LOCUS       NM_001291010            1661 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus tumor necrosis factor receptor superfamily, member 25
            (Tnfrsf25), transcript variant 1, mRNA.
ACCESSION   NM_001291010 XM_006539320
VERSION     NM_001291010.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1661)
  AUTHORS   Zhang D, Zhang J, Zhang J, Ji X, Qi Q, Xu J, Pan Y, Liu X, Sun F,
            Zeng R and Dong L.
  TITLE     Identification of a novel role for TL1A/DR3 deficiency in acute
            respiratory distress syndrome that exacerbates alveolar epithelial
            disruption
  JOURNAL   Respir Res 24 (1), 182 (2023)
   PUBMED   37434162
  REMARK    GeneRIF: Identification of a novel role for TL1A/DR3 deficiency in
            acute respiratory distress syndrome that exacerbates alveolar
            epithelial disruption.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1661)
  AUTHORS   Luo S, Liman N, Li C, Crossman A, Wang ECY, Meylan F and Park JH.
  TITLE     The cytokine receptor DR3 identifies and promotes the activation of
            thymic NKT17 cells
  JOURNAL   Cell Mol Life Sci 80 (3), 76 (2023)
   PUBMED   36847849
  REMARK    GeneRIF: The cytokine receptor DR3 identifies and promotes the
            activation of thymic NKT17 cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1661)
  AUTHORS   Adekoya TO, Smith N, Thomas AJ, Lane TS, Burnette N, Rivers EJ, Li
            Y, Chen XL and Richardson RM.
  TITLE     Host versus cell-dependent effects of beta-arrestin 1 expression in
            prostate tumorigenesis
  JOURNAL   Carcinogenesis 42 (5), 772-783 (2021)
   PUBMED   33710266
  REMARK    GeneRIF: Host versus cell-dependent effects of beta-arrestin 1
            expression in prostate tumorigenesis.
REFERENCE   4  (bases 1 to 1661)
  AUTHORS   Herro R, Miki H, Sethi GS, Mills D, Mehta AK, Nguyen XX,
            Feghali-Bostwick C, Miller M, Broide DH, Soloff R and Croft M.
  TITLE     TL1A Promotes Lung Tissue Fibrosis and Airway Remodeling
  JOURNAL   J Immunol 205 (9), 2414-2422 (2020)
   PUBMED   32958689
REFERENCE   5  (bases 1 to 1661)
  AUTHORS   Jacob N, Kumagai K, Abraham JP, Shimodaira Y, Ye Y, Luu J,
            Blackwood AY, Castanon SL, Stamps DT, Thomas LS, Gonsky R, Shih DQ,
            Michelsen KS and Targan SR.
  TITLE     Direct signaling of TL1A-DR3 on fibroblasts induces intestinal
            fibrosis in vivo
  JOURNAL   Sci Rep 10 (1), 18189 (2020)
   PUBMED   33097818
  REMARK    GeneRIF: Direct signaling of TL1A-DR3 on fibroblasts induces
            intestinal fibrosis in vivo.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1661)
  AUTHORS   Endres R, Hacker G, Brosch I and Pfeffer K.
  TITLE     Apparently normal tumor necrosis factor receptor 1 signaling in the
            absence of the silencer of death domains
  JOURNAL   Mol Cell Biol 23 (18), 6609-6617 (2003)
   PUBMED   12944486
REFERENCE   7  (bases 1 to 1661)
  AUTHORS   Migone TS, Zhang J, Luo X, Zhuang L, Chen C, Hu B, Hong JS, Perry
            JW, Chen SF, Zhou JX, Cho YH, Ullrich S, Kanakaraj P, Carrell J,
            Boyd E, Olsen HS, Hu G, Pukac L, Liu D, Ni J, Kim S, Gentz R, Feng
            P, Moore PA, Ruben SM and Wei P.
  TITLE     TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T
            cell costimulator
  JOURNAL   Immunity 16 (3), 479-492 (2002)
   PUBMED   11911831
REFERENCE   8  (bases 1 to 1661)
  AUTHORS   Wang EC, Thern A, Denzel A, Kitson J, Farrow SN and Owen MJ.
  TITLE     DR3 regulates negative selection during thymocyte development
  JOURNAL   Mol Cell Biol 21 (10), 3451-3461 (2001)
   PUBMED   11313471
REFERENCE   9  (bases 1 to 1661)
  AUTHORS   Locksley RM, Killeen N and Lenardo MJ.
