LOCUS       NM_001411506            2756 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus tumor necrosis factor receptor superfamily, member 11b
            (osteoprotegerin) (Tnfrsf11b), transcript variant 2, mRNA.
ACCESSION   NM_001411506 XM_036159230
VERSION     NM_001411506.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2756)
  AUTHORS   Houchen,C.J., Ghanem,S., Kaartinen,V. and Bumann,E.E.
  TITLE     TGF-beta signaling in the cranial neural crest affects late-stage
            mandibular bone resorption and length
  JOURNAL   Front Physiol 15, 1435594 (2024)
   PUBMED   39473613
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2756)
  AUTHORS   Lyu,Z., Chan,Y.T., Lu,Y., Fung Lam,T., Wu,X., Wu,J., Xu,L.,
            Yang,W., Zhang,C., Lidan Zhong,L. and Wang,N.
  TITLE     Osteoprotegerin mediates adipogenesis in obesity
  JOURNAL   J Adv Res 62, 245-255 (2024)
   PUBMED   38906326
  REMARK    GeneRIF: Osteoprotegerin mediates adipogenesis in obesity.
REFERENCE   3  (bases 1 to 2756)
  AUTHORS   Dutka,M., Garczorz,W., Kosowska,A., Buczek,E., Godek,P.,
            Wojakowski,W. and Francuz,T.
  TITLE     Osteoprotegerin Is Essential for the Development of Endothelial
            Dysfunction Induced by Angiotensin II in Mice
  JOURNAL   Int J Mol Sci 25 (12), 6434 (2024)
   PUBMED   38928140
  REMARK    GeneRIF: Osteoprotegerin Is Essential for the Development of
            Endothelial Dysfunction Induced by Angiotensin II in Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2756)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2756)
  AUTHORS   Hirata,W., Itatani,Y., Masui,H., Kawada,K., Mizuno,R., Yamamoto,T.,
            Okamoto,T., Ogawa,R., Inamoto,S., Maekawa,H., Okamura,R.,
            Kiyasu,Y., Hanada,K., Okamoto,M., Nishikawa,Y., Sugimoto,N.,
            Tamura,T., Hatano,E., Sakai,Y. and Obama,K.
  TITLE     Downregulation of osteoprotegerin in colorectal cancer cells
            promotes liver metastasis via activating tumor-associated
            macrophage
  JOURNAL   Sci Rep 13 (1), 22217 (2023)
   PUBMED   38097649
  REMARK    GeneRIF: Downregulation of osteoprotegerin in colorectal cancer
            cells promotes liver metastasis via activating tumor-associated
            macrophage.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2756)
  AUTHORS   Mizuno,A., Murakami,A., Nakagawa,N., Yasuda,H., Tsuda,E.,
            Morinaga,T. and Higashio,K.
  TITLE     Structure of the mouse osteoclastogenesis inhibitory factor (OCIF)
            gene and its expression in embryogenesis
  JOURNAL   Gene 215 (2), 339-343 (1998)
   PUBMED   9714833
REFERENCE   7  (bases 1 to 2756)
  AUTHORS   Mizuno,A., Amizuka,N., Irie,K., Murakami,A., Fujise,N., Kanno,T.,
            Sato,Y., Nakagawa,N., Yasuda,H., Mochizuki,S., Gomibuchi,T.,
            Yano,K., Shima,N., Washida,N., Tsuda,E., Morinaga,T., Higashio,K.
            and Ozawa,H.
  TITLE     Severe osteoporosis in mice lacking osteoclastogenesis inhibitory
            factor/osteoprotegerin
  JOURNAL   Biochem Biophys Res Commun 247 (3), 610-615 (1998)
   PUBMED   9647741
REFERENCE   8  (bases 1 to 2756)
  AUTHORS   Bucay,N., Sarosi,I., Dunstan,C.R., Morony,S., Tarpley,J.,
            Capparelli,C., Scully,S., Tan,H.L., Xu,W., Lacey,D.L., Boyle,W.J.
            and Simonet,W.S.
  TITLE     osteoprotegerin-deficient mice develop early onset osteoporosis and
            arterial calcification
  JOURNAL   Genes Dev 12 (9), 1260-1268 (1998)
   PUBMED   9573043
REFERENCE   9  (bases 1 to 2756)
  AUTHORS   Tsuda,E., Goto,M., Mochizuki,S., Yano,K., Kobayashi,F., Morinaga,T.
            and Higashio,K.
