LOCUS       NM_011612               2134 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus tumor necrosis factor receptor superfamily, member 9
            (Tnfrsf9), transcript variant 1, mRNA.
ACCESSION   NM_011612
VERSION     NM_011612.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2134)
  AUTHORS   Ziblat,A., Horton,B.L., Higgs,E.F., Hatogai,K., Martinez,A.,
            Shapiro,J.W., Kim,D.E.C., Zha,Y., Sweis,R.F. and Gajewski,T.F.
  TITLE     Batf3+ DCs and the 4-1BB/4-1BBL axis are required at the effector
            phase in the tumor microenvironment for PD-1/PD-L1 blockade
            efficacy
  JOURNAL   Cell Rep 43 (5), 114141 (2024)
   PUBMED   38656869
REFERENCE   2  (bases 1 to 2134)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2134)
  AUTHORS   Wang,Y., Zhang,X., Xu,C., Nan,Y., Fan,J., Zeng,X., Kwon,B.S. and
            Ju,D.
  TITLE     Targeting 4-1BB and PD-L1 induces potent and durable antitumor
            immunity in B-cell lymphoma
  JOURNAL   Front Immunol 13, 1004475 (2022)
   PUBMED   36544785
  REMARK    GeneRIF: Targeting 4-1BB and PD-L1 induces potent and durable
            antitumor immunity in B-cell lymphoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2134)
  AUTHORS   Wu,R., Ohara,R.A., Jo,S., Liu,T.T., Ferris,S.T., Ou,F., Kim,S.,
            Theisen,D.J., Anderson,D.A. 3rd, Wong,B.W., Gershon,T.,
            Schreiber,R.D., Murphy,T.L. and Murphy,K.M.
  TITLE     Mechanisms of CD40-dependent cDC1 licensing beyond costimulation
  JOURNAL   Nat Immunol 23 (11), 1536-1550 (2022)
   PUBMED   36271147
REFERENCE   5  (bases 1 to 2134)
  AUTHORS   Han,J., Wang,Y., Zhou,H., Zhang,Y. and Wan,D.
  TITLE     CD137 Regulates Bone Loss via the p53 Wnt/beta-Catenin Signaling
            Pathways in Aged Mice
  JOURNAL   Front Endocrinol (Lausanne) 13, 922501 (2022)
   PUBMED   35846320
  REMARK    GeneRIF: CD137 Regulates Bone Loss via the p53 Wnt/beta-Catenin
            Signaling Pathways in Aged Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2134)
  AUTHORS   Setareh,M., Schwarz,H. and Lotz,M.
  TITLE     A mRNA variant encoding a soluble form of 4-1BB, a member of the
            murine NGF/TNF receptor family
  JOURNAL   Gene 164 (2), 311-315 (1995)
   PUBMED   7590349
REFERENCE   7  (bases 1 to 2134)
  AUTHORS   Zhou,Z., Kim,S., Hurtado,J., Lee,Z.H., Kim,K.K., Pollok,K.E. and
            Kwon,B.S.
  TITLE     Characterization of human homologue of 4-1BB and its ligand
  JOURNAL   Immunol Lett 45 (1-2), 67-73 (1995)
   PUBMED   7622190
REFERENCE   8  (bases 1 to 2134)
  AUTHORS   Pollok,K.E., Kim,Y.J., Zhou,Z., Hurtado,J., Kim,K.K., Pickard,R.T.
            and Kwon,B.S.
  TITLE     Inducible T cell antigen 4-1BB. Analysis of expression and function
  JOURNAL   J Immunol 150 (3), 771-781 (1993)
   PUBMED   7678621
REFERENCE   9  (bases 1 to 2134)
  AUTHORS   Chalupny,N.J., Peach,R., Hollenbaugh,D., Ledbetter,J.A., Farr,A.G.
            and Aruffo,A.
