LOCUS       NM_020275               3197 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Mus musculus tumor necrosis factor receptor superfamily, member 10b
            (Tnfrsf10b), mRNA.
ACCESSION   NM_020275 NM_020294
VERSION     NM_020275.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3197)
  AUTHORS   Lin,Y., Tang,W., Huang,P., Wang,Z., Duan,L., Jia,C., Sun,R., Liu,L.
            and Shen,J.
  TITLE     Denticleless E3 ubiquitin protein ligase (DTL) maintains the
            proliferation and differentiation of epidermis and hair follicles
            during skin development
  JOURNAL   Dev Dyn 253 (7), 635-647 (2024)
   PUBMED   38131461
REFERENCE   2  (bases 1 to 3197)
  AUTHORS   Soma,S., Murakami,K., Fukuchi,Y., Kunimoto,H. and Nakajima,H.
  TITLE     O-Linked N-Acetylglucosamine Transferase Ensures Survival of Mouse
            Fetal Liver Hematopoietic Progenitors Partly by Regulating Bcl-xL
            and Oxidative Phosphorylation
  JOURNAL   Stem Cells 42 (1), 55-63 (2024)
   PUBMED   37813816
REFERENCE   3  (bases 1 to 3197)
  AUTHORS   Liu,J., Liu,K., Wang,Y., Shi,Z., Xu,R., Zhang,Y., Li,J., Liu,C. and
            Xue,B.
  TITLE     Death receptor 5 is required for intestinal stem cell activity
            during intestinal epithelial renewal at homoeostasis
  JOURNAL   Cell Death Dis 15 (1), 27 (2024)
   PUBMED   38199990
  REMARK    GeneRIF: Death receptor 5 is required for intestinal stem cell
            activity during intestinal epithelial renewal at homoeostasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3197)
  AUTHORS   Yang,C., Xu,H., Yang,D., Xie,Y., Xiong,M., Fan,Y., Liu,X.,
            Zhang,Y., Xiao,Y., Chen,Y., Zhou,Y., Song,L., Wang,C., Peng,A.,
            Petersen,R.B., Chen,H., Huang,K. and Zheng,L.
  TITLE     A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney
            injury
  JOURNAL   Nat Commun 14 (1), 4261 (2023)
   PUBMED   37460623
  REMARK    GeneRIF: A renal YY1-KIM1-DR5 axis regulates the progression of
            acute kidney injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3197)
  AUTHORS   Zhang,T., Xu,D., Trefts,E., Lv,M., Inuzuka,H., Song,G., Liu,M.,
            Lu,J., Liu,J., Chu,C., Wang,M., Wang,H., Meng,H., Liu,H.,
            Zhuang,Y., Xie,X., Dang,F., Guan,D., Men,Y., Jiang,S., Jiang,C.,
            Dai,X., Liu,J., Wang,Z., Yan,P., Wang,J., Tu,Z., Babuta,M.,
            Erickson,E., Hillis,A.L., Dibble,C.C., Asara,J.M., Szabo,G.,
            Sicinski,P., Miao,J., Lee,Y.R., Pan,L., Shaw,R.J., Yuan,J. and
            Wei,W.
  TITLE     Metabolic orchestration of cell death by AMPK-mediated
            phosphorylation of RIPK1
  JOURNAL   Science 380 (6652), 1372-1380 (2023)
   PUBMED   37384704
REFERENCE   6  (bases 1 to 3197)
  AUTHORS   Takeda,K., Yamaguchi,N., Akiba,H., Kojima,Y., Hayakawa,Y.,
            Tanner,J.E., Sayers,T.J., Seki,N., Okumura,K., Yagita,H. and
            Smyth,M.J.
  TITLE     Induction of tumor-specific T cell immunity by anti-DR5 antibody
            therapy
  JOURNAL   J Exp Med 199 (4), 437-448 (2004)
   PUBMED   14769851
  REMARK    GeneRIF: Antibody-based therapy targeting DR5 is an efficient
            strategy not only to eliminate TRAIL-sensitive tumor cells.
REFERENCE   7  (bases 1 to 3197)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   8  (bases 1 to 3197)
  AUTHORS   Locksley,R.M., Killeen,N. and Lenardo,M.J.
  TITLE     The TNF and TNF receptor superfamilies: integrating mammalian
            biology
  JOURNAL   Cell 104 (4), 487-501 (2001)
   PUBMED   11239407
  REMARK    Review article
REFERENCE   9  (bases 1 to 3197)
  AUTHORS   Kuang,A.A., Diehl,G.E., Zhang,J. and Winoto,A.