  TITLE     The TNF and TNF receptor superfamilies: integrating mammalian
            biology
  JOURNAL   Cell 104 (4), 487-501 (2001)
   PUBMED   11239407
  REMARK    Review article
REFERENCE   10 (bases 1 to 1661)
  AUTHORS   Wang EC, Kitson J, Thern A, Williamson J, Farrow SN and Owen MJ.
  TITLE     Genomic structure, expression, and chromosome mapping of the mouse
            homologue for the WSL-1 (DR3, Apo3, TRAMP, LARD, TR3, TNFRSF12)
            gene
  JOURNAL   Immunogenetics 53 (1), 59-63 (2001)
   PUBMED   11261933
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772240.7.
            
            [WARNING] On Oct 19, 2023 this sequence was replaced by
            NM_001291010.2.
            
            On Mar 21, 2014 this sequence version replaced XM_006539320.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF329969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AL772240.7         7583-7763
            182-320             AL772240.7         8234-8372
            321-455             AL772240.7         8580-8714
            456-620             AL772240.7         9027-9191
            621-675             AL772240.7         9289-9343
            676-731             AL772240.7         9896-9951
            732-830             AL772240.7         10050-10148
            831-868             AL772240.7         10339-10376
            869-1052            AL772240.7         10809-10992
            1053-1661           AL772240.7         11160-11768
FEATURES             Location/Qualifiers
     source          1..1661
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 82.89 cM"
     gene            1..1661
                     /gene="Tnfrsf25"
                     /gene_synonym="APO-3; DDR3; DR3; LARD; Tnfrsf12; TR3;
                     TRAMP; Wsl; WSL-1; WSL-LR"
                     /note="tumor necrosis factor receptor superfamily, member
                     25"
                     /db_xref="GeneID:85030"
                     /db_xref="MGI:MGI:1934667"
     exon            1..181
                     /gene="Tnfrsf25"
                     /gene_synonym="APO-3; DDR3; DR3; LARD; Tnfrsf12; TR3;
                     TRAMP; Wsl; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1381
                     /gene="Tnfrsf25"
                     /gene_synonym="APO-3; DDR3; DR3; LARD; Tnfrsf12; TR3;
                     TRAMP; Wsl; WSL-1; WSL-LR"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; tumor necrosis factor receptor superfamily,
                     member 12"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 25 isoform 1 precursor"
                     /protein_id="NP_001277939.1"
                     /db_xref="CCDS:CCDS71527.1"
                     /db_xref="GeneID:85030"
                     /db_xref="MGI:MGI:1934667"
                     /translation="MEARLLRGCVVEPLFLPLLLLLLLLLGGQGQGGMSGRCDCASES
                     QKRYGPFCCRGCPKGHYMKAPCAEPCGNSTCLPCPSDTFLTRDNHFKTDCTRCQVCDE
                     EALQVTLENCSAKSDTHCGCQSGWCVDCSTEPCGKSSPFSCVPCGATTPVHEAPTPRP
                     CLPGFYIRGNDCTSCPTGFSSVCPKACTAVCGWKQMFWVQVLLGVAFLFGAILICAYC
                     RWQPCKAVVTADTAGTETLASPQTAHLSASDSAHTLLAPPSSTGKICTTVQLVGNNWT
                     PGLSQTQEVVCGQASQPWDQLPNRTLGTPLASPLSPAPPAGSPAAVLQPGPQLYDVMD
                     AVPARRWKEFVRTLGLREAEIEAVEVEICRFRDQQYEMLKRWRQQQPAGLGAIYAALE
                     RMGLEGCAEDLRSRLQRGP"
     exon            182..320
                     /gene="Tnfrsf25"
                     /gene_synonym="APO-3; DDR3; DR3; LARD; Tnfrsf12; TR3;
                     TRAMP; Wsl; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     exon            321..455
                     /gene="Tnfrsf25"
                     /gene_synonym="APO-3; DDR3; DR3; LARD; Tnfrsf12; TR3;
