LOCUS       NM_001311145            4170 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus tumor necrosis factor receptor superfamily, member 22
            (Tnfrsf22), transcript variant 2, mRNA.
ACCESSION   NM_001311145 XM_006508662
VERSION     NM_001311145.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4170)
  AUTHORS   Uysal,H., Chavez-Galan,L., Vesin,D., Blaser,G., Benkhoucha,M.,
            Ryffel,B., Quesniaux,V.F.J. and Garcia,I.
  TITLE     Transmembrane TNF and Partially TNFR1 Regulate TNFR2 Expression and
            Control Inflammation in Mycobacterial-Induced Pleurisy
  JOURNAL   Int J Mol Sci 19 (7), 1959 (2018)
   PUBMED   29973541
  REMARK    GeneRIF: Transmembrane TNF, TNFR2 and TNFR1 (indirectly) are
            critical for preventing inflammation during BCG-induced pleurisy in
            mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4170)
  AUTHORS   de la Casa Esperon,E., Cordier,G. and Engel,N.
  TITLE     A genomic reservoir for Tnfrsf genes is developmentally regulated
            and imprinted in the mouse
  JOURNAL   Epigenetics 7 (6), 626-634 (2012)
   PUBMED   22595876
REFERENCE   3  (bases 1 to 4170)
  AUTHORS   Schneider,P., Olson,D., Tardivel,A., Browning,B., Lugovskoy,A.,
            Gong,D., Dobles,M., Hertig,S., Hofmann,K., Van Vlijmen,H.,
            Hsu,Y.M., Burkly,L.C., Tschopp,J. and Zheng,T.S.
  TITLE     Identification of a new murine tumor necrosis factor receptor locus
            that contains two novel murine receptors for tumor necrosis
            factor-related apoptosis-inducing ligand (TRAIL)
  JOURNAL   J Biol Chem 278 (7), 5444-5454 (2003)
   PUBMED   12466268
REFERENCE   4  (bases 1 to 4170)
  AUTHORS   Mahy,N.L., Perry,P.E. and Bickmore,W.A.
  TITLE     Gene density and transcription influence the localization of
            chromatin outside of chromosome territories detectable by FISH
  JOURNAL   J Cell Biol 159 (5), 753-763 (2002)
   PUBMED   12473685
REFERENCE   5  (bases 1 to 4170)
  AUTHORS   Clark,L., Wei,M., Cattoretti,G., Mendelsohn,C. and Tycko,B.
  TITLE     The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs
            and expressed at the trophoblast-decidua interface
  JOURNAL   BMC Genet 3, 11 (2002)
   PUBMED   12102730
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4170)
  AUTHORS   Engemann,S., Strodicke,M., Paulsen,M., Franck,O., Reinhardt,R.,
            Lane,N., Reik,W. and Walter,J.
  TITLE     Sequence and functional comparison in the Beckwith-Wiedemann
            region: implications for a novel imprinting centre and extended
            imprinting
  JOURNAL   Hum Mol Genet 9 (18), 2691-2706 (2000)
   PUBMED   11063728
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068006.10.
            
            On Mar 31, 2022 this sequence version replaced NM_001311145.1.
