LOCUS       NM_001159392            3696 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus tumor necrosis factor, alpha-induced protein 1
            (endothelial) (Tnfaip1), transcript variant 2, mRNA.
ACCESSION   NM_001159392
VERSION     NM_001159392.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3696)
  AUTHORS   Xu,C., Meng,J., Yu,X.H., Wang,R.J., Li,M.L., Yin,S.H. and Wang,G.
  TITLE     TNFAIP1 promotes macrophage lipid accumulation and accelerates the
            development of atherosclerosis through the LEENE/FoxO1/ABCA1
            pathway
  JOURNAL   J Physiol Biochem 80 (3), 523-539 (2024)
   PUBMED   38878215
  REMARK    GeneRIF: TNFAIP1 promotes macrophage lipid accumulation and
            accelerates the development of atherosclerosis through the
            LEENE/FoxO1/ABCA1 pathway.
REFERENCE   2  (bases 1 to 3696)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3696)
  AUTHORS   Qiu,F., He,S., Zhang,Z., Dai,S., Wang,J., Liu,N., Li,Z., Hu,X.,
            Xiang,S. and Wei,C.
  TITLE     MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by
            negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated
            degradation of CK2beta
  JOURNAL   Food Chem Toxicol 178, 113888 (2023)
   PUBMED   37302538
  REMARK    GeneRIF: MiR-93 alleviates DEHP plasticizer-induced neurotoxicity
            by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated
            degradation of CK2beta.
REFERENCE   4  (bases 1 to 3696)
  AUTHORS   Chen,J., Zhao,M., Fang,W. and Du,C.
  TITLE     Knocking down TNFAIP1 alleviates inflammation and oxidative stress
            in pediatric pneumonia through PI3K/Akt/Nrf2 pathway
  JOURNAL   Allergol Immunopathol (Madr) 51 (4), 94-100 (2023)
   PUBMED   37422785
  REMARK    GeneRIF: Knocking down TNFAIP1 alleviates inflammation and
            oxidative stress in pediatric pneumonia through PI3K/Akt/Nrf2
            pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3696)
  AUTHORS   Matsuki,T., Iio,A., Ueda,M., Tsuneura,Y., Howell,B.W. and
            Nakayama,A.
  TITLE     STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases
            during Cortical Development
  JOURNAL   J Neurosci 41 (43), 8887-8903 (2021)
   PUBMED   34518307
REFERENCE   6  (bases 1 to 3696)
  AUTHORS   Segre,J.A., Nemhauser,J.L., Taylor,B.A., Nadeau,J.H. and
            Lander,E.S.
  TITLE     Positional cloning of the nude locus: genetic, physical, and
            transcription maps of the region and mutations in the mouse and rat
  JOURNAL   Genomics 28 (3), 549-559 (1995)
   PUBMED   7490093
REFERENCE   7  (bases 1 to 3696)
  AUTHORS   Kalcheva,I., Plass,C., Sait,S., Eddy,R., Shows,T., Watkins-Chow,D.,
            Camper,S., Shibata,H., Ueda,T., Takagi,N. et al.
  TITLE     Comparative mapping of the imprinted U2afbpL gene on mouse
            chromosome 11 and human chromosome 5
  JOURNAL   Cytogenet Cell Genet 68 (1-2), 19-24 (1995)
   PUBMED   7956352
REFERENCE   8  (bases 1 to 3696)
  AUTHORS   Wolf,F.W., Marks,R.M., Sarma,V., Byers,M.G., Katz,R.W., Shows,T.B.
            and Dixit,V.M.
  TITLE     Characterization of a novel tumor necrosis factor-alpha-induced
            endothelial primary response gene
  JOURNAL   J Biol Chem 267 (2), 1317-1326 (1992)
   PUBMED   1370465
REFERENCE   9  (bases 1 to 3696)
  AUTHORS   Karolyi,I.J., Guenet,J.L., Rey-Campos,J. and Camper,S.A.
  TITLE     The gene coding for variant hepatic nuclear factor 1 (Tcf-2), maps
            between the Edp-1 and Erba genes on mouse chromosome 11
  JOURNAL   Mamm Genome 3 (3), 184-185 (1992)
   PUBMED   1352161
REFERENCE   10 (bases 1 to 3696)
  AUTHORS   Buckwalter,M.S., Katz,R.W. and Camper,S.A.
