LOCUS       NM_009425               4944 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus tumor necrosis factor (ligand) superfamily, member 10
            (Tnfsf10), mRNA.
ACCESSION   NM_009425
VERSION     NM_009425.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4944)
  AUTHORS   Cartland,S.P., Patil,M.S., Kelland,E., Le,N., Boccanfuso,L.,
            Stanley,C.P., Cholan,P.M., Dona,M.I., Patrick,R., McGrath,J.,
            Su,Q.P., Alwis,I., Ganss,R., Powell,J.E., Harvey,R.P., Pinto,A.R.,
            Griffith,T.S., Loa,J., Aitken,S.J., Robinson,D.A., Patel,S. and
            Kavurma,M.M.
  TITLE     The generation of stable microvessels in ischemia is mediated by
            endothelial cell derived TRAIL
  JOURNAL   Sci Adv 10 (40), eadn8760 (2024)
   PUBMED   39365855
  REMARK    GeneRIF: The generation of stable microvessels in ischemia is
            mediated by endothelial cell derived TRAIL.
REFERENCE   2  (bases 1 to 4944)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4944)
  AUTHORS   Krishnan,A., Ozturk,N.B., Cutshaw,K.A., Guicciardi,M.E.,
            Kitagataya,T., Olson,K.E., Pavelko,K.D., Sherman,W., Wixom,A.Q.,
            Jalan-Sakrikar,N., Baez-Faria,M., Gutierrez,F. and Gores,G.J.
  TITLE     Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
            deletion in myeloid cells augments cholestatic liver injury
  JOURNAL   Sci Rep 14 (1), 2145 (2024)
   PUBMED   38273071
  REMARK    GeneRIF: Tumor necrosis factor-related apoptosis-inducing ligand
            (TRAIL) deletion in myeloid cells augments cholestatic liver
            injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4944)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   5  (bases 1 to 4944)
  AUTHORS   Wu,B., Wu,B., Benkaci,S., Shi,L., Lu,P., Park,T., Morrow,B.E.,
            Wang,Y. and Zhou,B.
  TITLE     Crk and Crkl Are Required in the Endocardial Lineage for Heart
            Valve Development
  JOURNAL   J Am Heart Assoc 12 (18), e029683 (2023)
   PUBMED   37702066
REFERENCE   6  (bases 1 to 4944)
  AUTHORS   Hofmann,K.
  TITLE     The modular nature of apoptotic signaling proteins
  JOURNAL   Cell Mol Life Sci 55 (8-9), 1113-1128 (1999)
   PUBMED   10442092
  REMARK    Review article
REFERENCE   7  (bases 1 to 4944)
  AUTHORS   Walczak,H., Miller,R.E., Ariail,K., Gliniak,B., Griffith,T.S.,
            Kubin,M., Chin,W., Jones,J., Woodward,A., Le,T., Smith,C.,
            Smolak,P., Goodwin,R.G., Rauch,C.T., Schuh,J.C. and Lynch,D.H.
  TITLE     Tumoricidal activity of tumor necrosis factor-related
            apoptosis-inducing ligand in vivo
  JOURNAL   Nat Med 5 (2), 157-163 (1999)
   PUBMED   9930862
REFERENCE   8  (bases 1 to 4944)
  AUTHORS   French,L.E. and Tschopp,J.
  TITLE     The TRAIL to selective tumor death
  JOURNAL   Nat Med 5 (2), 146-147 (1999)
   PUBMED   9930856
REFERENCE   9  (bases 1 to 4944)
  AUTHORS   Lavenu,A., Roland,J., Poirier,C., Cazenave,P., Babinet,C. and
            Morello,D.
  TITLE     Genomic structure and precise mapping of a thymic regulatory region
            on mouse chromosome 17 revealed by a c-myc transgene insertion
  JOURNAL   Genomics 34 (3), 381-388 (1996)
   PUBMED   8786139
REFERENCE   10 (bases 1 to 4944)
  AUTHORS   Wiley,S.R., Schooley,K., Smolak,P.J., Din,W.S., Huang,C.P.,
            Nicholl,J.K., Sutherland,G.R., Smith,T.D., Rauch,C., Smith,C.A. et
            al.
