LOCUS       NM_009397               4437 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus tumor necrosis factor, alpha-induced protein 3
            (Tnfaip3), transcript variant 1, mRNA.
ACCESSION   NM_009397
VERSION     NM_009397.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4437)
  AUTHORS   Xing,D., Jin,Y., Sun,D., Liu,Y., Cai,B., Gao,C., Cui,Y. and Jin,B.
  TITLE     Protective effect of TNFAIP3 on testosterone production in Leydig
            cells under an aging inflammatory microenvironment
  JOURNAL   Arch Gerontol Geriatr 117, 105274 (2024)
   PUBMED   37995648
  REMARK    GeneRIF: Protective effect of TNFAIP3 on testosterone production in
            Leydig cells under an aging inflammatory microenvironment.
REFERENCE   2  (bases 1 to 4437)
  AUTHORS   Johann,L., Soldati,S., Muller,K., Lampe,J., Marini,F., Klein,M.,
            Schramm,E., Ries,N., Schelmbauer,C., Palagi,I., Karram,K.,
            Assmann,J.C., Khan,M.A., Wenzel,J., Schmidt,M.H., Korbelin,J.,
            Schluter,D., van Loo,G., Bopp,T., Engelhardt,B., Schwaninger,M. and
            Waisman,A.
  TITLE     A20 regulates lymphocyte adhesion in murine neuroinflammation by
            restricting endothelial ICOSL expression in the CNS
  JOURNAL   J Clin Invest 133 (24), e168314 (2023)
   PUBMED   37856217
  REMARK    GeneRIF: A20 regulates lymphocyte adhesion in murine
            neuroinflammation by restricting endothelial ICOSL expression in
            the CNS.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4437)
  AUTHORS   Tang,J., Yu,Z., Xia,J., Jiang,R., Chen,S., Ye,D., Sheng,H. and
            Lin,J.
  TITLE     METTL14-Mediated m6A Modification of TNFAIP3 Involved in
            Inflammation in Patients With Active Rheumatoid Arthritis
  JOURNAL   Arthritis Rheumatol 75 (12), 2116-2129 (2023)
   PUBMED   37327357
  REMARK    GeneRIF: METTL14-Mediated m6A Modification of TNFAIP3 Involved in
            Inflammation in Patients With Active Rheumatoid Arthritis.
REFERENCE   4  (bases 1 to 4437)
  AUTHORS   Van Damme,K.F.A., Hertens,P., Martens,A., Gilis,E., Priem,D.,
            Bruggeman,I., Fossoul,A., Declercq,J., Aegerter,H., Wullaert,A.,
            Hochepied,T., Hoste,E., Vande Walle,L., Lamkanfi,M., Savvides,S.N.,
            Elewaut,D., Lambrecht,B.N. and van Loo,G.
  TITLE     Protein citrullination and NET formation do not contribute to the
            pathology of A20/TNFAIP3 mutant mice
  JOURNAL   Sci Rep 13 (1), 17992 (2023)
   PUBMED   37865713
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4437)
  AUTHORS   Douglass,J.D., Ness,K.M., Valdearcos,M., Wyse-Jackson,A.,
            Dorfman,M.D., Frey,J.M., Fasnacht,R.D., Santiago,O.D., Niraula,A.,
            Banerjee,J., Robblee,M., Koliwad,S.K. and Thaler,J.P.
  TITLE     Obesity-associated microglial inflammatory activation paradoxically
            improves glucose tolerance
  JOURNAL   Cell Metab 35 (9), 1613-1629 (2023)
   PUBMED   37572666
REFERENCE   6  (bases 1 to 4437)
  AUTHORS   Van Huffel,S., Delaei,F., Heyninck,K., De Valck,D. and Beyaert,R.
  TITLE     Identification of a novel A20-binding inhibitor of nuclear
            factor-kappa B activation termed ABIN-2
  JOURNAL   J Biol Chem 276 (32), 30216-30223 (2001)
   PUBMED   11390377
REFERENCE   7  (bases 1 to 4437)
  AUTHORS   Lee,E.G., Boone,D.L., Chai,S., Libby,S.L., Chien,M., Lodolce,J.P.
            and Ma,A.
  TITLE     Failure to regulate TNF-induced NF-kappaB and cell death responses
            in A20-deficient mice
  JOURNAL   Science 289 (5488), 2350-2354 (2000)
   PUBMED   11009421
REFERENCE   8  (bases 1 to 4437)
  AUTHORS   Heyninck,K., De Valck,D., Vanden Berghe,W., Van Criekinge,W.,
            Contreras,R., Fiers,W., Haegeman,G. and Beyaert,R.
