LOCUS       NM_011659               1155 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus tumor necrosis factor receptor superfamily, member 4
            (Tnfrsf4), mRNA.
ACCESSION   NM_011659
VERSION     NM_011659.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1155)
  AUTHORS   Yu,J., Cui,J., Zhang,X., Xu,H., Chen,Z., Li,Y., Niu,Y., Wang,S.,
            Ran,S., Zou,Y., Ye,W., Zhang,D., Zhou,C., Xia,J. and Wu,J.
  TITLE     The OX40-TRAF6 axis promotes CTLA-4 degradation to augment
            antitumor CD8+ T-cell immunity
  JOURNAL   Cell Mol Immunol 20 (12), 1445-1456 (2023)
   PUBMED   37932534
  REMARK    GeneRIF: The OX40-TRAF6 axis promotes CTLA-4 degradation to augment
            antitumor CD8[+] T-cell immunity.
REFERENCE   2  (bases 1 to 1155)
  AUTHORS   Chen,Y., Liu,Z., Liu,F., Xu,L., Li,G., Qiao,W., Wang,Y. and Dong,N.
  TITLE     T cell specific deletion of IRF4 with Ox40-Cre impairs effector and
            memory T cell responses in heart transplantation
  JOURNAL   Clin Immunol 252, 109647 (2023)
   PUBMED   37211291
  REMARK    GeneRIF: T cell specific deletion of IRF4 with Ox40-Cre impairs
            effector and memory T cell responses in heart transplantation.
REFERENCE   3  (bases 1 to 1155)
  AUTHORS   Han,C., Sheng,Y., Wang,J., Zhou,X., Li,W., Guo,L., Yang,Y. and
            Cao,C.
  TITLE     TFAP4 promotes the progression of liver fibrosis through regulating
            double-negative T cell differentiation via OX40
  JOURNAL   Int Immunopharmacol 119, 110164 (2023)
   PUBMED   37060810
  REMARK    GeneRIF: TFAP4 promotes the progression of liver fibrosis through
            regulating double-negative T cell differentiation via OX40.
REFERENCE   4  (bases 1 to 1155)
  AUTHORS   Hofland,T., Danelli,L., Cornish,G., Donnarumma,T., Hunt,D.M., de
            Carvalho,L.P.S. and Kassiotis,G.
  TITLE     CD4+ T cell memory is impaired by species-specific cytotoxic
            differentiation, but not by TCF-1 loss
  JOURNAL   Front Immunol 14, 1168125 (2023)
   PUBMED   37122720
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1155)
  AUTHORS   van der Sluis,T.C., Beyrend,G., van der Gracht,E.T.I., Abdelaal,T.,
            Jochems,S.P., Belderbos,R.A., Wesselink,T.H., van Duikeren,S., van
            Haften,F.J., Redeker,A., Ouboter,L.F., Beyranvand Nejad,E.,
            Camps,M., Franken,K.L.M.C., Linssen,M.M., Hohenstein,P., de
            Miranda,N.F.C.C., Mei,H., Bins,A.D., Haanen,J.B.A.G., Aerts,J.G.,
            Ossendorp,F. and Arens,R.
  TITLE     OX40 agonism enhances PD-L1 checkpoint blockade by shifting the
            cytotoxic T cell differentiation spectrum
  JOURNAL   Cell Rep Med 4 (3), 100939 (2023)
   PUBMED   36796366
  REMARK    GeneRIF: OX40 agonism enhances PD-L1 checkpoint blockade by
            shifting the cytotoxic T cell differentiation spectrum.
REFERENCE   6  (bases 1 to 1155)
  AUTHORS   Stuber,E., Neurath,M., Calderhead,D., Fell,H.P. and Strober,W.
  TITLE     Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine
            family, induces proliferation and differentiation in murine splenic
            B cells
  JOURNAL   Immunity 2 (5), 507-521 (1995)
   PUBMED   7749983
REFERENCE   7  (bases 1 to 1155)
  AUTHORS   Birkeland,M.L., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Barclay,A.N.
  TITLE     Gene structure and chromosomal localization of the mouse homologue
            of rat OX40 protein
  JOURNAL   Eur J Immunol 25 (4), 926-930 (1995)
   PUBMED   7737295
REFERENCE   8  (bases 1 to 1155)
  AUTHORS   Baum,P.R., Gayle,R.B. 3rd, Ramsdell,F., Srinivasan,S.,
            Sorensen,R.A., Watson,M.L., Seldin,M.F., Baker,E., Sutherland,G.R.,
            Clifford,K.N. et al.
  TITLE     Molecular characterization of murine and human OX40/OX40 ligand
            systems: identification of a human OX40 ligand as the
            HTLV-1-regulated protein gp34
  JOURNAL   EMBO J 13 (17), 3992-4001 (1994)
   PUBMED   8076595
REFERENCE   9  (bases 1 to 1155)
  AUTHORS   Latza,U., Durkop,H., Schnittger,S., Ringeling,J., Eitelbach,F.,
            Hummel,M., Fonatsch,C. and Stein,H.
  TITLE     The human OX40 homolog: cDNA structure, expression and chromosomal
            assignment of the ACT35 antigen
  JOURNAL   Eur J Immunol 24 (3), 677-683 (1994)
   PUBMED   7510240
REFERENCE   10 (bases 1 to 1155)
  AUTHORS   Calderhead,D.M., Buhlmann,J.E., van den Eertwegh,A.J., Claassen,E.,
            Noelle,R.J. and Fell,H.P.
