LOCUS       NM_134131               3368 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus tumor necrosis factor, alpha-induced protein 8
            (Tnfaip8), transcript variant 1, mRNA.
ACCESSION   NM_134131
VERSION     NM_134131.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3368)
  AUTHORS   Lou,Y., Jiang,S., Song,M., Wang,H., Han,M., Tian,X., Zhao,Y.,
            Gao,J., Song,Y., Ma,S., Zhao,P., Zheng,Q., Niu,Z., Zhang,W.,
            Chang,T., Chen,Y.H. and Wang,H.
  TITLE     Epithelial TIPE1 Protein Guards against Colitis by Inhibiting
            TNF-alpha-Mediated Inflammation
  JOURNAL   J Immunol 211 (5), 874-884 (2023)
   PUBMED   37459052
REFERENCE   2  (bases 1 to 3368)
  AUTHORS   Lou,Y., Tian,X., Sun,C., Song,M., Han,M., Zhao,Y., Song,Y.,
            Song,X., Zhang,W., Chen,Y.H. and Wang,H.
  TITLE     TNFAIP8 protein functions as a tumor suppressor in
            inflammation-associated colorectal tumorigenesis
  JOURNAL   Cell Death Dis 13 (4), 311 (2022)
   PUBMED   35387985
  REMARK    GeneRIF: TNFAIP8 protein functions as a tumor suppressor in
            inflammation-associated colorectal tumorigenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3368)
  AUTHORS   Li,M., Li,X., Goldsmith,J.R., Shi,S., Zhang,L., Zamani,A., Wan,L.,
            Sun,H., Li,T., Yu,J., Etwebi,Z., Bou-Dargham,M.J. and Chen,Y.H.
  TITLE     Decoupling tumor cell metastasis from growth by cellular pilot
            protein TNFAIP8
  JOURNAL   Oncogene 40 (46), 6456-6468 (2021)
   PUBMED   34608264
  REMARK    GeneRIF: Decoupling tumor cell metastasis from growth by cellular
            pilot protein TNFAIP8.
REFERENCE   4  (bases 1 to 3368)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3368)
  AUTHORS   Hood,R., Chen,Y.H. and Goldsmith,J.R.
  TITLE     TNFAIP8 Regulates Intestinal Epithelial Cell Differentiation and
            May Alter Terminal Differentiation of Secretory Progenitors
  JOURNAL   Cells 10 (4), 871 (2021)
   PUBMED   33921306
  REMARK    GeneRIF: TNFAIP8 Regulates Intestinal Epithelial Cell
            Differentiation and May Alter Terminal Differentiation of Secretory
            Progenitors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3368)
  AUTHORS   Laliberte,B., Wilson,A.M., Nafisi,H., Mao,H., Zhou,Y.Y., Daigle,M.
            and Albert,P.R.
  TITLE     TNFAIP8: a new effector for Galpha(i) coupling to reduce cell death
            and induce cell transformation
  JOURNAL   J Cell Physiol 225 (3), 865-874 (2010)
   PUBMED   20607800
  REMARK    GeneRIF: Data suggest that Galphai-TNFAIP8-mediated rescue of
            pre-oncogenic cells enhances progression to oncogenic
            transformation, providing a selective target to inhibit cellular
            transformation.
REFERENCE   7  (bases 1 to 3368)
  AUTHORS   Woodward,M.J., de Boer,J., Heidorn,S., Hubank,M., Kioussis,D.,
            Williams,O. and Brady,H.J.
  TITLE     Tnfaip8 is an essential gene for the regulation of
            glucocorticoid-mediated apoptosis of thymocytes
  JOURNAL   Cell Death Differ 17 (2), 316-323 (2010)
   PUBMED   19730441
  REMARK    GeneRIF: Tnfaip8 is crucial in regulating glucocorticoid-mediated
            apoptosis of thymocytes
REFERENCE   8  (bases 1 to 3368)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   9  (bases 1 to 3368)
  AUTHORS   Barnhart,B.C., Lee,J.C., Alappat,E.C. and Peter,M.E.
  TITLE     The death effector domain protein family
  JOURNAL   Oncogene 22 (53), 8634-8644 (2003)
   PUBMED   14634625
REFERENCE   10 (bases 1 to 3368)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY108131.1, AK149901.1 and AC120859.12.