  TITLE     The zinc finger protein A20 inhibits TNF-induced
            NF-kappaB-dependent gene expression by interfering with an RIP- or
            TRAF2-mediated transactivation signal and directly binds to a novel
            NF-kappaB-inhibiting protein ABIN
  JOURNAL   J Cell Biol 145 (7), 1471-1482 (1999)
   PUBMED   10385526
REFERENCE   9  (bases 1 to 4437)
  AUTHORS   Schito,M.L., Chobotar,B. and Barta,J.R.
  TITLE     Major histocompatibility complex class I- and II-deficient
            knock-out mice are resistant to primary but susceptible to
            secondary Eimeria papillata infections
  JOURNAL   Parasitol Res 84 (5), 394-398 (1998)
   PUBMED   9610637
REFERENCE   10 (bases 1 to 4437)
  AUTHORS   Tewari,M., Wolf,F.W., Seldin,M.F., O'Shea,K.S., Dixit,V.M. and
            Turka,L.A.
  TITLE     Lymphoid expression and regulation of A20, an inhibitor of
            programmed cell death
  JOURNAL   J Immunol 154 (4), 1699-1706 (1995)
   PUBMED   7836754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC054806.1 and AK151921.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by NM_009397.4.
            
            On Oct 22, 2009 this sequence version replaced NM_009397.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060221.1, AK151921.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BC054806.1         1-39
            40-4416             AK151921.1         1-4377
            4417-4437           BC054806.1         4417-4437
FEATURES             Location/Qualifiers
     source          1..4437
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 8.08 cM"
     gene            1..4437
                     /gene="Tnfaip3"
                     /gene_synonym="A20; Tnfip3"
                     /note="tumor necrosis factor, alpha-induced protein 3"
                     /db_xref="GeneID:21929"
                     /db_xref="MGI:MGI:1196377"
     exon            1..258
                     /gene="Tnfaip3"
                     /gene_synonym="A20; Tnfip3"
                     /inference="alignment:Splign:2.1.0"
     exon            259..568
                     /gene="Tnfaip3"
                     /gene_synonym="A20; Tnfip3"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..2601
                     /gene="Tnfaip3"
                     /gene_synonym="A20; Tnfip3"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative DNA-binding protein A20; TNF alpha-induced
                     protein 3; tumor necrosis factor induced protein 3; zinc
                     finger protein A20"
                     /codon_start=1
                     /product="tumor necrosis factor alpha-induced protein 3
                     isoform 1"
                     /protein_id="NP_033423.3"
                     /db_xref="CCDS:CCDS23715.1"
                     /db_xref="GeneID:21929"
                     /db_xref="MGI:MGI:1196377"
                     /translation="MAEQLLPQALYLSNMRKAVKIRERTPEDIFKPTNGIIYHFKTMH
                     RYTLEMFRTCQFCPQFREIIHKALIDRSVQASLESQKKLNWCREVRKLVALKTNGDGN
                     CLMHAACQYMWGVQDTDLVLRKALCSTLKETDTRNFKFRWQLESLKSQEFVETGLCYD
                     TRNWNDEWDNLVKMASADTPAARSGLQYNSLEEIHIFVLSNILRRPIIVISDKMLRSL
                     ESGSNFAPLKVGGIYLPLHWPAQECYRYPIVLGYDSQHFVPLVTLKDSGPELRAVPLV
                     NRDRGRFEDLKVHFLTDPENEMKEKLLKEYLIVMEIPVQGWDHGTTHLINAAKLDEAN
                     LPKEINLVDDYFELVQHEYKKWQENSDQARRAAHAQNPLEPSTPQLSLMDIKCETPNC
                     PFFMSVNTQPLCHECSERRQKNQSKLPKLNSKLGPEGLPGVGLGSSNWSPEETAGGPH
