LOCUS       NM_023517               1679 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus tumor necrosis factor (ligand) superfamily, member 13
            (Tnfsf13), transcript variant 1, mRNA.
ACCESSION   NM_023517
VERSION     NM_023517.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1679)
  AUTHORS   Carvalho-Santos,A., Ballard Kuhnert,L.R., Hahne,M.,
            Vasconcellos,R., Carvalho-Pinto,C.E. and Villa-Verde,D.M.S.
  TITLE     Anti-inflammatory role of APRIL by modulating regulatory B cells in
            antigen-induced arthritis
  JOURNAL   PLoS One 19 (5), e0292028 (2024)
   PUBMED   38691538
  REMARK    GeneRIF: Anti-inflammatory role of APRIL by modulating regulatory B
            cells in antigen-induced arthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1679)
  AUTHORS   Ullah,M.A., Garcillan,B., Whitlock,E., Figgett,W.A., Infantino,S.,
            Eslami,M., Yang,S., Rahman,M.A., Sheng,Y.H., Weber,N.,
            Schneider,P., Tam,C.S. and Mackay,F.
  TITLE     An unappreciated cell survival-independent role for BAFF initiating
            chronic lymphocytic leukemia
  JOURNAL   Front Immunol 15, 1345515 (2024)
   PUBMED   38469292
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1679)
  AUTHORS   Doll,J.R., Moreno-Fernandez,M.E., Stankiewicz,T.E., Wayland,J.L.,
            Wilburn,A., Weinhaus,B., Chougnet,C.A., Giordano,D.,
            Cappelletti,M., Presicce,P., Kallapur,S.G., Salomonis,N.,
            Tilburgs,T. and Divanovic,S.
  TITLE     BAFF and APRIL counterregulate susceptibility to
            inflammation-induced preterm birth
  JOURNAL   Cell Rep 42 (4), 112352 (2023)
   PUBMED   37027297
  REMARK    GeneRIF: BAFF and APRIL counterregulate susceptibility to
            inflammation-induced preterm birth.
REFERENCE   4  (bases 1 to 1679)
  AUTHORS   Sturm,N., Roger-Margueritat,M., Pierrel,F., Lehours,P., Genevay,M.
            and Huard,B.
  TITLE     Spatial heterogeneity for APRIL production by eosinophils in the
            small intestine
  JOURNAL   J Leukoc Biol 113 (4), 376-382 (2023)
   PUBMED   36808499
  REMARK    GeneRIF: Spatial heterogeneity for APRIL production by eosinophils
            in the small intestine.
REFERENCE   5  (bases 1 to 1679)
  AUTHORS   Tsiantoulas,D., Eslami,M., Obermayer,G., Clement,M., Smeets,D.,
            Mayer,F.J., Kiss,M.G., Enders,L., Weisser,J., Goderle,L.,
            Lambert,J., Frommlet,F., Mueller,A., Hendrikx,T., Ozsvar-Kozma,M.,
            Porsch,F., Willen,L., Afonyushkin,T., Murphy,J.E., Fogelstrand,P.,
            Donze,O., Pasterkamp,G., Hoke,M., Kubicek,S., Jorgensen,H.F.,
            Danchin,N., Simon,T., Scharnagl,H., Marz,W., Boren,J., Hess,H.,
            Mallat,Z., Schneider,P. and Binder,C.J.
  TITLE     APRIL limits atherosclerosis by binding to heparan sulfate
            proteoglycans
  JOURNAL   Nature 597 (7874), 92-96 (2021)
   PUBMED   34433968
REFERENCE   6  (bases 1 to 1679)
  AUTHORS   Varfolomeev,E., Kischkel,F., Martin,F., Seshasayee,D., Wang,H.,
            Lawrence,D., Olsson,C., Tom,L., Erickson,S., French,D., Schow,P.,
            Grewal,I.S. and Ashkenazi,A.
  TITLE     APRIL-deficient mice have normal immune system development
  JOURNAL   Mol Cell Biol 24 (3), 997-1006 (2004)
   PUBMED   14729948
REFERENCE   7  (bases 1 to 1679)
  AUTHORS   MacLennan,I. and Vinuesa,C.
