LOCUS       NM_011609               2186 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus tumor necrosis factor receptor superfamily, member 1a
            (Tnfrsf1a), mRNA.
ACCESSION   NM_011609
VERSION     NM_011609.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2186)
  AUTHORS   Singh,S.S., Calvo,R., Kumari,A., Sable,R.V., Fang,Y., Tao,D.,
            Hu,X., Castle,S.G., Nahar,S., Li,D., Major,E., Sanchez,T.W.,
            Kato,R., Xu,X., Zhou,J., Liu,L., LeClair,C.A., Simeonov,A.,
            Baljinnyam,B., Henderson,M.J., Marugan,J. and Rudloff,U.
  TITLE     Fatty Acid Derivatization and Cyclization of the Immunomodulatory
            Peptide RP-182 Targeting CD206high Macrophages Improve Antitumor
            Activity
  JOURNAL   Mol Cancer Ther 23 (12), 1827-1841 (2024)
   PUBMED   39212669
REFERENCE   2  (bases 1 to 2186)
  AUTHORS   Boutou,A., Roufagalas,I., Politopoulou,K., Tastsoglou,S.,
            Abouzeid,M., Skoufos,G., Verdu de Juan,L., Ko,J.H., Kyrargyri,V.,
            Hatzigeorgiou,A.G., Barnum,C.J., Tesi,R.J., Bauer,J., Lassmann,H.,
            Johnson,M.R. and Probert,L.
  TITLE     Microglia regulate cortical remyelination via TNFR1-dependent
            phenotypic polarization
  JOURNAL   Cell Rep 43 (11), 114894 (2024)
   PUBMED   39446583
REFERENCE   3  (bases 1 to 2186)
  AUTHORS   Wallaeys,C., Garcia-Gonzalez,N., Timmermans,S., Vandewalle,J.,
            Vanderhaeghen,T., De Beul,S., Dufoor,H., Eggermont,M., Moens,E.,
            Bosteels,V., De Rycke,R., Thery,F., Impens,F., Verbanck,S.,
            Lienenklaus,S., Janssens,S., Blumberg,R.S., Iwawaki,T. and
            Libert,C.
  TITLE     Paneth cell TNF signaling induces gut bacterial translocation and
            sepsis
  JOURNAL   Cell Host Microbe 32 (10), 1725-1743 (2024)
   PUBMED   39243761
REFERENCE   4  (bases 1 to 2186)
  AUTHORS   Alam,M.S., Gaida,M.M., Witzel,H.R., Otsuka,S., Abbasi,A.,
            Guerin,T., Abdelmaksoud,A., Wong,N., Cam,M.C., Kozlov,S. and
            Ashwell,J.D.
  TITLE     TNFR1 signaling promotes pancreatic tumor growth by limiting
            dendritic cell number and function
  JOURNAL   Cell Rep Med 5 (9), 101696 (2024)
   PUBMED   39178856
  REMARK    GeneRIF: TNFR1 signaling promotes pancreatic tumor growth by
            limiting dendritic cell number and function.
REFERENCE   5  (bases 1 to 2186)
  AUTHORS   Roumelioti,F., Tzaferis,C., Konstantopoulos,D., Papadopoulou,D.,
            Prados,A., Sakkou,M., Liakos,A., Chouvardas,P., Meletakos,T.,
            Pandis,Y., Karagianni,N., Denis,M.C., Fousteri,M., Armaka,M. and
            Kollias,G.
  TITLE     Mir221/222 drive synovial hyperplasia and arthritis by targeting
            cell cycle inhibitors and chromatin remodeling components
  JOURNAL   Elife 13, e84698 (2024)
   PUBMED   39235454
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2186)
  AUTHORS   Yi,T., Gilbert,D.J., Jenkins,N.A., Copeland,N.G. and Ihle,J.N.
