LOCUS       NM_009396               3590 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus tumor necrosis factor, alpha-induced protein 2
            (Tnfaip2), mRNA.
ACCESSION   NM_009396
VERSION     NM_009396.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3590)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3590)
  AUTHORS   Jiajia,H., Ziyao,Y., Jiaqi,Z., Yanli,C., Xiaotao,Z. and Ming,S.
  TITLE     Screening UFMylation-associated genes in heart tissues of
            Ufm1-transgenic mice
  JOURNAL   BMC Cardiovasc Disord 23 (1), 567 (2023)
   PUBMED   37980507
  REMARK    GeneRIF: Screening UFMylation-associated genes in heart tissues of
            Ufm1-transgenic mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3590)
  AUTHORS   Barutta,F., Bellini,S., Kimura,S., Hase,K., Corbetta,B.,
            Corbelli,A., Fiordaliso,F., Bruno,S., Biancone,L., Barreca,A.,
            Papotti,M.G., Hirsh,E., Martini,M., Gambino,R., Durazzo,M., Ohno,H.
            and Gruden,G.
  TITLE     Protective effect of the tunneling nanotube-TNFAIP2/M-sec system on
            podocyte autophagy in diabetic nephropathy
  JOURNAL   Autophagy 19 (2), 505-524 (2023)
   PUBMED   35659195
REFERENCE   4  (bases 1 to 3590)
  AUTHORS   Jin,G., Liu,Y., Xu,W., Li,Y., Zhang,H., Qiu,S., Gao,C. and Liu,S.
  TITLE     Tnfaip2 promotes atherogenesis by enhancing oxidative stress
            induced inflammation
  JOURNAL   Mol Immunol 151, 41-51 (2022)
   PUBMED   36084515
  REMARK    GeneRIF: Tnfaip2 promotes atherogenesis by enhancing oxidative
            stress induced inflammation.
REFERENCE   5  (bases 1 to 3590)
  AUTHORS   Barutta,F., Kimura,S., Hase,K., Bellini,S., Corbetta,B.,
            Corbelli,A., Fiordaliso,F., Barreca,A., Papotti,M.G.,
            Ghiggeri,G.M., Salvidio,G., Roccatello,D., Audrito,V., Deaglio,S.,
            Gambino,R., Bruno,S., Camussi,G., Martini,M., Hirsch,E.,
            Durazzo,M., Ohno,H. and Gruden,G.
  TITLE     Protective Role of the M-Sec-Tunneling Nanotube System in Podocytes
  JOURNAL   J Am Soc Nephrol 32 (5), 1114-1130 (2021)
   PUBMED   33722931
REFERENCE   6  (bases 1 to 3590)
  AUTHORS   Park,Y.G., Song,C.W., Mori,N., Sugimoto,K., Hong,D.P. and
            Okumoto,M.
  TITLE     Analysis of highly frequent allelic loss region on distal
            chromosome 12 in murine radiation-induced lymphomas
  JOURNAL   Cancer Lett 148 (1), 95-103 (2000)
   PUBMED   10680598
REFERENCE   7  (bases 1 to 3590)
  AUTHORS   Kuan,A.P., Chamberlain,W., Malkiel,S., Lieu,H.D., Factor,S.M.,
            Diamond,B. and Kotzin,B.L.
  TITLE     Genetic control of autoimmune myocarditis mediated by
            myosin-specific antibodies
  JOURNAL   Immunogenetics 49 (2), 79-85 (1999)
   PUBMED   9887344
  REMARK    Erratum:[Immunogenetics 1999 Jun;49(6):595-6]
REFERENCE   8  (bases 1 to 3590)
  AUTHORS   Narducci,M.G., Virgilio,L., Engiles,J.B., Buchberg,A.M.,
            Billips,L., Facchiano,A., Croce,C.M., Russo,G. and Rothstein,J.L.
  TITLE     The murine Tcl1 oncogene: embryonic and lymphoid cell expression
  JOURNAL   Oncogene 15 (8), 919-926 (1997)
   PUBMED   9285687
REFERENCE   9  (bases 1 to 3590)
  AUTHORS   Taketo,M., Yokoyama,S., Rochelle,J., Kimura,Y., Higashida,H.,
            Taketo,M. and Seldin,M.F.
