LOCUS       NM_198295               4553 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus thioredoxin-related transmembrane protein 3 (Tmx3),
            mRNA.
ACCESSION   NM_198295 XM_129058
VERSION     NM_198295.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4553)
  AUTHORS   Siguero-Alvarez,M., Salguero-Jimenez,A., Grego-Bessa,J., de la
            Barrera,J., MacGrogan,D., Prados,B., Sanchez-Saez,F.,
            Pineiro-Sabaris,R., Felipe-Medina,N., Torroja,C., Gomez,M.J.,
            Sabater-Molina,M., Escriba,R., Richaud-Patin,I.,
            Iglesias-Garcia,O., Sbroggio,M., Callejas,S., O'Regan,D.P.,
            McGurk,K.A., Dopazo,A., Giovinazzo,G., Ibanez,B., Monserrat,L.,
            Perez-Pomares,J.M., Sanchez-Cabo,F., Pendas,A.M., Raya,A.,
            Gimeno-Blanes,J.R. and de la Pompa,J.L.
  TITLE     A Human Hereditary Cardiomyopathy Shares a Genetic Substrate With
            Bicuspid Aortic Valve
  JOURNAL   Circulation 147 (1), 47-65 (2023)
   PUBMED   36325906
  REMARK    Erratum:[Circulation. 2023 Jan 17;147(3):e63. doi:
            10.1161/CIR.0000000000001129. PMID: 36649398]
REFERENCE   2  (bases 1 to 4553)
  AUTHORS   Tanahashi,H. and Suzuki,T.
  TITLE     Deletion of Lrp4 increases the incidence of microphthalmia
  JOURNAL   Biochem Biophys Res Commun 506 (3), 478-484 (2018)
   PUBMED   30352686
REFERENCE   3  (bases 1 to 4553)
  AUTHORS   Chao,R., Nevin,L., Agarwal,P., Riemer,J., Bai,X., Delaney,A.,
            Akana,M., JimenezLopez,N., Bardakjian,T., Schneider,A.,
            Chassaing,N., Schorderet,D.F., FitzPatrick,D., Kwok,P.Y.,
            Ellgaard,L., Gould,D.B., Zhang,Y., Malicki,J., Baier,H. and
            Slavotinek,A.
  TITLE     A male with unilateral microphthalmia reveals a role for TMX3 in
            eye development
  JOURNAL   PLoS One 5 (5), e10565 (2010)
   PUBMED   20485507
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4553)
  AUTHORS   Holbrook,L.M., Watkins,N.A., Simmonds,A.D., Jones,C.I.,
            Ouwehand,W.H. and Gibbins,J.M.
  TITLE     Platelets release novel thiol isomerase enzymes which are recruited
            to the cell surface following activation
  JOURNAL   Br J Haematol 148 (4), 627-637 (2010)
   PUBMED   19995400
REFERENCE   5  (bases 1 to 4553)
  AUTHORS   Chatterjee,B., Richards,K., Bucan,M. and Lo,C.
  TITLE     Nt mutation causing laterality defects associated with deletion of
            rotatin
  JOURNAL   Mamm Genome 18 (5), 310-315 (2007)
   PUBMED   17551791
REFERENCE   6  (bases 1 to 4553)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 4553)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163277.4.
            
            On Jan 27, 2022 this sequence version replaced NM_198295.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129451.1, AK042787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AC163277.4         121046-121211
            167-221             AC163277.4         122113-122167
            222-261             AC163277.4         125039-125078
            262-385             AC163277.4         128228-128351
            386-431             AC163277.4         129939-129984
            432-512             AC163277.4         131791-131871
            513-612             AC163277.4         134364-134463
            613-690             AC163277.4         135115-135192
            691-757             AC163277.4         138710-138776
            758-856             AC163277.4         140894-140992
            857-914             AC163277.4         143817-143874
            915-968             AC163277.4         144055-144108
            969-1025            AC163277.4         145216-145272
            1026-1155           AC163277.4         147909-148038
            1156-1224           AC163277.4         149333-149401
            1225-4553           AC163277.4         150773-154101
FEATURES             Location/Qualifiers
     source          1..4553
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 59.37 cM"
     gene            1..4553
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /note="thioredoxin-related transmembrane protein 3"