  TITLE     Isolation of a novel cytokine from human fibroblasts that
            specifically inhibits osteoclastogenesis
  JOURNAL   Biochem Biophys Res Commun 234 (1), 137-142 (1997)
   PUBMED   9168977
REFERENCE   10 (bases 1 to 2756)
  AUTHORS   Simonet,W.S., Lacey,D.L., Dunstan,C.R., Kelley,M., Chang,M.S.,
            Luthy,R., Nguyen,H.Q., Wooden,S., Bennett,L., Boone,T.,
            Shimamoto,G., DeRose,M., Elliott,R., Colombero,A., Tan,H.L.,
            Trail,G., Sullivan,J., Davy,E., Bucay,N., Renshaw-Gegg,L.,
            Hughes,T.M., Hill,D., Pattison,W., Campbell,P., Sander,S., Van,G.,
            Tarpley,J., Derby,P., Lee,R. and Boyle,W.J.
  TITLE     Osteoprotegerin: a novel secreted protein involved in the
            regulation of bone density
  JOURNAL   Cell 89 (2), 309-319 (1997)
   PUBMED   9108485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121114.10.
            
            On Aug 26, 2022 this sequence version replaced XM_036159230.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1027302.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC121114.10        199231-199320       c
            91-207              AC121114.10        188865-188981       c
            208-574             AC121114.10        180820-181186       c
            575-766             AC121114.10        177001-177192       c
            767-991             AC121114.10        175057-175281       c
            992-2756            AC121114.10        171634-173398       c
FEATURES             Location/Qualifiers
     source          1..2756
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 21.15 cM"
     gene            1..2756
                     /gene="Tnfrsf11b"
                     /gene_synonym="OCIF; Opg; TR1"
                     /note="tumor necrosis factor receptor superfamily, member
                     11b (osteoprotegerin)"
                     /db_xref="GeneID:18383"
                     /db_xref="MGI:MGI:109587"
     exon            1..90
                     /gene="Tnfrsf11b"
                     /gene_synonym="OCIF; Opg; TR1"
                     /inference="alignment:Splign:2.1.0"
     exon            91..207
                     /gene="Tnfrsf11b"
                     /gene_synonym="OCIF; Opg; TR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1380
                     /gene="Tnfrsf11b"
                     /gene_synonym="OCIF; Opg; TR1"
                     /note="isoform 2 is encoded by transcript variant 2; tumor
                     necrosis factor receptor superfamily member 11B;
                     osteoprotegerin; osteoclastogenesis inhibitory factor"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 11B isoform 2"
                     /protein_id="NP_001398435.1"
                     /db_xref="GeneID:18383"
                     /db_xref="MGI:MGI:109587"
                     /translation="MAACSQDYNKKIQSSEAKIQAGVRFKLSKLLDIIEWTTQETLPP
                     KYLHYDPETGHQLLCDKCAPGTYLKQHCTVRRKTLCVPCPDHSYTDSWHTSDECVYCS
                     PVCKELQSVKQECNRTHNRVCECEEGRYLEIEFCLKHRSCPPGSGVVQAGTPERNTVC
                     KKCPDGFFSGETSSKAPCIKHTNCSTFGLLLIQKGNATHDNVCSGNREATQKCGIDVT
                     LCEEAFFRFAVPTKIIPNWLSVLVDSLPGTKVNAESVERIKRRHSSQEQTFQLLKLWK
                     HQNRDQEMVKKIIQDIDLCESSVQRHLGHSNLTTEQLLALMESLPGKKISPEEIERTR
                     KTCKSSEQLLKLLSLWRIKNGDQDTLKGLMYALKHLKTSHFPKTVTHSLRKTMRFLHS
                     FTMYRLYQKLFLEMIGNQVQSVKISCL"
     exon            208..574
                     /gene="Tnfrsf11b"
                     /gene_synonym="OCIF; Opg; TR1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..766
                     /gene="Tnfrsf11b"
                     /gene_synonym="OCIF; Opg; TR1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..991
                     /gene="Tnfrsf11b"
                     /gene_synonym="OCIF; Opg; TR1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..2756
                     /gene="Tnfrsf11b"