                     SAPPTAPSLFLFSETTAMKCRSPGCPFTLNVQHNGFCERCHARQINASHTADPGKCQA
                     CLQDVTRTFNGICSTCFKRTTAEPSSSLTSSIPASCHQRSKSDPSQLIQSLTPHSCHR
                     TGNVSPSGCLSQAARTPGDRAGTSKCRKAGCMYFGTPENKGFCTLCFIEYRENKQSVT
                     ASEKAGSPAPRFQNNVPCLGRECGTLGSTMFEGYCQKCFIEAQNQRFHEARRTEEQLR
                     SSQHRDMPRTTQVASRLKCARASCKNILACRSEELCMECQHLSQRVGSVAHRGEPTPE
                     EPPKQRCRAPACDHFGNAKCNGYCNECYQFKQMYG"
     exon            569..759
                     /gene="Tnfaip3"
                     /gene_synonym="A20; Tnfip3"
                     /inference="alignment:Splign:2.1.0"
     exon            760..907
                     /gene="Tnfaip3"
                     /gene_synonym="A20; Tnfip3"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1078
                     /gene="Tnfaip3"
                     /gene_synonym="A20; Tnfip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1259
                     /gene="Tnfaip3"
                     /gene_synonym="A20; Tnfip3"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..2134
                     /gene="Tnfaip3"
                     /gene_synonym="A20; Tnfip3"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2316
                     /gene="Tnfaip3"
                     /gene_synonym="A20; Tnfip3"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..4422
                     /gene="Tnfaip3"
                     /gene_synonym="A20; Tnfip3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttggcaaag catacaactg aaaggcaaaa aagggaactg cccagtctgt agtcttcgga
       61 gccggaggcg gagcggtgag ccaggccgcc gaaagacgtg cacaccccct cagccagcga
      121 gcccgatcgg gtgtccatgg ggctccgcct cggcccgacc cccaccacga cccggaccac
      181 gatcccgggc tgcggcgcgc gccagtgacg gccggccggc cacttgggct ctgcgagggc
      241 tccgcgcggc cccaagaggc cttgtcgagg accatggctg aacaacttct tcctcaggct
      301 ttgtatttga gcaatatgcg gaaagctgtg aagatacgag agagaacccc agaagacatt
      361 ttcaaaccta ccaatgggat catctatcac tttaaaacca tgcaccgata cacgctggag
      421 atgttcagaa catgccagtt ttgcccacag ttccgagaga tcatccacaa agcacttatt
      481 gacagaagtg tccaggcttc cctggaaagc cagaagaagc tcaactggtg tcgtgaagtc
      541 aggaagctcg tggctctgaa aaccaatggt gatggaaact gcctcatgca tgcagcttgt
      601 cagtacatgt ggggtgttca ggatactgac ctggtcctga ggaaggccct ctgcagcacc
      661 cttaaggaga cagacactcg gaactttaaa ttccgctggc agctggaatc tctgaaatct
      721 caggaatttg tggaaacagg actttgctac gacactcgga actggaatga cgaatgggac
      781 aacttggtca aaatggcatc agcagacaca cctgcagccc gaagtggact tcagtacaat
      841 tccctggaag aaatccacat atttgtcctc agcaacatcc tcagaagacc catcattgtc
      901 atttcagaca aaatgctaag aagtttggaa tctggttcca attttgctcc tttgaaagtg
      961 ggtgggattt atctgcctct tcactggcct gcccaggagt gttacagata tcccatcgtc
     1021 ctaggctatg acagccagca ctttgtaccc ctggtgaccc tgaaggacag tggacctgaa
     1081 cttcgcgctg ttccacttgt taacagagac cggggtaggt ttgaagactt aaaagttcac
     1141 ttcttgacag atcctgagaa tgagatgaag gaaaagcttc taaaggagta cttgatagtg
     1201 atggagatcc ctgtgcaagg ctgggaccac ggcacgactc acctgatcaa cgctgcaaaa
     1261 ttggatgaag ctaacttacc caaagaaata aatttggtag acgattactt tgagcttgtt
     1321 cagcacgaat acaagaaatg gcaggagaac agcgatcagg ccaggagagc ggcacatgcg
     1381 cagaacccct tggagccttc cacaccccag ctatcactca tggatataaa atgtgagaca
     1441 cccaactgtc ctttcttcat gtccgtgaac actcagcctt tatgccacga atgctcagag
     1501 aggcgccaaa agaatcagag caagctccca aagctgaact cgaagctagg ccctgaagga
     1561 ctcccaggcg tgggacttgg ctcctcaaac tggagccccg aggaaaccgc tggaggacct