  TITLE     Identification and characterization of a new member of the TNF
            family that induces apoptosis
  JOURNAL   Immunity 3 (6), 673-682 (1995)
   PUBMED   8777713
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY734631.1, U37522.1 and AC116585.3.
            
            On Nov 4, 2005 this sequence version replaced NM_009425.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157633.1, BC138807.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-200               BY734631.1         18-217
            201-1309            U37522.1           177-1285
            1310-4944           AC116585.3         137425-141059       c
FEATURES             Location/Qualifiers
     source          1..4944
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 10.82 cM"
     gene            1..4944
                     /gene="Tnfsf10"
                     /gene_synonym="A330042I21Rik; APO-2L; Ly81; TL2; Tnlg6a;
                     Trail"
                     /note="tumor necrosis factor (ligand) superfamily, member
                     10"
                     /db_xref="GeneID:22035"
                     /db_xref="MGI:MGI:107414"
     exon            1..214
                     /gene="Tnfsf10"
                     /gene_synonym="A330042I21Rik; APO-2L; Ly81; TL2; Tnlg6a;
                     Trail"
                     /inference="alignment:Splign:2.1.0"
     exon            215..352
                     /gene="Tnfsf10"
                     /gene_synonym="A330042I21Rik; APO-2L; Ly81; TL2; Tnlg6a;
                     Trail"
                     /inference="alignment:Splign:2.1.0"
     exon            353..395
                     /gene="Tnfsf10"
                     /gene_synonym="A330042I21Rik; APO-2L; Ly81; TL2; Tnlg6a;
                     Trail"
                     /inference="alignment:Splign:2.1.0"
     exon            396..500
                     /gene="Tnfsf10"
                     /gene_synonym="A330042I21Rik; APO-2L; Ly81; TL2; Tnlg6a;
                     Trail"
                     /inference="alignment:Splign:2.1.0"
     exon            501..4944
                     /gene="Tnfsf10"
                     /gene_synonym="A330042I21Rik; APO-2L; Ly81; TL2; Tnlg6a;
                     Trail"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4925..4930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfsf10"
                     /gene_synonym="A330042I21Rik; APO-2L; Ly81; TL2; Tnlg6a;
                     Trail"
                     /note="hexamer: AATAAA"
     polyA_site      4944
                     /gene="Tnfsf10"
                     /gene_synonym="A330042I21Rik; APO-2L; Ly81; TL2; Tnlg6a;
                     Trail"
                     /note="major polyA site"
ORIGIN      
        1 aactgtgacc ttctcaggca ctgctgctgg gctgcaagtc tgcattggga agtcagacct
       61 ggacagcagt atgccttcct caggggccct gaaggacctc agcttcagtc agcacttcag
      121 gatgatggtg atttgcatag tgctcctgca ggtgctcctg caggctgtgt ctgtggctgt
