LOCUS       NM_009400               1030 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus tumor necrosis factor receptor superfamily, member 18
            (Tnfrsf18), transcript variant 1, mRNA.
ACCESSION   NM_009400
VERSION     NM_009400.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1030)
  AUTHORS   Wang,X., Du,W., Li,Y., Yang,H.H., Zhang,Y., Akbar,R., Morgan,H.,
            Peng,T., Chen,J., Sadayappan,S., Hu,Y.C., Fan,Y., Huang,W. and
            Fan,G.C.
  TITLE     Macrophage-enriched Sectm1a promotes efficient efferocytosis to
            attenuate ischemia/reperfusion-induced cardiac injury
  JOURNAL   JCI Insight 9 (5), e173832 (2024)
   PUBMED   38456501
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1030)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1030)
  AUTHORS   Wiles,K.N., Tsikretsis,L.E., Alioto,C.M., Hermida de Viveiros,P.A.,
            Villaflor,V.M. and Tetreault,M.P.
  TITLE     GITR agonistic stimulation enhances the anti-tumor immune response
            in a mouse model of ESCC
  JOURNAL   Carcinogenesis 43 (9), 908-918 (2022)
   PUBMED   35880612
  REMARK    GeneRIF: GITR agonistic stimulation enhances the anti-tumor immune
            response in a mouse model of ESCC.
REFERENCE   4  (bases 1 to 1030)
  AUTHORS   Li,H., Hostager,B.S., Arkee,T. and Bishop,G.A.
  TITLE     Multiple mechanisms for TRAF3-mediated regulation of the T cell
            costimulatory receptor GITR
  JOURNAL   J Biol Chem 297 (3), 101097 (2021)
   PUBMED   34418432
  REMARK    GeneRIF: Multiple mechanisms for TRAF3-mediated regulation of the T
            cell costimulatory receptor GITR.
REFERENCE   5  (bases 1 to 1030)
  AUTHORS   Wang,Y., Liu,B., Niu,C., Zou,W., Yang,L., Wang,T., Tian,D., Luo,Z.,
            Dai,J., Li,Q., Liu,E., Gong,C., Fu,Z. and Ding,F.
  TITLE     Blockade of GITRL/GITR signaling pathway attenuates house dust
            mite-induced allergic asthma in mice through inhibition of MAPKs
            and NF-kappaB signaling
  JOURNAL   Mol Immunol 137, 238-246 (2021)
   PUBMED   34293591
  REMARK    GeneRIF: Blockade of GITRL/GITR signaling pathway attenuates house
            dust mite-induced allergic asthma in mice through inhibition of
            MAPKs and NF-kappaB signaling.
REFERENCE   6  (bases 1 to 1030)
  AUTHORS   McHugh,R.S., Whitters,M.J., Piccirillo,C.A., Young,D.A.,
            Shevach,E.M., Collins,M. and Byrne,M.C.
  TITLE     CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis
            reveals a functional role for the glucocorticoid-induced TNF
            receptor
  JOURNAL   Immunity 16 (2), 311-323 (2002)
   PUBMED   11869690
  REMARK    GeneRIF: a functional role for this receptor in regulating the
            CD4+CD25+ T cell subset.
REFERENCE   7  (bases 1 to 1030)
  AUTHORS   Locksley,R.M., Killeen,N. and Lenardo,M.J.
  TITLE     The TNF and TNF receptor superfamilies: integrating mammalian
            biology
  JOURNAL   Cell 104 (4), 487-501 (2001)
   PUBMED   11239407
  REMARK    Review article
REFERENCE   8  (bases 1 to 1030)
  AUTHORS   Nocentini,G., Ronchetti,S., Bartoli,A., Spinicelli,S., Delfino,D.,
            Brunetti,L., Migliorati,G. and Riccardi,C.
  TITLE     Identification of three novel mRNA splice variants of GITR
  JOURNAL   Cell Death Differ 7 (4), 408-410 (2000)
   PUBMED   10836847
REFERENCE   9  (bases 1 to 1030)
  AUTHORS   Nocentini,G., Bartoli,A., Ronchetti,S., Giunchi,L., Cupelli,A.,
            Delfino,D., Migliorati,G. and Riccardi,C.
  TITLE     Gene structure and chromosomal assignment of mouse GITR, a member
            of the tumor necrosis factor/nerve growth factor receptor family
  JOURNAL   DNA Cell Biol 19 (4), 205-217 (2000)
   PUBMED   10798444
REFERENCE   10 (bases 1 to 1030)
  AUTHORS   Nocentini,G., Giunchi,L., Ronchetti,S., Krausz,L.T., Bartoli,A.,
            Moraca,R., Migliorati,G. and Riccardi,C.
