LOCUS       NM_178931                893 bp    mRNA    linear   ROD 09-OCT-2024
DEFINITION  Mus musculus tumor necrosis factor receptor superfamily, member 14
            (herpesvirus entry mediator) (Tnfrsf14), mRNA.
ACCESSION   NM_178931
VERSION     NM_178931.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 893)
  AUTHORS   Guruprasad,P., Carturan,A., Zhang,Y., Cho,J.H., Kumashie,K.G.,
            Patel,R.P., Kim,K.H., Lee,J.S., Lee,Y., Kim,J.H., Chung,J.,
            Joshi,A., Cohen,I., Shestov,M., Ghilardi,G., Harris,J.,
            Pajarillo,R., Angelos,M., Lee,Y.G., Liu,S., Rodriguez,J., Wang,M.,
            Ballard,H.J., Gupta,A., Ugwuanyi,O.H., Hong,S.J.A.,
            Bochi-Layec,A.C., Sauter,C.T., Chen,L., Paruzzo,L., Kammerman,S.,
            Shestova,O., Liu,D., Vella,L.A., Schuster,S.J., Svoboda,J.,
            Porazzi,P. and Ruella,M.
  TITLE     The BTLA-HVEM axis restricts CAR T cell efficacy in cancer
  JOURNAL   Nat Immunol 25 (6), 1020-1032 (2024)
   PUBMED   38831106
  REMARK    GeneRIF: The BTLA-HVEM axis restricts CAR T cell efficacy in
            cancer.
REFERENCE   2  (bases 1 to 893)
  AUTHORS   Kugii,Y., Kuroki,Y., Hara,Y., Goitsuka,R. and Nakano,N.
  TITLE     Lack of Herpes Virus Entry Mediator Signals in Thymocytes Impairs
            Conventional CD8 T Cell Selection and Promotes Memory-like CD8 T
            Cell Development
  JOURNAL   J Immunol 210 (10), 1482-1493 (2023)
   PUBMED   37000475
  REMARK    GeneRIF: Lack of Herpes Virus Entry Mediator Signals in Thymocytes
            Impairs Conventional CD8 T Cell Selection and Promotes Memory-like
            CD8 T Cell Development.
REFERENCE   3  (bases 1 to 893)
  AUTHORS   Del Rio,M.L., de Juan,C.Y., Roncador,G., Caleiras,E.,
            Alvarez-Esteban,R., Perez-Simon,J.A. and Rodriguez-Barbosa,J.I.
  TITLE     Genetic deletion of HVEM in a leukemia B cell line promotes a
            preferential increase of PD-1- stem cell-like T cells over PD-1+ T
            cells curbing tumor progression
  JOURNAL   Front Immunol 14, 1113858 (2023)
   PUBMED   37033927
  REMARK    GeneRIF: Genetic deletion of HVEM in a leukemia B cell line
            promotes a preferential increase of PD-1[-] stem cell-like T cells
            over PD-1[+] T cells curbing tumor progression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 893)
  AUTHORS   Lai,D., Lv,Z., Lu,X., Shang,P., Geng,Y. and Wang,P.
  TITLE     LIGHT Amplification by NF-kappaB Contributes to TLR3 Signaling
            Pathway-Induced Acute Hepatitis
  JOURNAL   Mediators Inflamm 2023, 3732315 (2023)
   PUBMED   36654880
  REMARK    GeneRIF: LIGHT Amplification by NF-kappaB Contributes to TLR3
            Signaling Pathway-Induced Acute Hepatitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 893)
  AUTHORS   Seo,G.Y., Takahashi,D., Wang,Q., Mikulski,Z., Chen,A., Chou,T.F.,
            Marcovecchio,P., McArdle,S., Sethi,A., Shui,J.W., Takahashi,M.,
            Surh,C.D., Cheroutre,H. and Kronenberg,M.
  TITLE     Epithelial HVEM maintains intraepithelial T cell survival and
            contributes to host protection
  JOURNAL   Sci Immunol 7 (73), eabm6931 (2022)
   PUBMED   35905286
REFERENCE   6  (bases 1 to 893)
  AUTHORS   Sedy,J.R., Gavrieli,M., Potter,K.G., Hurchla,M.A., Lindsley,R.C.,
            Hildner,K., Scheu,S., Pfeffer,K., Ware,C.F., Murphy,T.L. and
            Murphy,K.M.
  TITLE     B and T lymphocyte attenuator regulates T cell activation through
            interaction with herpesvirus entry mediator
  JOURNAL   Nat Immunol 6 (1), 90-98 (2005)
   PUBMED   15568026
REFERENCE   7  (bases 1 to 893)
  AUTHORS   Kosuge,H., Suzuki,J., Kakuta,T., Haraguchi,G., Koga,N.,
            Futamatsu,H., Gotoh,R., Inobe,M., Isobe,M. and Uede,T.
  TITLE     Attenuation of graft arterial disease by manipulation of the LIGHT
            pathway
  JOURNAL   Arterioscler Thromb Vasc Biol 24 (8), 1409-1415 (2004)
   PUBMED   15178556
  REMARK    GeneRIF: In graft arterial disease, HVEM was detected in SMCs
            stimulated by IFN-gamma. The LIGHT pathway plays important roles in
            the regulation not only of T-cell activation but also of SMC
            proliferation.
REFERENCE   8  (bases 1 to 893)
  AUTHORS   Ono,E., Yoshino,S., Amagai,K., Taharaguchi,S., Kimura,C.,
            Morimoto,J., Inobe,M., Uenishi,T. and Uede,T.
