LOCUS       NM_009399               5027 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus tumor necrosis factor receptor superfamily, member
            11a, NFKB activator (Tnfrsf11a), mRNA.
ACCESSION   NM_009399
VERSION     NM_009399.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5027)
  AUTHORS   Cho,J.Y., Woo,H.E., Yeom,J., An,M., Ma,S., Yim,D.J., Kim,S.H. and
            Lim,Y.H.
  TITLE     Microbial chaperonin 60 inhibits osteoclast differentiation by
            interfering with RANK/RANKL binding and overexpression of
            lipocalin2
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119850 (2024)
   PUBMED   39303785
  REMARK    GeneRIF: Microbial chaperonin 60 inhibits osteoclast
            differentiation by interfering with RANK/RANKL binding and
            overexpression of lipocalin2.
REFERENCE   2  (bases 1 to 5027)
  AUTHORS   Houchen,C.J., Ghanem,S., Kaartinen,V. and Bumann,E.E.
  TITLE     TGF-beta signaling in the cranial neural crest affects late-stage
            mandibular bone resorption and length
  JOURNAL   Front Physiol 15, 1435594 (2024)
   PUBMED   39473613
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5027)
  AUTHORS   Pfeuffer,L., Siegert,V., Frede,J., Rieger,L., Trozzo,R., de Andrade
            Kratzig,N., Ring,S., Sarhadi,S., Beck,N., Niedermeier,S.,
            Abril-Gil,M., Elbahloul,M., Remke,M., Steiger,K., Eichner,R.,
            Jellusova,J., Rad,R., Bassermann,F., Winter,C., Ruland,J. and
            Buchner,M.
  TITLE     B-cell intrinsic RANK signaling cooperates with TCL1 to induce
            lineage-dependent B-cell transformation
  JOURNAL   Blood Cancer J 14 (1), 151 (2024)
   PUBMED   39198400
  REMARK    GeneRIF: B-cell intrinsic RANK signaling cooperates with TCL1 to
            induce lineage-dependent B-cell transformation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5027)
  AUTHORS   Sandor,L.F., Huh,J.B., Benko,P., Hiraga,T., Poliska,S.,
            Dobo-Nagy,C., Simpson,J.P., Homer,N.Z.M., Mahata,B. and Gyori,D.S.
  TITLE     De novo steroidogenesis in tumor cells drives bone metastasis and
            osteoclastogenesis
  JOURNAL   Cell Rep 43 (3), 113936 (2024)
   PUBMED   38489269
REFERENCE   5  (bases 1 to 5027)
  AUTHORS   Lai,Y., Guo,Y., Liao,C., Mao,C., Liu,J., Ren,C., Yang,W., Luo,L.
            and Chen,W.
  TITLE     Osteoclast differentiation and dynamic mRNA expression during mice
            embryonic palatal bone development
  JOURNAL   Sci Rep 13 (1), 15170 (2023)
   PUBMED   37704707
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5027)
  AUTHORS   Li,J., Sarosi,I., Yan,X.Q., Morony,S., Capparelli,C., Tan,H.L.,
            McCabe,S., Elliott,R., Scully,S., Van,G., Kaufman,S., Juan,S.C.,
            Sun,Y., Tarpley,J., Martin,L., Christensen,K., McCabe,J.,
            Kostenuik,P., Hsu,H., Fletcher,F., Dunstan,C.R., Lacey,D.L. and
            Boyle,W.J.
  TITLE     RANK is the intrinsic hematopoietic cell surface receptor that
            controls osteoclastogenesis and regulation of bone mass and calcium
            metabolism
  JOURNAL   Proc Natl Acad Sci U S A 97 (4), 1566-1571 (2000)
   PUBMED   10677500
REFERENCE   7  (bases 1 to 5027)
  AUTHORS   Dougall,W.C., Glaccum,M., Charrier,K., Rohrbach,K., Brasel,K., De
            Smedt,T., Daro,E., Smith,J., Tometsko,M.E., Maliszewski,C.R.,
            Armstrong,A., Shen,V., Bain,S., Cosman,D., Anderson,D.,
            Morrissey,P.J., Peschon,J.J. and Schuh,J.
