LOCUS       NM_027902               3206 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus transmembrane serine protease 6 (Tmprss6), transcript
            variant 1, mRNA.
ACCESSION   NM_027902
VERSION     NM_027902.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3206)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3206)
  AUTHORS   Zuo,Y., Bai,J., Bai,H., Tian,S., Sun,H., Shi,Z., Yu,P., Gao,G.,
            Li,Y. and Chang,Y.Z.
  TITLE     Transmembrane serine protease 6, a novel target for inhibition of
            neuronal tumor growth
  JOURNAL   Cell Death Dis 15 (1), 49 (2024)
   PUBMED   38218852
  REMARK    GeneRIF: Transmembrane serine protease 6, a novel target for
            inhibition of neuronal tumor growth.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3206)
  AUTHORS   Li,X., Lozovatsky,L., Tommasini,S.M., Fretz,J. and Finberg,K.E.
  TITLE     Bone marrow sinusoidal endothelial cells are a site of Fgf23
            upregulation in a mouse model of iron deficiency anemia
  JOURNAL   Blood Adv 7 (17), 5156-5171 (2023)
   PUBMED   37417950
REFERENCE   4  (bases 1 to 3206)
  AUTHORS   Hanudel,M.R., Czaya,B., Wong,S., Rappaport,M., Namjoshi,S.,
            Chua,K., Jung,G., Gabayan,V., Qiao,B., Nemeth,E. and Ganz,T.
  TITLE     Enteral ferric citrate absorption is dependent on the iron
            transport protein ferroportin
  JOURNAL   Kidney Int 101 (4), 711-719 (2022)
   PUBMED   34838540
REFERENCE   5  (bases 1 to 3206)
  AUTHORS   Asperti,M., Brilli,E., Denardo,A., Gryzik,M., Pagani,F., Busti,F.,
            Tarantino,G., Arosio,P., Girelli,D. and Poli,M.
  TITLE     Iron distribution in different tissues of homozygous Mask (msk/msk)
            mice and the effects of oral iron treatments
  JOURNAL   Am J Hematol 96 (10), 1253-1263 (2021)
   PUBMED   34343368
REFERENCE   6  (bases 1 to 3206)
  AUTHORS   Du,X., She,E., Gelbart,T., Truksa,J., Lee,P., Xia,Y.,
            Khovananth,K., Mudd,S., Mann,N., Moresco,E.M., Beutler,E. and
            Beutler,B.
  TITLE     The serine protease TMPRSS6 is required to sense iron deficiency
  JOURNAL   Science 320 (5879), 1088-1092 (2008)
   PUBMED   18451267
  REMARK    GeneRIF: findings show that TMPRSS6 is an essential component of a
            pathway that detects iron deficiency and blocks Hamp transcription,
            permitting enhanced dietary iron absorption
REFERENCE   7  (bases 1 to 3206)
  AUTHORS   Ramsay,A.J., Reid,J.C., Velasco,G., Quigley,J.P. and Hooper,J.D.
  TITLE     The type II transmembrane serine protease
            matriptase-2--identification, structural features, enzymology,
            expression pattern and potential roles
  JOURNAL   Front Biosci 13, 569-579 (2008)
   PUBMED   17981570
  REMARK    GeneRIF: identification, structural features, enzymology,
            expression pattern and potential roles of TMPRSS6 [review]
            Review article
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3206)
  AUTHORS   Kim,T.S., Heinlein,C., Hackman,R.C. and Nelson,P.S.
  TITLE     Phenotypic analysis of mice lacking the Tmprss2-encoded protease
  JOURNAL   Mol Cell Biol 26 (3), 965-975 (2006)
   PUBMED   16428450
REFERENCE   9  (bases 1 to 3206)
  AUTHORS   Hooper,J.D., Campagnolo,L., Goodarzi,G., Truong,T.N., Stuhlmann,H.
            and Quigley,J.P.