  TITLE     Enhanced resistance to herpes simplex virus type 1 infection in
            transgenic mice expressing a soluble form of herpesvirus entry
            mediator
  JOURNAL   Virology 320 (2), 267-275 (2004)
   PUBMED   15016549
  REMARK    GeneRIF: exerts a significant antiviral effect against HSV-1
            infection in vivo.
REFERENCE   9  (bases 1 to 893)
  AUTHORS   Ware,C.F.
  TITLE     The TNF superfamily
  JOURNAL   Cytokine Growth Factor Rev 14 (3-4), 181-184 (2003)
   PUBMED   12787557
  REMARK    Review article
REFERENCE   10 (bases 1 to 893)
  AUTHORS   Hsu,H., Solovyev,I., Colombero,A., Elliott,R., Kelley,M. and
            Boyle,W.J.
  TITLE     ATAR, a novel tumor necrosis factor receptor family member, signals
            through TRAF2 and TRAF5
  JOURNAL   J Biol Chem 272 (21), 13471-13474 (1997)
   PUBMED   9153189
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY264405.1.
            
            On Jun 3, 2003 this sequence version replaced NM_178931.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY264405.1, BC104054.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..893
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 85.81 cM"
     gene            1..893
                     /gene="Tnfrsf14"
                     /gene_synonym="Atar; HveA; Hvem; Tnfrs14; TR2"
                     /note="tumor necrosis factor receptor superfamily, member
                     14 (herpesvirus entry mediator)"
                     /db_xref="GeneID:230979"
                     /db_xref="MGI:MGI:2675303"
     exon            1..100
                     /gene="Tnfrsf14"
                     /gene_synonym="Atar; HveA; Hvem; Tnfrs14; TR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..859
                     /gene="Tnfrsf14"
                     /gene_synonym="Atar; HveA; Hvem; Tnfrs14; TR2"
                     /note="tumor necrosis factor receptor superfamily member
                     14; herpesvirus entry mediator A; herpes virus entry
                     mediator A; tumor necrosis factor receptor-like 2"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 14 precursor"
                     /protein_id="NP_849262.1"
                     /db_xref="CCDS:CCDS19017.1"
                     /db_xref="GeneID:230979"
                     /db_xref="MGI:MGI:2675303"
                     /translation="MEPLPGWGSAPWSQAPTDNTFRLVPCVFLLNLLQRISAQPSCRQ
                     EEFLVGDECCPMCNPGYHVKQVCSEHTGTVCAPCPPQTYTAHANGLSKCLPCGVCDPD
                     MGLLTWQECSSWKDTVCRCIPGYFCENQDGSHCSTCLQHTTCPPGQRVEKRGTHDQDT
                     VCADCLTGTFSLGGTQEECLPWTNCSAFQQEVRRGTNSTDTTCSSQVVYYVVSILLPL
                     VIVGAGIAGFLICTRRHLHTSSVAKELEPFQEQQENTIRFPVTEVGFAETEEETASN"
     exon            101..209
                     /gene="Tnfrsf14"
                     /gene_synonym="Atar; HveA; Hvem; Tnfrs14; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..335
                     /gene="Tnfrsf14"
                     /gene_synonym="Atar; HveA; Hvem; Tnfrs14; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            336..491
                     /gene="Tnfrsf14"
                     /gene_synonym="Atar; HveA; Hvem; Tnfrs14; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            492..582
                     /gene="Tnfrsf14"
                     /gene_synonym="Atar; HveA; Hvem; Tnfrs14; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            583..746
                     /gene="Tnfrsf14"
                     /gene_synonym="Atar; HveA; Hvem; Tnfrs14; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            747..778
                     /gene="Tnfrsf14"
                     /gene_synonym="Atar; HveA; Hvem; Tnfrs14; TR2"
                     /inference="alignment:Splign:2.1.0"
     exon            779..893
                     /gene="Tnfrsf14"
                     /gene_synonym="Atar; HveA; Hvem; Tnfrs14; TR2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcttggcc tgaagtttct tgatcaagaa aatggaacct ctcccaggat gggggtcggc
       61 accctggagc caggccccta cagacaacac cttcaggctg gtgccttgtg tcttcctttt
      121 gaacttgctg cagcgcatct ctgcccagcc ctcatgcaga caggaggagt tccttgtggg
      181 agacgagtgc tgccccatgt gcaacccagg ttaccatgtg aagcaggtct gcagtgagca
      241 tacaggcaca gtgtgtgccc cctgtccccc acagacatat accgcccatg caaatggcct
      301 gagcaagtgt ctgccctgcg gagtctgtga tccagacatg ggcctgctga cctggcagga
      361 gtgctccagc tggaaggaca ctgtgtgcag atgcatccca ggctacttct gtgagaacca
      421 ggatgggagc cactgttcca catgcttgca gcacaccacc tgccctccag ggcagagggt
      481 agagaagaga gggactcacg accaggacac tgtatgtgct gactgcctaa cagggacctt
      541 ctcacttgga gggactcagg aggaatgcct gccctggacc aactgcagtg catttcaaca
      601 ggaagtaaga cgtgggacca acagcacaga caccacctgc tcctcccagg tcgtctacta
      661 cgttgtgtcc atccttttgc cacttgtgat agtgggagct gggatagctg gattcctcat
      721 ctgcacgcga agacacctgc acaccagctc agtggccaag gagctggagc ctttccagga
      781 acaacaggag aacaccatca ggtttccagt caccgaggtt gggtttgctg agaccgagga
      841 ggagacagcc tccaactgaa caaattctgg gtgacaagac accgaggaga cgt
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