  TITLE     RANK is essential for osteoclast and lymph node development
  JOURNAL   Genes Dev 13 (18), 2412-2424 (1999)
   PUBMED   10500098
REFERENCE   8  (bases 1 to 5027)
  AUTHORS   Hsu,H., Lacey,D.L., Dunstan,C.R., Solovyev,I., Colombero,A.,
            Timms,E., Tan,H.L., Elliott,G., Kelley,M.J., Sarosi,I., Wang,L.,
            Xia,X.Z., Elliott,R., Chiu,L., Black,T., Scully,S., Capparelli,C.,
            Morony,S., Shimamoto,G., Bass,M.B. and Boyle,W.J.
  TITLE     Tumor necrosis factor receptor family member RANK mediates
            osteoclast differentiation and activation induced by
            osteoprotegerin ligand
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3540-3545 (1999)
   PUBMED   10097072
REFERENCE   9  (bases 1 to 5027)
  AUTHORS   Nakagawa,N., Kinosaki,M., Yamaguchi,K., Shima,N., Yasuda,H.,
            Yano,K., Morinaga,T. and Higashio,K.
  TITLE     RANK is the essential signaling receptor for osteoclast
            differentiation factor in osteoclastogenesis
  JOURNAL   Biochem Biophys Res Commun 253 (2), 395-400 (1998)
   PUBMED   9878548
REFERENCE   10 (bases 1 to 5027)
  AUTHORS   Anderson,D.M., Maraskovsky,E., Billingsley,W.L., Dougall,W.C.,
            Tometsko,M.E., Roux,E.R., Teepe,M.C., DuBose,R.F., Cosman,D. and
            Galibert,L.
  TITLE     A homologue of the TNF receptor and its ligand enhance T-cell
            growth and dendritic-cell function
  JOURNAL   Nature 390 (6656), 175-179 (1997)
   PUBMED   9367155
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101816.17 and AC132123.3.
            
            On Apr 1, 2021 this sequence version replaced NM_009399.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138990.1, AF019046.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC101816.17        86196-86307         c
            113-194             AC132123.3         202478-202559       c
            195-320             AC132123.3         201247-201372       c
            321-464             AC132123.3         196908-197051       c
            465-558             AC132123.3         192940-193033       c
            559-653             AC132123.3         190738-190832       c
            654-767             AC132123.3         189111-189224       c
            768-820             AC132123.3         185650-185702       c
            821-1565            AC132123.3         182967-183711       c
            1566-5027           AC132123.3         162720-166181       c
FEATURES             Location/Qualifiers
     source          1..5027
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 49.7 cM"
     gene            1..5027
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
                     /note="tumor necrosis factor receptor superfamily, member
                     11a, NFKB activator"
                     /db_xref="GeneID:21934"
                     /db_xref="MGI:MGI:1314891"
     exon            1..112
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1912
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
                     /note="receptor activator of NF-KB; osteoclast
