LOCUS       NM_011614               1694 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus tumor necrosis factor (ligand) superfamily, member 12
            (Tnfsf12), mRNA.
ACCESSION   NM_011614 XM_915848
VERSION     NM_011614.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1694)
  AUTHORS   Guerrero-Hue,M., Vallejo-Mudarra,M., Garcia-Caballero,C.,
            Cordoba-David,G.M., Palomino-Antolin,A., Herencia,C.,
            Vendrell-Casana,B., Rubio-Navarro,A., Egido,J., Blanco-Colio,L.M.
            and Moreno,J.A.
  TITLE     Tweak/Fn14 system is involved in rhabdomyolysis-induced acute
            kidney injury
  JOURNAL   Biomed Pharmacother 169, 115925 (2023)
   PUBMED   38007933
  REMARK    GeneRIF: Tweak/Fn14 system is involved in rhabdomyolysis-induced
            acute kidney injury.
REFERENCE   2  (bases 1 to 1694)
  AUTHORS   Kong,Y., Yang,Y., Wu,S. and Li,W.
  TITLE     TWEAK promotes inflammatory response in liver fibrosis
  JOURNAL   J Biochem Mol Toxicol 37 (12), e23483 (2023)
   PUBMED   37503908
  REMARK    GeneRIF: TWEAK promotes inflammatory response in liver fibrosis.
REFERENCE   3  (bases 1 to 1694)
  AUTHORS   Wu,B., Wu,B., Benkaci,S., Shi,L., Lu,P., Park,T., Morrow,B.E.,
            Wang,Y. and Zhou,B.
  TITLE     Crk and Crkl Are Required in the Endocardial Lineage for Heart
            Valve Development
  JOURNAL   J Am Heart Assoc 12 (18), e029683 (2023)
   PUBMED   37702066
REFERENCE   4  (bases 1 to 1694)
  AUTHORS   Wang,X., Lu,M., Gu,H., Xiao,T., Hu,G., Luo,M., Guo,X. and Xia,Y.
  TITLE     Conjugation of the Fn14 Ligand to a SMAC Mimetic Selectively
            Suppresses Experimental Squamous Cell Carcinoma in Mice
  JOURNAL   J Invest Dermatol 143 (2), 242-253 (2023)
   PUBMED   36063885
  REMARK    GeneRIF: Conjugation of the Fn14 Ligand to a SMAC Mimetic
            Selectively Suppresses Experimental Squamous Cell Carcinoma in
            Mice.
REFERENCE   5  (bases 1 to 1694)
  AUTHORS   Guner,G., Assfalg,M., Zhao,K., Dreyer,T., Lahiri,S., Lo,Y.,
            Slivinschi,B.I., Imhof,A., Jocher,G., Strohm,L., Behrends,C.,
            Langosch,D., Bronger,H., Nimsky,C., Bartsch,J.W., Riddell,S.R.,
            Steiner,H. and Lichtenthaler,S.F.
  TITLE     Proteolytically generated soluble Tweak Receptor Fn14 is a blood
            biomarker for gamma-secretase activity
  JOURNAL   EMBO Mol Med 14 (10), e16084 (2022)
   PUBMED   36069059
  REMARK    GeneRIF: Proteolytically generated soluble Tweak Receptor Fn14 is a
            blood biomarker for gamma-secretase activity.
REFERENCE   6  (bases 1 to 1694)
  AUTHORS   Saitoh,T., Nakayama,M., Nakano,H., Yagita,H., Yamamoto,N. and
            Yamaoka,S.
  TITLE     TWEAK induces NF-kappaB2 p100 processing and long lasting NF-kappaB
            activation
  JOURNAL   J Biol Chem 278 (38), 36005-36012 (2003)
   PUBMED   12840022
  REMARK    GeneRIF: TWEAK is a novel physiological regulator of the
            non-canonical pathway for NF-kappaB activation
REFERENCE   7  (bases 1 to 1694)
  AUTHORS   Polek,T.C., Talpaz,M., Darnay,B.G. and Spivak-Kroizman,T.
