LOCUS       NM_015775               3175 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transmembrane protease, serine 2 (Tmprss2), mRNA.
ACCESSION   NM_015775
VERSION     NM_015775.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3175)
  AUTHORS   Liu,H., Brostoff,T., Ramirez,A., Wong,T., Rowland,D.J., Heffner,M.,
            Flores,A., Willis,B., Evans,J.J., Lanoue,L., Lloyd,K.C.K. and
            Coffey,L.L.
  TITLE     Establishment and characterization of an hACE2/hTMPRSS2 knock-in
            mouse model to study SARS-CoV-2
  JOURNAL   Front Immunol 15, 1428711 (2024)
   PUBMED   39050847
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3175)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3175)
  AUTHORS   Pakula,H., Omar,M., Carelli,R., Pederzoli,F., Fanelli,G.N.,
            Pannellini,T., Socciarelli,F., Van Emmenis,L., Rodrigues,S.,
            Fidalgo-Ribeiro,C., Nuzzo,P.V., Brady,N.J., Dinalankara,W.,
            Jere,M., Valencia,I., Saladino,C., Stone,J., Unkenholz,C.,
            Garner,R., Alexanderani,M.K., Khani,F., de Almeida,F.N.,
            Abate-Shen,C., Greenblatt,M.B., Rickman,D.S., Barbieri,C.E.,
            Robinson,B.D., Marchionni,L. and Loda,M.
  TITLE     Distinct mesenchymal cell states mediate prostate cancer
            progression
  JOURNAL   Nat Commun 15 (1), 363 (2024)
   PUBMED   38191471
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3175)
  AUTHORS   Rickman,O.J., Guignard,E., Chabanon,T., Bertoldi,G., Auberson,M.
            and Hummler,E.
  TITLE     Tmprss2 maintains epithelial barrier integrity and transepithelial
            sodium transport
  JOURNAL   Life Sci Alliance 7 (3), e202302304 (2024)
   PUBMED   38171596
  REMARK    GeneRIF: Tmprss2 maintains epithelial barrier integrity and
            transepithelial sodium transport.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3175)
  AUTHORS   Zhang,W., Golynker,I., Brosh,R., Fajardo,A., Zhu,Y.,
            Wudzinska,A.M., Ordonez,R., Ribeiro-Dos-Santos,A.M., Carrau,L.,
            Damani-Yokota,P., Yeung,S.T., Khairallah,C., Vela Gartner,A.,
            Chalhoub,N., Huang,E., Ashe,H.J., Khanna,K.M., Maurano,M.T.,
            Kim,S.Y., tenOever,B.R. and Boeke,J.D.
  TITLE     Mouse genome rewriting and tailoring of three important disease
            loci
  JOURNAL   Nature 623 (7986), 423-431 (2023)
   PUBMED   37914927
REFERENCE   6  (bases 1 to 3175)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 3175)
  AUTHORS   Pletcher,M.T., Wiltshire,T., Cabin,D.E., Villanueva,M. and
            Reeves,R.H.
  TITLE     Use of comparative physical and sequence mapping to annotate mouse
            chromosome 16 and human chromosome 21
  JOURNAL   Genomics 74 (1), 45-54 (2001)
   PUBMED   11374901
REFERENCE   8  (bases 1 to 3175)
  AUTHORS   Jacquinet,E., Rao,N.V., Rao,G.V., Zhengming,W., Albertine,K.H. and
            Hoidal,J.R.
  TITLE     Cloning and characterization of the cDNA and gene for human
            epitheliasin
  JOURNAL   Eur J Biochem 268 (9), 2687-2699 (2001)
   PUBMED   11322890
REFERENCE   9  (bases 1 to 3175)
  AUTHORS   Vaarala,M.H., Porvari,K.S., Kellokumpu,S., Kyllonen,A.P. and
            Vihko,P.T.
  TITLE     Expression of transmembrane serine protease TMPRSS2 in mouse and
            human tissues
  JOURNAL   J Pathol 193 (1), 134-140 (2001)
   PUBMED   11169526
REFERENCE   10 (bases 1 to 3175)
  AUTHORS   Jacquinet,E., Rao,N.V., Rao,G.V. and Hoidal,J.R.
  TITLE     Cloning, genomic organization, chromosomal assignment and
            expression of a novel mosaic serine proteinase: epitheliasin
  JOURNAL   FEBS Lett 468 (1), 93-100 (2000)
   PUBMED   10683448
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC054348.1.