  TITLE     FADD is required for DR4- and DR5-mediated apoptosis: lack of
            trail-induced apoptosis in FADD-deficient mouse embryonic
            fibroblasts
  JOURNAL   J Biol Chem 275 (33), 25065-25068 (2000)
   PUBMED   10862756
REFERENCE   10 (bases 1 to 3197)
  AUTHORS   Wu,G.S., Burns,T.F., Zhan,Y., Alnemri,E.S. and El-Deiry,W.S.
  TITLE     Molecular cloning and functional analysis of the mouse homologue of
            the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing
            ligand (TRAIL) death receptor
  JOURNAL   Cancer Res 59 (12), 2770-2775 (1999)
   PUBMED   10383128
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050753.1 and BC065141.1.
            
            On Dec 12, 2009 this sequence version replaced NM_020275.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065141.1, AK080069.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AK050753.1         2-58
            58-2548             BC065141.1         1-2491
            2549-3197           BC065141.1         2494-3142
FEATURES             Location/Qualifiers
     source          1..3197
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 36.1 cM"
     gene            1..3197
                     /gene="Tnfrsf10b"
                     /gene_synonym="DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A;
                     TRICK2B; TRICKB"
                     /note="tumor necrosis factor receptor superfamily, member
                     10b"
                     /db_xref="GeneID:21933"
                     /db_xref="MGI:MGI:1341090"
     exon            1..320
                     /gene="Tnfrsf10b"
                     /gene_synonym="DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A;
                     TRICK2B; TRICKB"
                     /inference="alignment:Splign:2.1.0"
     exon            321..417
                     /gene="Tnfrsf10b"
                     /gene_synonym="DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A;
                     TRICK2B; TRICKB"
                     /inference="alignment:Splign:2.1.0"
     exon            418..528
                     /gene="Tnfrsf10b"
                     /gene_synonym="DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A;
                     TRICK2B; TRICKB"
                     /inference="alignment:Splign:2.1.0"
     exon            529..637
                     /gene="Tnfrsf10b"
                     /gene_synonym="DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A;
                     TRICK2B; TRICKB"
                     /inference="alignment:Splign:2.1.0"
     exon            638..834
                     /gene="Tnfrsf10b"
                     /gene_synonym="DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A;
                     TRICK2B; TRICKB"
                     /inference="alignment:Splign:2.1.0"
     exon            835..929
                     /gene="Tnfrsf10b"
                     /gene_synonym="DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A;
                     TRICK2B; TRICKB"
                     /inference="alignment:Splign:2.1.0"
     exon            930..999
                     /gene="Tnfrsf10b"
                     /gene_synonym="DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A;
                     TRICK2B; TRICKB"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..3179
                     /gene="Tnfrsf10b"
                     /gene_synonym="DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A;
                     TRICK2B; TRICKB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3159..3164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfrsf10b"
                     /gene_synonym="DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A;
                     TRICK2B; TRICKB"
                     /note="hexamer: AATAAA"
     polyA_site      3179
                     /gene="Tnfrsf10b"
                     /gene_synonym="DR5; KILLER; Ly98; MK; TRAILR2; TRICK2A;
                     TRICK2B; TRICKB"
                     /note="major polyA site"