                     /db_xref="GeneID:67988"
                     /db_xref="MGI:MGI:2442418"
     exon            1..166
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /inference="alignment:Splign:2.1.0"
     exon            167..221
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /inference="alignment:Splign:2.1.0"
     exon            222..261
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /inference="alignment:Splign:2.1.0"
     exon            262..385
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /inference="alignment:Splign:2.1.0"
     exon            386..431
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /inference="alignment:Splign:2.1.0"
     exon            432..512
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /inference="alignment:Splign:2.1.0"
     exon            513..612
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /inference="alignment:Splign:2.1.0"
     exon            613..690
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /inference="alignment:Splign:2.1.0"
     exon            691..757
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /inference="alignment:Splign:2.1.0"
     exon            758..856
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /inference="alignment:Splign:2.1.0"
     exon            857..914
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /inference="alignment:Splign:2.1.0"
     exon            915..968
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1025
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1155
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1224
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..4553
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3473..3478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /note="hexamer: ATTAAA"
     polyA_site      3491
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /note="major polyA site"
     regulatory      4524..4529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /note="hexamer: AATAAA"
     regulatory      4533..4538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /note="hexamer: ATTAAA"
     polyA_site      4542
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
                     /note="major polyA site"
     polyA_site      4553
                     /gene="Tmx3"
                     /gene_synonym="6430411B10Rik; A730024F05Rik; mKIAA1830;
                     Txndc10"
ORIGIN      
        1 gttcctggtg ggcgctgcgt cccaggtctt cctcactttc ctttcggggg aggcgggagc
       61 ctgcattatt tgtctctgct cgcgctcatc gcgggattca caccgcgctc catggcgaat
      121 gcagtggggc ggaggagctg ggcagccctc cggctctgcg ctgcggttat tttacttgat
      181 ctggctgttt gtaaaggatt tgtagaagat ctaaatgaat catttaaaga taatcgaaaa
      241 gatgacattt ggcttgttga tttctatgca ccctggtgtg gccattgtaa aaagttggaa
      301 ccaatttgga atgaagttgg gcttgaaatg aaaagtattg gttctccagt taaagttgga
      361 aagatggatg ctacttcata ttctagcatt gcttcagagt ttggagttcg aggttatcca
      421 acaattaagc tattaaaggg agacttggca tataattacc gaggaccacg gactaaagat
      481 gatataattg agtttgctca cagagtgtct ggggctctaa ttcggcctct tccaagtcaa
      541 caaatgttcg accatgtacg gaagaggcac cgtgtatttt ttgtttatat tggtggagaa
      601 tcacccttga aagagaaata catagatgct gcttcagagt taattgtata tacatacttt
      661 ttttctgcct cagaagatgt ggttcctgag tacgtgacgc tgaaagagat gcctgctgtg
      721 cttgttttca aagatgacac ttattttgtt tatgatgagt atgaagatgg cgatctgtcc
      781 tcatggatca gcagagagag gtttcagaac taccttacta tggatggttt tctcctgtat
      841 gaacttggag acacaggaaa gcttgtggcc atagcagtta ttgatgagaa aaacacatca
      901 cttgagcata ccagattaaa gtcaattatt caggaagttg ctagagattt cagagaccac
      961 ttccatagag attttcagtt tggccatatg gatggaaatg actatataaa cactttgttg
     1021 atggacgaat taacagtccc aacaatagtt gtactgaata cttcaaacca acagtacttt
     1081 ttgctagata gacatattaa ggatgcgagc gacatggtcc agttcattaa tagcattttg
     1141 gatggtacag taccagccca aggaggtgat agcatttttc agagattgaa aagaatagta
     1201 tttgatgcca aatctacaat tgtgtctata ttcaagagct ctccacttat gggctgcttt
     1261 cttttcgggc tgccactggg tgtcatcagt atcatgtgct atggaatcta tacagctgac