  TITLE     Assignment of a novel protein tyrosine phosphatase gene (Hcph) to
            mouse chromosome 6
  JOURNAL   Genomics 14 (3), 793-795 (1992)
   PUBMED   1427910
REFERENCE   7  (bases 1 to 2186)
  AUTHORS   Brownell,E., Ranges,G.E., Sarr,T., Fiorentino,L., Godfrey,M.,
            Pekar,S., Hart,J., Kamarck,M., Rae,P.M., Ruddle,F.H. et al.
  TITLE     Chromosome assignments of the human TNF p55 and p75 receptor genes
  JOURNAL   J Exp Zool 262 (3), 340-342 (1992)
   PUBMED   1322446
REFERENCE   8  (bases 1 to 2186)
  AUTHORS   Fuchs,P., Strehl,S., Dworzak,M., Himmler,A. and Ambros,P.F.
  TITLE     Structure of the human TNF receptor 1 (p60) gene (TNFR1) and
            localization to chromosome 12p13 [corrected]
  JOURNAL   Genomics 13 (1), 219-224 (1992)
   PUBMED   1315717
  REMARK    Erratum:[Genomics 1992 Aug;13(4):1384]
REFERENCE   9  (bases 1 to 2186)
  AUTHORS   Barrett,K., Taylor-Fishwick,D.A., Cope,A.P., Kissonerghis,A.M.,
            Gray,P.W., Feldmann,M. and Foxwell,B.M.
  TITLE     Cloning, expression and cross-linking analysis of the murine p55
            tumor necrosis factor receptor
  JOURNAL   Eur J Immunol 21 (7), 1649-1656 (1991)
   PUBMED   1647956
REFERENCE   10 (bases 1 to 2186)
  AUTHORS   Goodwin,R.G., Anderson,D., Jerzy,R., Davis,T., Brannan,C.I.,
            Copeland,N.G., Jenkins,N.A. and Smith,C.A.
  TITLE     Molecular cloning and expression of the type 1 and type 2 murine
            receptors for tumor necrosis factor
  JOURNAL   Mol Cell Biol 11 (6), 3020-3026 (1991)
   PUBMED   1645445
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CK624043.1 and L26349.1.
            
            On Oct 23, 2007 this sequence version replaced NM_011609.3.
            
            Summary: This gene encodes a member of the TNF receptor superfamily
            of proteins. The encoded receptor is found in membrane-bound and
            soluble forms that interact with membrane-bound and soluble forms,
            respectively, of its ligand, tumor necrosis factor alpha. Binding
            of membrane-bound tumor necrosis factor alpha to the membrane-bound
            receptor induces receptor trimerization and activation, which plays
            a role in cell survival, apoptosis, and inflammation. Proteolytic
            processing of the encoded receptor results in release of the
            soluble form of the receptor, which can interact with free tumor
            necrosis factor alpha to inhibit inflammation. Mice lacking a
            functional copy of this gene exhibit impaired immune function.