      181 gacttacatg tacttcacca acgagatgaa gcagctgcag gacaattact ccaaaattgg
      241 actagcttgc ttctcaaaga cggatgagga tttctgggac tccactgatg gagagatctt
      301 gaacagaccc tgcttgcagg ttaagaggca actgtatcag ctcattgaag aggtgacttt
      361 gagaaccttt caggacacca tttctacagt tccagaaaag cagctaagta ctcctccctt
      421 gcccagaggt ggaagacctc agaaagtggc agctcacatt actgggatca ctcggagaag
      481 caactcagct ttaattccaa tctccaagga tggaaagacc ttaggccaga agattgaatc
      541 ctgggagtcc tctcggaaag ggcattcatt tctcaaccac gtgctcttta ggaatggaga
      601 gctggtcatc gagcaggagg gcctgtatta catctattcc caaacatact tccgatttca
      661 ggaagctgaa gacgcttcca agatggtctc aaaggacaag gtgagaacca aacagctggt
      721 gcagtacatc tacaagtaca ccagctatcc ggatcccata gtgctcatga agagcgccag
      781 aaacagctgt tggtccagag atgccgagta cggactgtac tccatctatc agggaggatt
      841 gttcgagcta aaaaaaaatg acaggatttt tgtttctgtg acaaatgaac atttgatgga
      901 cctggatcaa gaagccagct tctttggagc ctttttaatt aactaaatga ccagtaaaga
      961 tcaaacacag ccctaaagta cccagtaatc ttctaggttg aaggcatgcc tggaaagcga
     1021 ctgaactggt taggatatgg cctggctgta gaaacctcag gacagatgtg acagaaaggc
     1081 agctggaact cagcagcgac aggccaacag tccagccaca gacactttcg gtgtttcatc
     1141 gagagacttg ctttctttcc gcaaaatgag atcactgtag cctttcaatg atctacctgg
     1201 tatcagtttg cagagatcta gaagacgtcc agtttctaaa tatttatgca acaattgaca
     1261 attttcacct ttgttatctg gtccaggggt gtaaagccaa gtgctcacag gctgtgtgca
     1321 gaccaggata gctatgaatg caggtcagca taaaaatcac agaatatctc acctaccaaa
     1381 tcagagtggg tgtgcccctg tgtgtatatg cgtgtctgtg tgtgtgtgca tgtatgtgtg
     1441 tgtgtgtgtg actgttcttt atggtaactg gttatgtttt tctcaagtga aaaacataac
     1501 tctatacatg ataacataat atcccatcat cagtggaacc ttgcccaaag aatgtatgaa
     1561 atctccaggc aatgaatgag ggcagcccaa gaaagaggcc cgcagagcca taccacaggg
     1621 ctgccccacc ctgctggagc tcagatcctg ccactgctgc aggccctggg taccaggtgt
     1681 agagttggag gaggtcttgc ctgtgggtct aggtctttgg tgcctacctc cttgatatgg
     1741 ccccagtcct cctttgcttg tttgctagtt ttatcatgtt tcccaggccg gcctcaagtc
     1801 caatatgtag tcaagagtga tctctaactg tgcaacctcc tgcctccaag atctgctgag
     1861 attataggca tgtgcccccc tgtctgattt gtgtagagcc aggcttcttg tacatgtgac
     1921 aaccatgcca ccctcagctc tgtcccagct ccatttcttc ctttctgaat gcaagcattt
     1981 actttgtgtc cctatattct agaatgtgca acagtgaaga atttgctctg actttcagga
     2041 taaagtttga actaggttca ccatgcttgc tttgtccaga ttgcgactgt cacccagtcc
     2101 tctggctctt ccatctgtct gtccactcca cctaccaaga tgttgaacac ttgttctttt
     2161 taagatgttg gtgcctggag tttcattaga gtaacacaaa actaactaaa accaaacaac
     2221 tccaaaggag cccatatgtg ttttaatgaa acatttttta agcctattgg gggcctgaag
     2281 agattgctca gaggaaaaca gcacttccag aggacccagg ttcaattctc atcgctgatg
     2341 tgatagttaa cagctgtaac ttcagttcca aggggtctga ctttctgccc tttgcttgca
     2401 atgcatgtat gtgatacaca gacatacatt ctgacaaaat atatccatac acaaaagtat
     2461 ttttttaaaa gcttatttga atgtaagagt atggctagct gtcacttctg ataccccttc
     2521 ttattttttt atgactcaag cccttataaa ctagcaaata gaagtcacag ctaccacttg
