LOCUS       NP_796342                836 aa            linear   ROD 04-JUN-2024
DEFINITION  protein O-mannosyl-transferase TMTC2 precursor [Mus musculus].
ACCESSION   NP_796342 NP_080051
VERSION     NP_796342.2
DBSOURCE    REFSEQ: accession NM_177368.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 836)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB652678.1, AK052344.1 and BC092226.1.
            
            On or before Aug 4, 2004 this sequence version replaced
            NP_080051.1, NP_796342.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092226.1, BC138362.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..836
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 54.72 cM"
     Protein         1..836
                     /product="protein O-mannosyl-transferase TMTC2 precursor"
                     /EC_number="2.4.1.109"
                     /note="transmembrane and TPR repeat-containing protein 2;
                     protein O-mannosyl-transferase TMTC2; transmembrane
                     O-mannosyltransferase targeting cadherins 2"
                     /calculated_mol_wt=92044
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2151
     Site            1..21
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Region          <78..>198
                     /region_name="ArnT"
                     /note="PMT family glycosyltransferase ArnT/Agl22, involved
                     in glycosylation of proteins and lipid IVA [Cell
                     wall/membrane/envelope biogenesis]; COG1807"
                     /db_xref="CDD:441412"
     Site            78..98
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Site            108..128
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Site            133..153
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Site            169..184
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Site            185..204
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Site            221..241
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Region          247..321
                     /region_name="TMTC_DUF1736"
                     /note="Protein O-mannosyl-transferase TMTC, DUF1736;
                     pfam08409"
                     /db_xref="CDD:462468"
     Site            313..333
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Site            393..415
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Site            423..443
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Site            450..470
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Region          488..707
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          493..526
                     /region_name="TPR 1.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Region          493..521
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          527..560
                     /region_name="TPR 2.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Region          527..555
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(528,531..532,535..536,538,562,565..566,569..570,
                     572..573,596,610..611,614..615,618)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          560..590
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          561..594
                     /region_name="TPR 3.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Region          595..634
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          606..639
                     /region_name="TPR 4.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Region          608..>812
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          642..671
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          643..676
                     /region_name="TPR 5.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Region          677..710
                     /region_name="TPR 6.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Region          679..705
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(681..682,685..686,688,712,715..716,719..720,
                     722..723,780,783..784,787..788,791)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          710..774
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          711..744
                     /region_name="TPR 7.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Region          745..778
                     /region_name="TPR 8.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Region          779..812
                     /region_name="TPR 9.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00339"
                     /note="propagated from UniProtKB/Swiss-Prot (Q56A06.1)"
     Region          779..807
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     CDS             1..836
                     /gene="Tmtc2"
                     /gene_synonym="8430438D04Rik; D330034A10Rik"
                     /coded_by="NM_177368.4:731..3241"
                     /db_xref="CCDS:CCDS24157.1"
                     /db_xref="GeneID:278279"
                     /db_xref="MGI:MGI:1914057"
ORIGIN      
        1 miaelvssal glalylntls adfcyddsra iktnqdllpe tpwthifynd fwgtllthsg
       61 shksyrplct lsfrlnhaig glnpwsyhlv nvllhaavtg lftrfskall gdgywtfmag
      121 lmfashpiht eavagivgra dvgaslffll sllcyikhcs trgysartwg wflgtglcag
      181 csmlwkeqgv tvlavsavyd vfvfhrlkmk qilptiykrk nlslflsisl ltfwgtcllg
      241 arlywmgnkp psfsnsdnpa adsdsllart ltflylptkn lwlllcpdtl sfdwsmdavp
      301 llktvcdwrn lhtvafysgl lllaycglkn pslegecngk altngkqnan ghschsdvey
      361 rnsemkpsfa skvengiknc vpqrtqlpst enivilslsl liipfipatn lffyvgfvia
      421 ervlyipsmg fcllitvgar alyvkvqkrf lkslvfyata tlivfygvkt airngdwqne
      481 emlyrsgikv npakawgnlg nvlksqskis eaesayrnal fyrsnmadml ynlglllqen
      541 srfaealhyy klaigsrptl asaylntgii lmnqgkteea rrtflkcsei pdenlkdpha
      601 hkssvtscly nlgklyheqg ryeealsvyr eaiqkmprhf apqslynmmg eaymrlsklp
      661 eaehwymesl rsktdhipah ltygkllalt grkseaekff lkaieldptk gncymhygqf
      721 lleesrltea aemakkaael dntefdvvfn aahmlrqasl neaaekyydl aarlrpnypa
      781 almnlgailh lngrlqkaea nylralqlkp ddvitqsnlr klwnimekqg lktskt
//
