LOCUS       NM_028651               3427 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus transmembrane and tetratricopeptide repeat containing
            4 (Tmtc4), transcript variant 2, mRNA.
ACCESSION   NM_028651 XM_127899
VERSION     NM_028651.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3427)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3427)
  AUTHORS   Li,J., Choi,B.Y., Eltawil,Y., Ismail Mohamad,N., Park,Y.,
            Matthews,I.R., Han,J.H., Kim,B.J., Sherr,E.H. and Chan,D.K.
  TITLE     TMTC4 is a hair cell-specific human deafness gene
  JOURNAL   JCI Insight 8 (24), e172665 (2023)
   PUBMED   37943620
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3427)
  AUTHORS   Li,J., Akil,O., Rouse,S.L., McLaughlin,C.W., Matthews,I.R.,
            Lustig,L.R., Chan,D.K. and Sherr,E.H.
  TITLE     Deletion of Tmtc4 activates the unfolded protein response and
            causes postnatal hearing loss
  JOURNAL   J Clin Invest 128 (11), 5150-5162 (2018)
   PUBMED   30188326
  REMARK    GeneRIF: mice with homozygous inactivation of both Tmtc4 and Chop
            had less hearing loss than knockout of Tmtc4 alone. This study
            implicated a novel mechanism for hearing impairment, highlighting a
            potential treatment approach for a broad range of human hearing
            loss disorders.
REFERENCE   4  (bases 1 to 3427)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3427)
  AUTHORS   Coulpier,F., Le Crom,S., Maro,G.S., Manent,J., Giovannini,M.,
            Maciorowski,Z., Fischer,A., Gessler,M., Charnay,P. and Topilko,P.
  TITLE     Novel features of boundary cap cells revealed by the analysis of
            newly identified molecular markers
  JOURNAL   Glia 57 (13), 1450-1457 (2009)
   PUBMED   19243017
REFERENCE   6  (bases 1 to 3427)
  AUTHORS   Pang,A.L., Taylor,H.C., Johnson,W., Alexander,S., Chen,Y., Su,Y.A.,
            Li,X., Ravindranath,N., Dym,M., Rennert,O.M. and Chan,W.Y.
  TITLE     Identification of differentially expressed genes in mouse
            spermatogenesis
  JOURNAL   J Androl 24 (6), 899-911 (2003)
   PUBMED   14581517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY125796.1, AK033947.1 and BX512100.1.
            
            On Feb 8, 2018 this sequence version replaced NM_028651.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033947.1, AK045271.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BY125796.1         1-22
            23-3412             AK033947.1         2-3391
            3413-3427           BX512100.1         376-390
FEATURES             Location/Qualifiers
     source          1..3427
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 66.04 cM"
     gene            1..3427
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /note="transmembrane and tetratricopeptide repeat
                     containing 4"
                     /db_xref="GeneID:70551"
                     /db_xref="MGI:MGI:1921050"
     exon            1..112
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            113..325
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..2392
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /EC_number="2.4.1.109"
                     /note="transmembrane and TPR repeat-containing protein 4;
                     transmembrane O-mannosyltransferase targeting cadherins 4"
                     /codon_start=1
                     /product="protein O-mannosyl-transferase TMTC4"
