LOCUS       NM_028339               2418 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus thioredoxin-related transmembrane protein 1 (Tmx1),
            mRNA.
ACCESSION   NM_028339
VERSION     NM_028339.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2418)
  AUTHORS   Zhao,Z., Wu,Y., Zhou,J., Chen,F., Yang,A. and Essex,D.W.
  TITLE     The transmembrane protein disulfide isomerase TMX1 negatively
            regulates platelet responses
  JOURNAL   Blood 133 (3), 246-251 (2019)
   PUBMED   30425049
REFERENCE   2  (bases 1 to 2418)
  AUTHORS   Phan,V., Schmidt,J., Matyash,V., Malchow,S., Thanisch,M.,
            Lorenz,C., Diepolder,I., Schulz,J.B., Stenzel,W., Roos,A. and
            Gess,B.
  TITLE     Characterization of Naive and Vitamin C-Treated Mouse Schwann Cell
            Line MSC80: Induction of the Antioxidative Thioredoxin Related
            Transmembrane Protein 1
  JOURNAL   J Proteome Res 17 (9), 2925-2936 (2018)
   PUBMED   30044099
  REMARK    GeneRIF: TMX1 as an oxidative stress protective factor.
REFERENCE   3  (bases 1 to 2418)
  AUTHORS   Guerra,C., Brambilla Pisoni,G., Solda,T. and Molinari,M.
  TITLE     The reductase TMX1 contributes to ERAD by preferentially acting on
            membrane-associated folding-defective polypeptides
  JOURNAL   Biochem Biophys Res Commun 503 (2), 938-943 (2018)
   PUBMED   29932915
REFERENCE   4  (bases 1 to 2418)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   5  (bases 1 to 2418)
  AUTHORS   Lee,J., Xu,Y., Chen,Y., Sprung,R., Kim,S.C., Xie,S. and Zhao,Y.
  TITLE     Mitochondrial phosphoproteome revealed by an improved IMAC method
            and MS/MS/MS
  JOURNAL   Mol Cell Proteomics 6 (4), 669-676 (2007)
   PUBMED   17208939
REFERENCE   6  (bases 1 to 2418)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC017603.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017603.1, AK150511.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2418
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 29.13 cM"
     gene            1..2418
                     /gene="Tmx1"
                     /gene_synonym="2810425A04Rik; Txndc1"
                     /note="thioredoxin-related transmembrane protein 1"
                     /db_xref="GeneID:72736"
                     /db_xref="MGI:MGI:1919986"
     exon            1..167
                     /gene="Tmx1"
                     /gene_synonym="2810425A04Rik; Txndc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..852
                     /gene="Tmx1"
                     /gene_synonym="2810425A04Rik; Txndc1"
                     /EC_number="5.3.4.1"
                     /note="thioredoxin domain containing 1; thioredoxin
                     domain-containing protein 1; protein disulfide-isomerase
                     TMX1"
                     /codon_start=1
                     /product="thioredoxin-related transmembrane protein 1
                     precursor"
                     /protein_id="NP_082615.1"
                     /db_xref="CCDS:CCDS25958.1"
                     /db_xref="GeneID:72736"
                     /db_xref="MGI:MGI:1919986"
                     /translation="MAHLGRLMVPLAALVLLLWAVPGAHGRRNNVRVLTDENWTSLLE
                     GEWMIEFYAPWCPACQNLQPEWESFAEWGEDLEVKVAKVDVTEQTGLSGRFIITALPS
                     IYHCKDGEFRRYVGPRTKKDFINFVSDKEWKNIEPISSWFGPSSVLMTMMSALFQLSV
                     YIRTSHSYFVHDLGIPAWGSYLVFAFATVLSGLLLGLCMIFVADCLCPSKRRKPQQQY
                     AKKTSPEFSQPLKKVEEEQEADEEDVSEEEAEDREGASKATSQSSIRQRCVGLPSATD
                     TS"
     exon            168..283
                     /gene="Tmx1"
                     /gene_synonym="2810425A04Rik; Txndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            284..329
                     /gene="Tmx1"
                     /gene_synonym="2810425A04Rik; Txndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..458
                     /gene="Tmx1"
                     /gene_synonym="2810425A04Rik; Txndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..504