                     /gene_synonym="OCIF; Opg; TR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2732..2737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfrsf11b"
                     /gene_synonym="OCIF; Opg; TR1"
                     /note="hexamer: ATTAAA"
     polyA_site      2756
                     /gene="Tnfrsf11b"
                     /gene_synonym="OCIF; Opg; TR1"
                     /note="major polyA site"
ORIGIN      
        1 agagacgcac ctagcactga cccagcggct gcctcctgag gtttcccgag gaccacaatg
       61 aacaagtggc tgtgctgcgc actcctggtg tcactgtcac atccatctct ttcatgagac
      121 atggcggctt gttcccaaga ctacaacaag aagatccagt cttcagaggc taagattcag
      181 gcaggggtta ggtttaaact ctcaaagctc ctggacatca ttgaatggac aacccaggaa
      241 acccttcctc caaagtactt gcattatgac ccagaaactg gtcatcagct cctgtgtgac
      301 aaatgtgctc ctggcaccta cctaaaacag cactgcacag tgaggaggaa gacattgtgt
      361 gtcccttgcc ctgaccactc ttatacggac agctggcaca ccagtgatga gtgtgtgtat
      421 tgcagcccag tgtgcaagga actgcagtcc gtgaagcagg agtgcaaccg cacccacaac
      481 cgagtgtgtg agtgtgagga agggcgttac ctggagatcg aattctgctt gaagcaccgg
      541 agctgtcccc cgggctccgg cgtggtgcaa gctggaaccc cagagcgaaa cacagtttgc
      601 aaaaaatgtc cagatgggtt cttctcaggt gagacttcat cgaaagcacc ctgtataaaa
      661 cacacgaact gcagcacatt tggcctcctg ctaattcaga aaggaaatgc aacacatgac
      721 aacgtgtgtt ccggaaacag agaagccacg caaaagtgtg gaatagatgt caccctgtgt
      781 gaagaggcct tcttcaggtt tgctgttcct accaagatta taccaaattg gctgagtgtt
      841 ttggtggaca gtttgcctgg gaccaaagtg aatgccgaga gtgtagagag gataaaacgg
      901 agacacagct cacaagagca aaccttccag ctgctgaagc tgtggaaaca tcaaaacaga
      961 gaccaggaaa tggtgaagaa gatcatccaa gacattgacc tctgtgaaag cagcgtgcag
     1021 cggcatctcg gccactcgaa cctcaccaca gagcagcttc ttgccttgat ggagagcctg
     1081 cctgggaaga agatcagccc agaagagatt gagagaacga gaaagacctg caaatcgagc
     1141 gagcagctcc tgaagctact cagtttatgg aggatcaaaa atggtgacca agacaccttg
     1201 aagggcctga tgtatgccct caagcacttg aaaacatccc actttcccaa aactgtcacc
     1261 cacagtctga ggaagaccat gaggttcctg cacagcttca caatgtacag actgtatcag
     1321 aagctctttt tagaaatgat agggaatcag gttcaatccg tgaaaataag ctgcttataa
     1381 ctaggaatgg tcactgggct gtttcttcaa gatgggccaa aactgactga ggagaagaag
     1441 actgtttctc aagcacttga aacggcccag tgattccttt ctcatcagtc ggggggaatg
     1501 aagaccgccc ccacccccaa cacacacact ggggactctg agtccggaga gtgaggcagg
     1561 ctattttata attgtataaa accaggtgta tacccagaaa gccaagcatg ctgagtgaga
     1621 acagagggta ttttttttat aacctcaaac atacgtccct tccttcctct cctcacagct
     1681 gagcaatcag atggcttcta ctattttatg tgtcacccct agatgaaggt ctgtttcctt
     1741 ctgcatctga tagtctatga cgttctgttt ataatgctta tcagagcctc atcacctttg
     1801 taggttgcta ggcaagcttg actgttagct atttttccct ctaaagattt gatttgagtt
     1861 gcagacttag ctagacaggc aggggtgggt tgtggtagtt tatttaacag attgccacca
     1921 agagcccagt gtttcttgtt cctctgtagt tggacctaag ctgactcaaa gtacttttag
     1981 tttgaaaaat aatcaactaa ttttatttct tacattaaca atggctggct tggtttcata
     2041 gcaccagaag aaactactat atggagaaag aattgatatc tcctccaata ttcaacaaat
     2101 ccccaacagt ttatccagct gtcatgtctg gttcagtatc tacagactgt gtgtcctctc
     2161 attaccacat gtagtaattc aactggaaat aatagtaata gtagtaatag aaatcaagtc
     2221 tagactccat tggatctctt tgaatatggt aatatcaacg taaaagtctt tgagatttca
     2281 gttgtattaa aggcttttat taaaaagctg atgttcttct gtaaaagtta ctaatatatc
     2341 tgtaagacta ttacagtatt gctatttata ttcatgcaga tatgttttgt acatattata
     2401 aacctagaga gaaatgttgt aggacttaat tttagaaaga aaaaaatatt ctgtttacta
     2461 ttgagacaaa taaaagagat aaaatatatt tttaatagaa actttgtagt gttttcccat
     2521 aggtactgtc agttttccag tgtggaatgt ttttataata taattttatc tgtataagat
     2581 gtaatatcat tttatagaaa aatacattat gtattcagtt gtttaatgtc agaaagtgta
     2641 tgaactataa attatctgaa tattagatgc tctgagaaat tgaatgtacc ttatttaaag
     2701 atttttatga tcatactata taaatagcat cattaaagtt ttcaaattat ttttca
//