  TITLE     TWEAK mediates signal transduction and differentiation of RAW264.7
            cells in the absence of Fn14/TweakR. Evidence for a second TWEAK
            receptor
  JOURNAL   J Biol Chem 278 (34), 32317-32323 (2003)
   PUBMED   12794080
  REMARK    GeneRIF: TWEAK mediated the differentiation of RAW
            monocyte/macrophage cells into osteoclasts; propose that the
            biological effects of TWEAK are mediated by binding to one of at
            least two receptors that induce differential activation of
            downstream signal pathways
            GeneRIF: findings indicate that a second TweakR, TweakR2, exists on
            RAW cells and is responsible for mediating TWEAK-induced
            differentiation [TweakR2]
REFERENCE   8  (bases 1 to 1694)
  AUTHORS   Nakayama,M., Harada,N., Okumura,K. and Yagita,H.
  TITLE     Characterization of murine TWEAK and its receptor (Fn14) by
            monoclonal antibodies
  JOURNAL   Biochem Biophys Res Commun 306 (4), 819-825 (2003)
   PUBMED   12821115
  REMARK    GeneRIF: characterization of murine TWEAK and TWEAK receptor (Fn14)
REFERENCE   9  (bases 1 to 1694)
  AUTHORS   Locksley,R.M., Killeen,N. and Lenardo,M.J.
  TITLE     The TNF and TNF receptor superfamilies: integrating mammalian
            biology
  JOURNAL   Cell 104 (4), 487-501 (2001)
   PUBMED   11239407
  REMARK    Review article
REFERENCE   10 (bases 1 to 1694)
  AUTHORS   Chicheportiche,Y., Bourdon,P.R., Xu,H., Hsu,Y.M., Scott,H.,
            Hession,C., Garcia,I. and Browning,J.L.
  TITLE     TWEAK, a new secreted ligand in the tumor necrosis factor family
            that weakly induces apoptosis
  JOURNAL   J Biol Chem 272 (51), 32401-32410 (1997)
   PUBMED   9405449
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603707.5.
            
            On Oct 29, 2010 this sequence version replaced NM_011614.2.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171014.1, AK170297.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               AL603707.5         74825-75327         c
            504-551             AL603707.5         74623-74670         c
            552-627             AL603707.5         73979-74054         c
            628-681             AL603707.5         72850-72903         c
            682-717             AL603707.5         72735-72770         c
            718-842             AL603707.5         66481-66605         c
            843-1694            AL603707.5         65469-66320         c
FEATURES             Location/Qualifiers
     source          1..1694
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.86 cM"
     gene            1..1694
                     /gene="Tnfsf12"
                     /gene_synonym="Apo3l; Dr3l; Dr3lg; Tweak"
                     /note="tumor necrosis factor (ligand) superfamily, member
                     12"
                     /db_xref="GeneID:21944"
                     /db_xref="MGI:MGI:1196259"
     exon            1..503
                     /gene="Tnfsf12"
                     /gene_synonym="Apo3l; Dr3l; Dr3lg; Tweak"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..1094
                     /gene="Tnfsf12"
                     /gene_synonym="Apo3l; Dr3l; Dr3lg; Tweak"
                     /note="TNF-related weak inducer of apoptosis"
                     /codon_start=1
                     /product="tumor necrosis factor ligand superfamily member
                     12"
                     /protein_id="NP_035744.1"
                     /db_xref="CCDS:CCDS24907.1"
                     /db_xref="GeneID:21944"
                     /db_xref="MGI:MGI:1196259"
                     /translation="MAARRSQRRRGRRGEPGTALLAPLVLSLGLALACLGLLLVVVSL
                     GSWATLSAQEPSQEELTAEDRREPPELNPQTEESQDVVPFLEQLVRPRRSAPKGRKAR
