LOCUS       NM_025566               2365 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus tumor necrosis factor, alpha-induced protein 8-like 1
            (Tnfaip8l1), mRNA.
ACCESSION   NM_025566
VERSION     NM_025566.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2365)
  AUTHORS   Ren,X., Song,H., Wang,Y., Wang,Y., Zhang,Q., Yue,X., Wu,Z., Li,C.,
            Gao,L., Ma,C. and Liang,X.
  TITLE     TIPE1 limits virus replication by disrupting PKM2/ HIF-1alpha/
            glycolysis feedback loop
  JOURNAL   Free Radic Biol Med 221, 52-63 (2024)
   PUBMED   38754745
  REMARK    GeneRIF: TIPE1 limits virus replication by disrupting PKM2/
            HIF-1alpha/ glycolysis feedback loop.
REFERENCE   2  (bases 1 to 2365)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2365)
  AUTHORS   Lou,Y., Jiang,S., Song,M., Wang,H., Han,M., Tian,X., Zhao,Y.,
            Gao,J., Song,Y., Ma,S., Zhao,P., Zheng,Q., Niu,Z., Zhang,W.,
            Chang,T., Chen,Y.H. and Wang,H.
  TITLE     Epithelial TIPE1 Protein Guards against Colitis by Inhibiting
            TNF-alpha-Mediated Inflammation
  JOURNAL   J Immunol 211 (5), 874-884 (2023)
   PUBMED   37459052
  REMARK    GeneRIF: Epithelial TIPE1 Protein Guards against Colitis by
            Inhibiting TNF-alpha-Mediated Inflammation.
REFERENCE   4  (bases 1 to 2365)
  AUTHORS   Zhang,X., Li,S., Ren,X., Xiang,P., Zhang,Y., Wang,T., Qin,Q.,
            Sun,F., Liu,J., Gao,L., Ma,C., Yue,X., Yang,X., Han,S. and Liang,X.
  TITLE     TIPE1 promotes liver regeneration by enhancing ROS-FoxO1 axis
            mediated autophagy
  JOURNAL   FEBS J 290 (4), 1117-1133 (2023)
   PUBMED   36111440
  REMARK    GeneRIF: TIPE1 promotes liver regeneration by enhancing ROS-FoxO1
            axis mediated autophagy.
REFERENCE   5  (bases 1 to 2365)
  AUTHORS   Liu,L., Bai,F., Song,H., Xiao,R., Wang,Y., Yang,H., Ren,X., Li,S.,
            Gao,L., Ma,C., Yang,X. and Liang,X.
  TITLE     Upregulation of TIPE1 in tubular epithelial cell aggravates
            diabetic nephropathy by disrupting PHB2 mediated mitophagy
  JOURNAL   Redox Biol 50, 102260 (2022)
   PUBMED   35152003
  REMARK    Erratum:[Redox Biol. 2022 Jun;52:102302. doi:
            10.1016/j.redox.2022.102302.. PMID: 35365434]
REFERENCE   6  (bases 1 to 2365)
  AUTHORS   Wu,H., Xu,X., Zheng,A., Wang,W., Mei,L., Chen,Y., Sun,S., Jiang,L.,
            Wu,Y., Zhou,Y., Zheng,M. and Chen,Q.
  TITLE     TNF-alpha-Induce Protein 8-Like 1 Inhibits Hepatic Steatosis,
            Inflammation, and Fibrosis by Suppressing Polyubiquitination of
            Apoptosis Signal-Regulating Kinase 1
  JOURNAL   Hepatology 74 (3), 1251-1270 (2021)
   PUBMED   33713358
  REMARK    GeneRIF: TNF-alpha-Induce Protein 8-Like 1 Inhibits Hepatic
            Steatosis, Inflammation, and Fibrosis by Suppressing
            Polyubiquitination of Apoptosis Signal-Regulating Kinase 1.
REFERENCE   7  (bases 1 to 2365)
  AUTHORS   Zhang,Z., Liang,X., Gao,L., Ma,H., Liu,X., Pan,Y., Yan,W., Shan,H.,
            Wang,Z., Chen,Y.H. and Ma,C.
