LOCUS       NM_011613               2235 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus tumor necrosis factor (ligand) superfamily, member 11
            (Tnfsf11), mRNA.
ACCESSION   NM_011613
VERSION     NM_011613.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2235)
  AUTHORS   Cho,J.Y., Woo,H.E., Yeom,J., An,M., Ma,S., Yim,D.J., Kim,S.H. and
            Lim,Y.H.
  TITLE     Microbial chaperonin 60 inhibits osteoclast differentiation by
            interfering with RANK/RANKL binding and overexpression of
            lipocalin2
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119850 (2024)
   PUBMED   39303785
  REMARK    GeneRIF: Microbial chaperonin 60 inhibits osteoclast
            differentiation by interfering with RANK/RANKL binding and
            overexpression of lipocalin2.
REFERENCE   2  (bases 1 to 2235)
  AUTHORS   Houchen,C.J., Ghanem,S., Kaartinen,V. and Bumann,E.E.
  TITLE     TGF-beta signaling in the cranial neural crest affects late-stage
            mandibular bone resorption and length
  JOURNAL   Front Physiol 15, 1435594 (2024)
   PUBMED   39473613
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2235)
  AUTHORS   Almubarak,A., Zhang,Q., Zhang,C.H., Abdelwahab,N., Kume,T.,
            Lassar,A.B. and Berry,F.B.
  TITLE     FOXC1 and FOXC2 regulate growth plate chondrocyte maturation
            towards hypertrophy in the embryonic mouse limb skeleton
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39012257
REFERENCE   4  (bases 1 to 2235)
  AUTHORS   Schiavone,M.L., Crisafulli,L., Camisaschi,C., De Simone,G.,
            Liberati,F.R., Palagano,E., Rucci,N., Ficara,F. and Sobacchi,C.
  TITLE     Rankl genetic deficiency and functional blockade undermine skeletal
            stem and progenitor cell differentiation
  JOURNAL   Stem Cell Res Ther 15 (1), 203 (2024)
   PUBMED   38971808
  REMARK    GeneRIF: Rankl genetic deficiency and functional blockade undermine
            skeletal stem and progenitor cell differentiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2235)
  AUTHORS   Ayyasamy,R., Fan,S., Czernik,P., Lecka-Czernik,B., Chattopadhyay,S.
            and Chakravarti,R.
  TITLE     14-3-3zeta suppresses RANKL signaling by destabilizing TRAF6
  JOURNAL   J Biol Chem 300 (7), 107487 (2024)
   PUBMED   38908751
  REMARK    GeneRIF: 14-3-3zeta suppresses RANKL signaling by destabilizing
            TRAF6.
REFERENCE   6  (bases 1 to 2235)
  AUTHORS   Lacey,D.L., Timms,E., Tan,H.L., Kelley,M.J., Dunstan,C.R.,
            Burgess,T., Elliott,R., Colombero,A., Elliott,G., Scully,S.,
            Hsu,H., Sullivan,J., Hawkins,N., Davy,E., Capparelli,C., Eli,A.,
            Qian,Y.X., Kaufman,S., Sarosi,I., Shalhoub,V., Senaldi,G., Guo,J.,
            Delaney,J. and Boyle,W.J.
  TITLE     Osteoprotegerin ligand is a cytokine that regulates osteoclast
            differentiation and activation
  JOURNAL   Cell 93 (2), 165-176 (1998)
   PUBMED   9568710
REFERENCE   7  (bases 1 to 2235)
  AUTHORS   Yasuda,H., Shima,N., Nakagawa,N., Yamaguchi,K., Kinosaki,M.,
            Mochizuki,S., Tomoyasu,A., Yano,K., Goto,M., Murakami,A., Tsuda,E.,
            Morinaga,T., Higashio,K., Udagawa,N., Takahashi,N. and Suda,T.