  TITLE     Mouse B2 bradykinin receptor gene maps to distal chromosome 12
  JOURNAL   Genomics 27 (1), 222-223 (1995)
   PUBMED   7665180
REFERENCE   10 (bases 1 to 3590)
  AUTHORS   Wolf,F.W., Sarma,V., Seldin,M., Drake,S., Suchard,S.J., Shao,H.,
            O'Shea,K.S. and Dixit,V.M.
  TITLE     B94, a primary response gene inducible by tumor necrosis
            factor-alpha, is expressed in developing hematopoietic tissues and
            the sperm acrosome
  JOURNAL   J Biol Chem 269 (5), 3633-3640 (1994)
   PUBMED   8106408
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY202445.1, L24118.1 and BP767166.1.
            
            On Jul 24, 2008 this sequence version replaced NM_009396.1.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by available conservation
            data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154405.1, AK170719.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BY202445.1         1-56
            57-3447             L24118.1           1-3391
            3448-3590           BP767166.1         34-176              c
FEATURES             Location/Qualifiers
     source          1..3590
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 60.99 cM"
     gene            1..3590
                     /gene="Tnfaip2"
                     /gene_synonym="B94; Exoc3l3; M-sec; tnfb94; Tnfip2"
                     /note="tumor necrosis factor, alpha-induced protein 2"
                     /db_xref="GeneID:21928"
                     /db_xref="MGI:MGI:104960"
     exon            1..23
                     /gene="Tnfaip2"
                     /gene_synonym="B94; Exoc3l3; M-sec; tnfb94; Tnfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            24..378
                     /gene="Tnfaip2"
                     /gene_synonym="B94; Exoc3l3; M-sec; tnfb94; Tnfip2"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..2114
                     /gene="Tnfaip2"
                     /gene_synonym="B94; Exoc3l3; M-sec; tnfb94; Tnfip2"
                     /note="primary response gene B94 protein; TNF
                     alpha-induced protein 2; tumor necrosis factor induced
                     protein 2"
                     /codon_start=1
                     /product="tumor necrosis factor alpha-induced protein 2"
                     /protein_id="NP_033422.2"
                     /db_xref="CCDS:CCDS26178.2"
                     /db_xref="GeneID:21928"
                     /db_xref="MGI:MGI:104960"
                     /translation="MLKMVTFFQGFPGQQSVPGTLNFAVSPQKPRSTSEAESETSMSE
                     ASSEDLMPSPEAPDGEEESAKKKEKKSKGLANMFSVFTKGKKKKKDQPRLSDLEVQPK
                     PRPELDGPLPTVEELKEALEHGRLEVAWQVLALERQLEAAAAAGGMSNEELVWRQSKV
                     EALYVLLCDQVLGVLRRPLEAAPERLSQALAVVSQEELEDRRASGGPLAAALEATRPR
                     RWLQRWRGVVAEVAAERLDAQPATAPEGRSEAESRFLHMGRTMKEDLEVVVERLKPLF
                     PDEFNVVRTYAESYHYHFASHLCALAQFELCERDTYLLLLWVQNLYPNDILNSPKLAQ
                     ELQGVGLGSLLPPKQIRLLEAMFLSNEVTSVKQLMARALELESQRWTQDVAPQSLDGH
                     CHSELAIDILQIISQGQTKAENITSDVGMQIKQLLLVELAALLRSYQRAFDEFLEKSK
                     LLRNYRVNIMANINNCLFFWTSVEQKWQISHDSLNRLLEPLKDLKAHGFDTLLQSLFL
                     DLKPLFKKFTQTRWANPVETLEEIITTVSSSLPEFSELQDCFREELMETVHLHLVKEY
                     IIRLCKRRLVLKTAEQQQQLARHILANADAIQGFCTENGSTATWLHRALPMIAEIIRL