  TITLE     Mouse matriptase-2: identification, characterization and
            comparative mRNA expression analysis with mouse hepsin in adult and
            embryonic tissues
  JOURNAL   Biochem J 373 (Pt 3), 689-702 (2003)
   PUBMED   12744720
  REMARK    GeneRIF: identification, characterization and comparative mRNA
            expression analysis with mouse hepsin in adult and embryonic
            tissues
REFERENCE   10 (bases 1 to 3206)
  AUTHORS   Netzel-Arnett,S., Hooper,J.D., Szabo,R., Madison,E.L.,
            Quigley,J.P., Bugge,T.H. and Antalis,T.M.
  TITLE     Membrane anchored serine proteases: a rapidly expanding group of
            cell surface proteolytic enzymes with potential roles in cancer
  JOURNAL   Cancer Metastasis Rev 22 (2-3), 237-258 (2003)
   PUBMED   12784999
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB872026.1 and AY240929.1.
            
            On Feb 13, 2007 this sequence version replaced NM_027902.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029645.1, AK004939.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BB872026.1         2-24
            24-3206             AY240929.1         1-3183
FEATURES             Location/Qualifiers
     source          1..3206
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.49 cM"
     gene            1..3206
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /note="transmembrane serine protease 6"
                     /db_xref="GeneID:71753"
                     /db_xref="MGI:MGI:1919003"
     exon            1..209
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            210..444
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            445..578
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            579..646
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            647..825
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            826..867
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1072
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1209
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1322
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1432
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1578
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1677
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1791
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1908
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2077
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2349
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2486
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..3192
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3162..3167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3186
                     /gene="Tmprss6"
                     /gene_synonym="1300008A22Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtttcattg tcgccctgga cctgacagga gaggcccatg gaacttgggg ccacaggcca
       61 caagggacaa gggccagaca ccccagccat ggctccaggc cattgatcca acctaagctg
      121 gccagttggg ggtggaaaga ccttggcctg gataaacaga ggcctccagg cctgtgtgca
      181 ggcccggcac ctaccttcca ctcttgaaga tgccgagatg tttccagctc ccctgttcta
      241 ccaggatgcc caccaccgag gtcccccaag cggctgatgg tcagggcgat gcgggtgatg
      301 gagaggaagc tgctgagcca gaggggaagt tcaagccccc aaaaaacacc aagagaaaaa
      361 accgggacta cgtccgcttc acgccactgt tgctggtctt ggctgcgctg gtctcagcag
      421 gggtcatgct ttggtatttc ctagggtaca aagcggaagt gaccgtaagc caggtgtact