            [provided by RefSeq, Sep 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L26349.1, X57796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-619               CK624043.1         1-619
            620-2186            L26349.1           588-2154
FEATURES             Location/Qualifiers
     source          1..2186
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.32 cM"
     gene            1..2186
                     /gene="Tnfrsf1a"
                     /gene_synonym="CD120a; FPF; p55; p55-R; TNF-alphaR1;
                     TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR;
                     Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55"
                     /note="tumor necrosis factor receptor superfamily, member
                     1a"
                     /db_xref="GeneID:21937"
                     /db_xref="MGI:MGI:1314884"
     exon            1..340
                     /gene="Tnfrsf1a"
                     /gene_synonym="CD120a; FPF; p55; p55-R; TNF-alphaR1;
                     TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR;
                     Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..1666
                     /gene="Tnfrsf1a"
                     /gene_synonym="CD120a; FPF; p55; p55-R; TNF-alphaR1;
                     TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR;
                     Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55"
                     /note="p60; TNF-RI; TNFR-I; tumor necrosis factor receptor
                     1; tumor necrosis factor receptor type I; TNF-alpha-R1;
                     TNF receptor alpha chain"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 1A precursor"
                     /protein_id="NP_035739.2"
                     /db_xref="CCDS:CCDS20550.1"
                     /db_xref="GeneID:21937"
                     /db_xref="MGI:MGI:1314884"
                     /translation="MGLPTVPGLLLSLVLLALLMGIHPSGVTGLVPSLGDREKRDSLC
                     PQGKYVHSKNNSICCTKCHKGTYLVSDCPSPGRDTVCRECEKGTFTASQNYLRQCLSC
                     KTCRKEMSQVEISPCQADKDTVCGCKENQFQRYLSETHFQCVDCSPCFNGTVTIPCKE
                     TQNTVCNCHAGFFLRESECVPCSHCKKNEECMKLCLPPPLANVTNPQDSGTAVLLPLV
                     ILLGLCLLSFIFISLMCRYPRWRPEVYSIICRDPVPVKEEKAGKPLTPAPSPAFSPTS
                     GFNPTLGFSTPGFSSPVSSTPISPIFGPSNWHFMPPVSEVVPTQGADPLLYESLCSVP
                     APTSVQKWEDSAHPQRPDNADLAILYAVVDGVPPARWKEFMRFMGLSEHEIERLEMQN
                     GRCLREAQYSMLEAWRRRTPRHEDTLEVVGLVLSKMNLAGCLENILEALRNPAPSSTT
                     RLPR"
     exon            341..494
                     /gene="Tnfrsf1a"
                     /gene_synonym="CD120a; FPF; p55; p55-R; TNF-alphaR1;
                     TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR;
                     Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55"
                     /inference="alignment:Splign:2.1.0"
     exon            495..623
                     /gene="Tnfrsf1a"
                     /gene_synonym="CD120a; FPF; p55; p55-R; TNF-alphaR1;
                     TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR;
                     Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55"
                     /inference="alignment:Splign:2.1.0"
     exon            624..773
                     /gene="Tnfrsf1a"
                     /gene_synonym="CD120a; FPF; p55; p55-R; TNF-alphaR1;
                     TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR;
                     Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55"
                     /inference="alignment:Splign:2.1.0"
     exon            774..852
                     /gene="Tnfrsf1a"
                     /gene_synonym="CD120a; FPF; p55; p55-R; TNF-alphaR1;
                     TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR;
                     Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55"
                     /inference="alignment:Splign:2.1.0"
     exon            853..929
                     /gene="Tnfrsf1a"
                     /gene_synonym="CD120a; FPF; p55; p55-R; TNF-alphaR1;
                     TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR;
                     Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1043
                     /gene="Tnfrsf1a"
                     /gene_synonym="CD120a; FPF; p55; p55-R; TNF-alphaR1;