ORIGIN      
        1 acccctgccc ggtgcgcgcg caagcccgcg gaggttggag gtaccactaa gcgtcaagtc
       61 gccgcgacaa gaatccagaa cttttctggg agtgaggaaa tccagagaac ttttttagga
      121 gtgaggggac agccatcctt cgtggctttt gggagctgaa gccgcagggt ttcggatgag
      181 ctgacaccat ggagcctcca ggacccagca cgcccacagc ctctgccgct gcccgggcag
      241 atcactacac cccaggcctc cggccactcc cgaagcgcag acttctatat agctttgcgt
      301 tgctgcttgc tgtgctacag gctgtctttg ttccagtaac agctaaccca gcccataatc
      361 gtccagctgg cctacagcgg ccggaggaga gcccatcaag aggaccctgt ctagcaggcc
      421 agtacctgtc agaagggaac tgcaagcctt gcagagaggg tattgactac accagccatt
      481 ccaaccattc tctggattca tgtattctct gcacagtctg taaggaagat aaagtcgtag
      541 aaacccgatg caacataacc acaaatacgg tgtgtcgatg caaaccaggc acctttgaag
      601 ataaagactc ccctgagatc tgccagtcat gctctaactg cactgacggg gaagaggaac
      661 tgacttcctg tacccccaga gaaaaccgga agtgtgtctc caaaacggct tgggcatctt
      721 ggcataagct aggcctctgg ataggactcc tggttccagt agtgctgctg attggagctc
      781 tgcttgtctg gaagactgga gcatggaggc aatggttgct ctgtataaaa agaggctgtg
      841 aacgggatcc cgaaagtgcg aactctgtgc attcgtctct cttggaccga cagacatcta
      901 gcacgacaaa tgactctaac cacaacacgg aacctggcaa gactcagaaa acaggaaaga
      961 agttgctggt tccggtaaac ggaaacgact cagctgacga cctgaagttt atcttcgagt
     1021 attgttcgga catagtgccc tttgactcct ggaaccgtct catgcggcag ttgggcctca
     1081 cagacaatca aatccaaatg gtcaaagccg aaacactggt cacacgtgag gccctgtacc
     1141 aaatgctgct caagtggcgc caccagactg ggcgaagtgc ctccatcaac catctgctgg
     1201 atgccttgga agccgtggaa gagagagatg ccatggagaa aattgaagac tacgcagtga
     1261 aatccgggag gtttacttat cagaacgctg cagcccaacc agagacaggg ccaggaggat
     1321 ctcagtgcgt ttgaagtcag cctgatctac ttagtgaact caggacagcc aaggctatgt
     1381 agagagcccc gaagatgcag gctcttcagt attatgagaa tgtacttaat tttttcttgt
     1441 agtagttagt gtatcatatt attgtattat ttatattatt actgttaagt actatgttct
     1501 cttattagaa gttgaacaca gaacctctga gaacacatat gctacaagtg ttctaacaca
     1561 cctccagcat cccggattac ctttgttcct gaacaaggca caattggtag ggtatgatag
     1621 ggcctgccta tcatcctaac actccggtga tggagccagg aagatcaaga gttcgaggcc
     1681 agctggttca cataagatcc catataatgt gcaggatggc taaacttgct gagagctgac
     1741 tctgtggtct cctgtcccag attctagcga tattcattac taagaccctt gtccagagac
     1801 aaaagaccac ctctgtaaca gagggaagaa taaaacagcc ctagggtgga aactccttgt
     1861 gaacacagcc actgctgttt actgttagac tactgctcag cactacacag ctgcacggca
     1921 cctccctgtg ccaggtgcta gtgggcagcc tactgagggt acatctaact tgaatctaac
     1981 acacttgaag tgagtttgct ggtttggaca cagagggagc attaagtgct acctggggtg
     2041 acccttgagg accacgcccc ctgtaagcat ttgaccattg tgagagtaaa cactgaaact
     2101 caccattgtc ctgcctcagc ctttctagag ctggaatcat aggtatgctg caccggatcc
     2161 agaaggagaa ataactacct ttagatactg tgatagggat ttctagaaag ctgccacata
     2221 cagatttttg tcctgtgtga attcctattg ttttttgttt gtttttaatt ttttattatt
     2281 tattttcttc attcacattt caaatgctat cccaaaagtc ccctatgccc tccccccccc
     2341 tgccccccgc cctgctcccc tacccactca ctcactccca cttttttttt tttttttgag
     2401 acagggtttc tctgtgtagc cctggctgtc ctggaactca ctctgtagac caggctggcc
     2461 tcgaactcag aaattcacct gcctctgcct cccaagtgct gggattaaag gtgtgtgcca
     2521 ccatgcccgg cctttttttt ttttttttaa ttaggtattt atttcattta aatttccaat
     2581 gctatcccaa aagtccccca catgctcccc cacccactcc ccacctgact ttatatgcct
     2641 cactcccact tcttggccct ggtgttcccc tgtactgggg catataacgt ttgcaagacc
     2701 aaggggcgtc tctttccact gatggccgac taggccatct tctgatacat atgcagctag
     2761 agacacgagc tctggggggg tactggttag ttcatattgt tgttccacct atagggttgc
     2821 cgaccccttc agctccttgg gtactttctc tagctcctcc actaggggcc ctgtgttcta
     2881 tccaatagat gactgtgagc atccacttct gtatttgcca ggcactggca tagcctcata
     2941 cgagacagct atatcagggt ccagttttgt tttgttttgt tttaaactag catgctggag
     3001 aggtagctca gcggttaaga gcagtggctg ctcttccaga ggtcctgagt tccaattccc
     3061 agcagctaca tagtggctca caaccttctc taatgggatc tgatgtcctt ttctagtgtg
     3121 tttgaagcca gtggcagtgt aattacatac acaaaataaa taaatctttt taaaaaagaa
     3181 aaaaaaaaaa aaaaaaa
//
