LOCUS       NM_008941               4185 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus transmembrane protease, serine 15 (Tmprss15),
            transcript variant 1, mRNA.
ACCESSION   NM_008941
VERSION     NM_008941.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4185)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4185)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4185)
  AUTHORS   Zhao,Y., Jin,M., Ma,J., Zhang,S., Li,W., Chen,Y., Zhou,Y., Tao,H.,
            Liu,Y., Wang,L., Han,H., Niu,G., Tao,H., Liu,C. and Gao,B.
  TITLE     Inhibition effect of enteropeptidase on RANKL-RANK signalling by
            cleavage of RANK
  JOURNAL   FEBS Lett 587 (18), 2958-2964 (2013)
   PUBMED   23954298
  REMARK    GeneRIF: Enteropeptidase could inhibit osteoclastogenesis in vitro
            through the cleavage of RANK.
REFERENCE   4  (bases 1 to 4185)
  AUTHORS   Kierstein,S., Noyes,H., Naessens,J., Nakamura,Y., Pritchard,C.,
            Gibson,J., Kemp,S. and Brass,A.
  TITLE     Gene expression profiling in a mouse model for African
            trypanosomiasis
  JOURNAL   Genes Immun 7 (8), 667-679 (2006)
   PUBMED   17066074
REFERENCE   5  (bases 1 to 4185)
  AUTHORS   Yuan,X., Zheng,X., Lu,D., Rubin,D.C., Pung,C.Y. and Sadler,J.E.
  TITLE     Structure of murine enterokinase (enteropeptidase) and expression
            in small intestine during development
  JOURNAL   Am J Physiol 274 (2), G342-G349 (1998)
   PUBMED   9486188
REFERENCE   6  (bases 1 to 4185)
  AUTHORS   Light,A. and Janska,H.
  TITLE     The amino-terminal sequence of the catalytic subunit of bovine
            enterokinase
  JOURNAL   J Protein Chem 10 (5), 475-480 (1991)
   PUBMED   1799406
  REMARK    GeneRIF: peptide sequencing of amino terminus of light chain of cow
            enterokinase, identifying the cleavage site
REFERENCE   7  (bases 1 to 4185)
  AUTHORS   Arsenault,P. and Menard,D.
  TITLE     Development of enteropeptidase activity in mouse small intestine:
            influence of hormones
  JOURNAL   Can J Physiol Pharmacol 63 (5), 472-475 (1985)
   PUBMED   3899338
REFERENCE   8  (bases 1 to 4185)
  AUTHORS   Isobe,M. and Ogita,Z.
  TITLE     Two-dimensional gel analysis of zymogen-activating factors in the
            small intestine of the mouse
  JOURNAL   J Exp Zool 231 (1), 19-26 (1984)
   PUBMED   6381640
REFERENCE   9  (bases 1 to 4185)
  AUTHORS   Isobe,M. and Ogita,Z.
  TITLE     Electrophoretic analysis of pancreatic proteases and
            zymogen-activating factors in the mouse
  JOURNAL   J Exp Zool 230 (3), 347-354 (1984)
   PUBMED   6379096
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112257.5 and AC161815.4.
            
            On Dec 21, 2022 this sequence version replaced NM_008941.3.
            
            Summary: This gene encodes an enzyme that proteolytically activates
            the pancreatic proenzyme trypsinogen, converting it into trypsin.
