LOCUS       NM_013869               4639 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus tumor necrosis factor receptor superfamily, member 19
            (Tnfrsf19), transcript variant 1, mRNA.
ACCESSION   NM_013869
VERSION     NM_013869.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4639)
  AUTHORS   Grommisch,D., Wang,M., Eenjes,E., Svetlicic,M., Deng,Q.,
            Giselsson,P. and Genander,M.
  TITLE     Defining the contribution of Troy-positive progenitor cells to the
            mouse esophageal epithelium
  JOURNAL   Dev Cell 59 (10), 1269-1283 (2024)
   PUBMED   38565145
REFERENCE   2  (bases 1 to 4639)
  AUTHORS   Deacon,E., Li,A., Boivin,F., Dvorkin-Gheva,A., Cunanan,J. and
            Bridgewater,D.
  TITLE     beta-Catenin in the kidney stroma modulates pathways and genes to
            regulate kidney development
  JOURNAL   Dev Dyn 252 (9), 1224-1239 (2023)
   PUBMED   37227110
REFERENCE   3  (bases 1 to 4639)
  AUTHORS   Lee,J.H., Kim,S., Han,S., Min,J., Caldwell,B., Bamford,A.D.,
            Rocha,A.S.B., Park,J., Lee,S., Wu,S.S., Lee,H., Fink,J.,
            Pilat-Carotta,S., Kim,J., Josserand,M., Szep-Bakonyi,R., An,Y.,
            Ju,Y.S., Philpott,A., Simons,B.D., Stange,D.E., Choi,E., Koo,B.K.
            and Kim,J.K.
  TITLE     p57Kip2 imposes the reserve stem cell state of gastric chief cells
  JOURNAL   Cell Stem Cell 29 (5), 826-839 (2022)
   PUBMED   35523142
REFERENCE   4  (bases 1 to 4639)
  AUTHORS   Douchi,D., Yamamura,A., Matsuo,J., Melissa Lim,Y.H.,
            Nuttonmanit,N., Shimura,M., Suda,K., Chen,S., Pang,S., Kohu,K.,
            Abe,T., Shioi,G., Kim,G., Shabbir,A., Srivastava,S., Unno,M.,
            Bok-Yan So,J., Teh,M., Yeoh,K.G., Chuang,L.S.H. and Ito,Y.
  TITLE     Induction of Gastric Cancer by Successive Oncogenic Activation in
            the Corpus
  JOURNAL   Gastroenterology 161 (6), 1907-1923 (2021)
   PUBMED   34391772
REFERENCE   5  (bases 1 to 4639)
  AUTHORS   Kretzschmar,K., Boonekamp,K.E., Bleijs,M., Asra,P., Koomen,M.,
            Chuva de Sousa Lopes,S.M., Giovannone,B. and Clevers,H.
  TITLE     Troy/Tnfrsf19 marks epidermal cells that govern interfollicular
            epidermal renewal and cornification
  JOURNAL   Stem Cell Reports 16 (9), 2379-2394 (2021)
   PUBMED   34358453
  REMARK    GeneRIF: Troy/Tnfrsf19 marks epidermal cells that govern
            interfollicular epidermal renewal and cornification.
REFERENCE   6  (bases 1 to 4639)
  AUTHORS   Naito,A., Yoshida,H., Nishioka,E., Satoh,M., Azuma,S., Yamamoto,T.,
            Nishikawa,S. and Inoue,J.
  TITLE     TRAF6-deficient mice display hypohidrotic ectodermal dysplasia
  JOURNAL   Proc Natl Acad Sci U S A 99 (13), 8766-8771 (2002)
   PUBMED   12060722
REFERENCE   7  (bases 1 to 4639)
  AUTHORS   Locksley,R.M., Killeen,N. and Lenardo,M.J.
  TITLE     The TNF and TNF receptor superfamilies: integrating mammalian
            biology
  JOURNAL   Cell 104 (4), 487-501 (2001)
   PUBMED   11239407
  REMARK    Review article
REFERENCE   8  (bases 1 to 4639)
  AUTHORS   Kojima,T., Morikawa,Y., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Senba,E. and Kitamura,T.