  TITLE     Osteoclast differentiation factor is a ligand for
            osteoprotegerin/osteoclastogenesis-inhibitory factor and is
            identical to TRANCE/RANKL
  JOURNAL   Proc Natl Acad Sci U S A 95 (7), 3597-3602 (1998)
   PUBMED   9520411
REFERENCE   8  (bases 1 to 2235)
  AUTHORS   Wong,B.R., Josien,R., Lee,S.Y., Sauter,B., Li,H.L., Steinman,R.M.
            and Choi,Y.
  TITLE     TRANCE (tumor necrosis factor [TNF]-related activation-induced
            cytokine), a new TNF family member predominantly expressed in T
            cells, is a dendritic cell-specific survival factor
  JOURNAL   J Exp Med 186 (12), 2075-2080 (1997)
   PUBMED   9396779
REFERENCE   9  (bases 1 to 2235)
  AUTHORS   Anderson,D.M., Maraskovsky,E., Billingsley,W.L., Dougall,W.C.,
            Tometsko,M.E., Roux,E.R., Teepe,M.C., DuBose,R.F., Cosman,D. and
            Galibert,L.
  TITLE     A homologue of the TNF receptor and its ligand enhance T-cell
            growth and dendritic-cell function
  JOURNAL   Nature 390 (6656), 175-179 (1997)
   PUBMED   9367155
REFERENCE   10 (bases 1 to 2235)
  AUTHORS   Wong,B.R., Rho,J., Arron,J., Robinson,E., Orlinick,J., Chao,M.,
            Kalachikov,S., Cayani,E., Bartlett,F.S. 3rd, Frankel,W.N., Lee,S.Y.
            and Choi,Y.
  TITLE     TRANCE is a novel ligand of the tumor necrosis factor receptor
            family that activates c-Jun N-terminal kinase in T cells
  JOURNAL   J Biol Chem 272 (40), 25190-25194 (1997)
   PUBMED   9312132
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126690.5.
            
            On Sep 13, 2022 this sequence version replaced NM_011613.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF053713.2, AF019048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-376               AC126690.5         42755-43130
            377-538             AC126690.5         50799-50960
            539-584             AC126690.5         66333-66378
            585-683             AC126690.5         66461-66559
            684-2235            AC126690.5         71801-73352
FEATURES             Location/Qualifiers
     source          1..2235
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 41.26 cM"
     gene            1..2235
                     /gene="Tnfsf11"
                     /gene_synonym="Ly109l; ODF; OPGL; RANKL; Trance"
                     /note="tumor necrosis factor (ligand) superfamily, member
                     11"
                     /db_xref="GeneID:21943"
                     /db_xref="MGI:MGI:1100089"
     exon            1..376
                     /gene="Tnfsf11"
                     /gene_synonym="Ly109l; ODF; OPGL; RANKL; Trance"
                     /inference="alignment:Splign:2.1.0"
     exon            377..538
                     /gene="Tnfsf11"
                     /gene_synonym="Ly109l; ODF; OPGL; RANKL; Trance"
                     /inference="alignment:Splign:2.1.0"
     exon            539..584
                     /gene="Tnfsf11"
                     /gene_synonym="Ly109l; ODF; OPGL; RANKL; Trance"
                     /inference="alignment:Splign:2.1.0"
     exon            585..683
                     /gene="Tnfsf11"
                     /gene_synonym="Ly109l; ODF; OPGL; RANKL; Trance"
                     /inference="alignment:Splign:2.1.0"
     exon            684..2235