            
            Transcript Variant: This variant (2) lacks an alternate 3' exon,
            compared to variant 1. The encoded isoform (2) has a longer and
            distinct C-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC076592.1, SRR17253012.3696083.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AC068006.10        155292-155421       c
            131-221             AC068006.10        150546-150636       c
            222-350             AC068006.10        149041-149169       c
            351-462             AC068006.10        146517-146628       c
            463-536             AC068006.10        145667-145740       c
            537-4170            AC068006.10        140568-144201       c
FEATURES             Location/Qualifiers
     source          1..4170
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.27 cM"
     gene            1..4170
                     /gene="Tnfrsf22"
                     /gene_synonym="2810028K06Rik; C130035G06Rik; mDcTrailr2;
                     SOBa; Tnfrh2; Tnfrsf1al2"
                     /note="tumor necrosis factor receptor superfamily, member
                     22"
                     /db_xref="GeneID:79202"
                     /db_xref="MGI:MGI:1930270"
     exon            1..130
                     /gene="Tnfrsf22"
                     /gene_synonym="2810028K06Rik; C130035G06Rik; mDcTrailr2;
                     SOBa; Tnfrh2; Tnfrsf1al2"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..622
                     /gene="Tnfrsf22"
                     /gene_synonym="2810028K06Rik; C130035G06Rik; mDcTrailr2;
                     SOBa; Tnfrh2; Tnfrsf1al2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; tumor necrosis factor receptor superfamily,
                     member 1a-like 2; TNF receptor homolog 2; decoy TRAIL
                     receptor 2; TNF receptor family member SOBa; tumor
                     necrosis factor receptor p60 homolog 2"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 22 isoform 2 precursor"
                     /protein_id="NP_001298074.1"
                     /db_xref="CCDS:CCDS80846.1"
                     /db_xref="GeneID:79202"
                     /db_xref="MGI:MGI:1930270"
                     /translation="MFGFFCSLVSSLSRWFLWRRLLLLLLLLLLNLPLQVKFAMLELH
                     SFKCPAGEYWSKDVCCKNCSAGTFVKAPCEIPHTQGQCEKCHPGTFTEKDNYLDACIL
                     CSTCDKDQEMVADCSATSDRKCQCRTGLYYYDPKFPESCRPCTKCPQGIPVLQECNST
                     ANTVCSSSVSNPRNRLFLLLSPLSVLIVSVVVFRIIRR"
     exon            131..221
                     /gene="Tnfrsf22"
                     /gene_synonym="2810028K06Rik; C130035G06Rik; mDcTrailr2;
                     SOBa; Tnfrh2; Tnfrsf1al2"
                     /inference="alignment:Splign:2.1.0"
     exon            222..350
                     /gene="Tnfrsf22"
                     /gene_synonym="2810028K06Rik; C130035G06Rik; mDcTrailr2;
                     SOBa; Tnfrh2; Tnfrsf1al2"
                     /inference="alignment:Splign:2.1.0"
     exon            351..462
                     /gene="Tnfrsf22"
                     /gene_synonym="2810028K06Rik; C130035G06Rik; mDcTrailr2;
                     SOBa; Tnfrh2; Tnfrsf1al2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..536
                     /gene="Tnfrsf22"
