LOCUS       NM_028076               2109 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus transmembrane and ubiquitin-like domain containing 2
            (Tmub2), transcript variant 2, mRNA.
ACCESSION   NM_028076 XM_001003487 XM_126502 XM_895149 XM_903057 XM_908162
            XM_920742 XM_920755 XM_920760 XM_984792
VERSION     NM_028076.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2109)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2109)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 2109)
  AUTHORS   Corbo,J.C. and Cepko,C.L.
  TITLE     A hybrid photoreceptor expressing both rod and cone genes in a
            mouse model of enhanced S-cone syndrome
  JOURNAL   PLoS Genet 1 (2), e11 (2005)
   PUBMED   16110338
  REMARK    Erratum:[PLoS Genet. 2008 Jan;4(1):e18]
REFERENCE   4  (bases 1 to 2109)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954730.15.
            
            On Jun 19, 2019 this sequence version replaced NM_028076.3.
            
            Summary: This gene encodes a predicted multi-pass membrane protein
            that features a C-terminal ubiquitin-related domain. This gene may
            be expressed in cone photoreceptors in the retina. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Oct 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132118.1, AK008158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AL954730.15        118517-118654
            139-193             AL954730.15        119230-119284
            194-757             AL954730.15        120874-121437
            758-2109            AL954730.15        121642-122993
FEATURES             Location/Qualifiers
     source          1..2109
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.29 cM"
     gene            1..2109
                     /gene="Tmub2"
                     /gene_synonym="2010008E23Rik"
                     /note="transmembrane and ubiquitin-like domain containing
                     2"
                     /db_xref="GeneID:72053"
                     /db_xref="MGI:MGI:1919303"
     exon            1..138
                     /gene="Tmub2"
                     /gene_synonym="2010008E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            139..193
                     /gene="Tmub2"
                     /gene_synonym="2010008E23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1118
                     /gene="Tmub2"
                     /gene_synonym="2010008E23Rik"
                     /note="isoform 1 is encoded by transcript variant 2;
                     transmembrane and ubiquitin-like domain-containing protein
                     2"
                     /codon_start=1
                     /product="transmembrane and ubiquitin-like
                     domain-containing protein 2 isoform 1"
                     /protein_id="NP_082352.1"
                     /db_xref="CCDS:CCDS25494.1"
                     /db_xref="GeneID:72053"
                     /db_xref="MGI:MGI:1919303"
                     /translation="MISRLLQNNLMSVDPVSSQAMELSDVTLIEGVGNEVMVVAGVVA
                     LTLALVLAWLSTYVADSGNNQLLGTIVSAGDTSVLHLGHVDQLVNQGTPEPTEHPHPS
                     GGNDDKAEETSDSGGDATGEPGARGEMEPSLEHLLDIQGLPKRQAGLGSSRPEAPLGL
                     DDGSCLSPSPSLINVRLKFLNDTEELAVARPEDTVGTLKSKYFPGQESQMKLIYQGRL
                     LQDPARTLSSLNITNNCVIHCHRSPPGAAVSGPSASLTPTTEQSSLGVNVGSLMVPVF
                     VVLLGVVWYFRINYRQFFTGPATISLVGVTVFFSILVFGMYGR"
     exon            194..757
                     /gene="Tmub2"