            
            On May 1, 2010 this sequence version replaced NM_134131.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus by 14-aa to an upstream AUG which is well supported by
            orthologs in many other species. The uAUG has a weak Kozak signal,
            but there is no indication that it is not used at least some of the
            time.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009090.1, AK149901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               BY108131.1         2-226
            226-1916            AK149901.1         2-1692
            1917-3368           AC120859.12        146432-147883
FEATURES             Location/Qualifiers
     source          1..3368
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 27.18 cM"
     gene            1..3368
                     /gene="Tnfaip8"
                     /gene_synonym="E130304C20Rik; Gg2-1; Gm10539; Nded; Ssc-2;
                     Tipe"
                     /note="tumor necrosis factor, alpha-induced protein 8"
                     /db_xref="GeneID:106869"
                     /db_xref="MGI:MGI:2147191"
     exon            1..338
                     /gene="Tnfaip8"
                     /gene_synonym="E130304C20Rik; Gg2-1; Gm10539; Nded; Ssc-2;
                     Tipe"
                     /inference="alignment:Splign:2.1.0"
     exon            339..3368
                     /gene="Tnfaip8"
                     /gene_synonym="E130304C20Rik; Gg2-1; Gm10539; Nded; Ssc-2;
                     Tipe"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1893..1898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfaip8"
                     /gene_synonym="E130304C20Rik; Gg2-1; Gm10539; Nded; Ssc-2;
                     Tipe"
                     /note="hexamer: AATAAA"
     polyA_site      1918
                     /gene="Tnfaip8"
                     /gene_synonym="E130304C20Rik; Gg2-1; Gm10539; Nded; Ssc-2;
                     Tipe"
                     /note="major polyA site"
     regulatory      3316..3321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfaip8"
                     /gene_synonym="E130304C20Rik; Gg2-1; Gm10539; Nded; Ssc-2;
                     Tipe"
                     /note="hexamer: AATACA"
     polyA_site      3346
                     /gene="Tnfaip8"
                     /gene_synonym="E130304C20Rik; Gg2-1; Gm10539; Nded; Ssc-2;
                     Tipe"
ORIGIN      
        1 attcgttctg tccagggcac ctttcctgca ctgggcccca cctgcctggt cgcctccacc
       61 cgcagtggcc cctcgggggc ggactcctgc agcccagccc cgcgcgattc gattcgtcac
      121 tcctgcggaa ctttcccctg aaaatccctc ccgcagccgc tcgctcgccc gccccgggag
      181 gttctgatct cagaggcttc ctcccaccgc gtcccgcccg ccggcgcaca tctcactcgt
      241 ctaggagcct cgcagcctca cgtccatgtc cgtggcggtg gcgcctgtgg ctgtgcaccc
      301 cgacagcatg ctctccgaag cggaggagcc cagggaagtg gctacagatg tcttcaattc
      361 caaaaacctg gccgttcagg cacaaaagaa gatcctgggc aaaatggtat ccaaatccat
      421 cgccaccacg ctgatcgacg acaccagcag cgaggtgcta gatgagctgt acagggtgac
      481 caaggagtac acccagaaca agaaggaggc ggagagggtc atcaagaacc tcatcaagac
      541 ggtcatcaag ctggccgtcc tccacaggaa caatcagttc aatcaagacg agctggcgct
      601 catggagaag ttcaagaaga aggtgcacca gcttgccatg acggtcgtca gcttccacca
      661 ggtagagtac accttcgacc gcaatgtgct gtccaggctg ctgaacgagt gccgagagct