                     differentiation factor receptor; receptor activator of
                     NF-kappaB"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 11A precursor"
                     /protein_id="NP_033425.3"
                     /db_xref="CCDS:CCDS15207.1"
                     /db_xref="GeneID:21934"
                     /db_xref="MGI:MGI:1314891"
                     /translation="MAPRARRRRQLPAPLLALCVLLVPLQVTLQVTPPCTQERHYEHL
                     GRCCSRCEPGKYLSSKCTPTSDSVCLPCGPDEYLDTWNEEDKCLLHKVCDAGKALVAV
                     DPGNHTAPRRCACTAGYHWNSDCECCRRNTECAPGFGAQHPLQLNKDTVCTPCLLGFF
                     SDVFSSTDKCKPWTNCTLLGKLEAHQGTTESDVVCSSSMTLRRPPKEAQAYLPSLIVL
                     LLFISVVVVAAIIFGVYYRKGGKALTANLWNWVNDACSSLSGNKESSGDRCAGSHSAT
                     SSQQEVCEGILLMTREEKMVPEDGAGVCGPVCAAGGPWAEVRDSRTFTLVSEVETQGD
                     LSRKIPTEDEYTDRPSQPSTGSLLLIQQGSKSIPPFQEPLEVGENDSLSQCFTGTEST
                     VDSEGCDFTEPPSRTDSMPVSPEKHLTKEIEGDSCLPWVVSSNSTDGYTGSGNTPGED
                     HEPFPGSLKCGPLPQCAYSMGFPSEAAASMAEAGVRPQDRADERGASGSGSSPSDQPP
                     ASGNVTGNSNSTFISSGQVMNFKGDIIVVYVSQTSQEGPGSAEPESEPVGRPVQEETL
                     AHRDSFAGTAPRFPDVCATGAGLQEQGAPRQKDGTSRPVQEQGGAQTSLHTQGSGQCA
                     E"
     exon            113..194
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
                     /inference="alignment:Splign:2.1.0"
     exon            195..320
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
                     /inference="alignment:Splign:2.1.0"
     exon            321..464
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
                     /inference="alignment:Splign:2.1.0"
     exon            465..558
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
                     /inference="alignment:Splign:2.1.0"
     exon            559..653
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
                     /inference="alignment:Splign:2.1.0"
     exon            654..767
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
                     /inference="alignment:Splign:2.1.0"
     exon            768..820
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1565
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..5027
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4587..4592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
                     /note="hexamer: CATAAA"
     polyA_site      4631
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
                     /note="major polyA site"
     regulatory      4968..4973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
                     /note="hexamer: AATAAA"
     polyA_site      4996
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
     regulatory      5003..5008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
                     /note="hexamer: ATTAAA"
     polyA_site      5027
                     /gene="Tnfrsf11a"
                     /gene_synonym="Ly109; mRANK; ODFR; OFE; Rank; TRANCE-R"
ORIGIN      
        1 agaggccgcg cgcccagccc gcccgcaccg cgccatggcc ccgcgcgccc ggcggcgccg