                     PRRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEETKINSSSPLRYDRQIGEFTVIRAGL
                     YYLYCQVHFDEGKAVYLKLDLLVNGVLALRCLEEFSATAASSPGPQLRLCQVSGLLPL
                     RPGSSLRIRTLPWAHLKAAPFLTYFGLFQVH"
     exon            504..551
                     /gene="Tnfsf12"
                     /gene_synonym="Apo3l; Dr3l; Dr3lg; Tweak"
                     /inference="alignment:Splign:2.1.0"
     exon            552..627
                     /gene="Tnfsf12"
                     /gene_synonym="Apo3l; Dr3l; Dr3lg; Tweak"
                     /inference="alignment:Splign:2.1.0"
     exon            628..681
                     /gene="Tnfsf12"
                     /gene_synonym="Apo3l; Dr3l; Dr3lg; Tweak"
                     /inference="alignment:Splign:2.1.0"
     exon            682..717
                     /gene="Tnfsf12"
                     /gene_synonym="Apo3l; Dr3l; Dr3lg; Tweak"
                     /inference="alignment:Splign:2.1.0"
     exon            718..842
                     /gene="Tnfsf12"
                     /gene_synonym="Apo3l; Dr3l; Dr3lg; Tweak"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1694
                     /gene="Tnfsf12"
                     /gene_synonym="Apo3l; Dr3l; Dr3lg; Tweak"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1566..1571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfsf12"
                     /gene_synonym="Apo3l; Dr3l; Dr3lg; Tweak"
                     /note="hexamer: AATAAA"
     polyA_site      1577
                     /gene="Tnfsf12"
                     /gene_synonym="Apo3l; Dr3l; Dr3lg; Tweak"
                     /note="major polyA site"
ORIGIN      
        1 ggggccaggg cccgcgtccc atccctggca cactggcctg ggtgggtgcc tgtccacttc
       61 tgctttcact ggccctcaga gttcttggtc tggagtgcca ctgcggtcgc ctgcctgcac
      121 gcgcccgggc gcaggacgtc tcttacttct tgcacagcac tccggggagg ttggagttta
      181 atcacacaaa cagtgtccgg cttcctgtcc tcatccgccc cccctccggc ccgcttccct
      241 ggtccctccc tctcccctgg cccgatccgc ccaccagctc cccctcccca tccctcgggt
      301 cccgggatgg gggggcggtg aggcaggcac agccccccgc ccccatggcc gcccgtcgga
      361 gccagaggcg gagggggcgc cggggggagc cgggcaccgc cctgctggcc ccgctggtgc
      421 tgagcctggg cctggcgctg gcctgccttg gcctcctgct ggtcgtggtc agcctgggga
      481 gctgggcaac gctgtctgcc caggagcctt ctcaggagga gctgacagca gaggaccgcc
      541 gggagccccc tgaactgaat ccccagacag aggaaagcca ggatgtggta cctttcttgg
      601 aacaactagt ccggcctcga agaagtgctc ctaaaggccg gaaggcgcgg cctcgccgag
      661 ctattgcagc ccattatgag gttcatcctc ggccaggaca ggatggagca caagcaggtg
      721 tggatgggac agtgagtggc tgggaagaga ccaaaatcaa cagctccagc cctctgcgct
      781 acgaccgcca gattggggaa tttacagtca tcagggctgg gctctactac ctgtactgtc
      841 aggtgcactt tgatgaggga aaggctgtct acctgaagct ggacttgctg gtgaacggtg
      901 tgctggccct gcgctgcctg gaagaattct cagccacagc agcaagctct cctgggcccc
      961 agctccgttt gtgccaggtg tctgggctgt tgccgctgcg gccagggtct tcccttcgga
     1021 tccgcaccct cccctgggct catcttaagg ctgccccctt cctaacctac tttggactct
     1081 ttcaagttca ctgaggggcc ttgctctccc agattcctta aactttccct ggctccagga
     1141 gcatcaccac acctccctac cccaccccca ctcctccacc ccctcgctgc tccttggtcc
     1201 agtcctgtcc tctcctcaaa ggcagccaga gcttgttcac atgttttcca ttccacagac
     1261 gtatccttgc tcttctttaa catcccatcc caccacaact atccacctca ctagctccca
     1321 aagcccctac ttatccctga ctcccccacc cactcacccg accacgtgtt tattgacttt
     1381 gtgcaccagg cactgagatg ggctggacct ggtggcagga agccagagaa cctgggacta
     1441 ggccagaagt tcccaactgt gagggggaag agctggggac aagctcctcc ctggatccct
     1501 gtggattttg aaaagatact atttttatta ttattgtgac aaaatgttaa atggatatta
     1561 aagagaataa atcatgattt ctcttctttg gggttcagag taactgaaga ttgtgggaag
     1621 gggatttagg ctttggggaa cagggacctg catgcctcca agctgcagtt ctgaatagaa
     1681 atcacaaagg tacc
//
