LOCUS       NM_027206               1116 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus tumor necrosis factor, alpha-induced protein 8-like 2
            (Tnfaip8l2), mRNA.
ACCESSION   NM_027206
VERSION     NM_027206.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1116)
  AUTHORS   Guo,P., Gao,X., Nelson,A.L., Huard,M., Lu,A., Hambright,W.S. and
            Huard,J.
  TITLE     TIPE2 gene transfer ameliorates aging-associated osteoarthritis in
            a progeria mouse model by reducing inflammation and cellular
            senescence
  JOURNAL   Mol Ther 32 (9), 3101-3113 (2024)
   PUBMED   39095992
  REMARK    GeneRIF: TIPE2 gene transfer ameliorates aging-associated
            osteoarthritis in a progeria mouse model by reducing inflammation
            and cellular senescence.
REFERENCE   2  (bases 1 to 1116)
  AUTHORS   Yang,Y., Ma,Y., Yu,S., Lin,Z., Yan,C., Wang,Y., Yuan,Q., Meng,Z.,
            Yan,G., Wu,Z., Tang,H., Peng,Z., Huang,J. and Zhuang,G.
  TITLE     TIPE2 knockout reduces myocardial cell damage by inhibiting
            IFN-gamma-mediated ferroptosis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (1), 166566 (2023)
   PUBMED   36216021
  REMARK    GeneRIF: TIPE2 knockout reduces myocardial cell damage by
            inhibiting IFN-gamma-mediated ferroptosis.
REFERENCE   3  (bases 1 to 1116)
  AUTHORS   Xia,X., Wang,S., Wu,L., Li,G., Hou,K., Yu,A. and Yang,Z.
  TITLE     TIPE2 attenuates neuroinflammation and brain injury through
            Bcl-2/Bax/cleaved caspase-3 apoptotic pathways after intracerebral
            hemorrhage in mice
  JOURNAL   Brain Res Bull 191, 1-8 (2022)
   PUBMED   36179971
  REMARK    GeneRIF: TIPE2 attenuates neuroinflammation and brain injury
            through Bcl-2/Bax/cleaved caspase-3 apoptotic pathways after
            intracerebral hemorrhage in mice.
REFERENCE   4  (bases 1 to 1116)
  AUTHORS   Yao,R., Kong,L., Yang,C., Du,J., Zhao,G. and Li,Y.
  TITLE     Tumor Necrosis Factor-alpha-Induced Protein 8-Like 2 Ameliorates
            Cardiac Hypertrophy by Targeting TLR4 in Macrophages
  JOURNAL   Oxid Med Cell Longev 2022, 9469143 (2022)
   PUBMED   35528518
  REMARK    GeneRIF: Tumor Necrosis Factor-alpha-Induced Protein 8-Like 2
            Ameliorates Cardiac Hypertrophy by Targeting TLR4 in Macrophages.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1116)
  AUTHORS   Lou,Y., Song,M., Han,M., Zhong,J., Tian,X., Ren,Y., Song,Y.,
            Duan,L., Zhao,P., Song,X., Zhang,W., Chen,Y.H. and Wang,H.
  TITLE     Tumor Necrosis Factor-alpha-Induced Protein 8-Like 2 Fosters
            Tumor-Associated Microbiota to Promote the Development of
            Colorectal Cancer
  JOURNAL   Cancer Immunol Res 10 (3), 354-367 (2022)
   PUBMED   35101901
  REMARK    GeneRIF: Tumor Necrosis Factor-alpha-Induced Protein 8-Like 2
            Fosters Tumor-Associated Microbiota to Promote the Development of
            Colorectal Cancer.
REFERENCE   6  (bases 1 to 1116)
  AUTHORS   Zhang,Y., Wei,X., Liu,L., Liu,S., Wang,Z., Zhang,B., Fan,B.,
            Yang,F., Huang,S., Jiang,F., Chen,Y.H. and Yi,F.
  TITLE     TIPE2, a novel regulator of immunity, protects against experimental
            stroke
  JOURNAL   J Biol Chem 287 (39), 32546-32555 (2012)
   PUBMED   22859306
  REMARK    GeneRIF: TIPE2 plays an essential role in a signal transduction
            pathway that links the inflammatory immune response to specific
            conditions after cerebral ischemia.
REFERENCE   7  (bases 1 to 1116)
  AUTHORS   Luan,Y.Y., Yao,Y.M., Zhang,L., Dong,N., Zhang,Q.H., Yu,Y. and
            Sheng,Z.Y.
  TITLE     Expression of tumor necrosis factor-alpha induced protein 8 like-2
            contributes to the immunosuppressive property of CD4(+)CD25(+)
            regulatory T cells in mice
  JOURNAL   Mol Immunol 49 (1-2), 219-226 (2011)
   PUBMED   21963221
  REMARK    GeneRIF: The results suggested that TIPE2 appeared to be a critical
            immunoregulatory molecule involved in immunosuppressive function of
            CD4(+)CD25(+) Tregs.
REFERENCE   8  (bases 1 to 1116)
  AUTHORS   Xi,W., Hu,Y., Liu,Y., Zhang,J., Wang,L., Lou,Y., Qu,Z., Cui,J.,
            Zhang,G., Liang,X., Ma,C., Gao,C., Chen,Y. and Liu,S.
  TITLE     Roles of TIPE2 in hepatitis B virus-induced hepatic inflammation in
            humans and mice
  JOURNAL   Mol Immunol 48 (9-10), 1203-1208 (2011)
   PUBMED   21466895
  REMARK    GeneRIF: These results indicate that TIPE2 plays an important role
            in taming Hepatitis B virus-induced hepatic inflammation.
