LOCUS       NM_009398               1601 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus tumor necrosis factor alpha induced protein 6
            (Tnfaip6), mRNA.
ACCESSION   NM_009398
VERSION     NM_009398.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1601)
  AUTHORS   Doni,A., Sironi,M., Del Prete,A., Pasqualini,F., Valentino,S.,
            Cuccovillo,I., Parente,R., Calvi,M., Tosoni,A., Vago,G.,
            Nebuloni,M., Garlanda,C., Vecchi,A., Bottazzi,B. and Mantovani,A.
  TITLE     PTX3 is expressed in terminal lymphatics and shapes their
            organization and function
  JOURNAL   Front Immunol 15, 1426869 (2024)
   PUBMED   39640269
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1601)
  AUTHORS   Srivastava,T., Nguyen,H., Haden,G., Diba,P., Sowa,S., LaNguyen,N.,
            Reed-Dustin,W., Zhu,W., Gong,X., Harris,E.N., Baltan,S. and
            Back,S.A.
  TITLE     TSG-6-Mediated Extracellular Matrix Modifications Regulate
            Hypoxic-Ischemic Brain Injury
  JOURNAL   J Neurosci 44 (21), e2215232024 (2024)
   PUBMED   38569926
  REMARK    GeneRIF: TSG-6-Mediated Extracellular Matrix Modifications Regulate
            Hypoxic-Ischemic Brain Injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1601)
  AUTHORS   Verma,S., Moreno,I.Y., Prinholato da Silva,C., Sun,M., Cheng,X.,
            Gesteira,T.F. and Coulson-Thomas,V.J.
  TITLE     Endogenous TSG-6 modulates corneal inflammation following chemical
            injury
  JOURNAL   Ocul Surf 32, 26-38 (2024)
   PUBMED   38151073
  REMARK    GeneRIF: Endogenous TSG-6 modulates corneal inflammation following
            chemical injury.
REFERENCE   4  (bases 1 to 1601)
  AUTHORS   Albtoush,N., Queisser,K.A., Zawerton,A., Lauer,M.E., Beswick,E.J.
            and Petrey,A.C.
  TITLE     TSG6 hyaluronan matrix remodeling dampens the inflammatory response
            during colitis
  JOURNAL   Matrix Biol 121, 149-166 (2023)
   PUBMED   37391162
  REMARK    GeneRIF: TSG6 hyaluronan matrix remodeling dampens the inflammatory
            response during colitis.
REFERENCE   5  (bases 1 to 1601)
  AUTHORS   Di Santo,C., La Russa,D., Greco,R., Persico,A., Zanaboni,A.M.,
            Bagetta,G. and Amantea,D.
  TITLE     Characterization of the Involvement of Tumour Necrosis Factor
            (TNF)-alpha-Stimulated Gene 6 (TSG-6) in Ischemic Brain Injury
            Caused by Middle Cerebral Artery Occlusion in Mouse
  JOURNAL   Int J Mol Sci 24 (6), 5800 (2023)
   PUBMED   36982872
  REMARK    GeneRIF: Characterization of the Involvement of Tumour Necrosis
            Factor (TNF)-alpha-Stimulated Gene 6 (TSG-6) in Ischemic Brain
            Injury Caused by Middle Cerebral Artery Occlusion in Mouse.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1601)
  AUTHORS   Ochsner,S.A., Day,A.J., Rugg,M.S., Breyer,R.M., Gomer,R.H. and
            Richards,J.S.
  TITLE     Disrupted function of tumor necrosis factor-alpha-stimulated gene 6
            blocks cumulus cell-oocyte complex expansion
  JOURNAL   Endocrinology 144 (10), 4376-4384 (2003)
   PUBMED   12959984
  REMARK    GeneRIF: TSG-6 mRNA is induced in cumulus cells in culture by cAMP
            and that the secreted TSG-6 protein is a key structural component
            of the mouse cumulus cell-oocyte complex matrix.
REFERENCE   7  (bases 1 to 1601)
  AUTHORS   Fulop,C., Szanto,S., Mukhopadhyay,D., Bardos,T., Kamath,R.V.,
            Rugg,M.S., Day,A.J., Salustri,A., Hascall,V.C., Glant,T.T. and
            Mikecz,K.