  TITLE     TROY, a newly identified member of the tumor necrosis factor
            receptor superfamily, exhibits a homology with Edar and is
            expressed in embryonic skin and hair follicles
  JOURNAL   J Biol Chem 275 (27), 20742-20747 (2000)
   PUBMED   10764796
REFERENCE   9  (bases 1 to 4639)
  AUTHORS   Eby,M.T., Jasmin,A., Kumar,A., Sharma,K. and Chaudhary,P.M.
  TITLE     TAJ, a novel member of the tumor necrosis factor receptor family,
            activates the c-Jun N-terminal kinase pathway and mediates
            caspase-independent cell death
  JOURNAL   J Biol Chem 275 (20), 15336-15342 (2000)
   PUBMED   10809768
REFERENCE   10 (bases 1 to 4639)
  AUTHORS   Hu,S., Tamada,K., Ni,J., Vincenz,C. and Chen,L.
  TITLE     Characterization of TNFRSF19, a novel member of the tumor necrosis
            factor receptor superfamily
  JOURNAL   Genomics 62 (1), 103-107 (1999)
   PUBMED   10585776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF727607.1, AK083283.1, AK028146.1 and BY637570.1.
            
            On Aug 20, 2009 this sequence version replaced NM_013869.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.2373.1, AK083283.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-386               CF727607.1         1-386
            387-998             AK083283.1         2-613
            999-2478            AK028146.1         306-1785
            2479-4437           AK083283.1         2094-4052
            4438-4623           AK028146.1         3745-3930
            4624-4639           BY637570.1         398-413
FEATURES             Location/Qualifiers
     source          1..4639
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 32.06 cM"
     gene            1..4639
                     /gene="Tnfrsf19"
                     /gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
                     /note="tumor necrosis factor receptor superfamily, member
                     19"
                     /db_xref="GeneID:29820"
                     /db_xref="MGI:MGI:1352474"
     exon            1..741
                     /gene="Tnfrsf19"
                     /gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
                     /inference="alignment:Splign:2.1.0"
     exon            742..834
                     /gene="Tnfrsf19"
                     /gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
                     /inference="alignment:Splign:2.1.0"
     CDS             766..2016
                     /gene="Tnfrsf19"
                     /gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
                     /note="Toxicity and JNK inducer"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 19 precursor"
                     /protein_id="NP_038897.4"
                     /db_xref="CCDS:CCDS36941.1"
                     /db_xref="GeneID:29820"
                     /db_xref="MGI:MGI:1352474"
                     /translation="MALKVLPLHRTVLFAAILFLLHLACKVSCETGDCRQQEFKDRSG
                     NCVLCKQCGPGMELSKECGFGYGEDAQCVPCRPHRFKEDWGFQKCKPCADCALVNRFQ
                     RANCSHTSDAVCGDCLPGFYRKTKLVGFQDMECVPCGDPPPPYEPHCTSKVNLVKISS
                     TVSSPRDTALAAVICSALATVLLALLILCVIYCKRQFMEKKPSWSLRSQDIQYNGSEL
                     SCFDQPRLRHCAHRACCQYHRDSAPMYGPVHLIPSLCCEEARSSARAVLGCGLRSPTT
                     LQERNPASVGDTMPAFFGSVSRSICAEFSDAWPLMQNPLGGDSSLCDSYPELTGEDTN
                     SLNPENESAASLDSSGGQDLAGTAALESSGNVSESTDSPRHGDTGTVWEQTLAQDAQR
                     TPSQGGWEDRENLNLAMPTAFQDA"
     exon            835..945
                     /gene="Tnfrsf19"
