LOCUS       NM_024290               3305 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus tumor necrosis factor receptor superfamily, member 23
            (Tnfrsf23), transcript variant 1, mRNA.
ACCESSION   NM_024290
VERSION     NM_024290.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3305)
  AUTHORS   de la Casa Esperon,E., Cordier,G. and Engel,N.
  TITLE     A genomic reservoir for Tnfrsf genes is developmentally regulated
            and imprinted in the mouse
  JOURNAL   Epigenetics 7 (6), 626-634 (2012)
   PUBMED   22595876
REFERENCE   2  (bases 1 to 3305)
  AUTHORS   Farrell,G.C., Larter,C.Z., Hou,J.Y., Zhang,R.H., Yeh,M.M.,
            Williams,J., dela Pena,A., Francisco,R., Osvath,S.R., Brooling,J.,
            Teoh,N. and Sedger,L.M.
  TITLE     Apoptosis in experimental NASH is associated with p53 activation
            and TRAIL receptor expression
  JOURNAL   J Gastroenterol Hepatol 24 (3), 443-452 (2009)
   PUBMED   19226377
  REMARK    GeneRIF: Apoptosis in experimental non-alcoholic steatohepatitis is
            associated with p53 activation and TRAIL receptor expression.
REFERENCE   3  (bases 1 to 3305)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   4  (bases 1 to 3305)
  AUTHORS   Schneider,P., Olson,D., Tardivel,A., Browning,B., Lugovskoy,A.,
            Gong,D., Dobles,M., Hertig,S., Hofmann,K., Van Vlijmen,H.,
            Hsu,Y.M., Burkly,L.C., Tschopp,J. and Zheng,T.S.
  TITLE     Identification of a new murine tumor necrosis factor receptor locus
            that contains two novel murine receptors for tumor necrosis
            factor-related apoptosis-inducing ligand (TRAIL)
  JOURNAL   J Biol Chem 278 (7), 5444-5454 (2003)
   PUBMED   12466268
REFERENCE   5  (bases 1 to 3305)
  AUTHORS   Mahy,N.L., Perry,P.E. and Bickmore,W.A.
  TITLE     Gene density and transcription influence the localization of
            chromatin outside of chromosome territories detectable by FISH
  JOURNAL   J Cell Biol 159 (5), 753-763 (2002)
   PUBMED   12473685
REFERENCE   6  (bases 1 to 3305)
  AUTHORS   Clark,L., Wei,M., Cattoretti,G., Mendelsohn,C. and Tycko,B.
  TITLE     The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs
            and expressed at the trophoblast-decidua interface
  JOURNAL   BMC Genet 3, 11 (2002)
   PUBMED   12102730
  REMARK    GeneRIF: The Tnfrh1 gene is weakly imprinted in several organs and
            expressed at the trophoblast-decidua interface.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3305)
  AUTHORS   Engemann,S., Strodicke,M., Paulsen,M., Franck,O., Reinhardt,R.,
            Lane,N., Reik,W. and Walter,J.
  TITLE     Sequence and functional comparison in the Beckwith-Wiedemann
            region: implications for a novel imprinting centre and extended
            imprinting
  JOURNAL   Hum Mol Genet 9 (18), 2691-2706 (2000)
   PUBMED   11063728
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY201915.1, BY036522.1,
            BG077775.2, AC068006.10 and BP768617.1.
            
            On Apr 22, 2015 this sequence version replaced NM_024290.3.