  TITLE     Impaired cumulus mucification and female sterility in tumor
            necrosis factor-induced protein-6 deficient mice
  JOURNAL   Development 130 (10), 2253-2261 (2003)
   PUBMED   12668637
  REMARK    GeneRIF: results provide clear evidence that TNFIP6 is a key
            catalyst in the formation of the cumulus extracellular matrix and
            indispensable for female fertility
REFERENCE   8  (bases 1 to 1601)
  AUTHORS   Ochsner,S.A., Russell,D.L., Day,A.J., Breyer,R.M. and Richards,J.S.
  TITLE     Decreased expression of tumor necrosis factor-alpha-stimulated gene
            6 in cumulus cells of the cyclooxygenase-2 and EP2 null mice
  JOURNAL   Endocrinology 144 (3), 1008-1019 (2003)
   PUBMED   12586778
  REMARK    GeneRIF: observations identify tumor necrosis
            factor-alpha-stimulated gene 6 as a target of prostaglandin action
            and show that its production in ovulatory follicles is associated
            with proper formation of the cumulus-derived extracellular matrix
REFERENCE   9  (bases 1 to 1601)
  AUTHORS   Lesley,J., English,N.M., Gal,I., Mikecz,K., Day,A.J. and Hyman,R.
  TITLE     Hyaluronan binding properties of a CD44 chimera containing the link
            module of TSG-6
  JOURNAL   J Biol Chem 277 (29), 26600-26608 (2002)
   PUBMED   12011075
  REMARK    GeneRIF: cells expressing CD44/TSG-6 failed to roll on hyaluronan,
            instead, they stuck and remained 'tethered' to the substrate under
            fluid flow
REFERENCE   10 (bases 1 to 1601)
  AUTHORS   Fulop,C., Kamath,R.V., Li,Y., Otto,J.M., Salustri,A., Olsen,B.R.,
            Glant,T.T. and Hascall,V.C.
  TITLE     Coding sequence, exon-intron structure and chromosomal localization
            of murine TNF-stimulated gene 6 that is specifically expressed by
            expanding cumulus cell-oocyte complexes
  JOURNAL   Gene 202 (1-2), 95-102 (1997)
   PUBMED   9427551
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL929138.15.
            
            On Nov 17, 2006 this sequence version replaced NM_009398.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U83903.1, AK139985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AL929138.15        59682-59838
            158-295             AL929138.15        65298-65435
            296-457             AL929138.15        69000-69161
            458-686             AL929138.15        72412-72640
            687-727             AL929138.15        73873-73913
            728-1601            AL929138.15        77377-78250
FEATURES             Location/Qualifiers
     source          1..1601
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 29.98 cM"
     gene            1..1601
                     /gene="Tnfaip6"
                     /gene_synonym="Tnfip6; TSG-6; Tsg6"
                     /note="tumor necrosis factor alpha induced protein 6"
                     /db_xref="GeneID:21930"
                     /db_xref="MGI:MGI:1195266"
     exon            1..157
                     /gene="Tnfaip6"
                     /gene_synonym="Tnfip6; TSG-6; Tsg6"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..891
                     /gene="Tnfaip6"
                     /gene_synonym="Tnfip6; TSG-6; Tsg6"
                     /note="tumor necrosis factor-inducible gene 6 protein;
                     TNF-stimulated gene 6 protein; TNF alpha-induced protein
                     6; tumor necrosis factor induced protein 6"
                     /codon_start=1
                     /product="tumor necrosis factor-inducible gene 6 protein