                     TRAMP; Wsl; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     exon            456..620
                     /gene="Tnfrsf25"
                     /gene_synonym="APO-3; DDR3; DR3; LARD; Tnfrsf12; TR3;
                     TRAMP; Wsl; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     exon            621..675
                     /gene="Tnfrsf25"
                     /gene_synonym="APO-3; DDR3; DR3; LARD; Tnfrsf12; TR3;
                     TRAMP; Wsl; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     exon            676..731
                     /gene="Tnfrsf25"
                     /gene_synonym="APO-3; DDR3; DR3; LARD; Tnfrsf12; TR3;
                     TRAMP; Wsl; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     exon            732..830
                     /gene="Tnfrsf25"
                     /gene_synonym="APO-3; DDR3; DR3; LARD; Tnfrsf12; TR3;
                     TRAMP; Wsl; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     exon            831..868
                     /gene="Tnfrsf25"
                     /gene_synonym="APO-3; DDR3; DR3; LARD; Tnfrsf12; TR3;
                     TRAMP; Wsl; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1052
                     /gene="Tnfrsf25"
                     /gene_synonym="APO-3; DDR3; DR3; LARD; Tnfrsf12; TR3;
                     TRAMP; Wsl; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1661
                     /gene="Tnfrsf25"
                     /gene_synonym="APO-3; DDR3; DR3; LARD; Tnfrsf12; TR3;
                     TRAMP; Wsl; WSL-1; WSL-LR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagttgtt ctggatggcg cgggggcggg cgggcaggca ggctagctct agtctaggaa
       61 cataggggct gagctggtgg ggaagccccg ggttacgcga ccgaccagag ccgcactcac
      121 aagggcccag gcggtacaga ccgcaatgga ggcacggctg ctgcggggct gcgtggtgga
      181 gcctctgttc ctaccactgc tgctgctgct gctgctgctg cttggtggcc agggccaggg
      241 cggcatgtct ggcaggtgtg actgtgccag tgagtcccag aagaggtatg gcccgttttg
      301 ttgcaggggc tgcccaaagg gacactacat gaaggccccc tgcgcagaac cctgtggcaa
      361 ctccacctgc cttccctgtc cctcggacac cttcttgacc agagacaacc actttaagac
      421 tgactgtacc cgctgccaag tctgtgatga agaggccctt caagtgaccc ttgagaactg
      481 ctcggcaaag tcggacaccc actgtggctg ccagtcaggc tggtgtgttg actgctccac
      541 cgagccatgt gggaaaagct cacctttctc ttgtgtccca tgcggggcta caacaccagt
      601 ccatgaggct ccaacccccc ggccctgcct gcctggcttc tatatacgtg gcaatgactg
      661 cacgtcctgc cccacgggct tcagcagcgt ttgccctaag gcttgcactg ctgtctgtgg
      721 ctggaagcag atgttttggg tccaggtgct tctaggagtc gcgttccttt ttggggctat
      781 cctgatctgt gcatattgtc gatggcagcc ttgtaaggcc gtggtcactg cagacacagc
      841 tgggacggag accctggcct caccacagac tgcccatctc tcagcctcag acagcgccca
      901 caccctcctg gcacctccaa gcagtactgg gaaaatctgt accactgtcc agttggtagg
      961 caacaactgg acccctggct tatcccagac tcaggaggtg gtctgcggac aggcctcaca
     1021 accctgggat cagctgccaa acagaactct tggaactcct ctggcatctc cgctctcgcc
     1081 agcgccccct gcgggctctc cggctgctgt gctccagcct ggcccgcagc tctacgatgt
     1141 gatggatgcg gtcccagcac gaaggtggaa ggagttcgtg cgcacgctgg ggctgcggga
     1201 agcggaaatt gaagccgtgg aggtggaaat ctgccgcttc cgagaccagc agtatgagat
     1261 gctcaagcgc tggcgtcagc agcagcctgc aggcctcggt gccatctatg cggctctgga
     1321 gcgcatgggt ctggaaggct gtgccgagga cctgcgcagc cgcctgcagc gtggcccgtg
     1381 atggaaggtc catcagccac tttgacaccc tagtgaccct tgaaggagcc ttaagtattg
     1441 ttacttatgc gtgtagacat tttatgtcaa ttactaaccc cctgccgtgg tcctgcgtag
     1501 cagggctggc tgcctcactt ttgcttatct gcagcacgga gctcctgcta agggaagcgt
     1561 catggagaaa taccagaagg ggccaagtga ttggttgctc agctgttaat tagcccgagt
     1621 ttggacttgg tattaaattt cgtaagaaaa gcagctgctt g
//
