LOCUS       NM_021278                670 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus thymosin, beta 4, X chromosome (Tmsb4x), mRNA.
ACCESSION   NM_021278
VERSION     NM_021278.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 670)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 670)
  AUTHORS   Hao,M., Zhong,K., Bai,X., Wu,S., Li,L., He,Y., Wang,Z., Sun,X.,
            Wang,Q., Guo,Y., Sun,Y. and Wu,L.
  TITLE     Upregulated Tbeta4 expression in inflammatory bowel disease impairs
            the intestinal mucus barrier by inhibiting autophagy in mice
  JOURNAL   Exp Cell Res 434 (1), 113871 (2024)
   PUBMED   38049080
  REMARK    GeneRIF: Upregulated Tbeta4 expression in inflammatory bowel
            disease impairs the intestinal mucus barrier by inhibiting
            autophagy in mice.
REFERENCE   3  (bases 1 to 670)
  AUTHORS   Wang,Z., Zhang,Y., Wang,Y., Mou,Q., Ren,T. and Zhu,L.
  TITLE     Mechanism of thymosin beta4 in ameliorating liver fibrosis via the
            MAPK/NF-kappaB pathway
  JOURNAL   J Biochem Mol Toxicol 37 (7), e23338 (2023)
   PUBMED   37211724
  REMARK    GeneRIF: Mechanism of thymosin beta4 in ameliorating liver fibrosis
            via the MAPK/NF-kappaB pathway.
REFERENCE   4  (bases 1 to 670)
  AUTHORS   Kim,J., Lee,C., Han,J., Jeong,H., Wang,S., Choi,Y.H. and Jung,Y.
  TITLE     Targeted Deletion of Thymosin Beta 4 in Hepatic Stellate Cells
            Ameliorates Liver Fibrosis in a Transgenic Mouse Model
  JOURNAL   Cells 12 (12), 1658 (2023)
   PUBMED   37371128
  REMARK    GeneRIF: Targeted Deletion of Thymosin Beta 4 in Hepatic Stellate
            Cells Ameliorates Liver Fibrosis in a Transgenic Mouse Model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 670)
  AUTHORS   Munshaw,S., Redpath,A.N., Pike,B.T. and Smart,N.
  TITLE     Thymosin beta4 preserves vascular smooth muscle phenotype in
            atherosclerosis via regulation of low density lipoprotein related
            protein 1 (LRP1)
  JOURNAL   Int Immunopharmacol 115, 109702 (2023)
   PUBMED   37724952
  REMARK    GeneRIF: Thymosin beta4 preserves vascular smooth muscle phenotype
            in atherosclerosis via regulation of low density lipoprotein
            related protein 1 (LRP1).
REFERENCE   6  (bases 1 to 670)
  AUTHORS   Carpinterio,P., Anadon,R., del Amo,F.F. and Gomez-Marquez,J.
  TITLE     The thymosin beta 4 gene is strongly activated in neural tissues
            during early postimplantation mouse development
  JOURNAL   Neurosci Lett 184 (1), 63-66 (1995)
   PUBMED   7739809
REFERENCE   7  (bases 1 to 670)
  AUTHORS   Jonk,L.J., de Jonge,M.E., Vervaart,J.M., Wissink,S. and Kruijer,W.
  TITLE     Isolation and developmental expression of retinoic-acid-induced
            genes
  JOURNAL   Dev Biol 161 (2), 604-614 (1994)
   PUBMED   8314004
REFERENCE   8  (bases 1 to 670)
  AUTHORS   Low,T.L., Pan,T.L. and Lin,Y.S.
  TITLE     Depression of prothymosin alpha production in murine thymus
            correlates with staphylococcal enterotoxin-B-induced
            immunosuppression [corrected]
  JOURNAL   FEBS Lett 273 (1-2), 1-5 (1990)
   PUBMED   2226839
  REMARK    Erratum:[FEBS Lett 1990 Dec 17;277(1-2):285]
REFERENCE   9  (bases 1 to 670)
  AUTHORS   Rudin,C.M., Engler,P. and Storb,U.