                     /gene="Tnfsf11"
                     /gene_synonym="Ly109l; ODF; OPGL; RANKL; Trance"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2214..2219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfsf11"
                     /gene_synonym="Ly109l; ODF; OPGL; RANKL; Trance"
                     /note="hexamer: AATAAA"
     polyA_site      2235
                     /gene="Tnfsf11"
                     /gene_synonym="Ly109l; ODF; OPGL; RANKL; Trance"
                     /note="major polyA site"
ORIGIN      
        1 gccatctctc ccacgtcccg gggagccact gccaggacct ctgtgaaccg gtcggggcgg
       61 gggccgcctg gccgggagtc tgctcggcgg tgggtggccg aggaagggag agaacgatcg
      121 cggagcaggg cgcccgaact ccgggcgccg cgccatgcgc cgggccagcc gagactacgg
      181 caagtacctg cgcagctcgg aggagatggg cagcggcccc ggcgtcccac acgagggtcc
      241 gctgcacccc gcgccttctg caccggctcc ggcgccgcca cccgccgcct cccgctccat
      301 gttcctggcc ctcctggggc tgggactggg ccaggtggtc tgcagcatcg ctctgttcct
      361 gtactttcga gcgcagatgg atcctaacag aatatcagaa gacagcactc actgctttta
      421 tagaatcctg agactccatg aaaacgcaga tttgcaggac tcgactctgg agagtgaaga
      481 cacactacct gactcctgca ggaggatgaa acaagccttt cagggggccg tgcagaagga
      541 actgcaacac attgtggggc cacagcgctt ctcaggagct ccagctatga tggaaggctc
      601 atggttggat gtggcccagc gaggcaagcc tgaggcccag ccatttgcac acctcaccat
      661 caatgctgcc agcatcccat cgggttccca taaagtcact ctgtcctctt ggtaccacga
      721 tcgaggctgg gccaagatct ctaacatgac gttaagcaac ggaaaactaa gggttaacca
      781 agatggcttc tattacctgt acgccaacat ttgctttcgg catcatgaaa catcgggaag
      841 cgtacctaca gactatcttc agctgatggt gtatgtcgtt aaaaccagca tcaaaatccc
      901 aagttctcat aacctgatga aaggagggag cacgaaaaac tggtcgggca attctgaatt
      961 ccacttttat tccataaatg ttgggggatt tttcaagctc cgagctggtg aagaaattag
     1021 cattcaggtg tccaaccctt ccctgctgga tccggatcaa gatgcgacgt actttggggc
     1081 tttcaaagtt caggacatag actgagactc atttcgtgga acattagcat ggatgtccta
     1141 gatgtttgga aacttcttaa aaaatggatg atgtctatac atgtgtaaga ctactaagag
     1201 acatggccca cggtgtatga aactcacagc cctctctctt gagcctgtac aggttgtgta
     1261 tatgtaaagt ccataggtga tgttagattc atggtgatta cacaacggtt ttacaatttt
     1321 gtaatgattt cctagaattg aaccagattg ggagaggtat tccgatgctt atgaaaaact
     1381 tacacgtgag ctatggaagg gggtcacagt ctctgggtct aacccctgga catgtgccac
     1441 tgagaacctt gaaattaaga ggatgccatg tcattgcaaa gaaatgatag tgtgaagggt
     1501 taagttcttt tgaattgtta cattgcgctg ggacctgcaa ataagttctt tttttctaat
     1561 gaggagagaa aaatatatgt atttttatat aatgtctaaa gttatatttc aggtgtaatg
     1621 ttttctgtgc aaagttttgt aaattatatt tgtgctatag tatttgattc aaaatattta
     1681 aaaatgtctc actgttgaca tatttaatgt tttaaatgta cagatgtatt taactggtgc
     1741 actttgtaat tcccctgaag gtactcgtag ctaagggggc agaatactgt ttctggtgac
     1801 cacatgtagt ttatttcttt attcttttta acttaataga gtcttcagac ttgtcaaaac
     1861 tatgcaagca aaataaataa ataaaaataa aatgaatacc ttgaataata agtaggatgt
     1921 tggtcaccag gtgcctttca aatttagaag ctaattgact ttaggagctg acatagccaa
     1981 aaaggataca taataggcta ctgaaatctg tcaggagtat ttatgcaatt attgaacagg
     2041 tgtctttttt tacaagagct acaaattgta aattttgttt cttttttttc ccatagaaaa
     2101 tgtactatag tttatcagcc aaaaaacaat ccacttttta atttagtgaa agttatttta
     2161 ttatactgta caataaaagc attgtctctg aatgttaatt ttttggtaca aaaaataaat
     2221 ttgtacgaaa acctg
//