                     /gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1124
                     /gene="Tnfrsf19"
                     /gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1210
                     /gene="Tnfrsf19"
                     /gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1375
                     /gene="Tnfrsf19"
                     /gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1501
                     /gene="Tnfrsf19"
                     /gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1604
                     /gene="Tnfrsf19"
                     /gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..2007
                     /gene="Tnfrsf19"
                     /gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..4639
                     /gene="Tnfrsf19"
                     /gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4599..4604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfrsf19"
                     /gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
                     /note="hexamer: AATAAA"
     polyA_site      4624
                     /gene="Tnfrsf19"
                     /gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
                     /note="major polyA site"
ORIGIN      
        1 cggagaaacg gcctaattaa acactgctgt gccgctctgc tgcgtttcgg actaccctgc
       61 tctggtaggg acttcgtgct ttttgtcaca ggcagcggct tgatgctgtc tactggaacc
      121 tgcaacgatc caggacctta caggcccgga gcacagaggc ccagagcagt cctggtgtgt
      181 ccctcccagc caagagacac actgcagggc tgtcgcgggc gaggcacaga ccaacgcgac
      241 tagaaatcag gctgactggc ttctcccggc cagccccacg gcacggcatg atgtcatggg
      301 agctgccact cagcgagatg aaagggatgc ggcgcagcag cgctggcact aggcagccca
      361 gctggggcac cgcgagagag agctgcagat ccagccgctc agcccaggct ggggaagcct
      421 gctctccaga gctggggcag aacaacgtgg cccacgttta acaaaagaac cagacggtag
      481 cgaactttct agatctgcgc gcgtagcgag taaactcagc cttgcctttg atgcgcagca
      541 actgatcggc gatcagatta caggcactcc atctcctagt tcgcctgcct ttgatctgcg
      601 cgggtaatcc attttcctgg atttgaagtt tgtctgggct tgcgcccaca cacatttttg
      661 ggaaggtaaa agcgtttggc gcggaagtgc taccaagctg cggaaagcgt gagtctggag
      721 cacagcactg gcgagtagca ggaataaaca cgtttggtga gagccatggc actcaaggtc
      781 ctacctctac acaggacggt gctcttcgct gccattctct tcctactcca cctggcatgt
      841 aaagtgagtt gcgaaaccgg agattgcagg cagcaggaat tcaaggatcg atctggaaac
      901 tgtgtcctct gcaaacagtg cggacctggc atggagttgt ccaaggaatg tggcttcggc
      961 tatggggagg atgcacagtg tgtgccctgc aggccgcacc ggttcaagga agactggggt
     1021 ttccagaagt gtaagccatg tgcggactgt gcgctggtga accgctttca gagggccaac
     1081 tgctcacaca ccagtgatgc tgtctgcggg gactgcctgc caggatttta ccggaagacc
     1141 aaactggttg gttttcaaga catggagtgt gtgccctgcg gagacccacc tcctccctac
     1201 gaaccacact gtaccagcaa ggtgaacctt gtgaagatct cctccaccgt ctccagccct
     1261 cgggacacgg cgctggctgc cgtcatctgc agtgctctgg ccacggtgct gctcgccctg
     1321 ctcatcctgt gtgtcatcta ctgcaagagg cagttcatgg agaagaaacc cagctggtct
     1381 ctgcggtcac aggacattca gtacaatggc tctgagctgt catgctttga ccagcctcgg
     1441 ctccgccact gtgcccatag agcatgctgt cagtatcacc gggactcagc cccaatgtat
     1501 gggcctgttc acctgattcc gtccttgtgc tgtgaagagg cccgcagctc tgcccgagct
     1561 gtgcttggct gtgggctgcg ttctcccact accctccagg agagaaaccc ggcttctgtg
     1621 ggggacacga tgccagcctt cttcgggtct gtttcccgtt ccatctgcgc tgaattttct
     1681 gatgcctggc ctctgatgca gaatcctctg ggtggtgaca gctctctctg tgactcttat
     1741 cctgaactca ctggagaaga taccaattcc ctcaatcccg aaaacgaaag cgcagcatct