                     TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR;
                     Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1072
                     /gene="Tnfrsf1a"
                     /gene_synonym="CD120a; FPF; p55; p55-R; TNF-alphaR1;
                     TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR;
                     Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1358
                     /gene="Tnfrsf1a"
                     /gene_synonym="CD120a; FPF; p55; p55-R; TNF-alphaR1;
                     TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR;
                     Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..2155
                     /gene="Tnfrsf1a"
                     /gene_synonym="CD120a; FPF; p55; p55-R; TNF-alphaR1;
                     TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR;
                     Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2132..2137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfrsf1a"
                     /gene_synonym="CD120a; FPF; p55; p55-R; TNF-alphaR1;
                     TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR;
                     Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55"
                     /note="hexamer: AATACA"
     polyA_site      2155
                     /gene="Tnfrsf1a"
                     /gene_synonym="CD120a; FPF; p55; p55-R; TNF-alphaR1;
                     TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR;
                     Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55"
                     /note="major polyA site"
ORIGIN      
        1 cgctcttgca acaccacccc cgccactctc ccttcccctc ctaccttctc tctcccctca
       61 gcttaaattt tctccgagtt ttccgaactc tggctcatga tcgggcctac tgggtgcgag
      121 gtcctggagg accgtaccct gatctctatc tgcctctgac tttcagcttc tcgaactcga
      181 ggcccaggct gccatcgccc gggccacctg gtccgatcat cttacttcat tcacgagcgt
      241 tgtcaattgc tgccctgtcc ccagccccaa tgggggagtg agaggccact gccggccgga
      301 catgggtctc cccaccgtgc ctggcctgct gctgtcactg gtgctcctgg ctctgctgat
      361 ggggatacat ccatcagggg tcactggact agtcccttct cttggtgacc gggagaagag
      421 ggatagcttg tgtccccaag gaaagtatgt ccattctaag aacaattcca tctgctgcac
      481 caagtgccac aaaggaacct acttggtgag tgactgtccg agcccagggc gggatacagt
      541 ctgcagggag tgtgaaaagg gcacctttac ggcttcccag aattacctca ggcagtgtct
      601 cagttgcaag acatgtcgga aagaaatgtc ccaggtggag atctctcctt gccaagctga
      661 caaggacacg gtgtgtggct gtaaggagaa ccagttccaa cgctacctga gtgagacaca
      721 cttccagtgc gtggactgca gcccctgctt caacggcacc gtgacaatcc cctgtaagga
      781 gactcagaac accgtgtgta actgccatgc agggttcttt ctgagagaaa gtgagtgcgt
      841 cccttgcagc cactgcaaga aaaatgagga gtgtatgaag ttgtgcctac ctcctccgct
      901 tgcaaatgtc acaaaccccc aggactcagg tactgcggtg ctgttgcccc tggttatctt
      961 gctaggtctt tgccttctat cctttatctt catcagttta atgtgccgat atccccggtg
     1021 gaggcccgaa gtctactcca tcatttgtag ggatcccgtg cctgtcaaag aggagaaggc
     1081 tggaaagccc ctaactccag ccccctcccc agccttcagc cccacctccg gcttcaaccc
     1141 cactctgggc ttcagcaccc caggctttag ttctcctgtc tccagtaccc ccatcagccc
     1201 catcttcggt cctagtaact ggcacttcat gccacctgtc agtgaggtag tcccaaccca
     1261 gggagctgac cctctgctct acgaatcact ctgctccgtg ccagccccca cctctgttca
     1321 gaaatgggaa gactccgccc acccgcaacg tcctgacaat gcagaccttg cgattctgta
     1381 tgctgtggtg gatggcgtgc ctccagcgcg ctggaaggag ttcatgcgtt tcatggggct
     1441 gagcgagcac gagatcgaga ggctggagat gcagaacggg cgctgcctgc gcgaggctca
     1501 gtacagcatg ctggaagcct ggcggcgccg cacgccgcgc cacgaggaca cgctggaagt
     1561 agtgggcctc gtgctttcca agatgaacct ggctgggtgc ctggagaata tcctcgaggc
     1621 tctgagaaat cccgccccct cgtccacgac ccgcctcccg cgataaagcc acacccacaa
     1681 ccttaggaag agggacttga acttcaagga ccattctgct agatgcccta ctccctgtgg
     1741 gtgaaaagtg ggcaaaggtc tctaagggga aggctcgagc tggtagccac ttccttggtg
     1801 ctaccaactt ggtgtacata gcttttctca gccgccgagg actgcctgag ccagccactt
     1861 gtgagtggca gggagatgta ccatcagctc ctggccagct gagggtgcca aagacaggat
     1921 tgtagaggaa aggcacaatg tatctggtgc ccacttggga tgcacagggc ccaagccaag
     1981 cttctcaggg cctcctcagt gggtttctgg gcctttttca cttttgataa gcaatctttg
     2041 tatcaattat atcacactaa tggatgaact gtgtaaggta aggacaagca tagaaaggcg
     2101 gggtctccag ctggagccct cgactcttgt aaatacacta aacgtctaaa aatgaaaaaa
     2161 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