     2581 aatataagca cttgaatacc tcctctcact agaatacaac atagcttaat agtaaaaatc
     2641 ttgccttagt aaagtacttg catgtcatgt ctacatgaac caaatgaatg tattaattaa
     2701 taatagacat aatgatcaca tcggaaaggc tgtgagaaat aatggagaac atttgaaagc
     2761 tcaagatgga agggaaaggc acttgtcaaa aatcttgaca acctgaattt gacctttggc
     2821 agggctgaaa actaaaccca gggtcttact cccagtaggc atgaaccccc acactgagcg
     2881 gcaccacagc cctaaggttt taaatggcag aaacaactga gcgcttttct aattcctggt
     2941 ccccaagtca tcactgatgg caaaattcac agcacttcat cttgtctgcc aagctggcaa
     3001 gcgaaatggt gtctgatttc ttttttgttt ttttaaagat ttattcatta ttatatctaa
     3061 gtacactgta gctgtcttca gatgcaccag aaaagggcgt cagatctcat tacggatggt
     3121 tgtgagccac catgtggttg ctgggatttg aactcagaaa cttcagaaga gcagtcggtg
     3181 ctcttaacca ctgagccacc tctccagccc cagtgtctga tttctaatgt ttgtgttgaa
     3241 cgtatacatt ctttgtctgc tgttaattct atagtaatct cctgtgaaag attttataac
     3301 gcccaggcct ggattcaacc acaatccaac aggatcggaa tcctggggtg gtgctcagag
     3361 atctttttgt gcgtgcattt tagtttttta aagtaattag caggcagcct gcaggacaca
     3421 tctttgccaa aatgtcaaat gctgtgactt ataaattaaa tatttaagaa tgcagcatac
     3481 ccagagaaat cattagatgt tcaaagattt aattcgtgtg caacattaaa tgccatgact
     3541 tgtttaaaca agcacaccta aatattcttt cttctgctag aatctgaagc ctgtgatgca
     3601 ggaagcaaga atggagagaa tattctagaa taagaacttt ctgggcgatt gtgagccctt
     3661 taataaaagg catgaatact tatctgtttg aaagagaaat caatttgggg tgggggcggg
     3721 ggttgtcctt tctttgctga gttctagccc aacaagccat ctgacttgaa gactaagacg
     3781 agcctgccac ctgggcaagc acagggacaa tgatcccagg gcagaggcca gctctgctgt
     3841 tttgagaagt gtctaggcaa aagctttctt tctttttttt tttttttcag accaaaaggg
     3901 gcctctttaa tgtcacacac cattagtgcc accaggtggc gaggttccct taatttcttc
     3961 agtatcaagt cttttaaaag tgtatgagta taaacatctt caaattctcg ggtttaaaaa
     4021 caaaatcaaa aatgaaaaaa ggtcgcttac ctttagacca taggcaactg gagctaaaga
     4081 caagagataa gctggtgtac cccgatggag cagcaggctt taactgaatc tgtgaggaac
     4141 agggtggggc ttcacatggt aaaactgaat ctgaggtgtg ttcttttgcc tgtttgggtt
     4201 gttgctgttg ttactgcttt gttttgtttt tttgttttta agtgaaacag aatttaagtc
     4261 ttttggaaga cttttgtaaa ttctcttggt cccaagggag ggctctgtga cgtctggagt
     4321 ctcaacagtt tggtctttgc cctgtctcct gttattatag actgtggcct ttgccactcc
     4381 atcactgcct actgtttttc ttggagacag ggtctctccc attacgggca gccagcagtg
     4441 ccctgagagt ctcttgacat gtggccatga aggcttttta caaggatgct ggggatttga
     4501 acccgggttc tcatgcttga gccataactg ctcttaccct agaactgtct ccccagtcca
     4561 atcactgcta ctattttttt ttcttggcaa atcaattcag ttctttagtt ttctttcaag
     4621 tattgtttta cctatttatc atatttatca ctttcattat caatgttaga aattttgttt
     4681 agccagcctt tttacttatt cttgaaataa agggttaaat agatattttt tcagttgtga
     4741 gacatgaaaa tcttagaaag aatttttctt ttctttttcc tttcatttta atagcagtga
     4801 atctagaaag agaattattt ttcatggtga ttatttcaaa tgtattgata ccattttgtg
     4861 ggctgggaaa tgttaaactt tgtaaactct gaaacgcaca aagtgttgct ttgaatttca
     4921 ccttaataaa aataacatca agta
//