                     /protein_id="NP_082927.1"
                     /db_xref="CCDS:CCDS27352.1"
                     /db_xref="GeneID:70551"
                     /db_xref="MGI:MGI:1921050"
                     /translation="MVELDADLDHIVPSVLPPFWAKLVVGFVSLLCFARSYDGDFVFD
                     DSEAIVNNKDLQSDTPLGDLWHHDFWGSKLSSNTSHKSYRPLTVLTFRINYYLSGGFH
                     PVGFHVVNILLHGSISILMLDVFSVLFGGLQYTGKGQRVHLAPRASLLATLLFAVHPV
                     HTECVAGVVGRADLLCALFFLLSFLGYCQAFKETGNKEGTHSSTFWVLLSIFLGAVAM
                     LCKEQGITVLGLNAVFDILVIGKLDILAAVRKVLHKDKSQENAGMFKNGGLLFRIALL
                     TIGGTSMLYIRWKIMGTGPPAFTEVDNPASFADSMLVRAINYNYYYSLNAWLLLCPWW
                     LCFDWSMGCIPLIKSVGDWRVIALAALWLCLIGLIFQALCSEDSCKRRILTLGLGFLV
                     IPFLPASNLFFRVGFVVAERVLYLPSAGYCVLLTFGFGALSRHTKKKKPVAAIILGIL
                     LINALRCVIRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADQGNQTAAIKYYREA
                     VRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRF
                     EEAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNM
                     IILLDNTGNLAQAEAVGREALQLIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKAN
                     PNVASYHGNLAVLYHRWGHLDSAKKHYEISLQLDPVAVGTKENYSLLRRKLEQTQKKD
                     V"
     exon            326..441
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            442..658
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            659..746
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            747..850
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            851..943
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1108
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1311
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1483
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1615
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1695
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1803
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1945
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2060
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2173
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2243
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..3416
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3386..3391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      3416
                     /gene="Tmtc4"
                     /gene_synonym="4930403J22Rik; 5730419O14Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggcggggtgg gagtgggagg gcagcccctc ccctggcggc ggcgggctgg ggagccgccg
       61 gagtttaagc acgcgggagg ggagatgaga tcgcggctcg tgctccttgc agatttctaa
      121 cgagcgtaat gctggagcag gtggctgtcg gcctgcagat ttcaagatgg ttgagctgga
      181 tgctgacttg gatcacattg tcccatccgt ccttccccct ttctgggcta agttagtagt
      241 gggatttgtt tcccttctgt gttttgcaag gagctatgat ggcgattttg tctttgatga
      301 ctctgaagct attgttaaca ataaggacct ccagtcagac acgccccttg gggacctgtg
      361 gcaccatgac ttctggggca gtaaattgag cagtaacacc agccacaagt cctaccggcc
      421 acttactgtc ctgactttca ggattaacta ctacctgtcc ggaggctttc accccgtggg
      481 tttccatgtg gtcaacatcc tcctgcatgg cagcatctcc atcctcatgc tggatgtctt
      541 ctcagtactg tttggtggcc tacagtacac cggtaaaggc cagagggtac acctggcccc
      601 cagggcttcc ctgctggcca cgttgctgtt tgctgtccat ccagtgcaca ctgagtgtgt
      661 tgctggtgtt gttggccgtg cagacctcct gtgtgccctg ttcttcttgt tgtctttcct
