LOCUS       NM_022418               1343 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus transmembrane and ubiquitin-like domain containing 1
            (Tmub1), mRNA.
ACCESSION   NM_022418
VERSION     NM_022418.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1343)
  AUTHORS   Ferracchiato,S., Di-Iacovo,N., Scopetti,D., Piobbico,D.,
            Castelli,M., Pieroni,S., Gargaro,M., Manni,G., Brancorsini,S.,
            Della-Fazia,M.A. and Servillo,G.
  TITLE     Hops/Tmub1 Heterozygous Mouse Shows Haploinsufficiency Effect in
            Influencing p53-Mediated Apoptosis
  JOURNAL   Int J Mol Sci 22 (13), 7186 (2021)
   PUBMED   34281239
  REMARK    GeneRIF: Hops/Tmub1 Heterozygous Mouse Shows Haploinsufficiency
            Effect in Influencing p53-Mediated Apoptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1343)
  AUTHORS   Bartoli,D., Piobbico,D., Castelli,M., Pieroni,S., Scopetti,D.,
            Ferracchiato,S., Di-Iacovo,N., Cagini,C., Servillo,G. and
            Della-Fazia,M.A.
  TITLE     Functional expression and localisation of HOPS/TMUB1 in mouse lens
  JOURNAL   Biosci Rep 41 (2) (2021)
   PUBMED   33543240
  REMARK    GeneRIF: Functional expression and localisation of HOPS/TMUB1 in
            mouse lens.
REFERENCE   3  (bases 1 to 1343)
  AUTHORS   Bellet,M.M., Pieroni,S., Castelli,M., Piobbico,D., Fallarino,F.,
            Romani,L., Della-Fazia,M.A. and Servillo,G.
  TITLE     HOPS/Tmub1 involvement in the NF-kB-mediated inflammatory response
            through the modulation of TRAF6
  JOURNAL   Cell Death Dis 11 (10), 865 (2020)
   PUBMED   33060567
  REMARK    GeneRIF: HOPS/Tmub1 involvement in the NF-kB-mediated inflammatory
            response through the modulation of TRAF6.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1343)
  AUTHORS   Castelli,M., Piobbico,D., Chiacchiaretta,M., Brunacci,C.,
            Pieroni,S., Bartoli,D., Gargaro,M., Fallarino,F., Puccetti,P.,
            Soddu,S., Della-Fazia,M.A. and Servillo,G.
  TITLE     HOPS/TMUB1 retains p53 in the cytoplasm and sustains p53-dependent
            mitochondrial apoptosis
  JOURNAL   EMBO Rep 21 (2), e48073 (2020)
   PUBMED   31867855
  REMARK    GeneRIF: HOPS/TMUB1 retains p53 in the cytoplasm and sustains
            p53-dependent mitochondrial apoptosis.
REFERENCE   5  (bases 1 to 1343)
  AUTHORS   Fu,H., Dong,R., Zhang,Y., Xu,J., Liu,M. and Chen,P.
  TITLE     Tmub1 negatively regulates liver regeneration via inhibiting STAT3
            phosphorylation
  JOURNAL   Cell Signal 55, 65-72 (2019)
   PUBMED   30610893
  REMARK    GeneRIF: The results of this study suggest that Tmub1 is an
            important negative regulator of hepatocyte proliferation in liver
            regeneration through STAT3 (signal transducer and activator of
            transcription 3 protein) signaling.
REFERENCE   6  (bases 1 to 1343)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   7  (bases 1 to 1343)
  AUTHORS   Yang,H., Takagi,H., Konishi,Y., Ageta,H., Ikegami,K., Yao,I.,
            Sato,S., Hatanaka,K., Inokuchi,K., Seog,D.H. and Setou,M.
  TITLE     Transmembrane and ubiquitin-like domain-containing protein 1
            (Tmub1/HOPS) facilitates surface expression of GluR2-containing
            AMPA receptors
  JOURNAL   PLoS One 3 (7), e2809 (2008)
   PUBMED   18665261
  REMARK    GeneRIF: transmission; it contributes to maintain the synaptic
            surface number of the GluR2-containing AMPARs by facilitating the
            recycling of GluR2 to the plasma membrane
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1343)
  AUTHORS   Pieroni,S., Della Fazia,M.A., Castelli,M., Piobbico,D., Bartoli,D.,
            Brunacci,C., Bellet,M.M., Viola-Magni,M. and Servillo,G.
  TITLE     HOPS is an essential constituent of centrosome assembly
  JOURNAL   Cell Cycle 7 (10), 1462-1466 (2008)
   PUBMED   18418082
  REMARK    GeneRIF: HOPS is involved in centrosome assembly and maintenance.
REFERENCE   9  (bases 1 to 1343)
  AUTHORS   Della Fazia,M.A., Castelli,M., Bartoli,D., Pieroni,S.,
            Pettirossi,V., Piobbico,D., Viola-Magni,M. and Servillo,G.
  TITLE     HOPS: a novel cAMP-dependent shuttling protein involved in protein
            synthesis regulation
  JOURNAL   J Cell Sci 118 (Pt 14), 3185-3194 (2005)
   PUBMED   16014383
REFERENCE   10 (bases 1 to 1343)
  AUTHORS   Inoue,S., Sano,H. and Ohta,M.
