LOCUS       NP_033451                291 aa            linear   ROD 24-DEC-2024
DEFINITION  tumor necrosis factor ligand superfamily member 10 [Mus musculus].
ACCESSION   NP_033451
VERSION     NP_033451.1
DBSOURCE    REFSEQ: accession NM_009425.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 291)
  AUTHORS   Cartland,S.P., Patil,M.S., Kelland,E., Le,N., Boccanfuso,L.,
            Stanley,C.P., Cholan,P.M., Dona,M.I., Patrick,R., McGrath,J.,
            Su,Q.P., Alwis,I., Ganss,R., Powell,J.E., Harvey,R.P., Pinto,A.R.,
            Griffith,T.S., Loa,J., Aitken,S.J., Robinson,D.A., Patel,S. and
            Kavurma,M.M.
  TITLE     The generation of stable microvessels in ischemia is mediated by
            endothelial cell derived TRAIL
  JOURNAL   Sci Adv 10 (40), eadn8760 (2024)
   PUBMED   39365855
  REMARK    GeneRIF: The generation of stable microvessels in ischemia is
            mediated by endothelial cell derived TRAIL.
REFERENCE   2  (residues 1 to 291)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 291)
  AUTHORS   Krishnan,A., Ozturk,N.B., Cutshaw,K.A., Guicciardi,M.E.,
            Kitagataya,T., Olson,K.E., Pavelko,K.D., Sherman,W., Wixom,A.Q.,
            Jalan-Sakrikar,N., Baez-Faria,M., Gutierrez,F. and Gores,G.J.
  TITLE     Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
            deletion in myeloid cells augments cholestatic liver injury
  JOURNAL   Sci Rep 14 (1), 2145 (2024)
   PUBMED   38273071
  REMARK    GeneRIF: Tumor necrosis factor-related apoptosis-inducing ligand
            (TRAIL) deletion in myeloid cells augments cholestatic liver
            injury.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 291)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   5  (residues 1 to 291)
  AUTHORS   Wu,B., Wu,B., Benkaci,S., Shi,L., Lu,P., Park,T., Morrow,B.E.,
            Wang,Y. and Zhou,B.
  TITLE     Crk and Crkl Are Required in the Endocardial Lineage for Heart
            Valve Development
  JOURNAL   J Am Heart Assoc 12 (18), e029683 (2023)
   PUBMED   37702066
REFERENCE   6  (residues 1 to 291)
  AUTHORS   Hofmann,K.
  TITLE     The modular nature of apoptotic signaling proteins
  JOURNAL   Cell Mol Life Sci 55 (8-9), 1113-1128 (1999)
   PUBMED   10442092
  REMARK    Review article
REFERENCE   7  (residues 1 to 291)
  AUTHORS   Walczak,H., Miller,R.E., Ariail,K., Gliniak,B., Griffith,T.S.,
            Kubin,M., Chin,W., Jones,J., Woodward,A., Le,T., Smith,C.,
            Smolak,P., Goodwin,R.G., Rauch,C.T., Schuh,J.C. and Lynch,D.H.
  TITLE     Tumoricidal activity of tumor necrosis factor-related
            apoptosis-inducing ligand in vivo
  JOURNAL   Nat Med 5 (2), 157-163 (1999)
   PUBMED   9930862
REFERENCE   8  (residues 1 to 291)
  AUTHORS   French,L.E. and Tschopp,J.
  TITLE     The TRAIL to selective tumor death
  JOURNAL   Nat Med 5 (2), 146-147 (1999)
   PUBMED   9930856
REFERENCE   9  (residues 1 to 291)
  AUTHORS   Lavenu,A., Roland,J., Poirier,C., Cazenave,P., Babinet,C. and
            Morello,D.
  TITLE     Genomic structure and precise mapping of a thymic regulatory region
            on mouse chromosome 17 revealed by a c-myc transgene insertion
  JOURNAL   Genomics 34 (3), 381-388 (1996)
   PUBMED   8786139
REFERENCE   10 (residues 1 to 291)
  AUTHORS   Wiley,S.R., Schooley,K., Smolak,P.J., Din,W.S., Huang,C.P.,
            Nicholl,J.K., Sutherland,G.R., Smith,T.D., Rauch,C., Smith,C.A. et
            al.
  TITLE     Identification and characterization of a new member of the TNF
            family that induces apoptosis
  JOURNAL   Immunity 3 (6), 673-682 (1995)
   PUBMED   8777713
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY734631.1, U37522.1 and AC116585.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157633.1, BC138807.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..291
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 10.82 cM"
     Protein         1..291
                     /product="tumor necrosis factor ligand superfamily member
                     10"
                     /note="TRAIL/APO2L; TNF-related apoptosis-inducing ligand;
                     tumor necrosis factor ligand 6a"
                     /calculated_mol_wt=33346
     Site            18..38
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P50592.1)"
     Site            52
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P50592.1)"
     Site            order(129,187,189,253,258,284,288)
                     /site_type="other"
                     /note="trimer interface [polypeptide binding]"
                     /db_xref="CDD:238108"
     Region          157..290
                     /region_name="TNF"
                     /note="TNF(Tumour Necrosis Factor) family; pfam00229"
                     /db_xref="CDD:425540"
     Site            order(159..160,166,217,224,228)
                     /site_type="active"
                     /note="receptor binding sites [active]"
                     /db_xref="CDD:238108"
     CDS             1..291
                     /gene="Tnfsf10"
                     /gene_synonym="A330042I21Rik; APO-2L; Ly81; TL2; Tnlg6a;
                     Trail"
                     /coded_by="NM_009425.2:71..946"
                     /db_xref="CCDS:CCDS17272.1"
                     /db_xref="GeneID:22035"
                     /db_xref="MGI:MGI:107414"
ORIGIN      
        1 mpssgalkdl sfsqhfrmmv icivllqvll qavsvavtym yftnemkqlq dnyskiglac
       61 fsktdedfwd stdgeilnrp clqvkrqlyq lieevtlrtf qdtistvpek qlstpplprg
      121 grpqkvaahi tgitrrsnsa lipiskdgkt lgqkieswes srkghsflnh vlfrngelvi
      181 eqeglyyiys qtyfrfqeae daskmvskdk vrtkqlvqyi ykytsypdpi vlmksarnsc
      241 wsrdaeygly siyqgglfel kkndrifvsv tnehlmdldq easffgafli n
//