                     /gene="Tmx1"
                     /gene_synonym="2810425A04Rik; Txndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            505..606
                     /gene="Tmx1"
                     /gene_synonym="2810425A04Rik; Txndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..673
                     /gene="Tmx1"
                     /gene_synonym="2810425A04Rik; Txndc1"
                     /inference="alignment:Splign:2.1.0"
     exon            674..2320
                     /gene="Tmx1"
                     /gene_synonym="2810425A04Rik; Txndc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2298..2303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmx1"
                     /gene_synonym="2810425A04Rik; Txndc1"
                     /note="hexamer: AATAAA"
     polyA_site      2320
                     /gene="Tmx1"
                     /gene_synonym="2810425A04Rik; Txndc1"
                     /note="major polyA site"
ORIGIN      
        1 gggtgagcgg ctgacatggc gcacttgggg cgtcttatgg ttcccctggc agctctggtc
       61 ctgctgctct gggcggtccc tggggcccac ggacggcgga ataacgtgcg cgtcctcacc
      121 gatgagaact ggacgtcgtt gctggaagga gagtggatga tagaatttta tgctccctgg
      181 tgtcctgctt gtcagaatct tcagccagaa tgggaaagtt ttgccgagtg gggagaagat
      241 cttgaggtga aagttgcaaa agtggatgtc acagagcaga caggactaag tggacggttt
      301 atcataactg ctcttccttc tatttatcat tgtaaagatg gtgaatttag gcgctatgtg
      361 ggcccaagga ctaagaagga cttcataaac ttcgtaagtg ataaagaatg gaagaatatt
      421 gaacctatat catcatggtt tggtccaagt tctgttctga tgactatgat gtcagcactt
      481 tttcaactct ctgtgtacat caggactagc cacagctatt ttgttcatga ccttggaata
      541 ccagcgtggg gttcatactt ggtttttgct tttgccacag tactctcagg actgctgctg
      601 ggactttgta tgatatttgt agcagattgc ctttgccctt caaaaagacg caaaccacag
      661 caacagtatg caaaaaaaac atcaccagaa ttttctcaac ctctgaaaaa agtggaggaa
      721 gagcaggagg ctgatgaaga agatgtttca gaagaggagg cagaagatag agagggagca
      781 agcaaagcca cttctcagag cagcataaga caacgctgtg tgggcctccc atctgccacg
      841 gacacatcct aagttttaca tatatcttaa tactatgact ttggcaaaac tgaagctggg
      901 tgatcatttc tattgcgagc tgaactatga cttgctgtgt atacagtgta ggtcctttag
      961 gttggacagt ttccattcag gaaataaaaa cagacataag agtttgaaaa tatgacttaa
     1021 gaatattatg atggtttaaa gttatttaat ttcagaagat cctggtgcca agcagtaaga
     1081 tttgtgttta tatttaataa tctattttgt gtgagattcg aaactgcctt tcccaagatt
     1141 tgcattactg gagtatttaa gaaaattacc ttagagagaa ggatttctca tttcacatca
     1201 tttttctcag tttcactgtg tgaaaaagga tcatatttcc cataagtggg aacattgccc
     1261 attatttcaa gacatatact tcattgatag tactgcactt aggtagagtc caaaatttcc
     1321 tcatagattt tggattatgc agctaacaaa actaccttac tttatagctt tcatttctac
     1381 acattacatt taggctatgt tgctgactta agaagttttt ataagtctat atggcattgg
     1441 attaattctt aaggctgacg cctattttgg tgtcttgttc actgtatgat ttttgttatt
     1501 tgccatgtgt tacatttcta agttggaaaa aattaccagt atcactgttg tgtttgctat
     1561 gggtaaacag aacttttcta tccttttagg atgaagttta ctgagagaac catcaaatcg
     1621 aactgtttac ttgaaaatgt acaaatttgg ctatacattc cagattttaa attattattc
     1681 tgaagttttc tcttttttaa tgtgaagatg aaattttctg atttttaaaa tttgatgtgg
     1741 aaaagctttg gtattttata ttttggaaat tcagaattta attgatgtag aatgaagtct
     1801 gcattctact caagaaacat ctactactat gtgtttttag tgtaattctg tcctccacgg
     1861 ggtcttgatg aattttataa tcaggatatt gctttgtgtt tgaatattgt aacactattg
     1921 tgttttaaag acaaattata tattgtattg ttgttgactg ctagtactgt gtatctcaca
     1981 aatggaaaca agatcggcaa aaggactaca tggatttcat cttacaaagt gggaagggta
     2041 tcatgggggc agggactgtc ttgatgtctg gagggggaaa gcagactgaa ttcttgatga
     2101 gtcagtcacc agcctttatg gaatagatgg tgtctgtgac actccctccc cttatgttct
     2161 ctgtgtgact tccttagact tgcagtactg tgatgggcaa cagcttcttt taggcctctc
     2221 ctttatagtt taaatgttct gctgtcagag tttggatatg tagtttgtgg tggcttagaa
     2281 aaacattcta agcacaaaat aaatgtttct aagcacttca aaaaaaaaaa aaaaaaaaaa
     2341 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2401 aaaaaaaaaa aaaaaaaa
//