  TITLE     Growth suppression of Escherichia coli by induction of expression
            of mammalian genes with transmembrane or ATPase domains
  JOURNAL   Biochem Biophys Res Commun 268 (2), 553-561 (2000)
   PUBMED   10679242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB871344.1 and AB030183.1.
            
            [WARNING] On Feb 6, 2025 this sequence was replaced by NM_022418.4.
            
            On Nov 28, 2007 this sequence version replaced NM_022418.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB030183.1, AK008109.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BB871344.1         1-41
            42-1031             AB030183.1         4-993
            1032-1343           AB030183.1         995-1306
FEATURES             Location/Qualifiers
     source          1..1343
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 11.79 cM"
     gene            1..1343
                     /gene="Tmub1"
                     /gene_synonym="2010004O20Rik; Hops"
                     /note="transmembrane and ubiquitin-like domain containing
                     1"
                     /db_xref="GeneID:64295"
                     /db_xref="MGI:MGI:1923764"
     exon            1..90
                     /gene="Tmub1"
                     /gene_synonym="2010004O20Rik; Hops"
                     /inference="alignment:Splign:2.1.0"
     exon            91..509
                     /gene="Tmub1"
                     /gene_synonym="2010004O20Rik; Hops"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..861
                     /gene="Tmub1"
                     /gene_synonym="2010004O20Rik; Hops"
                     /note="hepatocyte odd protein shuttling protein"
                     /codon_start=1
                     /product="transmembrane and ubiquitin-like
                     domain-containing protein 1"
                     /protein_id="NP_071863.1"
                     /db_xref="CCDS:CCDS19121.1"
                     /db_xref="GeneID:64295"
                     /db_xref="MGI:MGI:1923764"
                     /translation="MALIEGVGDEVTVLFAVLACLLVLALAWVSTHTTESTDPQPQPP
                     GTTTPAQPSEAMSASDSIREEAPGAESPSLRHRGPSAQPEPDTGVTASTPPDSPQEPL
                     LLRLKFLNDSEQVARAWPQDTIGSLKRTQFPGQEQQVRLIYQGQLLGDDTQTLGSLHL
                     PPNCVLHCHVSTRVGPPHPPCPPGSEPGPSGLEIGSLLLPLLLLLLLLLWYCQIQYRP
                     FFPLTATLGLAGFTLLLSLLAFAMYRP"
     exon            510..1320
                     /gene="Tmub1"
                     /gene_synonym="2010004O20Rik; Hops"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1295..1300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmub1"
                     /gene_synonym="2010004O20Rik; Hops"
                     /note="hexamer: ATTAAA"
     polyA_site      1320
                     /gene="Tmub1"
                     /gene_synonym="2010004O20Rik; Hops"
                     /note="major polyA site"
ORIGIN      
        1 ggaaggagag ggacctcagg tgtctgcgac ctcggtgcct tcggcccgga agtgcccgag
       61 gagccgagat ggagctggtg gagctgggcg ctccttagca cctctggcag cagcacgggt
      121 gccatggcct tgattgaagg cgtaggcgat gaggtgactg tcctttttgc ggtgcttgct
      181 tgccttctgg tgctggccct cgcctgggtc tcaacacata ccactgagag tacagacccc
      241 caaccacagc cgccggggac cacaacacca gcacagccca gtgaagccat gtcagcctct
      301 gacagcatca gagaggaggc cccaggggct gagagtccca gcctgagaca cagaggtcca
      361 tctgcacagc cagagcctga cacaggggtc acagcatcaa cacctccaga ctctccgcag
      421 gaacccctac ttctacggtt gaaatttctc aatgactctg agcaggtagc cagggcctgg
      481 cctcaggaca ccattggctc cttaaaaagg acccagtttc caggccagga acagcaggtt
      541 cggctcatct accaaggtca actgctagga gacgacactc agacactagg cagtctccac
      601 ctgcccccca actgcgttct ccactgccac gtgtccacga gagtcggtcc cccacatcct
      661 ccctgcccac cggggtcaga gcccggcccc tccgggctgg aaatcggcag ccttctgttg
      721 cccctgctgc ttctgctgct gctcctgctc tggtactgcc agatccagta ccggcccttc
      781 tttcccctga ccgctaccct gggtctggcc ggcttcaccc tgctcctcag tctcctggcc
      841 tttgccatgt atcggccgta gtgcctccac gggcttttgg cagtgtagcc agcccctctg
      901 gacctcattc cccaaggcgc aaagggagct gctgtctgcc caggcccact tcacccgctg
      961 cctgtctttt cccactaccc tggagcccag ctttgcgccg cagaggactt cgggtgttag
     1021 cggaggccgc tccgtgtgat cttcatagct ctaggccatc tcctggggct gctggacctc
     1081 agccttcgct ggcagtgggc tcttctggat caggcacttg ctgtcgctgc cttggccgcc
     1141 agggcacccc aatgggccca tcttagtgtg ctgacagagg atctagatac ttctagtttc
     1201 aaagagctgc ctaggctgaa ttggaaactg gtggactggg agactggtga aggggaatcg
     1261 agaggggcag agttgttttc tggaatttgt gcagattaaa gaaactgtga cgttttccta
     1321 aaaaaaaaaa aaaaaaaaaa aaa
//