                     /gene_synonym="2010008E23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            758..2109
                     /gene="Tmub2"
                     /gene_synonym="2010008E23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1897..1902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmub2"
                     /gene_synonym="2010008E23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1917
                     /gene="Tmub2"
                     /gene_synonym="2010008E23Rik"
                     /note="major polyA site"
     regulatory      2089..2094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmub2"
                     /gene_synonym="2010008E23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2107
                     /gene="Tmub2"
                     /gene_synonym="2010008E23Rik"
ORIGIN      
        1 aacagcttcc gagaaaagcc ggaagagatc ggaccctgga cagaatcctg agttgccagc
       61 ccctcccctg acccctacgg aaagagaact acaaagactg tcctggcgaa gtcaaaacat
      121 ttatcctggc tttgtcagtg ttaattattt ttgcttcgat gatttcacgt cttcttcaaa
      181 acaaccttat gagcgtggac ccagtcagca gccaggccat ggagctctct gatgtcaccc
      241 tcattgaggg tgtgggtaac gaggtgatgg tggtagcagg cgtggtggcg ctgactctag
      301 ccctggtcct agcctggctc tccacctatg tagcagacag tggtaacaac cagctgctgg
      361 gcaccattgt gtcagcaggt gacacgtctg ttctccacct gggccatgtg gaccagctgg
      421 taaaccaagg cactccagag ccaaccgaac acccccatcc atcagggggc aatgatgaca
      481 aggctgaaga gaccagtgac agtgggggag acgccactgg agaacctgga gctaggggag
      541 agatggagcc cagcctggag catctcctgg acatccaagg cctgcctaaa aggcaagcag
      601 gcctggggag cagtcgccca gaagccccgc tggggttaga tgatggctcc tgcctctctc
      661 ccagccccag cctcatcaat gttcgcctca agttcctcaa tgacaccgag gagctagctg
      721 tggccaggcc agaggacact gtgggtaccc taaaaagcaa atacttccct ggacaagaga
      781 gccaaatgaa gttgatctac cagggtcggc tgctgcagga cccagcacgc acactgagtt
      841 ccctgaacat taccaacaac tgcgtgatcc actgccaccg ctcaccccca ggggcagcag
      901 tttctggccc ctcagcctcc ttgaccccaa ccactgagca atctagcctt ggtgtcaacg
      961 tgggcagcct catggtgcct gtgtttgtgg tgctcttggg tgtggtctgg tacttccgta
     1021 tcaattaccg ccagttcttc actggacctg ccactatctc cttggttgga gtcacagtct
     1081 tcttcagcat cctggtattt gggatgtatg gaagataagg acatcaggag acaaagaaag
     1141 gcatggtctt cctccttcgt ggcctccctc ctttcctggc cagagctggg cccaaggacc
     1201 tgggagggag ggataggaag ggtatggtgg gtaccctgtc cataggaccc aggaagcagg
     1261 tgtgtggcct cccttcatgt ccagagggta cagatatctc tgcaagcaca actcaggtag
     1321 aaatgaggat atcatcttcc ctcttttgga atcccaaagt tcacaggcca agatcagtga
     1381 gaagcctggg ctctgggtct tccctcctgg ctgtggccca gtctcttgca tgtctgttcc
     1441 ctaaccccca gggttgctgc caggacagct cagcatggcc ttagcatact tctgtaggaa
     1501 gcctcaagta ccttccactc cttagatgag tgtggacctt ttgaaactaa attcacaggg
     1561 atgaagactg ccagccagcc ttccctacag cacccagctg ccaccacctc ctccttgtgc
     1621 cccttgtagc aggaatagga tattttgctt tcttttaaag cactttgctt gctctttttt
     1681 tgtttgtttg taaatagtcc tgtatagagc tcagtcagga aggggagtgg ggcagaaggc
     1741 caagccccca gcattgaggc caggccacag ctgctgttat cctaggcctc tagactgcaa
     1801 gagtactggc cctaatccag tgccctgccc agttccaagg atgagctctg ggtatagact
     1861 gccctcccct aagcccttag atggtcagta tgaatgaata aaaatccatt ttgtggctat
     1921 ggagcctctt tgtgactgct ctgccctcag caacatggca atgagagtgg gcaggccggg
     1981 ctaccaacgg gaaatgcagt ttatttacac cagcagccat gagggcagag gggaatacac
     2041 agcgtttaca aagttagcta cctgtacagg atggattaca tatgcaaaaa taaaaatctc
     2101 aagaccaca
//