     1621 cattcagccc cacccacagc acccagcctt tttctcttca gtgagaccac tgcaatgaag
     1681 tgcaggagtc ctgggtgccc ttttactttg aatgtgcagc ataatggatt ctgtgagcgt
     1741 tgccacgccc ggcagattaa tgccagccac accgcagacc ctggaaagtg ccaagcctgc
     1801 cttcaggatg tcactcggac ctttaatggc atctgcagta cctgtttcaa aaggactaca
     1861 gcagagccca gctccagcct cacttccagt atccctgcct cctgtcacca acgctccaag
     1921 tctgacccct cacaactcat ccaaagtctc actccacact cttgccaccg gactggaaat
     1981 gtctctcctt ctggctgcct ctcccaggct gcacggactc caggagacag agcagggaca
     2041 agcaagtgca ggaaagctgg ctgcatgtat tttgggactc cagaaaacaa gggcttttgc
     2101 actctatgtt tcatcgaata cagagaaaat aagcagtctg ttactgcctc tgagaaagct
     2161 ggttccccgg cccccaggtt ccagaacaat gtcccgtgcc tgggcaggga gtgcggcaca
     2221 ctcggaagca ccatgtttga agggtactgt cagaagtgtt tcatcgaagc tcagaaccag
     2281 agattccatg aagcaagaag aacggaagaa cagctgagat caagccagca tagagacatg
     2341 cctcgaacta cacaggtagc ctcaaggctg aaatgtgccc gggcctcctg caagaacatt
     2401 ctggcctgtc gcagtgagga actctgtatg gagtgccagc acctaagcca acgagtaggt
     2461 tctgtggccc accggggtga gcccacgcct gaagagcccc ctaaacagcg ctgccgggcc
     2521 cctgcttgtg atcactttgg caatgccaag tgtaatggtt actgcaatga gtgctaccag
     2581 ttcaagcaga tgtatggcta agtgcgaaca cattgacagg tccagcaaga aggagcctca
     2641 aactgccatt cacagtggta ctgtgatcca gacccctgag tgccacagga agggtaggcc
     2701 ctgggacagt ggcttcaagt gtctttgagc aagtaggcaa gataagctct tccttcgtca
     2761 cagccatgac catcaggtta gtaaccgaga ctttgccctg gtgagctgag agtagacctg
     2821 gttaccggca gtgcatgatg tcagggtcag cctgaagcta ttgctgctcg tctaccagga
     2881 ggatgtggag atctttagac acgaaatgcg tgctaggact ggcagcagtt cctgagcctg
     2941 gctgccaggc aacaggaaga aaggcgtatg ggaaagtagg atggagactg gaaccatcct
     3001 actgctgcca gctggaagct tttctcagag agccaaagct gaattctcag agctccaagg
     3061 ccctccacaa gatgctagag gaagctcagg gaaaaacagg acgtaggcgg agcacatctg
     3121 tggtcaatgg gcttccctat ctgccgactt ggctcccaag gttctgcagg aaagcagacc
     3181 tgcacacaga tcccgtggct gctgaaaaga cacatgttca catggagaca aaccaagctg
     3241 ctcgctctcg gctgtatgca ccttctagac agcagaacgt ctggtgggaa gacatgccag
     3301 tgttggccat tgtctcccat tccaaagaga ataactttga actgagggtg tgtatcagag
     3361 tatgtacata tgtaatatac ccttatatta tgtatgaggg atttaaaata ttgaaatggt
     3421 ttcctagtgg tagtaggaag actgaataag aacaacctat tttctggttg ttgtcagctt
     3481 gcccctgtct atacagcttg ttacgtgaat tcaacaagct gtcttcttaa cgggagccct
     3541 cattctggtt tatttattat gaacttccaa gttatttaaa tgaagatttc cttctgcagt
     3601 attttcttga gataacatat ttgctttcca ccatgtcctg ggggcctggt tagtccctgg
     3661 ccatggagtg tggtgggatg gctgtcttct ctctccttgt tacctcccta ggaaagaagg
     3721 ggttgcttta tggataagcc tgtagaatcg gctgcttcct atgactccct ggctgcacaa
     3781 gaagaaattg tctgtcttcc atatatgctt ctaagtatcc tacctctttg aagaaaagat
     3841 agggatggag tgaggtgaca gtgggaaggg acacaactac atggcctttc atgaccctgg
     3901 cttactgtgt aaatgctgtg cccttgggta ctggatagga acactgagaa agcaaagcca
     3961 atagccgtga ggacgaggaa gtttctgcca ctgcttgcag cttttctgtg tgctttggac
     4021 ttgctttagg agggaaatat agctttgtag agataaaggc tgacatctgg ggtctagcct
     4081 agcacctgaa gatacttgtg atgtctaact ctgcatagcc ttttctcttc atatctgcgg
     4141 cctatctttt ccccttacat atgtctttgt ccttctttcc caaagatgtc aaatacaatg
     4201 cagcattttc atcttgttct ttcaaagtta atagtctatt attttatgtc tattgatttt
     4261 cattgttaat gtgaaatggt tatttatact tatagaaagt ttgtgaaatt tgcacagttg
     4321 tctttcaaag gataggatct atcttttttg gacttcagat tgttttaaag aactgtaact
     4381 tcacaaaagt caatattaaa aaataaatta tttaagaaca aaaaaaaaaa aaaaaaa
//