REFERENCE   9  (bases 1 to 1116)
  AUTHORS   Zhang,G., Hao,C., Lou,Y., Xi,W., Wang,X., Wang,Y., Qu,Z., Guo,C.,
            Chen,Y., Zhang,Y. and Liu,S.
  TITLE     Tissue-specific expression of TIPE2 provides insights into its
            function
  JOURNAL   Mol Immunol 47 (15), 2435-2442 (2010)
   PUBMED   20663561
  REMARK    GeneRIF: TIPE2 expression was detected in various murine tissues by
            immunohistochemistry & RT-PCR. TIPE2 was a cytoplasmic protein
            expressed preferentially in lymphoid tissues and a small group of
            non-lymphoid tissues.
REFERENCE   10 (bases 1 to 1116)
  AUTHORS   Sun,H., Gong,S., Carmody,R.J., Hilliard,A., Li,L., Sun,J., Kong,L.,
            Xu,L., Hilliard,B., Hu,S., Shen,H., Yang,X. and Chen,Y.H.
  TITLE     TIPE2, a negative regulator of innate and adaptive immunity that
            maintains immune homeostasis
  JOURNAL   Cell 133 (3), 415-426 (2008)
   PUBMED   18455983
  REMARK    GeneRIF: This paper establishes that TIPE2 is an essential negative
            regulator of TLR and TCR function, and its selective expression in
            the immune system prevents hyperresponsiveness and maintains immune
            homeostasis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131769.3.
            
            On Jan 29, 2019 this sequence version replaced NM_027206.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094616.1, AK007540.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC131769.3         129570-129609       c
            41-1116             AC131769.3         126776-127851       c
FEATURES             Location/Qualifiers
     source          1..1116
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..1116
                     /gene="Tnfaip8l2"
                     /gene_synonym="1810019A08Rik; TIPE2"
                     /note="tumor necrosis factor, alpha-induced protein 8-like
                     2"
                     /db_xref="GeneID:69769"
                     /db_xref="MGI:MGI:1917019"
     exon            1..40
                     /gene="Tnfaip8l2"
                     /gene_synonym="1810019A08Rik; TIPE2"
                     /inference="alignment:Splign:2.1.0"
     exon            41..1116
                     /gene="Tnfaip8l2"
                     /gene_synonym="1810019A08Rik; TIPE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..641
                     /gene="Tnfaip8l2"
                     /gene_synonym="1810019A08Rik; TIPE2"
                     /note="tumor necrosis factor, alpha-induced protein 8-like
                     protein 2; TNFAIP8-like protein 2; TNF alpha-induced
                     protein 8-like protein 2"
                     /codon_start=1
                     /product="tumor necrosis factor alpha-induced protein
                     8-like protein 2"
                     /protein_id="NP_081482.1"
                     /db_xref="CCDS:CCDS17603.1"
                     /db_xref="GeneID:69769"
                     /db_xref="MGI:MGI:1917019"
                     /translation="MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYR
                     VSKEYTHSRPKAQRVIKDLIKVAVKVAVLHRSGCFGPGELALATRFRQKLRQGAMTAL
                     SFGEVDFTFEAAVLAGLLVECRDILLELVEHHLTPKSHDRIRHVFDHYSDPDLLAALY
                     GPDFTQHLGKICDGLRKLLDEGKL"
     regulatory      1097..1102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfaip8l2"
                     /gene_synonym="1810019A08Rik; TIPE2"
                     /note="hexamer: AATAAA"
     polyA_site      1116
                     /gene="Tnfaip8l2"
                     /gene_synonym="1810019A08Rik; TIPE2"
                     /note="major polyA site"
ORIGIN      
        1 agaaacatcc aaggccagac tggcacccag cacacggcag ccggttgcct cttccagtga
       61 ctgatcacac accgaccgca agcaccatgg agtccttcag ctcaaagagt ctggcactac
      121 aagcggagaa gaagctgctg agtaaaatgg ctggtcggtc cgtggcgcat ctctttatcg
      181 acgagaccag cagcgaggtg ctagacgagc tttaccgcgt gtccaaagaa tacacgcaca
      241 gccggcccaa ggcacagcgg gtgatcaaag acctcatcaa ggtagcggtt aaagtggctg
      301 tgctgcaccg cagtggctgc tttggccctg gggagctggc tctggctaca cgatttcgtc
      361 agaagctacg gcagggcgcc atgaccgcac ttagcttcgg tgaggtggac ttcacctttg
      421 aggctgccgt gctagcaggt ctgctcgtcg agtgccggga cattctgctg gagctggtgg
      481 agcaccacct cacacccaag tcacatgacc gcatcaggca cgtgtttgat cactactctg
      541 accccgacct gctggctgcc ctctatgggc ctgacttcac tcagcacctt ggcaagatct
      601 gtgatgggct ccggaagctg ctggacgagg gcaagctctg aagctccgga gctcagcaca
      661 ctggactttg gcaaaatgac tgactgggaa atgacacatc gggctctcta accctgcacc
      721 aatgcttctc gatcccctgg cttcactctc tcccaagagt gctatagaca ctgaggccac
      781 ccccaccccc aaactactgc tggggcaaag caaggctgaa ctgagtgagg cggctctcgc
      841 tcccatccag ttccagtaaa ggaaacagct gactgaagaa gaagtgaaac tcaggtccgc
      901 ttctcccggg agggctgccc agaaccaggg gatcctcctc ctccacaaac ccgaggaagg
      961 ggacactaaa ggccacacgc aggaaggtgg tcattagaga cctcctggat ctagagttgg
     1021 aggcagcact aggacacata cagacgctgt gttccagagc ttctagaagg agctggggga
     1081 agggaggcac aggggaaata aaaccactaa agcatg
//