                     QDSSAIKIEVATYATWYPDFSKGHLNAILAIKGNLPSSEVRSIRNILDINTGVQEPPR
                     PLFSLIKVT"
     exon            379..1009
                     /gene="Tnfaip2"
                     /gene_synonym="B94; Exoc3l3; M-sec; tnfb94; Tnfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1124
                     /gene="Tnfaip2"
                     /gene_synonym="B94; Exoc3l3; M-sec; tnfb94; Tnfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1247
                     /gene="Tnfaip2"
                     /gene_synonym="B94; Exoc3l3; M-sec; tnfb94; Tnfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1348
                     /gene="Tnfaip2"
                     /gene_synonym="B94; Exoc3l3; M-sec; tnfb94; Tnfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1447
                     /gene="Tnfaip2"
                     /gene_synonym="B94; Exoc3l3; M-sec; tnfb94; Tnfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1571
                     /gene="Tnfaip2"
                     /gene_synonym="B94; Exoc3l3; M-sec; tnfb94; Tnfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1694
                     /gene="Tnfaip2"
                     /gene_synonym="B94; Exoc3l3; M-sec; tnfb94; Tnfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1850
                     /gene="Tnfaip2"
                     /gene_synonym="B94; Exoc3l3; M-sec; tnfb94; Tnfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1972
                     /gene="Tnfaip2"
                     /gene_synonym="B94; Exoc3l3; M-sec; tnfb94; Tnfip2"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..3570
                     /gene="Tnfaip2"
                     /gene_synonym="B94; Exoc3l3; M-sec; tnfb94; Tnfip2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3548..3553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfaip2"
                     /gene_synonym="B94; Exoc3l3; M-sec; tnfb94; Tnfip2"
                     /note="hexamer: TATAAA"
     polyA_site      3570
                     /gene="Tnfaip2"
                     /gene_synonym="B94; Exoc3l3; M-sec; tnfb94; Tnfip2"
                     /note="major polyA site"
ORIGIN      
        1 taaggcgtcc tgtcctggac acagcctgag ccagggtgat gctgaagatg gtgactttct
       61 tccaagggtt tcctggccag cagtctgtgc cagggaccct gaacttcgct gtaagccccc
      121 aaaagccacg ctctacatcc gaggctgaat cagagacctc catgtctgag gcgtcctctg
      181 aggacctgat gccatccccg gaggctcccg atggggagga ggagtctgcg aagaagaagg
      241 agaagaagtc caaaggactg gccaacatgt tcagtgtctt caccaaaggg aaaaagaaaa
      301 aaaaggacca gcccagatta tcagatctgg aagtgcagcc caagcccagg cccgagttag
      361 atggtccact gcccacagtg gaggagctca aggaggccct ggagcacggg cggctggagg
      421 tggcctggca ggtgctggcg ttggagaggc agctcgaggc tgcggcagcg gcgggtggca
      481 tgagcaacga ggagctggtg tggcggcaga gcaaggtgga ggctctgtac gtgctgcttt
      541 gcgaccaggt gctcggggta ctgcggcggc cgctggaggc ggcgcccgag cggctgagcc
      601 aggcgctagc cgtggtgtcg caggaggagc tcgaggaccg gcgggcgtcc gggggaccct
      661 tggcggcggc actggaggcc acgcgcccgc ggcgatggct gcagcggtgg aggggcgtcg
      721 tggcggaggt ggcagcggaa cgtctggacg cgcagccggc cacagcgccc gagggccgct
      781 cggaggcgga gagcaggttc ctgcacatgg gtcgcaccat gaaggaggac ctggaggtgg
      841 tggtggagag gctgaagccg ctgttccccg acgagttcaa cgtcgtgcgc acctacgccg
      901 aaagctacca ctaccacttc gccagccacc tgtgcgcctt ggcgcagttc gagttgtgtg