  TITLE     Localization of the panhypopituitary dwarf mutation (df) on mouse
            chromosome 11 in an intersubspecific backcross
  JOURNAL   Genomics 10 (3), 515-526 (1991)
   PUBMED   1889803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY060883.1, AK147809.1, AK168805.1, CB205355.1 and AK034305.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168805.1, AK147809.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                BY060883.1         73-165
            94-1022             AK147809.1         2-930
            1023-2237           AK168805.1         932-2146
            2238-2795           CB205355.1         210-767
            2796-3696           AK034305.1         2744-3644
FEATURES             Location/Qualifiers
     source          1..3696
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.74 cM"
     gene            1..3696
                     /gene="Tnfaip1"
                     /gene_synonym="Bacurd2; Edp-1; Edp1; Tnfip1"
                     /note="tumor necrosis factor, alpha-induced protein 1
                     (endothelial)"
                     /db_xref="GeneID:21927"
                     /db_xref="MGI:MGI:104961"
     exon            1..175
                     /gene="Tnfaip1"
                     /gene_synonym="Bacurd2; Edp-1; Edp1; Tnfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            176..495
                     /gene="Tnfaip1"
                     /gene_synonym="Bacurd2; Edp-1; Edp1; Tnfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..665
                     /gene="Tnfaip1"
                     /gene_synonym="Bacurd2; Edp-1; Edp1; Tnfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            666..755
                     /gene="Tnfaip1"
                     /gene_synonym="Bacurd2; Edp-1; Edp1; Tnfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..808
                     /gene="Tnfaip1"
                     /gene_synonym="Bacurd2; Edp-1; Edp1; Tnfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1004
                     /gene="Tnfaip1"
                     /gene_synonym="Bacurd2; Edp-1; Edp1; Tnfip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..3696
                     /gene="Tnfaip1"
                     /gene_synonym="Bacurd2; Edp-1; Edp1; Tnfip1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3618..3623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tnfaip1"
                     /gene_synonym="Bacurd2; Edp-1; Edp1; Tnfip1"
                     /note="hexamer: AATAAA"
     polyA_site      3641
                     /gene="Tnfaip1"
                     /gene_synonym="Bacurd2; Edp-1; Edp1; Tnfip1"
                     /note="major polyA site"
ORIGIN      
        1 tgtgcatgcc gggtcttgta gtctctttcc cgatctgtag ggttgggctg taactccgga
       61 gtcggcgggc gcaggatgtg agctcacagc cgagattgca ggcagccgca ggccagaggt
      121 ggcaccgagt ccgcttgcta cttgactgag actcggagag gcgtccccgc ggacggcact
      181 gagagtatga ggccctggcc tctgagggcc actcactcgt gatcacttcc accacggcag
      241 aaccttctaa gcctacctcc tgccgtgtgg tgatctacct gcagcgggag atgtcagggg
      301 acacctgtct gtgtccagcc tcgggggcca agcccaagat cagtggcttc aagggaggcg
      361 ggctgggcaa caagtacgtg cagctcaatg tgggaggctc cctgtactac accacagtgc
      421 gggccctcac ccggcacgac accatgctca aggccatgtt cagtgggcga atggaggtgc
      481 tgactgacaa agaaggctgg attctcatag accgatgtgg aaagcacttt ggcaccatct
      541 tgaattacct ccgagatgac accatcaccc tccctcaaag ccggcaagaa atccaggagt
      601 tgatggctga agcaaaatat tacctcattc aagggctggt gagcacgtgc cagactgccc
      661 tgcaggacaa gaaagactcc taccagcctg tgtgcaacat ccccatcatc acgtccctga
      721 gggaggagga caggctcatt gaatcctcca caaagcctgt ggtgaagctg ctgtacaaca