            
            Summary: This gene encodes a member of the tumor necrosis factor
            superfamily of proteins. The encoded receptor has been shown to
            bind to the ligand TRAIL (tumor necrosis factor-related
            apoptosis-inducing ligand), but to have no signaling capacity. This
            gene shows elevated expression in mice with diet-induced fatty
            liver disease. This gene and other family members are present in a
            gene cluster on chromosome 7. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY165625.1, AK154786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BY201915.1         2-4
            4-344               BY036522.1         1-341
            345-666             BG077775.2         318-639
            667-2766            AC068006.10        172092-174191       c
            2767-3305           BP768617.1         27-565              c
FEATURES             Location/Qualifiers
     source          1..3305
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.28 cM"
     gene            1..3305
                     /gene="Tnfrsf23"
                     /gene_synonym="mDcTRAILR1; mSOB; SOB; Tnfrh1; Tnfrsf1al1;
                     TNFRSFH23"
                     /note="tumor necrosis factor receptor superfamily, member
                     23"
                     /db_xref="GeneID:79201"
                     /db_xref="MGI:MGI:1930269"
     exon            1..94
                     /gene="Tnfrsf23"
                     /gene_synonym="mDcTRAILR1; mSOB; SOB; Tnfrh1; Tnfrsf1al1;
                     TNFRSFH23"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..550
                     /gene="Tnfrsf23"
                     /gene_synonym="mDcTRAILR1; mSOB; SOB; Tnfrh1; Tnfrsf1al1;
                     TNFRSFH23"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; tumor necrosis factor receptor superfamily,
                     member 1a-like 1; decoy TRAIL receptor 1; TNF receptor
                     homolog 1; TNF receptor family member SOB; tumor necrosis
                     factor receptor p60 homolog 1"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 23 isoform 1 precursor"
                     /protein_id="NP_077252.2"
                     /db_xref="CCDS:CCDS22044.1"
                     /db_xref="GeneID:79201"
                     /db_xref="MGI:MGI:1930269"
                     /translation="MVTFSHVSSLSHWFLLLLLLNLFLPVIFAMPESYSFNCPDGEYQ
                     SNDVCCKTCPSGTFVKAPCKIPHTQGQCEKCHPGTFTGKDNGLHDCELCSTCDKDQNM
                     VADCSATSDRKCECQIGLYYYDPKFPESCRPCTKCPQGIPVLQECNSTANTVCSSSVS
                     NPRNWLFLLMLIVFCI"
     exon            95..185
                     /gene="Tnfrsf23"
                     /gene_synonym="mDcTRAILR1; mSOB; SOB; Tnfrh1; Tnfrsf1al1;
                     TNFRSFH23"
                     /inference="alignment:Splign:2.1.0"
     exon            186..314
                     /gene="Tnfrsf23"
                     /gene_synonym="mDcTRAILR1; mSOB; SOB; Tnfrh1; Tnfrsf1al1;
                     TNFRSFH23"
                     /inference="alignment:Splign:2.1.0"
     exon            315..426
                     /gene="Tnfrsf23"
                     /gene_synonym="mDcTRAILR1; mSOB; SOB; Tnfrh1; Tnfrsf1al1;
                     TNFRSFH23"
                     /inference="alignment:Splign:2.1.0"
     exon            427..500
                     /gene="Tnfrsf23"
                     /gene_synonym="mDcTRAILR1; mSOB; SOB; Tnfrh1; Tnfrsf1al1;
                     TNFRSFH23"
                     /inference="alignment:Splign:2.1.0"
     exon            501..3286
                     /gene="Tnfrsf23"
                     /gene_synonym="mDcTRAILR1; mSOB; SOB; Tnfrh1; Tnfrsf1al1;
                     TNFRSFH23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3260..3265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfrsf23"
                     /gene_synonym="mDcTRAILR1; mSOB; SOB; Tnfrh1; Tnfrsf1al1;
                     TNFRSFH23"
                     /note="hexamer: AATAAA"
     polyA_site      3286
                     /gene="Tnfrsf23"
                     /gene_synonym="mDcTRAILR1; mSOB; SOB; Tnfrh1; Tnfrsf1al1;
                     TNFRSFH23"