  TITLE     Dendritic cells, BAFF, and APRIL: innate players in adaptive
            antibody responses
  JOURNAL   Immunity 17 (3), 235-238 (2002)
   PUBMED   12354377
  REMARK    GeneRIF: Review. Dendritic cell-derived TNF-family ligand APRIL
            enhances plasmablast survival and differentiation to plasma cells.
            Review article
REFERENCE   8  (bases 1 to 1679)
  AUTHORS   Stein,J.V., Lopez-Fraga,M., Elustondo,F.A., Carvalho-Pinto,C.E.,
            Rodriguez,D., Gomez-Caro,R., De Jong,J., Martinez-A,C., Medema,J.P.
            and Hahne,M.
  TITLE     APRIL modulates B and T cell immunity
  JOURNAL   J Clin Invest 109 (12), 1587-1598 (2002)
   PUBMED   12070306
REFERENCE   9  (bases 1 to 1679)
  AUTHORS   Locksley,R.M., Killeen,N. and Lenardo,M.J.
  TITLE     The TNF and TNF receptor superfamilies: integrating mammalian
            biology
  JOURNAL   Cell 104 (4), 487-501 (2001)
   PUBMED   11239407
  REMARK    Review article
REFERENCE   10 (bases 1 to 1679)
  AUTHORS   Yu,G., Boone,T., Delaney,J., Hawkins,N., Kelley,M.,
            Ramakrishnan,M., McCabe,S., Qiu,W.R., Kornuc,M., Xia,X.Z., Guo,J.,
            Stolina,M., Boyle,W.J., Sarosi,I., Hsu,H., Senaldi,G. and
            Theill,L.E.
  TITLE     APRIL and TALL-I and receptors BCMA and TACI: system for regulating
            humoral immunity
  JOURNAL   Nat Immunol 1 (3), 252-256 (2000)
   PUBMED   10973284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009514.1, AK134028.1 and BY463961.1.
            
            On Oct 13, 2005 this sequence version replaced NM_023517.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009514.1, BC069900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1035              AK009514.1         3-1037
            1036-1649           AK134028.1         739-1352
            1650-1679           BY463961.1         419-448
FEATURES             Location/Qualifiers
     source          1..1679
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.86 cM"
     gene            1..1679
                     /gene="Tnfsf13"
                     /gene_synonym="2310026N09Rik; April; Tall2; Tnlg7b; Trdl1"
                     /note="tumor necrosis factor (ligand) superfamily, member
                     13"
                     /db_xref="GeneID:69583"
                     /db_xref="MGI:MGI:1916833"
     exon            1..526
                     /gene="Tnfsf13"
                     /gene_synonym="2310026N09Rik; April; Tall2; Tnlg7b; Trdl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1021
                     /gene="Tnfsf13"
                     /gene_synonym="2310026N09Rik; April; Tall2; Tnlg7b; Trdl1"
                     /note="isoform 1 is encoded by transcript variant 1; a
                     proliferation-inducing ligand; tumor necrosis factor
                     ligand 7b"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     13 isoform 1"
                     /protein_id="NP_076006.2"
                     /db_xref="GeneID:69583"
                     /db_xref="MGI:MGI:1916833"
                     /translation="MPASSPGHMGGSVREPALSVALWLSWGAVLGAVTCAVALLIQQT
                     ELQSLRREVSRLQRSGGPSQKQGERPWQSLWEQSPDVLEAWKDGAKSRRRRAVLTQKH
                     KKKHSVLHLVPVNITSKADSDVTEVMWQPVLRRGRGLEAQGDIVRVWDTGIYLLYSQV
                     LFHDVTFTMGQVVSREGQGRRETLFRCIRSMPSDPDRAYNSCYSAGVFHLHQGDIITV
                     KIPRANAKLSLSPHGTFLGFVKL"
     exon            527..605