      481 ctggcagcct ccgggtgctc aaccgtcatt tctcccagga cctgggccga cgggagtcta
      541 ttgctttccg cagtgaatct gccaaagccc agaagatgct ccaagaactg gttgccagca
      601 cccgcctggg tacttactac aactctagtt ctgtctactc ctttggggag ggacccctca
      661 cctgcttctt ctggtttatc cttgacatcc ctgagtacca gcgactgacc ctgagccctg
      721 aagtagtgcg cgagctcctg gtggatgagc tactgtccaa cagctcaacc ctggcttcct
      781 ataagaccga atatgaggtg gacccggaag gcctggtgat cctggaagcc agtgtgaacg
      841 acatagtcgt actgaattcc acgctgggct gttatcgcta cagctatgtg aacccaggcc
      901 aggtcctccc attgaagggg cctgaccagc agaccacaag ctgcctgtgg catctgcaag
      961 ggcccgaaga cctcatgatc aaagtgcggc tggagtggac ccgggtcgat tgcagagaca
     1021 gggtggcgat gtacgacgca gctgggcccc tggagaagag acttatcacc tcggtctatg
     1081 ggtgcagccg ccaggaacct gtgatggagg tgctggcatc gggctccgtc atggccgtgg
     1141 tgtggaaaaa gggcatgcat agctactatg accctttcct gctctcagtg aagtctgtgg
     1201 ccttccagga ctgccaggtg aacctgacac tggagggccg gctggacaca cagggcttcc
     1261 tccgtacacc ctactacccc agttactact ctcccagtac ccactgctcc tggcatctca
     1321 cggtaccctc tctggactac ggcttggcgc tctggttcga tgcctacgca ctgaggaggc
     1381 agaagtacaa ccgactgtgt actcagggcc agtggatgat ccagaacagg aggctgtgtg
     1441 gcttccgtac cctgcagcca tatgctgaga ggatccccat ggtggcctca gatggtgtca
     1501 ccatcaactt cacctcccag atctccctca caggcccggg tgtgcaagtg tactacagct
     1561 tgtacaacca atcagacccc tgccctggtg agttcctctg ctctgtgaat ggactgtgtg
     1621 tccctgcgtg tgacgggatc aaggactgcc ccaatggcct ggatgagaga aactgtgtct
     1681 gcagagccat gttccagtgc caagaggaca gcacgtgcat ttcactgcct agagtctgtg
     1741 accggcagcc cgactgtctc aatggcagtg acgaagaaca gtgccaagaa ggagtgccct
     1801 gtgggacatt cactttccag tgtgaggacc ggagctgtgt gaagaagccc aacccagagt
     1861 gtgacggcca gtcagattgc agagacggct cagatgagca acactgtgac tgtggcctcc
     1921 agggcctctc cagccgtatt gtgggcggga ccgtgtcctc cgagggtgag tggccatggc
     1981 aggccagcct ccagattcgg ggtcgacaca tctgtggggg ggctctcatc gctgaccgct
     2041 gggtcataac ggccgcccac tgcttccagg aggacagcat ggcctccccg aagctgtgga
     2101 ccgtgttcct gggaaagatg cggcagaact cgcgctggcc aggcgaggtg tccttcaagg
     2161 tgagccgtct gttcctgcac ccgtaccacg aggaggacag ccatgactac gacgtggccc
     2221 tgctgcagct cgaccacccc gtggtgtact cggccactgt gcgccccgtc tgcctgcctg
     2281 cccgctccca cttctttgag ccaggccagc actgctggat cacaggctgg ggagcccagc
     2341 gagagggtgg tccggtgagc aacaccctgc agaaggtgga cgtacagctg gtccctcagg
     2401 acctctgcag tgaggcctac cgctaccagg tgtccccacg catgctctgt gctggctacc
     2461 gcaagggcaa gaaagatgcc tgccagggtg actctggagg cccactggtt tgcagggagc
     2521 ccagtggccg ctggttcctg gcagggttgg ttagctgggg cctgggctgt ggccgaccca
     2581 atttctttgg cgtctacacc cgtgtcacac gtgtgatcaa ctggatccag caggtgctga
     2641 cctgagggct gttctacaga gctggacctg cctccaggcc aagttcaggg tgtccaccca
     2701 gccaggacac aagtattctg gggcaagtga ccctgctaag gcctgtttcc ctcaggccta
     2761 ccccagtgac agtacagaga aggatgtcag ctggtggtta ggatgcctcc tgaggtccag
     2821 gggccagcct cggctaggtt tcacttctaa ccctttctta ttctagtcct ttcccctccc
     2881 tgctcctacc actgttttgg agtggggtct ggcggccatg accttggcct ccgggtctct
     2941 gtaggaaaga aagaatcctt ccccttgcaa aagcctcttg ggggaactgc acagagaaag
     3001 aaggtgcctc tatcaaggct ctatcagagc ccttgagtct gccaagtggg ctgtactcta
     3061 agccaaatca ccgggcagcc tcagctgcag atgcctgctg aagctctgcc tgctacaggg
     3121 gcctccctgc cattcactgg aggcccactg tctgttctgg gaataaagca cttgaccaag
     3181 ccctgacact gaaaaaaaaa aaaaaa
//