            The encoded protein is cleaved into two chains that form a
            heterodimer linked by a disulfide bond. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: U73378.1, BC117918.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849377,
                                           SAMN00849378 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-328               AC112257.5         102620-102947
            329-459             AC112257.5         105827-105957
            460-527             AC112257.5         106204-106271
            528-679             AC112257.5         114620-114771
            680-724             AC112257.5         117900-117944
            725-760             AC112257.5         120508-120543
            761-805             AC112257.5         122275-122319
            806-850             AC112257.5         122424-122468
            851-982             AC112257.5         131452-131583
            983-1091            AC112257.5         136001-136109
            1092-1198           AC112257.5         139580-139686
            1199-1339           AC161815.4         4472-4612
            1340-1489           AC161815.4         5369-5518
            1490-1595           AC161815.4         14864-14969
            1596-1746           AC161815.4         15284-15434
            1747-1882           AC161815.4         18201-18336
            1883-1972           AC161815.4         33504-33593
            1973-2098           AC161815.4         36274-36399
            2099-2239           AC161815.4         37846-37986
            2240-2350           AC161815.4         51969-52079
            2351-2483           AC161815.4         53716-53848
            2484-2579           AC161815.4         67448-67543
            2580-2629           AC161815.4         71407-71456
            2630-2816           AC161815.4         71599-71785
            2817-2998           AC161815.4         77528-77709
            2999-3094           AC161815.4         79088-79183
            3095-3237           AC161815.4         82271-82413
            3238-4185           AC161815.4         85768-86715
FEATURES             Location/Qualifiers
     source          1..4185
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 45.41 cM"
     gene            1..4185
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /note="transmembrane protease, serine 15"
                     /db_xref="GeneID:19146"
                     /db_xref="MGI:MGI:1197523"
     exon            1..328
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..3393
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /EC_number="3.4.21.9"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protease, serine, 7 (enterokinase);
                     enteropeptidase"
                     /codon_start=1
                     /product="enteropeptidase isoform 1 precursor"
                     /protein_id="NP_032967.1"
                     /db_xref="CCDS:CCDS28280.1"
                     /db_xref="GeneID:19146"
                     /db_xref="MGI:MGI:1197523"
                     /translation="MKSSRDEAVGHHSISSFEVMLSALFIMLMVFSIGLIAVSWLAVK
                     ESEGDAALGKSHEVRGTFKITSGVTYNPNLQDKHSVDFKVLAFDLQQMIDEIFESSSL
                     KNEYEKSKVFQFEKGSVIVLFDLFFAQWVSDKNVKEELIQGIEANISSQLVTLHIDLN
                     SIDITASLSDFTTAVPVTTSDKLTTSSPMTTSASLGNLSTTVAATTSAPLCNLSTATF
                     ATTSGHVSIECQPGSRPCAHAWNCVATDLFCDGEVNCPDGSDEDTGLCATACDGRFLL
                     TGDSGVFQADRYPRPDESGVVCRWIIRVNQGLSIRMNFGSFIPHYTDVLDIYEGIGPS
                     KILRGSFWETDPGTIRIFSNLVTVTFLIKSDEYDYIGFNATYSTFNNSELNNYEKIDC
                     TFDDGFCFWTQDLDDDNEWERIQVTTFPCYTGPRFDHTYGNGSGFYISTPTEQGWRSE
                     RVGLSSLSLDLTSEPVCLHFWYYMCCENVYNLNIHISSAETTDKIVFQRKGNYGRNWN
                     YGQVTLNETGEFKVVFNAFRNRGCSTIALDDISLTNGICSQSPYPEPTLVPTPPPELP
                     TDCGGPFELWEPNSTFSSPNFPDKYPNQASCIWNLNAQRGKNIQLHFQEFDLENINDV
                     VEVRDGGEFDSLLLAVYTGPGPVKDLFSTTNRMTVIFTTNMETRRKGFKANFTSGYYL
                     GIPEPCQDDEFQCKDGNCIPLGNLCDSYPHCRDGSDEASCVRFLNGTRSNNGLVQFNI
                     HSIWHIACAENWTTQISNEVCHLLGLGSANSSMPISSTGGGPFVRVNQAPNGSLILTP
                     SLQCSQDSLILLQCNHKSCGEKKVTQKVSPKIVGGSDAQAGAWPWVVALYHRDRSTDR
                     LLCGASLVSSDWLVSAAHCVYRRNLDPTRWTAVLGLHMQSNLTSPQVVRRVVDQIVIN
                     PHYDRRRKVNDIAMMHLEFKVNYTDYIQPICLPEENQIFIPGRTCSIAGWGYDKINAG
                     STVDVLKEADVPLISNEKCQQQLPEYNITESMICAGYEEGGIDSCQGDSGGPLMCQEN
                     NRWFLVGVTSFGVQCALPNHPGVYVRVSQFIEWIHSFLH"
