LOCUS       NM_178589               3626 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus tumor necrosis factor receptor superfamily, member 21
            (Tnfrsf21), mRNA.
ACCESSION   NM_178589 NM_052975
VERSION     NM_178589.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3626)
  AUTHORS   Huang,X., Qi,J., Su,Y., Zhou,Y., Wang,Q., Huang,T., Xue,D.,
            Zeng,Y., Verkhratsky,A., Zhou,B., Chen,H. and Yi,C.
  TITLE     Endothelial DR6 in blood-brain barrier malfunction in Alzheimer's
            disease
  JOURNAL   Cell Death Dis 15 (4), 258 (2024)
   PUBMED   38609388
  REMARK    GeneRIF: Endothelial DR6 in blood-brain barrier malfunction in
            Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3626)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   3  (bases 1 to 3626)
  AUTHORS   Zhang,J.Y., Zhou,B., Sun,R.Y., Ai,Y.L., Cheng,K., Li,F.N.,
            Wang,B.R., Liu,F.J., Jiang,Z.H., Wang,W.J., Zhou,D., Chen,H.Z. and
            Wu,Q.
  TITLE     The metabolite alpha-KG induces GSDMC-dependent pyroptosis through
            death receptor 6-activated caspase-8
  JOURNAL   Cell Res 31 (9), 980-997 (2021)
   PUBMED   34012073
  REMARK    GeneRIF: The metabolite alpha-KG induces GSDMC-dependent pyroptosis
            through death receptor 6-activated caspase-8.
REFERENCE   4  (bases 1 to 3626)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3626)
  AUTHORS   Yong,Y., Gamage,K., Cushman,C., Spano,A. and Deppmann,C.
  TITLE     Regulation of degenerative spheroids after injury
  JOURNAL   Sci Rep 10 (1), 15472 (2020)
   PUBMED   32963272
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3626)
  AUTHORS   Schmidt,C.S., Liu,J., Zhang,T., Song,H.Y., Sandusky,G., Mintze,K.,
            Benschop,R.J., Glasebrook,A., Yang,D.D. and Na,S.
  TITLE     Enhanced B cell expansion, survival, and humoral responses by
            targeting death receptor 6
  JOURNAL   J Exp Med 197 (1), 51-62 (2003)
   PUBMED   12515813
  REMARK    GeneRIF: Enhanced B cell expansion, survival, and humoral responses
            by targeting death receptor 6.
REFERENCE   7  (bases 1 to 3626)
  AUTHORS   Liu,J., Heuer,J.G., Na,S., Galbreath,E., Zhang,T., Yang,D.D.,
            Glasebrook,A. and Song,H.Y.
  TITLE     Accelerated onset and increased severity of acute graft-versus-host
            disease following adoptive transfer of DR6-deficient T cells
  JOURNAL   J Immunol 169 (7), 3993-3998 (2002)
   PUBMED   12244201
  REMARK    GeneRIF: T cells lacking the DR6 receptor generate a severe form of
            acute graft-versus-host disease with accelerated onset, increased
            severity, rapid weight loss, and earlier organ damage and
            mortality.
REFERENCE   8  (bases 1 to 3626)
  AUTHORS   Zhao,H., Yan,M., Wang,H., Erickson,S., Grewal,I.S. and Dixit,V.M.
  TITLE     Impaired c-Jun amino terminal kinase activity and T cell
            differentiation in death receptor 6-deficient mice
  JOURNAL   J Exp Med 194 (10), 1441-1448 (2001)
   PUBMED   11714751
REFERENCE   9  (bases 1 to 3626)
  AUTHORS   Liu,J., Na,S., Glasebrook,A., Fox,N., Solenberg,P.J., Zhang,Q.,
            Song,H.Y. and Yang,D.D.
  TITLE     Enhanced CD4+ T cell proliferation and Th2 cytokine production in
            DR6-deficient mice
  JOURNAL   Immunity 15 (1), 23-34 (2001)
   PUBMED   11485735
REFERENCE   10 (bases 1 to 3626)
  AUTHORS   Locksley,R.M., Killeen,N. and Lenardo,M.J.
  TITLE     The TNF and TNF receptor superfamilies: integrating mammalian
            biology
  JOURNAL   Cell 104 (4), 487-501 (2001)
   PUBMED   11239407
  REMARK    Review article
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK043823.1.
