LOCUS       NM_001081688            3454 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus transmembrane protease, serine 9 (Tmprss9), mRNA.
ACCESSION   NM_001081688 XM_982870
VERSION     NM_001081688.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3454)
  AUTHORS   Chen,C.A., Pal,R., Yin,J., Tao,H., Amawi,A., Sabo,A.,
            Bainbridge,M.N., Gibbs,R.A., Zoghbi,H.Y. and Schaaf,C.P.
  TITLE     Combination of whole exome sequencing and animal modeling
            identifies TMPRSS9 as a candidate gene for autism spectrum disorder
  JOURNAL   Hum Mol Genet 29 (3), 459-470 (2020)
   PUBMED   31943016
  REMARK    GeneRIF: Combination of whole exome sequencing and animal modeling
            identifies TMPRSS9 as a candidate gene for autism spectrum
            disorder.
REFERENCE   2  (bases 1 to 3454)
  AUTHORS   Hayama,M., Okumura,Y., Takahashi,E., Shimabukuro,A., Tamura,M.,
            Takeda,N., Kubo,T. and Kido,H.
  TITLE     Identification and analysis of the promoter region of the type II
            transmembrane serine protease polyserase-1 and its transcript
            variants
  JOURNAL   Biol Chem 388 (8), 853-858 (2007)
   PUBMED   17655505
  REMARK    GeneRIF: These data suggest that the expression of mpolyserase-1
            and its transcript variants is positively regulated by the E-box in
            its 5'-UTR.
REFERENCE   3  (bases 1 to 3454)
  AUTHORS   Okumura,Y., Hayama,M., Takahashi,E., Fujiuchi,M., Shimabukuro,A.,
            Yano,M. and Kido,H.
  TITLE     Serase-1B, a new splice variant of polyserase-1/TMPRSS9, activates
            urokinase-type plasminogen activator and the proteolytic activation
            is negatively regulated by glycosaminoglycans
  JOURNAL   Biochem J 400 (3), 551-561 (2006)
   PUBMED   16872279
  REMARK    GeneRIF: The isolation and characterization of serase-1B, a splice
            variant of polyserase-1, is reported.
REFERENCE   4  (bases 1 to 3454)
  AUTHORS   Cal,S., Quesada,V., Garabaya,C. and Lopez-Otin,C.
  TITLE     Polyserase-I, a human polyprotease with the ability to generate
            independent serine protease domains from a single translation
            product
  JOURNAL   Proc Natl Acad Sci U S A 100 (16), 9185-9190 (2003)
   PUBMED   12886014
  REMARK    GeneRIF: Figure 6 in the publisher's supporting information shows
            an alignment of the identified (human) and predicted (mouse and
            rat) amino acid sequences.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166937.2 and AC152413.5.
            
            On Dec 5, 2007 this sequence version replaced NM_001081688.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC172169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC166937.2         4745-4892           c
            149-276             AC166937.2         1946-2073           c
            277-344             AC166937.2         922-989             c
            345-520             AC166937.2         590-765             c
            521-562             AC152413.5         135242-135283
            563-676             AC152413.5         136160-136273
            677-848             AC152413.5         137478-137649
            849-1123            AC152413.5         138380-138654
            1124-1260           AC152413.5         139424-139560
            1261-1579           AC152413.5         140272-140590
            1580-1751           AC152413.5         142251-142422
            1752-2023           AC152413.5         143080-143351
            2024-2160           AC152413.5         144385-144521
            2161-2566           AC152413.5         144896-145301
            2567-2738           AC152413.5         147292-147463
            2739-3001           AC152413.5         147938-148200
            3002-3138           AC152413.5         148279-148415
            3139-3454           AC152413.5         149273-149588
FEATURES             Location/Qualifiers