  TITLE     A new member of the tumor necrosis factor/nerve growth factor
            receptor family inhibits T cell receptor-induced apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 94 (12), 6216-6221 (1997)
   PUBMED   9177197
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK020762.1, AY157833.1 and AK081878.1.
            
            On Sep 27, 2017 this sequence version replaced NM_009400.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081878.1, AK020762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-833               AK020762.1         2-834
            834-834             AY157833.1         814-814
            835-1025            AK020762.1         836-1026
            1026-1030           AK081878.1         996-1000
FEATURES             Location/Qualifiers
     source          1..1030
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 87.76 cM"
     gene            1..1030
                     /gene="Tnfrsf18"
                     /gene_synonym="AITR; Gitr"
                     /note="tumor necrosis factor receptor superfamily, member
                     18"
                     /db_xref="GeneID:21936"
                     /db_xref="MGI:MGI:894675"
     exon            1..216
                     /gene="Tnfrsf18"
                     /gene_synonym="AITR; Gitr"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..752
                     /gene="Tnfrsf18"
                     /gene_synonym="AITR; Gitr"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; glucocorticoid-induced TNFR-related protein"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 18 isoform 1 precursor"
                     /protein_id="NP_033426.1"
                     /db_xref="CCDS:CCDS19056.1"
                     /db_xref="GeneID:21936"
                     /db_xref="MGI:MGI:894675"
                     /translation="MGAWAMLYGVSMLCVLDLGQPSVVEEPGCGPGKVQNGSGNNTRC
                     CSLYAPGKEDCPKERCICVTPEYHCGDPQCKICKHYPCQPGQRVESQGDIVFGFRCVA
                     CAMGTFSAGRDGHCRLWTNCSQFGFLTMFPGNKTHNAVCIPEPLPTEQYGHLTVIFLV
                     MAACIFFLTTVQLGLHIWQLRRQHMCPRETQPFAEVQLSAEDACSFQFPEEERGEQTE
                     EKCHLGGRWP"
     exon            217..339
                     /gene="Tnfrsf18"
                     /gene_synonym="AITR; Gitr"
                     /inference="alignment:Splign:2.1.0"
     exon            340..427
                     /gene="Tnfrsf18"
                     /gene_synonym="AITR; Gitr"
                     /inference="alignment:Splign:2.1.0"
     exon            428..630
                     /gene="Tnfrsf18"
                     /gene_synonym="AITR; Gitr"
                     /inference="alignment:Splign:2.1.0"
     exon            631..1030
                     /gene="Tnfrsf18"
                     /gene_synonym="AITR; Gitr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagacaagg caagttggag cgggaactcc tgaaatcagc cgacagaaga ctcaggagaa
       61 gcactatggg ggcatgggcc atgctgtatg gagtctcgat gctctgtgtg ctggacctag
      121 gtcagccgag tgtagttgag gagcctggct gtggccctgg caaggttcag aacggaagtg
      181 gcaacaacac tcgctgctgc agcctgtatg ctccaggcaa ggaggactgt ccaaaagaaa
      241 ggtgcatatg tgtcacacct gagtaccact gtggagaccc tcagtgcaag atctgcaagc
      301 actacccctg ccaaccaggc cagagggtgg agtctcaagg ggatattgtg tttggcttcc
      361 ggtgtgttgc ctgtgccatg ggcaccttct ccgcaggtcg tgacggtcac tgcagacttt
      421 ggaccaactg ttctcagttt ggatttctca ccatgttccc tgggaacaag acccacaatg
      481 ctgtgtgcat cccggagcca ctgcccactg agcaatacgg ccatttgact gtcatcttcc
      541 tggtcatggc tgcatgcatt ttcttcctaa ccacagtcca gctcggcctg cacatatggc
      601 agctgaggag gcaacacatg tgtcctcgag agacccagcc attcgcggag gtgcagttgt
      661 cagctgagga tgcttgcagc ttccagttcc ctgaggagga acgcggggag cagacagaag
      721 aaaagtgtca tctggggggt cggtggccat gaggcctggt cttcctctgt gccccaagcc
      781 agacgctaca agacttgccc agctataccc ttggtgagag caggggccat gttctgcacc
      841 cttccctggg cctggccctg ctcccctcaa cagtggcgga agtgggtgta tgagagcggt
      901 gagttacgat tgggccctat ggctgccttt ctcatttgac agctctgttg gagtagggtc
      961 tttgggccca ccaagagcac cacgtttagc acaagatctt gtacaagaat aaatacttgt
     1021 ctagtaacct
//