            
            On Aug 28, 2003 this sequence version replaced NM_015775.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054348.1, AK141350.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3175
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 57.53 cM"
     gene            1..3175
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /note="transmembrane protease, serine 2"
                     /db_xref="GeneID:50528"
                     /db_xref="MGI:MGI:1354381"
     exon            1..177
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /inference="alignment:Splign:2.1.0"
     exon            178..245
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..1703
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /EC_number="3.4.21.122"
                     /note="plasmic transmembrane protein X; epitheliasin"
                     /codon_start=1
                     /product="transmembrane protease serine 2"
                     /protein_id="NP_056590.2"
                     /db_xref="CCDS:CCDS37417.1"
                     /db_xref="GeneID:50528"
                     /db_xref="MGI:MGI:1354381"
                     /translation="MALNSGSPPGIGPCYENHGYQSEHICPPRPPVAPNGYNLYPAQY
                     YPSPVPQYAPRITTQASTSVIHTHPKSSGALCTSKSKKSLCLALALGTVLTGAAVAAV
                     LLWRFWDSNCSTSEMECGSSGTCISSSLWCDGVAHCPNGEDENRCVRLYGQSFILQVY
                     SSQRKAWYPVCQDDWSESYGRAACKDMGYKNNFYSSQGIPDQSGATSFMKLNVSSGNV
                     DLYKKLYHSDSCSSRMVVSLRCIECGVRSVKRQSRIVGGLNASPGDWPWQVSLHVQGV
                     HVCGGSIITPEWIVTAAHCVEEPLSSPRYWTAFAGILRQSLMFYGSRHQVEKVISHPN
                     YDSKTKNNDIALMKLQTPLAFNDLVKPVCLPNPGMMLDLDQECWISGWGATYEKGKTS
                     DVLNAAMVPLIEPSKCNSKYIYNNLITPAMICAGFLQGSVDSCQGDSGGPLVTLKNGI
                     WWLIGDTSWGSGCAKALRPGVYGNVTVFTDWIYQQMRANS"
     exon            246..465
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /inference="alignment:Splign:2.1.0"
     exon            466..552
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /inference="alignment:Splign:2.1.0"
     exon            553..672
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /inference="alignment:Splign:2.1.0"
     exon            673..799
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /inference="alignment:Splign:2.1.0"
     exon            800..910
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /inference="alignment:Splign:2.1.0"
     exon            911..954
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1123
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1299
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1395
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1538
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1691
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..3161
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3139..3144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /note="hexamer: AATAAA"
     polyA_site      3161
                     /gene="Tmprss2"
                     /gene_synonym="D16Ertd61e"
                     /note="major polyA site"
ORIGIN      
        1 gcctttcctg gccgttccct ccttctggcc gaggtgcctg cgtttagggg tgtcaccctg
       61 gctcccggga cgccgcctcc ggagatttaa gcgagaactg gagtaggtcg tgtacttgga
      121 gcggacgagg aagccaagag ctcggacaga ggcggagagg ggcgggaagc gcaacaggtc
      181 acctggagga agccccatac tgacctcctc atgctgctga cacaggcagg atggcattga
      241 actcagggtc acctccagga atcggacctt gctatgagaa ccacgggtat cagtctgagc
      301 acatctgtcc tccgagacca ccagtggctc ccaatggcta caacttgtat ccagcccagt