       61 ccagctgccc gcgccgctgc tggcgctctg cgtgctgctc gttccactgc aggtgactct
      121 ccaggtcact cctccatgca cccaggagag gcattatgag catctcggac ggtgttgcag
      181 cagatgcgaa ccaggaaagt acctgtcctc taagtgcact cctacctccg acagtgtgtg
      241 tctgccctgt ggccccgatg agtacttgga cacctggaat gaagaagata aatgcttgct
      301 gcataaagtc tgtgatgcag gcaaggccct ggtggcggtg gatcctggca accacacggc
      361 cccgcgtcgc tgtgcttgca cggctggcta ccactggaac tcagactgcg agtgctgccg
      421 caggaacacg gagtgtgcac ctggcttcgg agctcagcat cccttgcagc tcaacaagga
      481 tacggtgtgc acaccctgcc tcctgggctt cttctcagat gtcttttcgt ccacagacaa
      541 atgcaaacct tggaccaact gcaccctcct tggaaagcta gaagcacacc aggggacaac
      601 ggaatcagat gtggtctgca gctcttccat gacactgagg agaccaccca aggaggccca
      661 ggcttacctg cccagtctca tcgttctgct cctcttcatc tctgtggtag tagtggctgc
      721 catcatcttc ggcgtttact acaggaaggg agggaaagcg ctgacagcta atttgtggaa
      781 ttgggtcaat gatgcttgca gtagtctaag tggaaataag gagtcctcag gggaccgttg
      841 tgctggttcc cactcggcaa cctccagtca gcaagaagtg tgtgaaggta tcttactaat
      901 gactcgggag gagaagatgg ttccagaaga cggtgctgga gtctgtgggc ctgtgtgtgc
      961 ggcaggtggg ccctgggcag aagtcagaga ttctaggacg ttcacactgg tcagcgaggt
     1021 tgagacgcaa ggagacctct cgaggaagat tcccacagag gatgagtaca cggaccggcc
     1081 ctcgcagcct tcgactggtt cactgctcct aatccagcag ggaagcaaat ctataccccc
     1141 attccaggag cccctggaag tgggggagaa cgacagttta agccagtgtt tcaccgggac
     1201 tgaaagcacg gtggattctg agggctgtga cttcactgag cctccgagca gaactgactc
     1261 tatgcccgtg tcccctgaaa agcacctgac aaaagaaata gaaggtgaca gttgcctccc
     1321 ctgggtggtc agctccaact caacagatgg ctacacaggc agtgggaaca ctcctgggga
     1381 ggaccatgaa ccctttccag ggtccctgaa atgtggacca ttgccccagt gtgcctacag
     1441 catgggcttt cccagtgaag cagcagccag catggcagag gcgggagtac ggccccagga
     1501 cagggctgat gagaggggag cctcagggtc cgggagctcc cccagtgacc agccacctgc
     1561 ctctgggaac gtgactggaa acagtaactc cacgttcatc tctagcgggc aggtgatgaa
     1621 cttcaagggt gacatcatcg tggtgtatgt cagccagacc tcgcaggagg gcccgggttc
     1681 cgcagagccc gagtcggagc ccgtgggccg ccctgtgcag gaggagacgc tggcacacag
     1741 agactccttt gcgggcaccg cgccgcgctt ccccgacgtc tgtgccaccg gggctgggct
     1801 gcaggagcag ggggcacccc ggcagaagga cgggacatcg cggccggtgc aggagcaggg
     1861 tggggcgcag acttcactcc atacccaggg gtccggacaa tgtgcagaat gacctcacct
     1921 tctctgtctg ccctgggtgc agggcaccag tgcctttcca aaaacatggt gtagctagcc
     1981 actgtgcacc tcctcactgg tgcaggctgc tggcatggtg atggagccca cctctcactt
     2041 cctccagtgc ccctctcctc tgcctcctac cacctggcat cattcagttt ggcctttttt
     2101 tgcaacgttg gtgtcctgca ttattgagat ctgtatcacc ccacccccat atttattatt
     2161 cacttgcttt tgtagtgttt tctgatactc tctctctctg tctctgtctc tctctctctc
     2221 tctctctctc tctctctctc tctctctctc tatatatata tatatatata tatatatata
     2281 tatatatatc tcaggttttt tttccaaaga gtgaaaggga tgcacggcca ctaccactaa
     2341 ggctttgagt ttgtgtggat ccttgagagc taagttcagg tgaccttgtc ccctgcctgg
     2401 ttttggtttt gtttcatttt ttgtttttta gtcttttttt tttcctacag tggcaggtac
     2461 ttggccacta aatctcaaaa aaaaaaaatc ataccttttg tggttttggc atccttattt
     2521 tttttaaact attggctgtc tagaaaagat ggagggagta aataggacgt caggccaaag