  TITLE     TIPE1 induces apoptosis by negatively regulating Rac1 activation in
            hepatocellular carcinoma cells
  JOURNAL   Oncogene 34 (20), 2566-2574 (2015)
   PUBMED   25043299
  REMARK    GeneRIF: TIPE1 induced apoptosis in HCC cells by negatively
            regulating Rac1 pathway
REFERENCE   8  (bases 1 to 2365)
  AUTHORS   Cui,J., Zhang,G., Hao,C., Wang,Y., Lou,Y., Zhang,W., Wang,J. and
            Liu,S.
  TITLE     The expression of TIPE1 in murine tissues and human cell lines
  JOURNAL   Mol Immunol 48 (12-13), 1548-1555 (2011)
   PUBMED   21600655
  REMARK    GeneRIF: TIPE1(TNFAIP8-like 1)protein was detected in a variety of
            tissues such as neurons, brain, hepatocytes, germ cells of female
            and male reproductive organs, muscular tissues and cells of
            epithelial origin it was not expressed in mature T or B lymphocytes
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY733616.1 and AK136962.1.
            
            On Aug 15, 2009 this sequence version replaced NM_025566.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136962.1, BC032199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BY733616.1         1-39
            40-2365             AK136962.1         2-2327
FEATURES             Location/Qualifiers
     source          1..2365
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.19 cM"
     gene            1..2365
                     /gene="Tnfaip8l1"
                     /gene_synonym="2600017J23Rik; TIPE1"
                     /note="tumor necrosis factor, alpha-induced protein 8-like
                     1"
                     /db_xref="GeneID:66443"
                     /db_xref="MGI:MGI:1913693"
     exon            1..116
                     /gene="Tnfaip8l1"
                     /gene_synonym="2600017J23Rik; TIPE1"
                     /inference="alignment:Splign:2.1.0"
     exon            117..2365
                     /gene="Tnfaip8l1"
                     /gene_synonym="2600017J23Rik; TIPE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..682
                     /gene="Tnfaip8l1"
                     /gene_synonym="2600017J23Rik; TIPE1"
                     /note="tumor necrosis factor, alpha-induced protein 8-like
                     protein 1; TNFAIP8-like protein 1; TNF alpha-induced
                     protein 8-like protein 1; oxy-beta; oxidative stress
                     regulated gene-beta"
                     /codon_start=1
                     /product="tumor necrosis factor alpha-induced protein
                     8-like protein 1"
                     /protein_id="NP_079842.2"
                     /db_xref="CCDS:CCDS28897.1"
                     /db_xref="GeneID:66443"
                     /db_xref="MGI:MGI:1913693"
                     /translation="MDTFSTKSLALQAQKKVLSKMASKAMVAVFVDNTSSEVLDELYQ
                     ATKEFTRSRKEAQRVVKNLVKVAVKLAVLLRADQLDSNELAQLQRFRGRVRSLAMTAL
                     SFHQVDFTFDRRVLATGLLECRDLLHQAIGPHLTAKSHGRINHIFSHFANGDFLAALY
                     SPAEPYRSHLCRICDGLGRMLDEGGI"
     regulatory      1400..1405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfaip8l1"
                     /gene_synonym="2600017J23Rik; TIPE1"
                     /note="hexamer: AATAGA"
     polyA_site      1443
                     /gene="Tnfaip8l1"
                     /gene_synonym="2600017J23Rik; TIPE1"
     polyA_site      1447
                     /gene="Tnfaip8l1"
                     /gene_synonym="2600017J23Rik; TIPE1"
                     /note="major polyA site"
     regulatory      1726..1731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfaip8l1"