            
            On Apr 6, 2007 this sequence version replaced NM_178589.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043823.1, AK134704.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3626              AK043823.1         3-3628
FEATURES             Location/Qualifiers
     source          1..3626
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 19.69 cM"
     gene            1..3626
                     /gene="Tnfrsf21"
                     /gene_synonym="DR6; TR7"
                     /note="tumor necrosis factor receptor superfamily, member
                     21"
                     /db_xref="GeneID:94185"
                     /db_xref="MGI:MGI:2151075"
     exon            1..538
                     /gene="Tnfrsf21"
                     /gene_synonym="DR6; TR7"
                     /inference="alignment:Splign:2.1.0"
     CDS             443..2410
                     /gene="Tnfrsf21"
                     /gene_synonym="DR6; TR7"
                     /note="Death receptor 6; TNFR-related death receptor-6"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 21 precursor"
                     /protein_id="NP_848704.1"
                     /db_xref="CCDS:CCDS28794.1"
                     /db_xref="GeneID:94185"
                     /db_xref="MGI:MGI:2151075"
                     /translation="MGTRASSITALASCSRTAGQVGATMVAGSLLLLGFLSTITAQPE
                     QKTLSLPGTYRHVDRTTGQVLTCDKCPAGTYVSEHCTNMSLRVCSSCPAGTFTRHENG
                     IERCHDCSQPCPWPMIERLPCAALTDRECICPPGMYQSNGTCAPHTVCPVGWGVRKKG
                     TENEDVRCKQCARGTFSDVPSSVMKCKAHTDCLGQNLEVVKPGTKETDNVCGMRLFFS
                     STNPPSSGTVTFSHPEHMESHDVPSSTYEPQGMNSTDSNSTASVRTKVPSGIEEGTVP
                     DNTSSTSGKEGTNRTLPNPPQVTHQQAPHHRHILKLLPSSMEATGEKSSTAIKAPKRG
                     HPRQNAHKHFDINEHLPWMIVLFLLLVLVLIVVCSIRKSSRTLKKGPRQDPSAIVEKA
                     GLKKSLTPTQNREKWIYYRNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSN
                     GYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDK
                     LALPMSPSPLSPSPMPSPNVKLENSTLLTVEPSPLDKNKCFFVDESEPLLRCDSTSSG
                     SSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHILNPEELRVIEEIPQAEDK
                     LDRLFEIIGVKSQEASQTLLDSVYSHLPDLL"
     exon            539..1190
                     /gene="Tnfrsf21"
                     /gene_synonym="DR6; TR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1685
                     /gene="Tnfrsf21"
                     /gene_synonym="DR6; TR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1951
                     /gene="Tnfrsf21"
                     /gene_synonym="DR6; TR7"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2180
                     /gene="Tnfrsf21"
                     /gene_synonym="DR6; TR7"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..3626
                     /gene="Tnfrsf21"
                     /gene_synonym="DR6; TR7"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3626
                     /gene="Tnfrsf21"
                     /gene_synonym="DR6; TR7"
                     /note="putative"
ORIGIN      
        1 gtgtccccga gctgagtggc catccgactc agtccctcgc cggccggtct aggcagcgga
       61 ggaggcgagt gcttgatagt ggctggaagc ttcgctatgg gaagtcgctc tttagcactg
      121 tcgcggctag ccctgctctc tggttctccg cagccgctgt cgttggagag caccgggagg
      181 cgcgggttgc gagcgcgcct gcttctcacc gcccgggcgc cagcgcccct gggcaggtgc
      241 tgagcgcctt tcggagcctc ccctgctgcc tccctcttcc gcctgggtgc ctggctgctg
      301 cagtgcacat gggctgctgg aggtagatgg gctcaccgcc cgtgaggcgg cggtggatgc
      361 ggcgctgggc agaaacagcc accaattcca gctgccgtgg ggccgagcgc cccgggcgcc
      421 gctgcgagcc ccgagctcgg ccatggggac ccgggcaagc agcatcaccg ccctcgcctc
      481 ttgcagccgc accgccggcc aagtcggagc cacgatggtc gccggctctc ttctcctgct
      541 tggattcctc agcaccatca cagctcaacc agaacaaaag actctgagtc tccctggcac