     1801 ctggattcca gtggcggcca ggatctggct gggacagctg ctctagagtc ttctgggaat
     1861 gtttcagaat ctactgactc acctagacat ggtgacactg gtacagtctg ggagcagacg
     1921 ctagctcagg atgctcaaag gactccaagc caaggaggct gggaagacag ggaaaacctg
     1981 aatctagcca tgcccacagc cttccaggat gcctgaaggc catcttcctg acgtggaggt
     2041 gtgggtctgg acaagcctgt gatgaggcct acagactgag cagtcttggt gtctggaagc
     2101 aaaaataaat ctgaaccaaa ctgacaacat ttccatcctt tcagccacta gcttctgagc
     2161 cagaccagct gtaagctgaa accccagcaa gaagcaagga gagactgact gtaggcggcc
     2221 ttgggacatg tgcttcttcc ctaagcgaga accttagctg gggccaattt gaaggaccca
     2281 tgggtggaat gtgctgcctg tgagcttgtg ggcacagcag gacccagcct ggctccttct
     2341 tatgtccacg gtgaatgtgg tttcacaaga cccagagtat aaactttcat agacattctc
     2401 ttttagaaat aatccattac cctgtgaaaa agccttagca gattcctttc ttagatttta
     2461 ggcagagctc tggcggtttc tgttgaagaa aggcactttc taatcagcag aatgctatac
     2521 ttcagtggtt taaaggggct tcgtagccct gcctgagtcg tagtttggtg aagtcgactg
     2581 gcctatctgt tatgagcagt tctggcctct tccccacgaa ggtacaacag cactggcagg
     2641 agaggaggcc tgagttattg aaagtggcgg tgaatgtggt taagaattta gcaggttggg
     2701 gggagggaag atagaaaagg agagggcaat gctttaaagt taaaaccacc tactatgcat
     2761 atcctgaagc ctggctgtga atgttaggac tggtgactgt ggatgcgtgt gttagtattg
     2821 ctctgtgctg aacttccaag gcccagattt cttatataaa aaggagacat ttatgagtct
     2881 agtaatctgt gatcgacacc cgagcttgta caaaaggctt cagcacacca agctcacttc
     2941 tggagaatcc ttcagtgaga acacaatgct cattagaccc ggacatggaa gagcatggtt
     3001 gacccagttt gggagaatag aatgcctgtg ccaactagtc taaccaaggc tttgtaatac
     3061 ggcattctga tataggggtg ctgtgtaagg tatcccctct tcttccgtga cagcatttac
     3121 cttccagaac aatctctaag gctaaagaaa acctggggct cattttctct tcatccttcg
     3181 ccctatggct tcactgagca gaatgtcttt gttttccagt ttgaagtgac ttgagcagat
     3241 ccgacctcag tctttcaacc ctctgctagt gctctgttcc actcgaactt taaaaggagc
     3301 ccgatctgtg agcatcagtg tgagaggatt caccagcata tttgttctga ggctgccctg
     3361 gttaaatcag gctcttaccg aacactgaaa ccaaacatca agatgctacc ttcctagact
     3421 ttttaaaatc ttctgtttac ccacagtgtt ttctcattat aagacatgag tagatttaat
     3481 gagccctctt cctgtagctt ctctccattc ctaattatag ctttttgatg tgtgtcttct
     3541 ggcttggcca tatctattgc ttctcatgcc gtctgttcct ttaccagatg taggaagaac
     3601 actgccatac agcatcccgt ggtagcccac atctgctttt atgtccccat ggtgcccagt
     3661 cataacctat tggcattttt gtttgtatgt ccccaaccgt tattatgaga actgacttta
     3721 gggaagtcgt aaagtattta ggatgtaagc aacaggcatc catgaggatg caagctgagc
     3781 tcccctgagt ggcctcctcc tcgtgcacat gtgtgtgtca ttgcttgcaa cccaatcatc
     3841 tctgttatga cagggatgat caaagccagc agggttgtgt tcctttgtgt aacctgaaga
     3901 tattttccac atgccgagcc ctgatggact tcaaagacag acacagctgg ggaaagtcaa
     3961 tctgatggaa gggagactct agcccccaaa tcctgaaaca tcacttttaa tcagaagaga
     4021 aatcctgggg gttaaaaatt gatttcattt gatactgcat ttggacgatc ctggattatc
     4081 atcaaaaagg agacatcctc ccaccagaca ctctagaaac atgtaatggt gttttacagt
     4141 tcacattctt tggaaacaag agggaaaatc tacaacctgc acttcacatt attggaacat
     4201 cttaaaaggc tgtttacata ggagctggca ttctgatatc agacactggt atagagaggc
     4261 atctaggcat agggggcacc agtgccacct ttcctgtggc agaagccagg acaagatgga
     4321 ggagacaagg acttttgaat cagtcaggtc aagtcatgtg ttttcgattt tgaatatatg
     4381 gaatatattt tgaatcgcag gattttctac tctaaagagt gctgctgtct gtgttagaag
     4441 aaaaagaaca gaaaaggaaa gagacacaat catggctctt aagagagttt gtttcagctt
     4501 agattttatc acaactgttt tacatactga atttattatt aatagtatgt tatcgctttc
     4561 caatacaaac ctttttttag tgctttttaa aaattgtgaa taaaattgat acttgttatt
     4621 cttagttatg tgtcaagtc
//