     source          1..3454
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3454
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /note="transmembrane protease, serine 9"
                     /db_xref="GeneID:432478"
                     /db_xref="MGI:MGI:3612246"
     CDS             1..3300
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /note="polyserase-1; polyserine protease-1; polyserase-I"
                     /codon_start=1
                     /product="transmembrane protease serine 9"
                     /protein_id="NP_001075157.2"
                     /db_xref="CCDS:CCDS48641.1"
                     /db_xref="GeneID:432478"
                     /db_xref="MGI:MGI:3612246"
                     /translation="MEPTAPDLQLVPEVTKAVSVSAPDPGPCRTAVIAVVGISMAIVT
                     LGVLSAFFSAQGAHVEHIAELHGIRFTSSLQQENSDFYRLLTHALQTLFVSSFQKTEL
                     ESSCAGCTVLSYRDGNSTVIVHFRLHFLLRALQPLSLKQEADILQKGIQARLQEQGLS
                     LAAYGTIVSVELTGRCEGPVTERDLKSGHCPGNVFSCQNGQCVSKENPECDDRVDCSD
                     ESDEAQCDCGWQPAWRSAGRIVGGVEAAPGEFPWQVSLRENHEHFCGATIIGARWLVS
                     AAHCFNEFQDPAQWAAQAGSVHLSGSEASAVRTRVLRIAKHPAYDADTADFDVAVLEL
                     ARPLPFGRYVQPACLPAATHVFPPGKKCLISGWGYLKEDFLVKPEVLQKATVELLDQS
                     LCSSLYGHSLTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAE
                     ARRPGVYTRVTRLRDWILEVTSAADMPVVPTATPAPATPSTPWPTSPESWAPNTFAKP
                     TAAPSPVPLHPSTTAKPQECGARPAMDKPTRIVGGISAVSGEVPWQASLKEGPRHFCG
                     ATVVGDRWLLSAAHCFNHTKVEQVQAHLGTVSLLGVGGSPVKLGLRRVALHPRYNPGI
                     LDFDVALLELAQPLVFNKYIQPVCLPLAIHKFPVGRKCMISGWGNMQEGNATKPDILQ
                     KASVGIIEQKMCGALYNFSLTDRMLCAGFLEGRVDSCQGDSGGPLACEETPGVFYLAG
                     IVSWGIGCAQAKKPGVYARITRLKDWILKAMSSDPSSMARPHTSSTRLIPSEPPKTTA
                     AGLIIPEATTSRLATPRATIRVTTRPLNTTLSARSTTTRGQTAAPSAPGTTIHSHLPD
                     CGLAPPGALTRIVGGSAASLGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDIY
                     GDPMQWAAFLGTPFLSSTEGQLERVARIYRHPFYNIYTLDYDVALLELAGPVRRSRLV
                     RPICLPGPARPPDGARCVITGWGSLREGGSMARQLQKAAVRVLSEQTCRRFYPVQISS
                     RMLCAGFPQGGVDSCSGDAGGPLACREPSGQWVLTGVTSWGYGCGRPHFPGVYTRVAA
                     VLGWIGQNIQE"
     exon            1..148
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            149..276
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            277..344
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            345..520
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            521..562
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            563..676
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            677..848
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1123
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1260
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1579
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1751
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..2023
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2160
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2566
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2738
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..3001
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3138
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3454
                     /gene="Tmprss9"
                     /gene_synonym="Serase-1B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagccca ctgcaccaga cttacaactt gtgccagagg tgacaaaggc tgtctctgta
       61 tctgctccag accctggccc ttgtcgaacg gctgtcatcg cagtggtggg catcagcatg
      121 gccatcgtga ccctgggagt cctttcagcc ttcttctccg cacagggcgc ccacgtggag
      181 cacatagcag agctacatgg gatccgtttc accagttctt tgcagcagga gaactctgac
      241 ttctaccgcc tactcacgca tgctctgcag acactgtttg tgagtagttt ccagaaaaca
      301 gagttagagt cgagctgcgc aggctgcacc gtgcttagtt acagggatgg caattccact