      361 actacccatc tccagtgcct cagtatgctc cgaggattac aacgcaagcc tcaacatctg
      421 tcatccacac acatcccaag tcctcaggag cactgtgcac ctcaaagtct aagaaatcgc
      481 tgtgtttagc cctcgccctg ggcactgtcc tcacgggagc tgctgtggct gctgtcttgc
      541 tttggaggtt ctgggacagc aactgttcta cgtctgagat ggagtgtggg tcttcaggca
      601 catgcatcag ctcttctctc tggtgtgacg gggtagcaca ttgtcccaac ggagaagatg
      661 agaaccgttg tgttcgtctc tacggacaaa gcttcatcct ccaggtttac tcatctcaga
      721 ggaaagcctg gtatcccgtg tgccaggatg attggagtga gagctacggg agagcagcat
      781 gtaaagacat gggatacaag aacaattttt attctagcca agggatacca gaccagagcg
      841 gggcaacgag ctttatgaag ctgaatgtga gctcaggcaa cgttgacctc tataaaaaac
      901 tctaccacag tgactcatgt tcatcccgca tggtggtttc tttgcgctgt atagaatgcg
      961 gggttcgctc agtgaaacgc cagagcagga ttgtgggtgg attgaatgcc tcaccaggag
     1021 actggccctg gcaggtcagc ctgcacgtcc aaggcgtcca cgtctgcgga ggctccatca
     1081 tcacccccga gtggattgtg acggccgccc actgtgtgga agaacccctc agcagcccga
     1141 ggtactggac ggcatttgcg ggaattctga gacagtctct catgttctat ggaagtagac
     1201 accaggtaga aaaagtaatt tcccatccaa attacgactc taagaccaag aataacgaca
     1261 ttgctctcat gaagctgcag acacctttgg cttttaatga tctagtgaag ccagtgtgtc
     1321 tgccgaaccc aggcatgatg ctagacctag accaggaatg ctggatttcg gggtgggggg
     1381 ccacctatga gaaagggaag acctcggacg tgttgaatgc tgccatggta cccttgatcg
     1441 agccctccaa atgtaatagt aaatacatat acaacaacct aatcacacca gccatgatct
     1501 gtgccggctt cctccagggg tctgtcgact cttgccaggg agacagtgga gggccgctgg
     1561 ttactttgaa gaatgggatc tggtggctga ttggggacac gagctggggc tcgggctgtg
     1621 ccaaggcact cagacctgga gtatacggga acgtgacggt atttacagat tggatctacc
     1681 agcaaatgag ggcgaacagc taatccacgt ggctttgtcc cagacttcct ttgtcttcaa
     1741 caaccttctg caagaaaacc aagggcctga attttaactt cctgtgcaca atgtaccttt
     1801 tgagatgatt cgaagggcct ttcactttta ttaaacagtg acttgtttga ctgtgctccc
     1861 tggtcctgtg agggcttcag tgccccaccc ctgggccact tctgcagctc ccaccagaat
     1921 ggatgaccag attctgttgg gtttgggcac atagggccaa aggcagagga gggtggcact
     1981 ctcatgttgg aacttctttt gggctcatgc tcaggccttt tttggatcac taaggactat
     2041 gacctctgag taacctgatg acctgagaaa gagtaaggag gccaggcagg gccttgggcc
     2101 caggaacagg taccttgaga gtgagagcta cccattgcct gtggcctaaa tctgctgtgc
     2161 aggttgggct ggtcatactg tcatgatttc attaacagcc tgggtgaaca tggctgggag
     2221 taaagggctt gctctcctgc atgttgacat gacggccctt tccaagggtg atggaggctt
     2281 tcccaagcta agggcctagg cagatctctc agagcaagaa gctaatgccg gcatgtccct
     2341 tgggtgagct ctacatggtg ttattcagtc tggttcttgg ctccccacta ctgtttctct
     2401 cagcctctca gagcctgaaa cttacctctt agctttggct acaggcatgg cctagtacct
     2461 gatggagcct gtatagctca gctaatcaaa tggaggctca ggtccatcag aatcagggac
     2521 ttgtgatttc agtcaccttg cttctgggtt gtgtttcttc tcttactacc tcactgcacc
     2581 tggacactag agtggatgaa tgtctggagt tcacctgcat ttggactgtg tgattgtgcc
     2641 tcagacacta gacctcttcc agatggttag gttgttctgt agactggcaa tgagattaga
     2701 agttcctagc ttcagataaa gatgaaagag aggagatcat tgtcttctgt cttcttctgg
     2761 ccctgggttt ataccaggaa agccatgcca gaattaccaa atatgaagta tgaatgtctt
     2821 acccacggtg aggctctgcc tccttctctc tgcctggttc ttcagaaggc agtgaatggg
     2881 tcataactgg gactccatct ttgctgggga aagtctccca cctagggaat ggttaccact
     2941 ccatgtaaag aaaactccct catgcgtcct ctgggacctt cttagatgct gtaaggtacc
     3001 tacatacaga ctaaatgtgc aagcaccttg aagtgtgaga acctgtcccc tccttagctc
     3061 tccttgtctt tgctgttggt tggttatttc ctgctttgtg tctgttctga gctgtgagat
     3121 tccactgtga aatatatgaa taaagtatat aattctttta aaaaaaaaaa aaaaa
//