  TITLE     Differential splicing of thymosin beta 4 mRNA
  JOURNAL   J Immunol 144 (12), 4857-4862 (1990)
   PUBMED   2351831
REFERENCE   10 (bases 1 to 670)
  AUTHORS   Moscinski,L.C. and Prystowsky,M.B.
  TITLE     Identification of a series of differentiation-associated gene
            sequences from GM-CSF stimulated bone marrow
  JOURNAL   Oncogene 5 (1), 31-37 (1990)
   PUBMED   2181376
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ127748.1 and AK169108.1.
            
            [WARNING] On Feb 27, 2025 this sequence was replaced by
            NM_021278.3.
            
            On Feb 4, 2006 this sequence version replaced NM_021278.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY763059.1, BY762296.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                BQ127748.1         1-54
            55-670              AK169108.1         2-617
FEATURES             Location/Qualifiers
     source          1..670
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.28 cM"
     gene            1..670
                     /gene="Tmsb4x"
                     /gene_synonym="Ptmb4; Tb4; Tbeta4"
                     /note="thymosin, beta 4, X chromosome"
                     /db_xref="GeneID:19241"
                     /db_xref="MGI:MGI:99510"
     exon            1..113
                     /gene="Tmsb4x"
                     /gene_synonym="Ptmb4; Tb4; Tbeta4"
                     /inference="alignment:Splign:2.1.0"
     exon            114..228
                     /gene="Tmsb4x"
                     /gene_synonym="Ptmb4; Tb4; Tbeta4"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..263
                     /gene="Tmsb4x"
                     /gene_synonym="Ptmb4; Tb4; Tbeta4"
                     /note="t beta 4; prothymosin beta 4"
                     /codon_start=1
                     /product="thymosin beta-4"
                     /protein_id="NP_067253.1"
                     /db_xref="CCDS:CCDS30529.1"
                     /db_xref="GeneID:19241"
                     /db_xref="MGI:MGI:99510"
                     /translation="MSDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES
                     "
     exon            229..670
                     /gene="Tmsb4x"
                     /gene_synonym="Ptmb4; Tb4; Tbeta4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      652..657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmsb4x"
                     /gene_synonym="Ptmb4; Tb4; Tbeta4"
                     /note="putative"
     polyA_site      670
                     /gene="Tmsb4x"
                     /gene_synonym="Ptmb4; Tb4; Tbeta4"
                     /note="putative"
ORIGIN      
        1 atcacctcat ttgcatagaa gcacacataa agcggcgttc gccgcgcccc tcccgacaat
       61 ccgcagcggc ttctgagcag atcagactct cctcgttcgc gcagctcgct cggctccttc
      121 cagcaaccat gtctgacaaa cccgatatgg ctgagatcga gaaattcgat aagtcgaagt
      181 tgaagaaaac agaaacgcaa gagaaaaatc ctctgccttc aaaagaaaca attgaacaag
      241 agaagcaagc tggcgaatcg taatgaggcg agcgccgcca atatgcactg tacattccac
      301 gagcattgcc ttcttatttt acttctttta gctgtttaac tttgtaagat gcaaagaggt
      361 tggatcaagt ttaaatgact gtgctgcccc tttcacatca aagaatcaga actactgagc
      421 aggaaggcct cccctgcctc tcccacccat ctgatggtct ggctagcaga gagggaaaag
      481 aacttgcatg ttggtgaagg aaaaagctgg gtgggagatg atgaaataga gaggaaaatt
      541 caagatggtc aaagatgtcc tgcaggatgt aaaatgcagt ttaatcagag tgccattttt
      601 ttttgttcaa acaattttaa ttattggaat gcacaatttt tttaatatgc aaataaagtt
      661 ttaaaacctg
//