      961 aaagggatac ctacttgctg ctgctctggg tgcagaacct ctaccccaat gatattctca
     1021 acagcccgaa gttggcacag gagcttcaag gtgtcgggct tgggagcctc ctgcccccaa
     1081 agcagatcag attgctggag gccatgttct tgtccaatga ggtgaccagc gtgaagcagc
     1141 tcatggcccg agctttagag ctggagtctc agcgctggac ccaggatgtg gctccccaga
     1201 gcctggatgg ccactgtcac agtgagctgg ccatcgacat tctccagatc atttcacaag
     1261 gccagactaa ggctgagaac atcacttcgg acgtggggat gcagataaag cagttgctgc
     1321 tggtggagct ggctgcacta ctgaggagct accagcgcgc ctttgatgag tttctagaga
     1381 agagcaaact cctgaggaat tacagagtca acatcatggc caacatcaac aactgcctgt
     1441 tcttctggac ttccgtggag cagaaatggc agatatctca tgattctctg aaccgcctgc
     1501 tggagccttt gaaagacctc aaggcccatg gcttcgacac cctgctccag agcctatttt
     1561 tggacctgaa gccgctgttt aagaagttca cacagacccg ttgggcaaat ccagttgaga
     1621 ccctggagga aatcatcact actgtgagca gcagcctgcc tgaattctca gagctgcagg
     1681 actgtttccg ggaggagctc atggagactg tgcacctgca cctagtgaaa gaatacatca
     1741 tcaggctctg caaacggcgc ctggtcctca agacggccga gcagcagcag cagctggcaa
     1801 ggcacatcct ggccaacgcg gatgccattc aggggttctg cactgagaat ggctccactg
     1861 caacctggct gcaccgcgcc ctccctatga ttgctgagat cattcgcctg caagattcca
     1921 gtgccattaa gatcgaggtg gccacatacg ccacttggta ccctgacttc agcaaaggcc
     1981 acctgaacgc catcctggcc atcaagggca atctaccaag cagtgaagtc aggagcatcc
     2041 ggaacatact ggacatcaac acgggagtgc aggagcctcc caggcccctg ttctccctta
     2101 taaaggttac ttagcttttc tgaaggtctg atatgctaat gaggcccagg gaacaccagg
     2161 caccacacca gttggggatg ctcagtggct ccagctccat gacccatcat caggctccca
     2221 cattctgctg ttgcttctgc ccagccctgg ctctggaaca agatctgaca gccaagatcg
     2281 cacagatgat ggatccagtg gggtccagac ctcactgaag ggagctgaca tctgagcatg
     2341 caagagattt cttgtaaatg attattcatc ttgggtagag tgacctttgt ctacctacac
     2401 tgtagtctgc cttttaacgg tctgagttgc cctgtccagc tccctaggat caggggtgaa
     2461 gcctcattta taccatttcc ttcagcccag ggatgtcatg agatagaact aaaaacaagg
     2521 gaagaaagaa gaactagtat ctgacccggg gcctggaagc aggcctgtga agtgcccatg
     2581 acagagctag accctgcaaa gtgtcccctg gtaccactca gctagcagga ccctcttatt
     2641 cactccccat gggctgccct gcccctctgt gtgtgtatgg atgtgtttgg gaagtgaccc
     2701 tggaagcctt cgcagagcag ggacctcccg ggttctctca gatcaaatct tcttgcattt
     2761 aggaataagc cagaggccac cgtctggagt ctggtgggag tgcaggggtc tggcaagtgc
     2821 tttactggct tcctgttggt gctgtgccaa acttccacgg caagtgggct tgaactacca
     2881 cttttccttc agttctgcaa atcacaagtc tattatcaga ctgaagtcta aatgtggtca
     2941 gggcccactg cctctggaag ccccagggag aattgtttcc tggtcttccc cagtctttag
     3001 aggttacccc catcttttgt ctgaggacct tgtaccttca gagccaggga cagctacata
     3061 tgctcctcac accaccacag tctccactgg ttcggatccc actgtgactt aggatccccg
     3121 tgactgcagt gaatctgccc agagactcag cagccacccc attaactaac tcctgtcacc
     3181 caatagtcat tggctctggg gaccagtggg tcccacgggg gctacactgg aaaacagcaa
     3241 ggcagtttgc catcaaggca cctgctactc cacagatcct gctcctctct agccatgaga
     3301 gctcttctcg gcactggccc agccttgact tgtcatgatt cgaggctggg atttgaagct
     3361 tctcctctgt cccctccccc aggtacttgc tggagctggc cagggtgagc agcacacaca
     3421 gcctttgtat tcttgtagac gaccgcttgt tgatgacatt aatattgtta atattatttt
     3481 tatagtgttg gttttgtatg tgtgtactca ggacagaatc cagagatttc ttttttatat
     3541 agcttgatat aaaacagatt tcaaaagtga aaaaaaaaaa aaaaaaaaaa
//
