LOCUS       NM_013749                980 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus tumor necrosis factor receptor superfamily, member 12a
            (Tnfrsf12a), transcript variant 1, mRNA.
ACCESSION   NM_013749
VERSION     NM_013749.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 980)
  AUTHORS   Hazell,G., McCallion,E., Ahlskog,N., Sutton,E.R., Okoh,M.,
            Shaqoura,E.I.H., Hoolachan,J.M., Scaife,T., Iqbal,S., Bhomra,A.,
            Kordala,A.J., Scamps,F., Raoul,C., Wood,M.J.A. and Bowerman,M.
  TITLE     Exercise, disease state and sex influence the beneficial effects of
            Fn14-depletion on survival and muscle pathology in the SOD1G93A
            amyotrophic lateral sclerosis (ALS) mouse model
  JOURNAL   Skelet Muscle 14 (1), 23 (2024)
   PUBMED   39396990
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 980)
  AUTHORS   Guerrero-Hue,M., Vallejo-Mudarra,M., Garcia-Caballero,C.,
            Cordoba-David,G.M., Palomino-Antolin,A., Herencia,C.,
            Vendrell-Casana,B., Rubio-Navarro,A., Egido,J., Blanco-Colio,L.M.
            and Moreno,J.A.
  TITLE     Tweak/Fn14 system is involved in rhabdomyolysis-induced acute
            kidney injury
  JOURNAL   Biomed Pharmacother 169, 115925 (2023)
   PUBMED   38007933
  REMARK    GeneRIF: Tweak/Fn14 system is involved in rhabdomyolysis-induced
            acute kidney injury.
REFERENCE   3  (bases 1 to 980)
  AUTHORS   Tomaz da Silva,M., Joshi,A.S., Castillo,M.B., Koike,T.E., Roy,A.,
            Gunaratne,P.H. and Kumar,A.
  TITLE     Fn14 promotes myoblast fusion during regenerative myogenesis
  JOURNAL   Life Sci Alliance 6 (12), e202302312 (2023)
   PUBMED   37813488
  REMARK    GeneRIF: Fn14 promotes myoblast fusion during regenerative
            myogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 980)
  AUTHORS   Ruiz,B.I., Lowman,X.H., Yang,Y., Fan,Q., Wang,T., Wu,H., Hanse,E.A.
            and Kong,M.
  TITLE     Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression via Histone
            Modification and Prevents Cancer-Induced Cachexia
  JOURNAL   Genes (Basel) 14 (9), 1818 (2023)
   PUBMED   37761958
  REMARK    GeneRIF: Alpha-Ketoglutarate Regulates Tnfrsf12a/Fn14 Expression
            via Histone Modification and Prevents Cancer-Induced Cachexia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 980)
  AUTHORS   Short,C., Zhong,A., Xu,J., Mahdi,E., Glazier,A., Malkoff,N.,
            Noriega,N., Yeo,T., Asahina,K. and Wang,K.S.
  TITLE     TWEAK/FN14 promotes profibrogenic pathway activation in
            Prominin-1-expressing hepatic progenitor cells in biliary atresia
  JOURNAL   Hepatology 77 (5), 1639-1653 (2023)
   PUBMED   36626628
  REMARK    GeneRIF: TWEAK/FN14 promotes profibrogenic pathway activation in
            Prominin-1-expressing hepatic progenitor cells in biliary atresia.
REFERENCE   6  (bases 1 to 980)
  AUTHORS   Polek,T.C., Talpaz,M., Darnay,B.G. and Spivak-Kroizman,T.
  TITLE     TWEAK mediates signal transduction and differentiation of RAW264.7
            cells in the absence of Fn14/TweakR. Evidence for a second TWEAK
            receptor
  JOURNAL   J Biol Chem 278 (34), 32317-32323 (2003)
   PUBMED   12794080
  REMARK    GeneRIF: findings show that the Fn14/TWEAK receptor (TweakR) was
            not responsible for the osteoclastic effect of TWEAK on RAW cells
REFERENCE   7  (bases 1 to 980)
  AUTHORS   Brown,S.A., Richards,C.M., Hanscom,H.N., Feng,S.L. and Winkles,J.A.
  TITLE     The Fn14 cytoplasmic tail binds
            tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5
            and mediates nuclear factor-kappaB activation
  JOURNAL   Biochem J 371 (Pt 2), 395-403 (2003)
   PUBMED   12529173
  REMARK    GeneRIF: The cytoplasmic tail of this protein binds
            tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5
            and mediates nuclear factor-kappaB activation.
REFERENCE   8  (bases 1 to 980)
  AUTHORS   Wiley,S.R., Cassiano,L., Lofton,T., Davis-Smith,T., Winkles,J.A.,
            Lindner,V., Liu,H., Daniel,T.O., Smith,C.A. and Fanslow,W.C.
  TITLE     A novel TNF receptor family member binds TWEAK and is implicated in
            angiogenesis
  JOURNAL   Immunity 15 (5), 837-846 (2001)
   PUBMED   11728344
REFERENCE   9  (bases 1 to 980)
  AUTHORS   Feng,S.L., Guo,Y., Factor,V.M., Thorgeirsson,S.S., Bell,D.W.,
            Testa,J.R., Peifley,K.A. and Winkles,J.A.