  TITLE     Cloning of mouse Ox40: a T cell activation marker that may mediate
            T-B cell interactions
  JOURNAL   J Immunol 151 (10), 5261-5271 (1993)
   PUBMED   8228223
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL627204.7.
            
            On Nov 17, 2006 this sequence version replaced NM_011659.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC139266.1, Z21674.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-312               AL627204.7         89335-89646
            313-435             AL627204.7         89868-89990
            436-543             AL627204.7         90542-90649
            544-610             AL627204.7         91026-91092
            611-807             AL627204.7         91518-91714
            808-927             AL627204.7         91794-91913
            928-1155            AL627204.7         92002-92229
FEATURES             Location/Qualifiers
     source          1..1155
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 87.68 cM"
     gene            1..1155
                     /gene="Tnfrsf4"
                     /gene_synonym="ACT35; CD134; Ly-70; Ox40; Txgp1; TXGP1L"
                     /note="tumor necrosis factor receptor superfamily, member
                     4"
                     /db_xref="GeneID:22163"
                     /db_xref="MGI:MGI:104512"
     exon            1..312
                     /gene="Tnfrsf4"
                     /gene_synonym="ACT35; CD134; Ly-70; Ox40; Txgp1; TXGP1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..998
                     /gene="Tnfrsf4"
                     /gene_synonym="ACT35; CD134; Ly-70; Ox40; Txgp1; TXGP1L"
                     /note="OX40 antigen; OX40L receptor; tax-transcriptionally
                     activated glycoprotein 1"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 4 precursor"
                     /protein_id="NP_035789.1"
                     /db_xref="CCDS:CCDS19055.1"
                     /db_xref="GeneID:22163"
                     /db_xref="MGI:MGI:104512"
                     /translation="MYVWVQQPTALLLLGLTLGVTARRLNCVKHTYPSGHKCCRECQP
                     GHGMVSRCDHTRDTLCHPCETGFYNEAVNYDTCKQCTQCNHRSGSELKQNCTPTQDTV
                     CRCRPGTQPRQDSGYKLGVDCVPCPPGHFSPGNNQACKPWTNCTLSGKQTRHPASDSL
                     DAVCEDRSLLATLLWETQRPTFRPTTVQSTTVWPRTSELPSPPTLVTPEGPAFAVLLG
                     LGLGLLAPLTVLLALYLLRKAWRLPNTPKPCWGNSFRTPIQEEHTDAHFTLAKI"
     exon            313..435
                     /gene="Tnfrsf4"
                     /gene_synonym="ACT35; CD134; Ly-70; Ox40; Txgp1; TXGP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            436..543
                     /gene="Tnfrsf4"
                     /gene_synonym="ACT35; CD134; Ly-70; Ox40; Txgp1; TXGP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            544..610
                     /gene="Tnfrsf4"
                     /gene_synonym="ACT35; CD134; Ly-70; Ox40; Txgp1; TXGP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            611..807
                     /gene="Tnfrsf4"
                     /gene_synonym="ACT35; CD134; Ly-70; Ox40; Txgp1; TXGP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            808..927
                     /gene="Tnfrsf4"
                     /gene_synonym="ACT35; CD134; Ly-70; Ox40; Txgp1; TXGP1L"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1155
                     /gene="Tnfrsf4"
                     /gene_synonym="ACT35; CD134; Ly-70; Ox40; Txgp1; TXGP1L"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaaagcact tcttagctta tcatgggact ctgcatacgc ctgtgccaaa tacacaggaa
       61 cacgttcaca taccttcttg cctgtccgcc tactcttctt gccccacctc catagttctt
      121 atagccacac cctgcaagga aaaaccccag actcctgtga aggcagaaag cagacaagga
      181 tgtatgtgtg ggttcagcag cccacagccc ttctgctgct gggactcaca cttggagtta
      241 cagcaaggcg gctcaactgt gttaaacata cctaccccag tggtcacaag tgctgtcgtg
      301 agtgccagcc aggccatggt atggtgagcc gctgtgatca taccagggat actctatgtc
      361 atccgtgtga gactggcttc tacaatgaag ctgtcaatta tgatacctgc aagcagtgta
      421 cacagtgcaa ccatcgaagt ggaagtgaac tcaagcagaa ttgcacacct actcaggata
      481 ctgtctgcag atgtagacca ggcacccaac ctcggcagga cagcggctac aagcttggag
      541 ttgactgtgt tccctgccct cctggccact tttctccagg caacaaccag gcctgcaagc
      601 cctggaccaa ttgtacctta tctggaaagc agacccgcca cccagccagt gacagcttgg
      661 acgcagtctg tgaggacaga agcctcctgg ccacactgct ctgggagacc cagcgcccta
      721 cattcaggcc aaccactgtc caatccacca cagtctggcc caggacttct gagttgccct
      781 ctccacccac cttggtgact cctgagggcc ctgcatttgc tgttctccta ggcctgggcc
      841 tgggcctgct ggctcccttg actgtcctgc tggccttgta cctgctccgg aaggcttgga
      901 gattgcctaa cactcccaaa ccttgttggg gaaacagctt caggaccccg atccaggagg
      961 aacacacaga cgcacacttt actctggcca agatctgagc attactacag gagtggattt
     1021 tatggggcac ggacaaccca tatcctgatg cctgccagta ccctccacac cgttctaggt
     1081 gctgggctgg ctctgggctt tcctatgtat gctatgcata ctacctgcct ggtggtgctc
     1141 ctaataaaca tgcta
//