     2581 gacaaaatga aggtgccagg gaaattcaag aaagaatgaa tagagttgac atgtcaattt
     2641 gctttttctc ttcctccatt agaatgtcag aaacacactt aggcagtagg ccctctttcc
     2701 ttccaaagtg tttgtgcatg agtaatttag cctatggaag taaaaacatt cttctgtgtg
     2761 tgtctgtgtg tgtgtgtctg tgtgtgtgtg tctgtgttca tgtgtgtgtg tgtctgtatg
     2821 tgtgtgtctg tgtgtgtgtg gatgtgtgtg tctgtgtgtg tgtgtgtctg tgtgtgtgta
     2881 tgtgtgtgtc tgtgtgtgtg tggatgtgtg tgtctgtgtg tgtgtggatg tgtgtgtctg
     2941 tgtgtgtatg gatgtgtgtg tctgtgtgtg tgtgttgctc ccacatttaa atgacaaacc
     3001 aggagatcta aagagatgcc tcacagttaa gaagaagagt ttgggttcag tacccagtac
     3061 cccactgttc agtccacaac tccatgtaac tccagctcca tgggattcca tggccacaca
     3121 cacacacaca cacacacaca cacacacaca caattacaaa tcaaatctca tgaggtaaat
     3181 gtaaggaaat caattgtcct atgggtgatt ttcttttggt gggtccttat acaagaaagc
     3241 agtttaaaac tgaaagaggc cacaggcata gttatcacga gcactggttc ttggataatg
     3301 gagataaagc taaccactta agtgaactac aagcagtttt gtaattgttg gggtccagga
     3361 gtcacctcac aaaccattca aacacccacc tcagacaggg atggcttatt tagcatacac
     3421 cacaggtcta accaatcagg gccacaattc aggctcagaa gctgaaccat gacattgagt
     3481 taagatccta cagggttttc aagcataaag tccacaaaca tctgtgccaa gttatttcac
     3541 caatcaggat ttagagatag gggattttct tacaaacatg tctttgttgt acacttatcc
     3601 tgttctcatt ggttggggta ttcagttgtg gcaggggact ttaacatgca tgccttaact
     3661 tgtctaccag gacgtcagtt acccatatac atgcctcttt ctgccaagta ggatgacagt
     3721 tctctctctc tctttttttt ttcttgtttt tttttctttt acctttctca aacccttgtg
     3781 ttgagggcag gatgacaatt ctcggtgagg tcttgggaac ttaaaacttt acctgaccct
     3841 acacaaaatg aaagtcttat tccaaatagc ttcttatatt ggtgtctctc ttatgttggg
     3901 gtccatccca taggcagctt ataaaaccaa atagcataaa agcttatatt acaggtgcag
     3961 gaagtgctgc tgggtagttg gttcggggct aagcttattg tgggtcacta tacaaaacaa
     4021 ttctactgac ttctatcatg attttttttt tttttacaaa ggcacagaac ataacaatat
     4081 gcaaccagtt tgggcatgag aaagtttcct agtaacagca tatgagaaag tctctttata
     4141 acattagtaa cggcataaaa tggtgggcta cccaggtgac aagtacctag gccttaacat
     4201 tccatctagg ccttaatatt ttatctagac cttaacagta atccggcagg tatctagacc
     4261 ttaacagtaa gttaaacatg ctaagaatga tcactgtgca gccgcaagta tccagctgag
     4321 cagaagccca tctctccctg gtttcctcct gactgaagtt ctcctgtggt tgtagcagtt
     4381 gattctgatt tttaacacaa aattggtgaa tagctctgta atgtatgggc tcctatgcta
     4441 acataaagaa cttcaggaaa taagcccagg gccagaatga tgcaatgata gaaattttgt
     4501 tagtactttt ccaaagagag atgttactaa attcagcaaa gccattatac ctttttcgta
     4561 cggaatgtat tgtattaaat aaactccata aagtaggatg tggagctcaa accccacacc
     4621 caggactatc atcatctctc catgcctact tcttttttgc tgtacttccc ttttctccat
     4681 acaaagtcaa taatgacagc tcaacaccat ttcccgaccc agagatatca gaagatgctt
     4741 tggtgggtgt taaagtaccg taattcctaa aatcaaaagt gctaagagca ttaagaatct
     4801 actttcagag agaaaacgaa aggtattaag gttcctcaca ctgatcccga ctgaggttat
     4861 attggttcaa agccaacgaa accttaggaa acacgtaaca aagatatata gttgcatgtg
     4921 tgtagttgaa atgtttatga caaatataaa caatataaag aaaatacaat aaaagttact
     4981 ccaatgtcat ggtaaagaga ttattaaaac tttatttttc cataaaa
//