  TITLE     T-cell activation molecule 4-1BB binds to extracellular matrix
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 89 (21), 10360-10364 (1992)
   PUBMED   1279676
REFERENCE   10 (bases 1 to 2134)
  AUTHORS   Kwon,B.S. and Weissman,S.M.
  TITLE     cDNA sequences of two inducible T-cell genes
  JOURNAL   Proc Natl Acad Sci U S A 86 (6), 1963-1967 (1989)
   PUBMED   2784565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY206772.1, AK019885.1 and BY539760.1.
            
            On Nov 3, 2006 this sequence version replaced NM_011612.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 3 encode the same protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019885.1, SRR5189676.3274.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               BY206772.1         1-356
            357-499             AK019885.1         323-465
            500-2125            AK019885.1         467-2092
            2126-2134           BY539760.1         390-398
FEATURES             Location/Qualifiers
     source          1..2134
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 81.52 cM"
     gene            1..2134
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB; A930040I11Rik; Cd137; CDw137; ILA;
                     Ly63"
                     /note="tumor necrosis factor receptor superfamily, member
                     9"
                     /db_xref="GeneID:21942"
                     /db_xref="MGI:MGI:1101059"
     exon            1..106
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB; A930040I11Rik; Cd137; CDw137; ILA;
                     Ly63"
                     /inference="alignment:Splign:2.1.0"
     exon            107..231
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB; A930040I11Rik; Cd137; CDw137; ILA;
                     Ly63"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..902
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB; A930040I11Rik; Cd137; CDw137; ILA;
                     Ly63"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD137 antigen; secreted CD137 antigen; T-cell
                     antigen 4-1BB; 4-1BB ligand receptor"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 9 isoform 1 precursor"
                     /protein_id="NP_035742.1"
                     /db_xref="CCDS:CCDS18976.1"
                     /db_xref="GeneID:21942"
                     /db_xref="MGI:MGI:1101059"
                     /translation="MGNNCYNVVVIVLLLVGCEKVGAVQNSCDNCQPGTFCRKYNPVC
                     KSCPPSTFSSIGGQPNCNICRVCAGYFRFKKFCSSTHNAECECIEGFHCLGPQCTRCE
                     KDCRPGQELTKQGCKTCSLGTFNDQNGTGVCRPWTNCSLDGRSVLKTGTTEKDVVCGP
                     PVVSFSPSTTISVTPEGGPGGHSLQVLTLFLALTSALLLALIFITLLFSVLKWIRKKF
                     PHIFKQPFKKTTGAAQEEDACSCRCPQEEEGGGGGYEL"
     exon            232..336
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB; A930040I11Rik; Cd137; CDw137; ILA;
                     Ly63"
                     /inference="alignment:Splign:2.1.0"
     exon            337..474
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB; A930040I11Rik; Cd137; CDw137; ILA;
                     Ly63"
                     /inference="alignment:Splign:2.1.0"
     exon            475..544
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB; A930040I11Rik; Cd137; CDw137; ILA;
                     Ly63"
                     /inference="alignment:Splign:2.1.0"
     exon            545..669
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB; A930040I11Rik; Cd137; CDw137; ILA;
                     Ly63"