                     precursor"
                     /protein_id="NP_033424.1"
                     /db_xref="CCDS:CCDS16032.1"
                     /db_xref="GeneID:21930"
                     /db_xref="MGI:MGI:1195266"
                     /translation="MVVLLCLCVLLWEEAHGWGFKNGIFHNSIWLEQAAGVYHREARA
                     GRYKLTYAEAKAVCEFEGGRLATYKQLEAARKIGFHVCAAGWMAKGRVGYPIVKPGPN
                     CGFGKTGIIDYGIRLNRSERWDAYCYNPHAKECGGVFTDPKRIFKSPGFPNEYDDNQV
                     CYWHIRLKYGQRIHLSFLDFDLEHDPGCLADYVEIYDSYDDVHGFVGRYCGDELPEDI
                     ISTGNVMTLKFLSDASVTAGGFQIKYVTVDPASKSSQAKNTSTTGNKKFLPGRFSHL"
     exon            158..295
                     /gene="Tnfaip6"
                     /gene_synonym="Tnfip6; TSG-6; Tsg6"
                     /inference="alignment:Splign:2.1.0"
     exon            296..457
                     /gene="Tnfaip6"
                     /gene_synonym="Tnfip6; TSG-6; Tsg6"
                     /inference="alignment:Splign:2.1.0"
     exon            458..686
                     /gene="Tnfaip6"
                     /gene_synonym="Tnfip6; TSG-6; Tsg6"
                     /inference="alignment:Splign:2.1.0"
     exon            687..727
                     /gene="Tnfaip6"
                     /gene_synonym="Tnfip6; TSG-6; Tsg6"
                     /inference="alignment:Splign:2.1.0"
     exon            728..1601
                     /gene="Tnfaip6"
                     /gene_synonym="Tnfip6; TSG-6; Tsg6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgctgctct gagaatttcg tgtgggcagc cccgacattg taaccggctc tgcaaccgaa
       61 gagatggtcg tcctcctttg cttatgcgtc ttgctgtggg aagaggctca cggatgggga
      121 ttcaagaacg ggatctttca taactccata tggcttgaac aagcagcggg cgtataccac
      181 agagaagctc gggctggcag atacaagctc acctacgccg aagccaaggc cgtatgtgaa
      241 tttgaaggtg gtcgtctcgc aacctacaag cagctagagg cagccagaaa aattggattc
      301 catgtctgtg ctgctggatg gatggccaag ggtagagtcg gataccccat tgtgaaacct
      361 gggcccaact gtggatttgg gaaaacgggt atcatcgatt atggaatccg gctcaacagg
      421 agtgagcgat gggatgccta ttgctacaac ccacatgcaa aggagtgtgg tggtgtcttc
      481 acagatccga agcgaatttt taaatccccg ggcttcccaa atgagtacga tgacaaccag
      541 gtctgctact ggcacattcg gctcaagtac ggtcagcgaa ttcacctgag ctttttggac
      601 tttgaccttg aacatgatcc aggctgcttg gctgactatg tagaaatcta tgacagttat
      661 gatgacgtcc acggctttgt aggaagatac tgtggtgatg aacttccaga agacatcatt
      721 agcacaggaa atgtcatgac cttgaagttt ctgagtgatg catccgtcac ggctggaggc
      781 ttccagatta aatacgtcac agtggatcct gcatctaaat ccagtcaagc caaaaataca
      841 agtactactg gaaataagaa gttcttacct ggaaggttta gccatctata aaaaattttt
      901 tttaaaaatg ttcaaaacat ccagtacaat atttatattt gtttttgttg ttgttgttgg
      961 tttttttttt tttattttgt tttgttttgt ttttttgaga cggggtttct ctgtatagcc
     1021 ttggctgtcc tggaactcac tttgaagacc aggctggcct cgaactcaga aatccacctg
     1081 cctccgccta ccaagtgctg ggattaaagg cgtccaccac caccgcccgg cttcaatatt
     1141 tatatttgta gctcttggac ctcgtttgtt ctcttttgta tttttattat taacatgtat
     1201 ttattatttt tccaaatgtg aaagccatat gtaattatgt ggaaaattga caaataaata
     1261 cagagaactt caaatgagtt ttttttttaa atctcataat tgtactacac agaaataact
     1321 aatgttaaag tttttaaatg tttgtctttc attcattttt ctacttgtag tatatgtaca
     1381 tatgtaactc tatgatttgc gtttgaattt tggcattctg ccttttgtaa cctgatattt
     1441 ttaaccttga cattgtatag ctcaagcact tcccaagatc tctgagtttt ctacaaaatg
     1501 ggactttgta aatatgattg ttccctgctt tatttaagct gaatttatat taggatttaa
     1561 ggttgttttc ataaatattg ctgtaataaa tacttttgga t
//