      721 cctacacgag atcattcagc gccaccttac cgccaagtct cacggacggg ttaataatgt
      781 ctttgaccat ttttcagatt gtgatttttt ggctgccttg tacaatccct ttggaaagtt
      841 taaacctcac ttacagaaac tttgcgacgg catcaacaaa atgttagatg aagagaacat
      901 atgagcttgc gaagtaagat tgtgaccagc agcgagttag gtgaagtcca gcaccgatga
      961 cttgtaaagg gaagacggag actcttttat caatcacatg tatttcagaa aggcttggcc
     1021 cccatatgac ctgttattgt tgttggacat taatagtagt acttctgtgt ggcttgttgt
     1081 atttgaaagg aaaaaaaaaa gtgtattgcc aaaaattctg gctgcaaacg tcttaatgat
     1141 tggcaagatg tgagaaaaac ggatagttgg tcattcagat gtcaagggat acaaagacag
     1201 atgagtgtgg ccccaagcgc tggcacttct tgtgttttag ggaaatcatg ttggtggcac
     1261 gttggatatt tctaatatgt ataaagccgt gtatcttgac tcaccttgat cctttgctac
     1321 gtctgtgtat ctctcttaca atgtcgagag cctctctttg ctgtcattga tccttttgaa
     1381 acaactctgc ttctttggtt acagatcgtc attgaccttc aggagttaaa tttgaggcag
     1441 tcaaaccgaa tgctcaggaa agcaaaaaaa actgtgcatc tgaaatcatg actgtgggag
     1501 tgaacaatct tagacatcat gagcagtgtc cattgcaaga gtgtgttttt gaagctgact
     1561 tctacctttt agtactatca gtgatactta gagtctcaga gctagtggca tgatattgcc
     1621 ttgaaatatc tgcttagggc ataactttga tgtcatcttg aacatgtact gacatgttcc
     1681 cgtattaaca tctatttcac ctgtaggaag aataaatctc tagattggct ttgatattga
     1741 gacaataaaa tgtaagtagc gtttcaaaaa gaaaaacttc ttgaatttaa agatgaattc
     1801 atcagactga tttatgggtg aaaggataga aaggacgttg ctaagtaaca taagaaagat
     1861 gcatgtattt cagtgtgtaa cagggattga tgaataaaag atgccatttt ttatttaacg
     1921 actcgggatt tagattgtgt tatttggttt ttcaacgagt agactgatga ccgtgtctgt
     1981 cttcggtgct tggtgtgcca tttctgtata atttttggtg tgtggataat gaagtagacc
     2041 cttgcttatt gtgtaaaaga gctagaagcc atctgggaag taacagaccc aaccactggc
     2101 cctaaacatt ggaattgcca ccaaacctgt catttaccta cctcaagaac attgactgaa
     2161 aatctaccag caaagatccc acaagtgaaa attctcaaag ttaagatccg ctttgaccca
     2221 tcatagctta gaaggaagtg gtcaggtttc tctgagaccc agctttctca gtaaagataa
     2281 acagcaatgg caaaaattac ctatgcaggt gtgatgtcat attgatttga gctggaaagt
     2341 ataattcttc cctccgggag cctctggatg atcctagagg tgataacact agtgtaatgg
     2401 ctgcattact gaggattgga cttcctaagt gctaaacggc tcagaaacag agctcagcag
     2461 ccttccttaa ccaacatcag ggaagctaag agtgtgctct catgggagcc actggtctga
     2521 ctcactctgc tctaccagtc cttgtgcagc aaaagcacag atactgaagc ttctcaggaa
     2581 tttttagctc aggacgtgac cgacaaaact gaagaccttg ggagaaattg agagacgtcc
     2641 gcacatttga gtcatactga tggacctgta ggtagcaaca ctatgcacat gatgcggaca
     2701 gtggtagcac cccttagttt tgtatgccag agtcctcctt agggttatcg ttgctgtgat
     2761 gaaacaccat gaccaaaaac caagttgaag agggaagggt ctcttcttct tacagttcta
     2821 tataaaagtt catcatcaaa agcagtaagg gtagcaactc aaacagtcca ggaacctaga
     2881 ggcaggagct gatgcacagg ccacagaggg gtgatgctta ctggcttgct ccccacggtt
     2941 tgcccagcct gcttgcttat ggaacctagg accaccagcc cagggagtgg ccccgtccac
     3001 aatggtctga atcactaatt gtgaaatgcc ctacaggcat gcctacagcc cgatcttatg
     3061 gagacatttt ctcaattgag gcgccctaat ctctgatgac tgtagcttgt gtaaactgat
     3121 ataaaactag ccaacatacc caggaaggca taaaaaaaga atatgtggaa agttagttca
     3181 agaacaccct gtagatgtca aactctgctt atcggtagat gtcccttata gaaaatggca
     3241 tattgtattt gtatctagcc tgcctgtata tctttctata tttacaagtc tcaagaattg
     3301 taacttataa cacataatac aatgtaattg ctgatttggg ggaaaagggt gttttgctta
     3361 tggaataa
//