      781 ggagcaacaa caagtactca tacaccagca actctgatga tcacctgcta aagaacattg
      841 aactgtttga caagctgtcc ctgcgcttca acggccgcgt gctcttcatc aaggatgtca
      901 ttggggacga gatctgctgc tggtctttct atggccaggg ccgtaagctg gcagaggtgt
      961 gctgcacctc gattgtgtac gccacagaga agaagcagac caaggtggaa ttcccagagg
     1021 cccgtatcta tgaggaaaca ctcaatgtcc tactctatga gacccctcga gtccctgaca
     1081 attccttact ggaggccaca agccggagcc gcagccaggc ttcccccagt gaagatgaag
     1141 acacctttga actacgggac cgtgtccgtc gcattcatgt caagcgctat agcacttacg
     1201 atgaccggca acttggccat cagtccactc atcgtgactg atgagaccct taagaaatcg
     1261 gggcacaaga agtcctgtct gccaccctgt ggaacgtacc cattggccac cctatgctgc
     1321 tcctgctagc tgggagcctg ctctagtatg tacaggtgac agccctgctt gggaggttgg
     1381 ggagctgaga gagggaaggc cacattgtct tggctggccc ccctcccccc agcacttcca
     1441 gatgccaccc cacttcctgc caataaggag ctacttctgc tctagggtga gtgcactgat
     1501 ttcccacctc ctgccaagaa taccccctgg cccttggctg agtgcccctt tcttctgaag
     1561 agctccttta gctcctcagc tgaggcccac gagaacagct ttgttctagg ggaaaggagg
     1621 cttctggtgc tgcgaggacc caattttgaa cagaaaaagt ggcctttttt tttcctaagg
     1681 tgtttaaaca ttggtataac ctggattttt gtttgttttt aaatctagat gttagcatgg
     1741 ccgtacctat aatcccagct atggagaagc cgaggtggga taacatgttc taggctagcc
     1801 tggacaacat agcaaggccc tcaatataaa attttaaaaa gggggctcac ctagcaagag
     1861 tgaggccctg ggctcaatct ccagtactgc cacactcact aggtatctac gaaatgacta
     1921 gtttttagtc tggggggaaa gctaggacta agcagagtgc caggacccca cctagtaggc
     1981 acacactcac acactcactc cacccttttc agtatcctag gacccatctt taaagcactt
     2041 tgtatgtcta tcattcaggg gaatctattc tgccttgacc caaagctttt tctgacactg
     2101 atcccctcct gcacaatctt aaggaaaggc tgagacagga ggatcacaag tttgagacca
     2161 gcctgtgcta tgtagttaaa agttccaggc cagcctgggc tacataggct ttgtttcaaa
     2221 aaaaaaaaaa aaaaaaaaag tagactgacc agctttggct tgtcagcctg actacccaaa
     2281 gaataccaag agggaaagga cgtccaagtt gaaaatggtt ttaatagcat cctgtgggga
     2341 aagggtaggg tcacatcact gactcagact taacaggatt ctttggtgtg agcctcatac
     2401 ttgggtatgt tcagctctaa gacacagatg tgctgcagcc cctgatacta tgtctcagtt
     2461 tatgtcctgg ttctgcctag tgatgcatct ccaaatacat agtaactagg accacctaag
     2521 cctttgaaag acctttcttc tgggtcactg accacggatg taccaagatc tagacctggt
     2581 gtcaattctt cctttgcgct ttggtttccc tccctttctt tgttgggact ggctctctta
     2641 cctggattct atccagagga atgttgtcac tggagggggc tgtttgtaag cctaaggaag
     2701 tgtgtaccca tcaacagtgc ccaagaaggg ccacagatta tcagctgtat cccttgacta
     2761 ctcttatgat tgccacatgg gcacacaaag gctcacctct tagagcctat gggcagatgc
     2821 caagcccagg gttgggctct cacaaggatc tagcctgaca gggcaagggg aaatgggaaa
     2881 tgtgacttaa taatcaggca tgttatgtta atcacgatct tgaatgtata aatagctcta
     2941 agatgcttgg gtcaggcacc ttagtgacga gcaactatta gttcgtccag atctcgctgg
     3001 aactaagatg acaatccaac ttttttggcc aaatagaggc tttggctttc agtctttccc
     3061 acagactttg gaatgtgaca gcatgaggcc accaatctgt tttctcagct gtcccctaga
     3121 agcctttaac actcagattc tcagacccct gcggtgtttc cagtttgtct ctttaccgcc
     3181 acaccccctt tagcctccat gaggcgcttt gacatccatc tcctctgctg ttcagtgctg
     3241 tctagtcatg ggctgaggaa acatagcagg agtcccgggt tgggcattca tcttctttga
     3301 ctgaaaattt ctccttggtt taaggaaata atactgaagt gatctggact cgtgagattt
     3361 accagccctg tcctaaagga gttgtagcag gatgggtttt ttgatcacag gcagtccagg
     3421 ggacttaaac ataaaacatg catgagggtc agactggacg ctgctcacaa acaccagctg
     3481 tgtgctgttg aacctgggac atgtgactgg ttggcctgaa gggtaacaca ggttctggca
     3541 ggaaagaatg tgccctttac tacatacctg cggtctcagt tgcttacctt aagtgatgga
     3601 agtaaacact aacttctaat aaagttgttt tacactgctg agccatgttt ccagtgagca
     3661 gagcctggcc agctcacagc tgtgggctca gttctt
//