      361 gtgattgtac atttccggct acactttctg ctccgagccc tccagcccct gagcctgaag
      421 caggaagcag acatcttgca gaaaggaatc caggcaaggc tgcaggaaca aggtctttcc
      481 ctggctgcct atggcaccat cgtgtcagtc gagctgacag gaaggtgtga aggtccggtg
      541 actgagaggg acttaaagtc aggccactgc cccgggaatg tcttctcctg tcagaatggt
      601 cagtgcgtga gcaaagagaa cccggagtgt gatgacagag tggactgctc cgacgagtct
      661 gatgaggctc agtgcgactg cggctggcag cctgcctgga ggtcagctgg caggatcgtg
      721 ggaggagtgg aggcggctcc cggggagttc ccctggcagg tcagtcttcg agagaatcac
      781 gaacacttct gtggcgccac catcatcggt gccaggtggc tggtgtctgc tgcccactgc
      841 ttcaacgaat tccaggaccc tgcgcagtgg gccgcccagg cgggcagtgt gcacctgagc
      901 gggtcagagg ccagcgctgt gcgcacacgc gtgctccgca tagccaagca tcctgcctat
      961 gatgcggaca cagcggactt cgacgtggcg gtgctggagc tggcgcgccc gctgcccttc
     1021 ggacgctatg tgcagcctgc ctgcctcccc gcggccacgc acgtcttccc gccgggcaag
     1081 aagtgtctga tctcgggctg gggttacctg aaagaggact tcctggtgaa gccagaggtc
     1141 cttcagaaag ccacggtgga attgctggac cagagcctgt gttccagcct gtacggccac
     1201 tcgctcaccg acaggatggt gtgtgccggc tacctggacg ggaaggtaga ctcctgccag
     1261 ggggactccg ggggacccct ggtctgcgag gagccttcag gaaggttctt cctggctggt
     1321 atcgtgagct ggggaatcgg ctgcgcagaa gcgcggcgcc caggggtcta cacccgagtc
     1381 accaggctgc gggattggat cttggaggtg accagcgctg ctgacatgcc tgtggtcccc
     1441 accgcgactc cagcgcccgc cacccccagc actccctggc ctaccagccc tgagagctgg
     1501 gcgcccaaca cctttgccaa acccaccgct gcccccagcc ctgtgccact gcaccccagc
     1561 actacggcca agccacaaga gtgtggggcc agacccgcca tggacaagcc cactcggatt
     1621 gtgggcggga tcagcgccgt gtctggggag gtgccctggc aggccagcct gaaggaagga
     1681 cccagacatt tctgcggagc caccgtggtg ggtgaccgct ggctgctgtc tgccgcccac
     1741 tgtttcaacc acaccaaagt ggagcaggtg caggcgcacc tgggcaccgt gtccctgctg
     1801 ggtgtcggcg ggagccccgt gaaactgggg ctccgaaggg tggccctgca tccccgctac
     1861 aacccaggaa tcctggactt tgacgtggcc ctgctggagt tagcccagcc attggtcttc
     1921 aacaagtaca tccaaccggt ttgtctgccc ctggccatcc acaagttccc agtcggccgg
     1981 aagtgtatga tctcaggctg gggcaacatg caggagggaa atgccaccaa gcctgacatc
     2041 ttgcagaagg cgtccgtggg catcatagag cagaagatgt gtggagccct gtacaacttc
     2101 tccctcactg accgcatgct ctgtgctggc ttcctggagg gcagagttga ctcctgccag
     2161 ggtgattctg gtggcccctt ggcatgtgaa gagacacctg gtgtctttta cctggctggc
     2221 atcgtgagct ggggcattgg ctgtgcccag gctaagaagc ctggcgtata tgcacgaatc
     2281 acacgcctca aggactggat cctgaaagcg atgtcctcag accccagctc catggctcgc
     2341 ccccacacct ccagcacacg gctcatccct agtgagcccc ccaaaaccac agctgctggc
     2401 ctcattatcc cagaggccac caccagcaga cttgctaccc ccagggccac catcagagtg
     2461 accactagac cactcaacac aacactgtct gccaggagta ccaccaccag gggacagaca
     2521 gcagccccaa gtgcaccggg caccaccata cactctcacc tgccagattg tggcctggca
     2581 ccccccgggg ccctgacccg gatagtgggc ggcagcgcag cctcgcttgg ggagtggccc
     2641 tggcaagtga gcctgtggct gcggcgcagg gagcaccgat gtggggcggt actggtggcc
     2701 gagaggtggc ttctgtctgc agcacactgt ttcgacatct atggggaccc tatgcagtgg
     2761 gcggccttcc tgggcacccc attcctgagc agcacggagg gccagttgga gcgcgtggca
     2821 cgcatctatc gccacccgtt ctacaacatc tacacactgg actatgacgt ggcactgctg
     2881 gagctggcgg gacccgtgcg ccgcagccgc ttggtgcgac ccatctgcct accaggtccc
     2941 gcaaggcccc ctgacggcgc tcgatgcgtc atcaccggct ggggctcgct gcgcgaggga
     3001 ggctccatgg cgcggcagct gcagaaggcc gcagtaaggg tcctcagtga acagacatgt
     3061 cgccgcttct acccagtgca gatcagcagc cgtatgttgt gtgcaggctt cccacagggt
     3121 ggcgtggaca gctgctcggg tgatgcaggg ggacccctgg cctgcaggga gccatctggc
     3181 caatgggtgc taactggggt caccagctgg ggctacggct gtggcaggcc ccacttccca
     3241 ggtgtctaca ctcgagtggc tgctgtgctg ggatggatag gccagaacat ccaggaatga
     3301 ttgccctgtg gctagcaacc caggcgtgga ctgagaaaca cagctacggg ccacccaccc
     3361 cacgctgagg agttggtagc aggcaaacat gggagtccga tgggaactag ctgtgactgt
     3421 gtatattgtt ccaataaaca gagtcctttc tcct
//