     1321 acagatggag gctatataga agaacgatat gaagtatcta aaagtgaaat ggaaaaccag
     1381 gaacagatag aagagagcaa agagcaagag tccagcagtg gagggtctct agcacctact
     1441 gtgcaagagc ccaaagatgt attagaaaag aagaaagatt gagacttcac agataaaaaa
     1501 tatttgatag aatgtcaagt tattaaagag tatttattga atttagagat ttaatcatga
     1561 tctatttaca gaagagaaca tattctttgt attttgctaa taacaactgc atgaattaaa
     1621 ataattcttc cataagtagg aagatgtttg gaacaaagtg atgaacagtt tgtccaaaac
     1681 aaagccagat cattgtatca attactttac agatgcccat tatatacaca cttctctgtg
     1741 tgcatgttct atgacaaagt taagaagctt ggacagaata ttaaattgac cattaatgtg
     1801 gaagatgggt tttttgcaaa gagaaatagt actttcacct actatatcaa ttctcctata
     1861 ttttggataa aatttatata aacaaataaa gtctttaaaa tttagacatt ttaagaggac
     1921 tggtaacatt ttctgtgtat caaatttaag gttctaagtt taaaactagt gtttttatat
     1981 atagcatagt gattttattt tactagttgt ttttaaagga gaaatgttac ttttttactt
     2041 atactctgtt acattattat gataatggca tataacccta tgaagtgggt gaagaatctt
     2101 gtaattgact tttaaaaatg accatggtat tttgggtggc ttcagccttt tcctgtgctg
     2161 tttagtagag tgcactgtcc accactggag gaagaaatgg ccctcttagt atatcttgat
     2221 tttagccaaa gcagcctagt attttgtttt ggttttattt tacagcttga cataacttct
     2281 aatatttctg ttaattatga atgctttcaa aagttatata aaccatgttt ttatgatata
     2341 taaactaatt atttaaaatt tattaccaca cctctattgt gggaggccat aacaggttgg
     2401 tgatataatc aacatgttaa attcagattt catgaacaag gggagagatc ctagttctct
     2461 tctctagact cagctttgcc tctatgacag tcacaacctc gcatctttca tcagaatgca
     2521 gtcgtgtcta agagtgggta ttttgtgata atgtttacta tagatcattt gttaattttg
     2581 atgccttcat tttagctaat ttcagaattt ttattaggta atgtctaggt cctgttcttt
     2641 gagtatctta gagtgtgttg aaaggatccg ctgagcattt acaaacatgg tttgtagctc
     2701 taaccctgaa gttacttggg gactttgctt tgattgccaa gggagcttct ggtttctgat
     2761 gcaatactaa ccaatattgc atcatagtaa tgaattaaag catgtatatc tgtagagcaa
     2821 gagaattgct aattatagtc tgtgtccaag tgttcttttc atatttaaaa gcaaccattt
     2881 ttaatattta atcacctatc attaacttta ttgataattg tgtatgtatg tagtcatggg
     2941 gaatgttcag aaaataaaag aatattctca aatggaaact ggagataagc actgttaaaa
     3001 gttactgtaa caaactcctc tatagaataa acttcttaga ctctttggga agcttcatgg
     3061 tagtggtccc aatggtcaag ccttattgca ggagaaaaaa cctgaagtct gtacagatgc
     3121 ctcattaatg ataatgtgtg gtaagaagag agacgtgaag aaatagggag taccactatt
     3181 acattttatt attgtttatc actaccaaat gttaaatgta tcttgtctgg tcaatcatcc
     3241 ttgtaaataa gttctcaata ggaaaaaaga gtaaagcaca gctttgcatt aataaacata
     3301 tgcacagagg tgattcattg tattctgaaa tagttttctt tttgaatgag tgctttggtt
     3361 ctctgttgtg aagcaacttt atattgatct tcaattctat ttgtactttt ataatgtgca
     3421 ttagggaaaa tgtgtaagtg gtttgtaagt aaatagtttt atttcttttt gtattaaact
     3481 tttgattttt acatgtttct ttttgaggat atttttattt gcattgtcag agtgctcaca
     3541 taaaaaaaga acttaaaatt tgctcactca tgtgcttttc tttttaatgt tttatcagag
     3601 tactatttgc ttatcaggag aacatacttt agctctattc ataatctaag aaaaaaattg
     3661 atcctctaat tcccttggtt agataccaac aatagaatcc tttcaggaaa ttgggattct
     3721 accttttttt tttaatgtgt caagttctga tttctgaaat tcaaaaacat agctcatagg
     3781 tctttaaaca atatttaaga gtatttcaga ggatgcatgc ttagcccaac atcctcagca
     3841 cctctgttct gaaatctctc tttgttgtgt ttatcaatat ttttatagtt tcttttgtct
     3901 ggaaattgtt tgacgtttat tagatctaga ggtttttact caaaggactt ctgaaacctg
     3961 gtttagaaat aatgtaaaaa atgccaaatg agtaaaggtg atggaaaggt ctcttgaaga
     4021 gctgaagcga tcatttatgt tgtttctgtt tattcagttt tattgcccat gatgtttcta
     4081 atgttttggc ttggtaggta gctctaaatt ttaagaaaag aatcatttcc agcattgggg
     4141 acacagagac aagtgaatct ctgtgagttc gaggtcagcc agggctacag acaaatatat
     4201 acaaaaaaat atatacattt tttatcagtg tttcatgagg aaatgaacgg ggggggggat
     4261 cactcagcta ttcttatgta gaaattgtta aaacaagtgt gagatattaa gacttaaata
     4321 acaggactga gtttgcaatt ttatttttac aaatatatat tttttctgaa tgagtctaag
     4381 tcccaagaat gagaataata ataataaata atgttctagt ttgggctaag ctataaaagt
     4441 ttttgaaaga ctttattact actaacttgt ttaattgtga tactctgctt tatgacacca
     4501 gttggaaacc tttgtttttc taaaataaag taattaaaaa catcattgca taa
//
