to 1699)
  AUTHORS   Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N,
            Ambrose C, Lawton P, Bixler S, Acha-Orbea H, Valmori D, Romero P,
            Werner-Favre C, Zubler RH, Browning JL and Tschopp J.
  TITLE     BAFF, a novel ligand of the tumor necrosis factor family,
            stimulates B cell growth
  JOURNAL   J Exp Med 189 (11), 1747-1756 (1999)
   PUBMED   10359578
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF119383.1.
            
            [WARNING] On Oct 19, 2023 this sequence was replaced by
            NM_033622.3.
            
            On Dec 21, 2017 this sequence version replaced NM_033622.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF119383.1, AF352245.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1699              AF119383.1         7-1705
FEATURES             Location/Qualifiers
     source          1..1699
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 4.55 cM"
     gene            1..1699
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; BLyS; D8Ertd387e; TALL-1; TALL1;
                     THANK; TNFSF20; Tnlg7a; zTNF4"
                     /note="tumor necrosis factor (ligand) superfamily, member
                     13b"
                     /db_xref="GeneID:24099"
                     /db_xref="MGI:MGI:1344376"
     exon            1..528
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; BLyS; D8Ertd387e; TALL-1; TALL1;
                     THANK; TNFSF20; Tnlg7a; zTNF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1140
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; BLyS; D8Ertd387e; TALL-1; TALL1;
                     THANK; TNFSF20; Tnlg7a; zTNF4"
                     /note="isoform 1 is encoded by transcript variant 1; b
                     cell-activating factor; tumor necrosis factor ligand 7a"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     13B isoform 1"
                     /protein_id="NP_296371.1"
                     /db_xref="CCDS:CCDS22094.1"
                     /db_xref="GeneID:24099"
                     /db_xref="MGI:MGI:1344376"
                     /translation="MDESAKTLPPPCLCFCSEKGEDMKVGYDPITPQKEEGAWFGICR
                     DGRLLAATLLLALLSSSFTAMSLYQLAALQADLMNLRMELQSYRGSATPAAAGAPELT
                     AGVKLLTPAAPRPHNSSRGHRNRRAFQGPEETEQDVDLSAPPAPCLPGCRHSQHDDNG
                     MNLRNIIQDCLQLIADSDTPTIRKGTYTFVPWLLSFKRGNALEEKENKIVVRQTGYFF
                     IYSQVLYTDPIFAMGHVIQRKKVHVFGDELSLVTLFRCIQNMPKTLPNNSCYSAGIAR
                     LEEGDEIQLAIPRENAQISRNGDDTFFGALKLL"
     exon            529..613
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; BLyS; D8Ertd387e; TALL-1; TALL1;
                     THANK; TNFSF20; Tnlg7a; zTNF4"
                     /inference="alignment:Splign:2.1.0"
     exon            614..706
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; BLyS; D8Ertd387e; TALL-1; TALL1;
                     THANK; TNFSF20; Tnlg7a; zTNF4"
                     /inference="alignment:Splign:2.1.0"
     exon            707..763
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; BLyS; D8Ertd387e; TALL-1; TALL1;
                     THANK; TNFSF20; Tnlg7a; zTNF4"
                     /inference="alignment:Splign:2.1.0"
     exon            764..876
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; BLyS; D8Ertd387e; TALL-1; TALL1;
                     THANK; TNFSF20; Tnlg7a; zTNF4"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1027
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; BLyS; D8Ertd387e; TALL-1; TALL1;
                     THANK; TNFSF20; Tnlg7a; zTNF4"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1699
                     /gene="Tnfsf13b"
                     /gene_synonym="BAFF; BLyS; D8Ertd387e; TALL-1; TALL1;
                     THANK; TNFSF20; Tnlg7a; zTNF4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcagattg agcaatccat ggaaggccag agccagagaa cctacttcag ggtagcaaaa
       61 gatgcagaag aaagtcagga gagcgctcct gggggaaccc agccctgcca tgctctgagg
      121 gcagtctccc aggacacaga tgacaggaaa tgacccaccc ctgtggtcac ttactccaaa
      181 ggcctagacc ttcaaagtgc tcctcgtgga atggatgagt ctgcaaagac cctgccacca
      241 ccgtgcctct gtttttgctc cgagaaagga gaagatatga aagtgggata tgatcccatc
      301 actccgcaga aggaggaggg tgcctggttt gggatctgca gggatggaag gctgctggct
      361 gctaccctcc tgctggccct gttgtccagc agtttcacag cgatgtcctt gtaccagttg
      421 gctgccttgc aagcagacct gatgaacctg cgcatggagc tgcagagcta ccgaggttca
      481 gcaacaccag ccgccgcggg tgctccagag ttgaccgctg gagtcaaact cctgacaccg
      541 gcagctcctc gaccccacaa ctccagccgc ggccacagga acagacgcgc tttccaggga
      601 ccagaggaaa cagaacaaga tgtagacctc tcagctcctc ctgcaccatg cctgcctgga
      661 tgccgccatt ctcaacatga tgataatgga atgaacctca gaaacatcat tcaagactgt
      721 ctgcagctga ttgcagacag cgacacgccg actatacgaa aaggaactta cacatttgtt
      781 ccatggcttc tcagctttaa aagaggaaat gccttggagg agaaagagaa caaaatagtg
      841 gtgaggcaaa caggctattt cttcatctac agccaggttc tatacacgga ccccatcttt
      901 gctatgggtc atgtcatcca gaggaagaaa gtacacgtct ttggggacga gctgagcctg
      961 gtgaccctgt tccgatgtat tcagaatatg cccaaaacac tgcccaacaa ttcctgctac
     1021 tcggctggca tcgcgaggct ggaagaagga gatgagattc agcttgcaat tcctcgggag
     1081 aatgcacaga tttcacgcaa cggagacgac accttctttg gtgccctaaa actgctgtaa
     1141 ctcacttgct ggagtgcgtg atccccttcc ctcgtcttct ctgtacctcc gagggagaaa
     1201 cagacgactg gaaaaactaa aagatgggga aagccgtcag cgaaagtttt ctcgtgaccc
     1261 gttgaatctg atccaaacca ggaaatataa cagacagcca caaccgaagt gtgccatgtg
     1321 agttatgaga aacggagccc gcgctcagaa agaccggatg aggaagaccg ttttctccag
     1381 tcctttgcca acacgcaccg caaccttgct ttttgccttg ggtgacacat gttcagaatg
     1441 cagggagatt tccttgtttt gcgatttgcc atgagaagag ggcccacaac tgcaggtcac
     1501 tgaagcattc acgctaagtc tcaggattta ctctcccttc tcatgctaag tacacacacg
     1561 ctcttttcca ggtaatacta tgggatacta tggaaaggtt gtttgttttt aaatctagaa
     1621 gtcttgaact ggcaatagac aaaaatcctt ataaattcaa gtgtaaaata aacttaatta
     1681 aaaaggttta agtgtgaaa
//