                     /gene="Tnfsf13"
                     /gene_synonym="2310026N09Rik; April; Tall2; Tnlg7b; Trdl1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..653
                     /gene="Tnfsf13"
                     /gene_synonym="2310026N09Rik; April; Tall2; Tnlg7b; Trdl1"
                     /inference="alignment:Splign:2.1.0"
     exon            654..772
                     /gene="Tnfsf13"
                     /gene_synonym="2310026N09Rik; April; Tall2; Tnlg7b; Trdl1"
                     /inference="alignment:Splign:2.1.0"
     exon            773..911
                     /gene="Tnfsf13"
                     /gene_synonym="2310026N09Rik; April; Tall2; Tnlg7b; Trdl1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1679
                     /gene="Tnfsf13"
                     /gene_synonym="2310026N09Rik; April; Tall2; Tnlg7b; Trdl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1174..1179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfsf13"
                     /gene_synonym="2310026N09Rik; April; Tall2; Tnlg7b; Trdl1"
                     /note="hexamer: ATTAAA"
     polyA_site      1208
                     /gene="Tnfsf13"
                     /gene_synonym="2310026N09Rik; April; Tall2; Tnlg7b; Trdl1"
                     /note="major polyA site"
ORIGIN      
        1 gaaggctggc cgctccttct gggtgtcacg gctgccctgt ccttcctaga taatggcacc
       61 aaattctcct gaggctaggg gggaaggagt gtcagagtgt cactagctcg accctgggga
      121 caagggggac taatagtacc ctagcttgat ttcttcctat tctcaagttc ctttttattt
      181 ctcccttgcg taacccgctc ttcccttctg tgcctttgcc tgtattccca ccctccctgc
      241 tacctcttgg ccacctcact tctgagacca cagctgttgg cagggtccct agctcatgcc
      301 agcctcatct ccaggccaca tggggggctc agtcagagag ccagcccttt cggttgctct
      361 ttggttgagt tggggggcag ttctgggggc tgtgacttgt gctgtcgcac tactgatcca
      421 acagacagag ctgcaaagcc taaggcggga ggtgagccgg ctgcagcgga gtggagggcc
      481 ttcccagaag cagggagagc gcccatggca gagcctctgg gagcagagtc ctgatgtcct
      541 ggaagcctgg aaggatgggg cgaaatctcg gagaaggaga gcagtactca cccagaagca
      601 caagaagaag cactcagtcc tgcatcttgt tccagttaac attacctcca aggcagactc
      661 tgacgtgaca gaggtgatgt ggcaaccagt acttaggcgt gggagaggcc tggaggccca
      721 gggagacatt gtacgagtct gggacactgg aatttatctg ctctatagtc aggtcctgtt
      781 tcatgatgtg actttcacaa tgggtcaggt ggtatctcgg gaaggacaag ggagaagaga
      841 aactctattc cgatgtatca gaagtatgcc ttctgatcct gaccgtgcct acaatagctg
      901 ctacagtgca ggtgtctttc atttacatca aggggatatt atcactgtca aaattccacg
      961 ggcaaacgca aaacttagcc tttctccgca tggaacattc ctggggtttg tgaaactatg
     1021 attgttataa agggggtggg gatttcccat tccaaaaact ggctagacaa aggacaagga
     1081 acggtcaaga acagctctcc atggctttgc cttgactgtt gttcctccct ttgcctttcc
     1141 cgctcccact atctgggctt tgactccatg gatattaaaa aagtagaata ttttgtgttt
     1201 atctcccaca cagccccaaa ttcttttgtt gtgtgtgcga agggggtttt gcgcactgtg
     1261 ccaagccttg tccactggaa tgcatccaga acagcagcac catctagcgg caggttgagg
     1321 aaagactatg gtctctgcta gggaaaacct tatccaactc ttcaagtacc ctctgcttca
     1381 attaacaaga agcccggctt tcagtatttc acctattgcg tccaaattct tgttactatc
     1441 tagaaaaaga tatatgttag gtgcctcgat atgcatgcca ttcatcctcc ccattctcct
     1501 atacacttcc gagctgggca ctgagcttta cgccttaaat cacagtactc gggaggcaga
     1561 tctcgatgag ttcgaggcca acttggtcta aatagtgagt tccaggccac ccaggggtta
     1621 caatggtgag accctgtctc aaacaaacta acaaacaaat aaacgaaagg ctctccacg
//