  TITLE     The Fn14 immediate-early response gene is induced during liver
            regeneration and highly expressed in both human and murine
            hepatocellular carcinomas
  JOURNAL   Am J Pathol 156 (4), 1253-1261 (2000)
   PUBMED   10751351
REFERENCE   10 (bases 1 to 980)
  AUTHORS   Meighan-Mantha,R.L., Hsu,D.K., Guo,Y., Brown,S.A., Feng,S.L.,
            Peifley,K.A., Alberts,G.F., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Richards,C.M. and Winkles,J.A.
  TITLE     The mitogen-inducible Fn14 gene encodes a type I transmembrane
            protein that modulates fibroblast adhesion and migration
  JOURNAL   J Biol Chem 274 (46), 33166-33176 (1999)
   PUBMED   10551889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK160136.1 and AI853177.1.
            
            On Jun 13, 2009 this sequence version replaced NM_013749.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF156164.1, AK160136.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415127 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-963               AK160136.1         2-964
            964-980             AI853177.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..980
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 11.99 cM"
     gene            1..980
                     /gene="Tnfrsf12a"
                     /gene_synonym="Fn14; HPIP; TWEAK-R; TweakR"
                     /note="tumor necrosis factor receptor superfamily, member
                     12a"
                     /db_xref="GeneID:27279"
                     /db_xref="MGI:MGI:1351484"
     exon            1..123
                     /gene="Tnfrsf12a"
                     /gene_synonym="Fn14; HPIP; TWEAK-R; TweakR"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..419
                     /gene="Tnfrsf12a"
                     /gene_synonym="Fn14; HPIP; TWEAK-R; TweakR"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; tweak-receptor; FGF-inducible 14; fibroblast
                     growth factor-regulated protein 2; fibroblast growth
                     factor-inducible immediate-early response protein 14; type
                     I transmembrane protein Fn14"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 12A isoform 1 precursor"
                     /protein_id="NP_038777.2"
                     /db_xref="CCDS:CCDS28456.1"
                     /db_xref="GeneID:27279"
                     /db_xref="MGI:MGI:1351484"
                     /translation="MASAWPRSLPQILVLGFGLVLMRAAAGEQAPGTSPCSSGSSWSA
                     DLDKCMDCASCPARPHSDFCLGCAAAPPAHFRLLWPILGGALSLVLVLALVSSFLVWR
                     RCRRREKFTTPIEETGGEGCPGVALIQ"
     exon            124..228
                     /gene="Tnfrsf12a"
                     /gene_synonym="Fn14; HPIP; TWEAK-R; TweakR"
                     /inference="alignment:Splign:2.1.0"
     exon            229..363
                     /gene="Tnfrsf12a"
                     /gene_synonym="Fn14; HPIP; TWEAK-R; TweakR"
                     /inference="alignment:Splign:2.1.0"
     exon            364..965
                     /gene="Tnfrsf12a"
                     /gene_synonym="Fn14; HPIP; TWEAK-R; TweakR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      943..948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfrsf12a"
                     /gene_synonym="Fn14; HPIP; TWEAK-R; TweakR"
                     /note="hexamer: AATAAA"
     polyA_site      965
                     /gene="Tnfrsf12a"
                     /gene_synonym="Fn14; HPIP; TWEAK-R; TweakR"
                     /note="major polyA site"
ORIGIN      
        1 agacagttct tgcctcggga ccggcaatca tggcttcggc ttggccgcgg tctctgccgc
       61 agatcctcgt gttgggattc ggcttggtgt tgatgcgcgc cgcggccggg gagcaagcac
      121 caggcacctc cccatgctct agcggcagct cctggagcgc ggacctcgac aagtgcatgg
      181 actgcgcttc ttgtccagcg cgaccacaca gcgacttctg cctgggatgc gccgcagcac
      241 ctcctgccca cttcaggcta ctgtggccca ttctgggggg cgctcttagt ctggtcctgg
      301 ttttggcgct ggtttctagt ttcctggtct ggagaagatg ccgccggaga gaaaagttta
      361 ctacccccat agaggagact ggtggagagg gctgcccagg tgtggcactg atccagtgag
      421 gagcacccgc gctggggccc actcgtcgtc cattcattca ttctggagtc agcctggcct
      481 tccagacaga agccgagcca gactctttca accacaaggg ggtggggcga ggtggtgatt
      541 cacctccaag gactgggctt agagttcagg gagccttcca aggtgtccaa ttgccctatc
      601 tctgggtctg gggcagacag agagcctcaa tctgggtcac aaagcgaccc atactaagga
      661 actgcagcat ttgcacaagg gaatctcttg ttccccacaa gtcctggcag tctggctgac
      721 ttgaggggca gacacaacac tgggtcccac ccactcggag gggctataat gccactccct
      781 gagttttagc cctaggagtg ggtcagattg acagacctgt tcttaacact aagggggctg
      841 gccctctggg agggctggcc ccagtacaca cggaaacaac catctcccaa ggggggtgat
      901 atttattgtg gggataatgt ttggagggga gggagactta ttaataaaag aatctttaac
      961 tttaaaaaaa aaaaaaaaaa
//