      721 tggctactgt caagcattta aagaaacagg taacaaggag ggaacacatt cttccacctt
      781 ctgggtattg ctgagtatct ttctgggagc tgtggccatg ctgtgcaaag agcaaggaat
      841 cactgtgctg ggcttgaatg ctgtgttcga tatcctggtg ataggcaaac tcgacattct
      901 ggcagctgtc cggaaggtcc tacataagga caagtcacaa gagaatgcag gcatgttcaa
      961 gaatggaggc ctccttttcc gaatagccct acttaccatt ggaggcacca gcatgcttta
     1021 tatacgctgg aaaatcatgg gaacaggccc accggcattt actgaggtgg acaacccagc
     1081 atcctttgct gacagcatgt tggttagggc cataaactat aattactact attcattgaa
     1141 tgcctggctg ctgctgtgtc cctggtggct gtgttttgat tggtcaatgg gctgcatccc
     1201 cctcattaag tcagttggtg actggagggt aattgctcta gcggcacttt ggctctgcct
     1261 aattggccta atattccaag ccctgtgctc tgaggatagc tgcaagagaa gaatccttac
     1321 tctgggtttg ggatttcttg tgatcccctt tcttcctgca agcaacttgt ttttccgagt
     1381 gggctttgtg gtcgcagaac gtgtcctcta ccttcccagc gctgggtact gcgtgctgct
     1441 gacctttgga tttggagctc tgagcagaca cactaagaaa aagaaacctg ttgccgccat
     1501 catcctgggc atccttctca tcaatgcact gagatgtgtg atacgcagtg gtgagtggcg
     1561 gagtgaagag cagctctttc gaagcgccct gtctgtgtgt cccctcaatg ctaaggttca
     1621 ctacaacatt ggcaaaaacc tggctgatca aggcaaccaa acagcggcca tcaaatatta
     1681 ccgggaagca gtcagactaa atcccaagta cgttcatgcc atgaataacc tcgggaatat
     1741 cttaaaagaa aggaatgagc tacaggaagc tgaagagctg ctgtcgttgg ctgtccaaat
     1801 acagccagac tttgcagccg catggatgaa tttgggcata gttcagaaca gcctgaaacg
     1861 gtttgaggaa gcagagcaga gctaccggac agcgattaaa cacaggagga aatacccaga
     1921 ctgctactac aacctcgggc ggctgtatgc agatctaaat cgccacgtgg atgcattgaa
     1981 cgcttggaga aatgccaccg tactgaagcc ggagcacagc ctggcgtgga acaacatgat
     2041 catacttctg gataacacag gtaacttagc ccaggctgaa gctgttggaa gagaggccct
     2101 gcaattaata cctaatgatc actcccttat gttctcattg gcaaacgtgc tggggaaatc
     2161 ccagaaatac aaggagtctg aagctttatt cctcaaggca attaaagcaa atccaaatgt
     2221 tgcaagttac catggtaatt tggctgtgct ttatcatcgc tggggacatc ttgactctgc
     2281 caagaaacac tatgagatct ccttgcagct tgaccctgtg gcagtaggca ccaaggagaa
     2341 ttacagtctt ctgagaagaa agctagaaca aacgcagaag aaagatgtct gatcttcccc
     2401 ctaatgtttt gagtttgtga gtgtgtgcat gaagcctctg ttcagattgt gtgtttagtc
     2461 atttaaaagt ctcagacatt tattttattc tattgttatt tttttcctat gaaaacaaac
     2521 acatgcaaaa agattatagc accagcaata cactcttgaa tgcttgatag gatttttgca
     2581 ttgaaattgt attttttcac acaactcaaa tgtaattcta aaatctcaaa aaaaaagaaa
     2641 ccttttttta aaaactaaac agaaaaaaat attattttga gtgaattttg attgtgttaa
     2701 actgcatttg ggatgtgatg gagtgactta gacatgcctc ctacaattta catagccatc
     2761 taccgttatc tgtatattag cttgtttatt taatgacaag aaagagtaaa tcaggtttgg
     2821 gttttttttt aagtctcttt gcaacagtgt aacttgaagt ttgtaagaaa attatttatt
     2881 cacatttttg tgttgaacag gataaataat tgaagaaggg aaaattttaa tgtctatata
     2941 tttatctata tatttttttc ataggaagtt atggactccc atgctttttt gatatgtata
     3001 tgtattctcc aatgtgtgtg atgttagtat gcaggataat attccactgt taatagagta
     3061 cccctgacgt actttaggca acctaacatc ctggtctctg ttctgtccac tgttcagagg
     3121 gctacctgtg tgtatatgct gtgttttcat gttttagttg taaagtgggt ttccatctca
     3181 catgataaaa tcacagacat tactctatcc agaaaatgca aaaaggttct ctttcaaaag
     3241 aagtcatagc tctggattgt gtgctgttct tataaactgg gtttgttttt ccttttcaca
     3301 ttagatctca acaatttgtt tacttagttt gttctttata tactgttgac ctaataattt
     3361 atgccatcgc tgtcatttct tatgcagtaa aattatcaca caaactgtca tgaaaaaaaa
     3421 aaaaaaa
//