                     /gene_synonym="2600017J23Rik; TIPE1"
                     /note="hexamer: ATTATA"
     regulatory      1747..1752
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfaip8l1"
                     /gene_synonym="2600017J23Rik; TIPE1"
                     /note="hexamer: AACAAA"
     polyA_site      1752
                     /gene="Tnfaip8l1"
                     /gene_synonym="2600017J23Rik; TIPE1"
     polyA_site      1771
                     /gene="Tnfaip8l1"
                     /gene_synonym="2600017J23Rik; TIPE1"
ORIGIN      
        1 tttctcgggg gcgtggcctc ctagccagcg gccgggctca gatccagcgg ccaatgcctc
       61 tggccccaca gaggcaccta cagaaaactg aaggcttgac acatcccgag gagcagaacc
      121 catggacacc ttcagcacga agagcctggc cctgcaggcc cagaagaaag tcctcagcaa
      181 gatggcttcc aaggccatgg tggctgtgtt tgtggacaat accagcagtg aggtcttgga
      241 tgaactgtac caggccacga aggagttcac gcgcagccgg aaggaggcac agagggtagt
      301 gaagaacctg gtgaaggtgg ctgtgaagct ggctgtgttg ctgagggcgg accagctgga
      361 cagcaatgag ctggcccagc tgcagcggtt ccggggccgc gtccgcagcc tggccatgac
      421 agccctcagc ttccaccagg tagacttcac ctttgaccgg cgtgtgctgg ccactgggct
      481 gctggagtgc agggacctgt tgcaccaggc tattggcccg cacctcactg ccaagtccca
      541 cggccgcatc aatcacatct tcagtcactt tgccaatggt gacttcctgg ccgcgctgta
      601 cagcccagca gagccctacc ggagccatct gtgccgcatc tgtgatggcc tcgggaggat
      661 gttggacgag ggtggcatct gacctggagt cagccacctg gagactatcc tccactggtg
      721 acggtcccca agaactcaga actgcctgtg cctggggtag tctctcctct gtttctcctg
      781 ctgtaactta tctgcttttg tctagcttct gcttcgtctc ctgacctcct cttcttactt
      841 ctgagacagg tctcatgtag cccaggctga ccccaaacac cctatgtagc aaaggctgac
      901 cttgacctcc tgagcctcct gcccccacca ccgagagtgc tggatgatag gtgtgtgcca
      961 acgccccact gtctggacat tctcagtctt tcaaataagg ttgtggagaa ttgggagaca
     1021 agaattgtac tcccctgacc cttacccctg ccaaatgact atgtttgttt cctaagcctc
     1081 aggtcgtccc aaggtgactt gctttagaaa atggagttca aactcttgtt gtaccagact
     1141 agagttgaac aagtactgga ctgctacaac aggtccttat gtatagattg gcccaggaag
     1201 gctcactctg ccaatgctgc aggacactgg acactgagga gtgatgctac tgcaaaccaa
     1261 gaacaccagc agacagatgc tgtgcggcag atcgtggctt ctctcaatgg ttttgaaagg
     1321 agagactcca agcacacttc ggtgttggga tctgaggtcc tgttagggga ctggaccctc
     1381 gcattgaaga gaagaaataa atagagccgg tgagatggct cagcatgtaa gaatgcttgt
     1441 caccaaactt gtctggagtt taccaaaatc tgtgtggtgg atggagtctt agaaagctgg
     1501 cctctgacct ccatgtggat gtgcccacac agaaccacac cgcggcttcc ggtgcttgga
     1561 aacatggcag ggccctgacc actcagcaag gaggcgctaa tcaggcagaa atgtggggtc
     1621 ttcactgagt gatagtacag gacttgctgt gaaacatggg gaccccagag gctgtcccca
     1681 gcttcggacc agggtaaagc cactggagac acgagcatgt gttacattat aattccatat
     1741 ttgggaaaca aatccatctt ttctctttga atggtaccga gttggtaact gacactgacc
     1801 acgcatgtga aagcctgcag cctctactat ctgagtgtgc ctgtggtcat gtgagacacc
     1861 gttaactggc ttaacccaac tggtacttag atcttttatc cttggaaagc agacttcagc
     1921 tacacatgtg tctagctgag gtgtgggtta gttgtctaga atcctccagc gagggttcgg
     1981 ggggcatggt caggggtgga gcccagccta gaatcctcca gtgagggact gggggcgtgg
     2041 ccagtgatag atgtacctag aatccccagg tcagaagctt ggctcagggg tagcatgcat
     2101 gtcatggggt cgacccctga gatctgtgaa gatcgagtct gtggaggggc tggcacagct
     2161 gtggaggggc tggcacagcg gttacgcagt gctgccgatg gaaaggctat ctggggcatt
     2221 gggagaggac acaaaatgtg cagagctgag tgtatttaag gcaatgtgta caacctggag
     2281 cctgtggtga cgggtgggag tcactgcctc aatgtttcag tgtatgcaga cagatgcaag
     2341 tacaaagaag agtctgtcaa tagct
//