                     /note="major polyA site"
ORIGIN      
        1 accatgctag ctcacagcca tggttacctt cagccacgtc tccagtctga gtcactggtt
       61 cctcttgctg ctgctgctga atctgttctt gccggtaata tttgctatgc ctgaatcata
      121 ctccttcaac tgtcccgatg gtgaatacca gtctaatgat gtctgttgca agacctgtcc
      181 ctcaggtaca tttgtcaagg cgccctgcaa aatcccccat actcaaggac aatgtgagaa
      241 gtgtcaccca ggaacattca cagggaaaga taatggcctg catgattgtg aactttgctc
      301 cacctgtgat aaagaccaga atatggtggc tgactgttct gccaccagtg accggaaatg
      361 cgagtgccaa ataggtcttt actactatga cccaaaattt ccggaatcat gccgcccatg
      421 taccaagtgt ccccaaggaa tccctgtcct ccaggaatgc aactccacag ctaacactgt
      481 gtgcagttca tctgtttcaa atcccagaaa ctggctgttc ctactgatgc taattgtctt
      541 ctgtatctga agaagataaa ggttctacag atggtgtctg tagcttcctt ttattgctgt
      601 gaagagaaac catggaggca actctttcat tttattttat tttttaatgt cttgaacttg
      661 atttgaagac caggctggac tcaaactcac agagatccgg actaggcacc tctaatatag
      721 gaaaacattg aattgggact ggcttacagt ttcagaagtt ctgtccatga ttatcatagt
      781 gcgaagcatg gaggcacgga ggcacacatg gtgctggaga agaagctgag agttctgcat
      841 cttgatctgc aagcaataaa aggagactgt gtgccacact acacatagct tgaacatagg
      901 agacctcaaa gcctgtcccc acagtgacaa acttcctcca acaaggtcat acctcctaat
      961 aataccattt cttatgaggc aagcattcaa acacatgagt ctatgagggc caaaccaatt
     1021 caaaccacca caggttaaca attgccctct gcagctctct ggtggaggcc ctccttgaga
     1081 gtaagtaaca atttagatga aggcaagtcc tggtatcagg tccaaaagaa actcaggatg
     1141 aatggtccac tgtggttcct attaacatac tgaagaacat gacctcacct tagacttctc
     1201 cacctcactg gcttcccttc ccctagcttc tcattcccag gtaaccctgc cattttttgg
     1261 taatgtgcct tcttggttct tcctctcctt tccccctctc ttctggtcct tatttctctt
     1321 cctctcccac tctccaccag ccgcctctta aggcctgagt cagtctgcag gccatgttta
     1381 atctactact ttctctctgc tctggactca tccagatgtc tctggctgag ctctccctcc
     1441 tatctacaat aaaacccttc cccctaacca gaaatggaac agttttgtcc tcactttgta
     1501 catctggtgc ctgaaaccag agaggaatat atatgacccc atccaagaga ctcagcctct
     1561 cctagccaaa ccatgctgtt ggtttgacga cttcctaagg tatgcatgga tggatcactt
     1621 gttcctgcag gcttctgcaa cctaccatag tgaactccaa acctggaatt cacctcttca
     1681 gctgcttctc ccctctactt gctctaacca tttgcttctc ctcaccatag caggaaattt
     1741 ccacttgcct aggggtgtgg tcaatgcctt gctatcacta ctcagaaatt tccccttggc
     1801 tagaggtgtg gtcagtgcac tgctctcact gctcagtaaa tttccacttg cctaggggtg
     1861 tggtcagtgc cttgttctca ctgctcagta aatttcccct tggctagggg tgtggtcagt
     1921 gcctttttct cactgctcag taaatttcct cttggctagg ggtgtggtca gtgccttgct
     1981 ctcactgctc agtaaatttc cacttgccta ggggtgtggt cagtgccttt ttctcaatgc
     2041 tcagtaagtt tccacttgcc taggggtgtg atcagtgcct tgctctcact gctaagtaaa
     2101 ttttcacttg cctatgggtt tggttagtgc cttgtgctca ctgctcagta aatttccact
     2161 tgcctagggg tgtggtcagt gcctttttct cactgctcag taagtttcca cttgcctagg
     2221 ggtgtgatca ctgcactgct ctcacttctc agtaaatttc ctcttggcta ggggtgtggt
     2281 cagtgccttg ttctcactgc tcagtaaatt ttcacttgcc taggggtgtg gtcagtgcct
     2341 tgtgctcact actcagtaaa tttccacttg cctaggggtg tggtcagtgc cttactctca
     2401 ctgttcagta aatttcctct tggctaaggg tgtgatcagt gccttgtgct cactactcag
     2461 caaatttcca ctatctaggg gtgtggtcag tggcttgctc tcactgctca gtaaacttcc
     2521 atgtaactag ggtgtggtca gtgctttgct ctcccaccat gaccagctct cctatgattt
     2581 ccagatgagg agtggggtca gttggacaga gccctcaaac atttatgtgt ccccaagcag
     2641 aaaccaagac caggggtgtc cacctcgatt ttggtaggag tcccctgctg ccacaggacc
     2701 aaaactgtta cctataggtg ctccagccca gcctcacaga atccttcaat tgggtgtgtg
     2761 cactcctagc accagatggt cccacagcct ggacagcagg gagacagcca gctcctccca
     2821 gaagtagcca acaatcaagc tttttggcca cccccataat gatgccccaa tgtcagcagg
     2881 aagaaatcat aaatgaataa atacatcacc ccttattctt ttattatcaa cagaaggctg
     2941 gaatgtttgg tttcagagcc ctggacaagt tgcttagttg catattttac ataccaaagc
     3001 agacctggcc tccaggttct cccagcatcc ttctgtcctt acctggcata acctgccccc
     3061 aatcctgaac ttcccaccta gggactgggc tgccattccc gcagaggctc ttccctatat
     3121 aatccagagg attttggtct tcctgttctc tctctgcaca tgggcacttt ctcttcccct
     3181 ttgcctttta ccccatacct gtggtaactt ccctcacctt cttccctggg tcagtgaact
     3241 caactgagag caatattcca ataaaactgt gtttaatata atctaaaaaa aaaaaaaaaa
     3301 aaaaa
//