                     /gene_synonym="2810028K06Rik; C130035G06Rik; mDcTrailr2;
                     SOBa; Tnfrh2; Tnfrsf1al2"
                     /inference="alignment:Splign:2.1.0"
     exon            537..4170
                     /gene="Tnfrsf22"
                     /gene_synonym="2810028K06Rik; C130035G06Rik; mDcTrailr2;
                     SOBa; Tnfrh2; Tnfrsf1al2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      618..623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfrsf22"
                     /gene_synonym="2810028K06Rik; C130035G06Rik; mDcTrailr2;
                     SOBa; Tnfrh2; Tnfrsf1al2"
                     /note="hexamer: GATAAA"
     polyA_site      639
                     /gene="Tnfrsf22"
                     /gene_synonym="2810028K06Rik; C130035G06Rik; mDcTrailr2;
                     SOBa; Tnfrh2; Tnfrsf1al2"
                     /note="major polyA site"
     regulatory      4144..4149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfrsf22"
                     /gene_synonym="2810028K06Rik; C130035G06Rik; mDcTrailr2;
                     SOBa; Tnfrh2; Tnfrsf1al2"
                     /note="hexamer: AATAAA"
     polyA_site      4170
                     /gene="Tnfrsf22"
                     /gene_synonym="2810028K06Rik; C130035G06Rik; mDcTrailr2;
                     SOBa; Tnfrh2; Tnfrsf1al2"
                     /note="major polyA site"
ORIGIN      
        1 agcagcggcg tgcttgcact cggccatgtt tggcttcttc tgcagcttgg tgtccagtct
       61 gagtcgctgg ttcctttggc ggcggctgct gctgctgctg ctgctgctgc tgctgaatct
      121 gcccttgcag gtaaaatttg ctatgctaga attacactcc ttcaaatgtc ccgctggtga
      181 atactggtct aaagacgtct gttgcaagaa ctgttctgca ggtacatttg tcaaggcgcc
      241 ctgcgaaatc ccccatactc aaggacaatg tgagaagtgt cacccaggaa cattcacaga
      301 gaaagataat tacctggatg cttgtatact ttgctccacc tgtgataaag atcaggaaat
      361 ggtggccgac tgctcagcca ccagtgaccg gaaatgccag tgccgaacag gtctttacta
      421 ctatgaccca aaatttccag aatcgtgccg cccatgtacc aagtgtcccc aaggaatccc
      481 tgtcctccag gaatgcaact ccacagctaa cactgtgtgc agttcatctg tttcaaatcc
      541 cagaaaccgg ctgttcctac tgttatcacc tttgagtgtg ctaattgtgt ccgttgttgt
      601 cttccgtatc ataagaagat aaaggttcta cagatgtttt cttagcttcc ttttattgct
      661 atgaagtgat actatggagg caactctttt attttattta ttttatttta ttttttaatg
      721 tcttgaactt gatttgaaga ccaggctggc ctcaaaatca cagagatcca gactaagaca
      781 actctaataa gggaaacatt taattgggac tggcttacag tttcggacgt tttgtccatg
      841 attatcatag tgggaagcat ggcagcatct aagcagacat gatgttggag aaggagctga
      901 gatttctgca tcttgatctg caagcaataa aaggagactg tgtgccacac tatacacagc
      961 ttgaacatag gagacctcaa agcctgtccc cacagtgaca aacttcctcc aacaaggtca
     1021 tacctcctaa taataccatt tcttatgagg caagcattca aacacatgag tctatgaggg
     1081 ccaaaccaat tcaaaccacc acaggttaac aattgccctc tgcagctctc tggtggaggc
     1141 cctccttgag agtaagtaac aatttagatg aaggcaagtc ctggtatcag gtccaaaaga
     1201 aactcaggat gaatggtcca ctgtggttcc tattaacata ctgaagaaca tgacctcacc
     1261 ttacacgtct ccacctcact gacttccctt cccctagctt ctcattccca ggtaaccctg
     1321 ccattttttg gtaatgtgcc ttcttggttc ttcctctcct ttccccctct cttctggtcc
     1381 ttacttctct tcctctccca ctctccacca gcctcctctt aaggcctgaa tcagtctgta
     1441 ggtcatgttt aatctactac tttctctctg ctctggactc atccagatgt ctctggctga
     1501 gctctccctc ctatctacaa taaaaccctt ccccctaacc agaaatggaa cagttttgtc