      601 ctaccgccat gttgaccgta ccactggcca ggtgctaacc tgcgacaagt gcccagcagg
      661 aacgtacgtc tccgagcact gtaccaacat gagcctgcga gtctgcagca gctgccccgc
      721 ggggaccttt accaggcacg agaacggcat agagagatgc catgactgta gtcagccatg
      781 tccatggccg atgattgaga gattaccttg tgctgccttg actgaccgag agtgcatctg
      841 cccacctgga atgtatcagt ctaatggtac ctgcgctccc catacagtgt gccccgtggg
      901 ctggggtgtg cggaagaaag ggacagagaa tgaagatgtg cgctgtaagc agtgcgctcg
      961 gggtaccttc tctgacgtgc cttccagtgt gatgaagtgt aaagctcaca cggactgtct
     1021 gggtcagaac ctggaggtgg tcaagccagg gaccaaggag acagacaacg tctgtggcat
     1081 gcgcctgttc ttctccagca caaacccacc ttcctctggc acagttacct tttctcaccc
     1141 tgagcatatg gaatcccacg atgtcccttc ctccacctat gagccccaag gcatgaactc
     1201 aacagattcc aactctactg cctctgttag aactaaggta ccaagtggca tcgaggaagg
     1261 gacagtgcct gacaatacga gctcaaccag tgggaaggaa ggcactaata ggaccctgcc
     1321 aaacccacca caagttaccc accagcaagc cccccaccac agacacattc tgaagctgct
     1381 gccatcgtcc atggaggcca cgggtgagaa gtccagcaca gccatcaagg cccccaagag
     1441 gggtcacccc agacagaacg ctcacaagca tttcgacatc aacgagcact tgccttggat
     1501 gatcgtcctc ttccttctgc tggtcctggt gctgatagtg gtgtgcagta tccgaaagag
     1561 ctccaggact ctcaaaaagg ggccccggca ggatcccagc gccatagtgg aaaaggcggg
     1621 gctgaagaag tccctgactc ccacccagaa ccgggagaaa tggatctact accgcaacgg
     1681 ccatggtatt gacatcttga agcttgtagc agcccaggtg ggaagccagt ggaaggacat
     1741 ctatcagttt ctttgcaacg ccagcgagag ggaggtggcg gccttctcca atggatacac
     1801 tgcagatcat gaacgggcct acgcggctct gcagcactgg accatccgtg gccctgaggc
     1861 cagccttgcc cagctcatta gcgccttgcg ccagcaccga cgcaatgatg ttgtggagaa
     1921 gattcgtggg ctgatggaag acaccacgca gttggaaaca gacaaactgg ctctccccat
     1981 gagccccagt ccgcttagcc cgagccccat gcccagtcct aacgtgaaac ttgagaattc
     2041 cactctcctg acagtggagc cctcaccgct ggacaagaac aagtgcttct tcgtggacga
     2101 gtcagagccc cttctgcgat gcgactccac atccagtggc tcttcagcac tgagcagaaa
     2161 cggctccttt attaccaaag aaaagaagga cacagtgttg cggcaggtcc gcctggaccc
     2221 ctgtgacttg cagcccatct ttgatgacat gctgcatatc ctgaaccccg aggagctgcg
     2281 ggtgattgaa gagattcccc aggctgagga caaactggac cgcctcttcg agatcattgg
     2341 ggtcaagagc caagaagcca gccagaccct cttggactct gtgtacagtc atcttcctga
     2401 cctattgtag aacacagggg cactgcattc tgggaatcaa cctactggcg gggtgatttc
     2461 atttcgtttc tgacttttgt gttttggtgt gtatgtatgt gtttaacaga gtgtatggcc
     2521 ggtgagtttg ggttctttct ttctttcttt ctttctttct ttctttcttt ctttctttct
     2581 ttctttcttt ctttctttct tccttcctga aagtgaatgt ataaagcctt tacaatgtat
     2641 aactgttgga aaatgcccac cactaaattt ttttttaagt tccacatatt ctccattttt
     2701 gccttcttat atatatcttc aacactattc tgtgcacttt aaaaacttaa cataaacgca
     2761 gtgtgacttc tcccatatgc tgggtcccga gactctcaac ttcttaaaaa cctaatggca
     2821 tcttgtgact cctagaagta gacataagtc tttcaacctt cacacctact ctttctgttt
     2881 taattattat tgctatttgt cttattgttt gtgctttaca agcgttcttg aggacggagg
     2941 gaatctacga ccctgttgat gactgtaact ctattcgact ttgagttgtc ttcttcatgt
     3001 cttgttatat agttcatatt catggctgaa acttgaccat actccctagc gctgattgta
     3061 tggttttcgt ctggacaccg tacactgcct gataacttgt gcacctctta acgctactat
     3121 gctctgggct ggagaatgaa atctttaagt caccaggact tgctgtttca gtggcttgac
     3181 acctgggcca ccaaagaact cgatcttcat cttttaggga cacctctgct gcaccttgga
     3241 aagccaacct taagtgccag tggcacttta tgcccagctt tgctttgaaa gatatctttc
     3301 ttgttttttt tatccttctc tttctctctt ttttttaaaa atacacatag tcaataggtc
     3361 cagtctgccc tcaaggcctt gctgggtttt cttcatcatc caatcacttt cattaaaaat
     3421 ggctgcagct gtaagaactc ttgtctgata aattttcaac tatgctctca tttatctacc
     3481 tgccctctga tgctcagtcg tcagactcta atgcaaaggt ggacgtcggc tgcctttgcg
     3541 tgggcgggct tagtggtgag gaactgatat cagaaaaaaa atgccttcaa gtatactaat
     3601 ttattaataa atattaggtg tttgtt
//