                     /inference="alignment:Splign:2.1.0"
     exon            670..804
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB; A930040I11Rik; Cd137; CDw137; ILA;
                     Ly63"
                     /inference="alignment:Splign:2.1.0"
     exon            805..2134
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB; A930040I11Rik; Cd137; CDw137; ILA;
                     Ly63"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2109..2114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB; A930040I11Rik; Cd137; CDw137; ILA;
                     Ly63"
                     /note="hexamer: ATTAAA"
     polyA_site      2131
                     /gene="Tnfrsf9"
                     /gene_synonym="4-1BB; A930040I11Rik; Cd137; CDw137; ILA;
                     Ly63"
                     /note="major polyA site"
ORIGIN      
        1 ttcctgaaat tcaggtgctg caggcagccc tcagcacaga gagctgacag ggaccctggg
       61 tcaggggttc tgagttccag ctgccactat tcttcttcac ctttggtgtc ctgtgcatgt
      121 gacatttcgc catgggaaac aactgttaca acgtggtggt cattgtgctg ctgctagtgg
      181 gctgtgagaa ggtgggagcc gtgcagaact cctgtgataa ctgtcagcct ggtactttct
      241 gcagaaaata caatccagtc tgcaagagct gccctccaag taccttctcc agcataggtg
      301 gacagccgaa ctgtaacatc tgcagagtgt gtgcaggcta tttcaggttc aagaagtttt
      361 gctcctctac ccacaacgcg gagtgtgagt gcattgaagg attccattgc ttggggccac
      421 agtgcaccag atgtgaaaag gactgcaggc ctggccagga gctaacgaag cagggttgca
      481 aaacctgtag cttgggaaca tttaatgacc agaacggtac tggcgtctgt cgaccctgga
      541 cgaactgctc tctagacgga aggtctgtgc ttaagaccgg gaccacggag aaggacgtgg
      601 tgtgtggacc ccctgtggtg agcttctctc ccagtaccac catttctgtg actccagagg
      661 gaggaccagg agggcactcc ttgcaggtcc ttaccttgtt cctggcgctg acatcggctt
      721 tgctgctggc cctgatcttc attactctcc tgttctctgt gctcaaatgg atcaggaaaa
      781 aattccccca catattcaag caaccattta agaagaccac tggagcagct caagaggaag
      841 atgcttgtag ctgccgatgt ccacaggaag aagaaggagg aggaggaggc tatgagctgt
      901 gatgtactat cctaggagat gtgtgggccg aaaccgagaa gcactaggac cccaccatcc
      961 tgtggaacag cacaagcaac cccaccaccc tgttcttaca catcatccta gatgatgtgt
     1021 gggcgcgcac ctcatccaag tctcttctaa cgctaacata tttgtcttta ccttttttaa
     1081 atcttttttt aaatttaaat tttatgtgtg tgagtgtttt gcctgcctgt atgcacacgt
     1141 gtgtgtgtgt gtgtgtgtga cactcctgat gcctgaggag gtcagaagag aaagggttgg
     1201 ttccataaga actggagtta tggatggctg tgagcctttg tgtgggtgct aggaatcaaa
     1261 cctgggtcct ctacaagggc agccagtgct cttaaccact gagtcagctt tccagccctg
     1321 ccctggacag tttttaaaat ttaacttaat tttttttttt ttttacttaa gcccttaaca
     1381 tttttaatag gactgtggga agatcaattt ctagattctc cttaacaata tacatcatat
     1441 acatatacac atacatatac atatacatat atattctgag aaaatgacag tttcagttgg
     1501 atctcataga ccaatggtcc agttaaaata actgtaaaat cagtgtgtgt gtgtgtgtgt
     1561 gtgtgtgtgt gcaaatatga tgcatgacaa tagccataag atgcagtata ttaccctatc
     1621 ccattttcct ttggtttctc actcactata ataacacctc cactgtctga agggggagac
     1681 ccatgcatcc ctgtctggag gaagcctgac agattttgag gggaatcttc agagcagttc
     1741 aagggcctgc ttctcctgtt tcctctgtgt caggcttttc aataaaaagg ccgtttagga
     1801 aagggacaaa gcactgtgag gtggggaaca cctgtgaact cacagtagga acgcggcctt
     1861 ccagtccacc atgggcagac atggctgccg cttgcctctg catgactcct ggacagctca
     1921 agagctgaga atggttgtta cttttcttta ttttgagaca gcacctccct ctgtagtgct
     1981 ggctggcctg gaagtcacag aaatcctcct gcctctgctt ccagagtact gggtcttaaa
     2041 ctgttcacca cgtctcccct ccccaacccc caaactagcc tttccatttt taaaagccag
     2101 ctaaaaatat taaagttgtg ctcttacaaa agtc
//