     1561 ctcactttgt acatctggtg cctgaaacca gagaggaata tgacccccat ccaagagact
     1621 cagcctctcc tagccaaacc atgctgttgg tttgacgact tcctaaggta tgcatggatg
     1681 gatcacttgt tcctgcaggc ttctgcaacc taccatagtg aactccaaac ctggaattca
     1741 cctcttcagc tgcttctccc ctctacttgc gctaaccatt tgcttctcct cagcacatca
     1801 ggaaactccc ccttgcctag gggtgtgatc agtgctttgc tctcactgct cagtaaattt
     1861 ccacttgtct aggggtgtgg tcagtgcctt gctctcactg ctcagtaaac tttcccttgc
     1921 ctaggggtgt gatcagtgcc ttgctctcac tgctcagtaa atttccactt acctaagggt
     1981 gtggtcagtg ccttgctctc actgctcagt aaattctcct tgcctagggg tgtggtcagt
     2041 gccttgctct cactgcttag taaatttccc cttggctagg ggtgcggtca gtgctgtgcc
     2101 ttgtgctcac tactcagtaa atttccactt gcctagggat gtggtcagtg ccttgctcta
     2161 actgctcagt aaatttcttt ttgcctaggg gtgtgatcag tgccttgttc tcaatgctca
     2221 gtaaatttcc ccttggttag gggtgtggtc agtgctgtgc cttgtgctca ctactaggta
     2281 aatttccact tgcctagggg tgtggtcagt gccttgctct cactgctcag taaatttcca
     2341 cttgcctagg ggtgtgatca gtgccttgct ctcactgctc agtaaatttc cacttgccta
     2401 ggggtgtgat cagtgccttg ctctcactgc tcagtaaatt tccacttgcc taggggtgtg
     2461 atcagtgccc tgctctcact gctcagtaaa tttcctcctg gctagtggtg tggtcgacta
     2521 tgtggtcaac tatgtggtcc ctatgatgga ctgaccgaag aggagaagac tagagcctgg
     2581 tttactgatg gctctgcgcg ttatgcaggc accacccaga agtggacagc tgcagcatta
     2641 caaccccttt ctgggacaac cctgaaagac acaggtgaag ggaaatcttc acagtgggca
     2701 gaacttcggg cagtacacat ggtattacag tttgtttgca agaagaaatg gccagatgta
     2761 cgattattca ctgactcatg ggctgtagcc aatggattgg ctggatggtc aggcacttgg
     2821 aaagatcaca attggaaaat tggtgagaaa gacatctggg gaagaagtat gtggatagat
     2881 ctctccaaat gggcaaagga tgtgaagata tttgtgtccc atgtaaatgc tcaccaaaag
     2941 gtgacttcag ccgaggagga gttcaataat caagtggata cgatgacccc ttctgtggac
     3001 agtcagcctc tctccccagc catccctgtc attgctcaat gggcacatga acaaagtggc
     3061 catggtggtc gggatggagg ttatgcttgg gctcagcaac atgggcttcc gctcaccaag
     3121 tccgacctgg ctacagctgc tgctgattgc cagatctgcc aacagccgaa accaacactg
     3181 agccccagat atggcatcat tcctcgaggt gaccagccag caacctggtg gcaggttgac
     3241 tacattggac cacttccttc gtggaaagga cagcgttttg ttcttactgg agtagatacc
     3301 cttggatagg ggtgtggtca gtgccctgct ctcactgctc agtaaatttc tacatgccta
     3361 gggatgtggt cagtgccttg ctctcactgc tcagtaaatt tccacttgcc taggagtgtg
     3421 gtcagtgcct tgctctccca ccgtgaccag ctctcctatg atttccagat gaggagtggg
     3481 gtcagttgga cagagacctc aaatatttat gtgtccccaa gcagaagcca agaccagggg
     3541 tatctacctg gactttggta ggagacccct gctgccacag gaccaaaaca gttactgaca
     3601 ggtgctccag cccagtctca cagggtcctt gaattggggt gtgcactcct agcaccagat
     3661 ggtcccacag cctggacagc agggagacag ccagctcctc ccagaaatag ccaacaatca
     3721 agttttttgg gccaccccat aatgatgccc caatgtcagc aggaagaaat catagatgaa
     3781 taaatacatc accccttatt cttttattat caacagaagg ctggaatgtt tggtttcaga
     3841 gccctggaca agttgcttag ttgcatattt tacataccaa agcagacctg gcctccaggt
     3901 tctcccagca tccctcagtc cttacctggc ataccctgac cccaatcctg agctttccac
     3961 ctagggactg ggctgccatt cccccagagg ctcttcccta tataatccag aggattttgg
     4021 tcttccttgt tctctctctg cacatgggca ctttctcttc cccttcccct ttctccccat
     4081 acctatggta acttccctca ccttcttccc tgggtcagtg aactcaactg agaacaattt
     4141 cccaataaac ctgtgtttaa tataatctaa
//