     exon            329..459
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            460..527
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            528..679
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            680..724
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            725..760
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            761..805
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            806..850
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            851..982
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1091
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1198
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1339
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1489
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1595
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1746
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1882
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..1972
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2098
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2239
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2350
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2483
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2579
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2629
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2816
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2998
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            2999..3094
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3237
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
     exon            3238..4185
                     /gene="Tmprss15"
                     /gene_synonym="Entk; Prss7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accatttcca gagacacgca gcagactcac agtgaagact cccaacatta gcttgaatgg
       61 ttgacgactt cagaatcctt aggaacttga gaggttttac tctctagttc atatcagagt
      121 atccattttg ttgatgtgga aaactacatt ttctcacagt tcctagcact caaaaatcaa
      181 aaaatgaaat ccagcagaga cgaggctgta ggacatcact ctatcagctc ttttgaagtg
      241 atgctctcag ctctcttcat tatgctcatg gtcttctcta ttggattaat tgcagtgtcc
      301 tggcttgcag tcaaggaatc tgaaggagat gcagccctgg ggaaaagtca tgaagtcaga
      361 gggacattta aaataacatc tggagtgaca tataatccta atttacaaga caaacactct
      421 gtggatttca aagttcttgc ttttgacctt cagcaaatga tagacgagat ctttgaatca
      481 agtagtctga agaatgaata tgaaaaatcg aaggtttttc aatttgaaaa aggcagcgtt
      541 attgtcctct ttgacctctt ttttgctcag tgggtgtcag ataaaaatgt aaaagaagaa
      601 ctgattcagg gcattgaagc aaatatatcc agccaactgg tcactctcca tattgatttg
      661 aacagcattg atatcacagc atccttgagt gacttcacaa cagcagtccc tgtaacaact
      721 tcagataagc taacaaccag cagtcctatg acaacttcag catcactggg taacttatca
      781 acaacagtgg ctgcaacaac ttcagcacca ttgtgtaatt tatcaacagc aacttttgca
      841 acaacttcag gccatgtctc aatagagtgc cagcctggtt cacggccctg tgctcatgct
      901 tggaactgtg tagcaactga tttgttttgt gatggagaag tgaactgtcc agatggttca
      961 gatgaagaca ctgggctatg tgccacagct tgtgatggaa gatttttgtt gactggagat
     1021 tctggggttt tccaagctga tcgttatcca aggccagatg aatcaggtgt tgtttgccga
     1081 tggatcatcc gtgtaaacca aggactttcc attagaatga actttggatc ttttattcca
     1141 cattatacag atgtgttaga tatctatgaa ggtataggac ctagcaaaat tttaagaggc
     1201 tccttttggg aaactgatcc tggaacaatt cgaatttttt ccaacctagt tactgtcacc
     1261 tttctgataa aatcagatga atatgattac attggtttta atgcaacgta cagcactttc
     1321 aacaacagcg aacttaacaa ttatgagaaa atcgactgta catttgatga tggattttgc
     1381 ttctggaccc aggatcttga tgatgataat gagtgggaaa gaatccaagt gaccacgttt
     1441 ccttgctaca ctggcccacg ttttgaccac acatatggga atggctcagg attttacatt
     1501 tctacaccaa ctgaacaggg atggagaagc gaaagagtag gcctttcaag cctctcttta
     1561 gacctcactt cagagcctgt ctgccttcat ttttggtatt acatgtgctg tgaaaatgtc
     1621 tacaatttaa acattcatat cagcagtgct gaaaccacag acaagatagt ttttcaaagg
     1681 aaaggaaact atgggaggaa ctggaattat ggtcaagtca cattaaatga aacaggagaa
     1741 tttaaggttg tgttcaatgc tttcagaaac cgaggttgca gtacaatagc cctggatgat
     1801 ataagcctaa caaatggaat ttgtagtcag agtccttatc cagaaccaac cttggttccc
     1861 acccctccac cagagcttcc aactgactgc ggaggacctt ttgaactatg ggagccaaat
     1921 tcaaccttca gttctccgaa ctttccagac aaatatccca atcaagcttc ctgtatatgg
     1981 aatttaaatg cacagagagg gaaaaatatt caacttcatt ttcaagaatt cgatttagaa
     2041 aacatcaatg atgtggtgga agttagagat gggggagaat ttgactccct gctcctagct
     2101 gtgtacacag gacctggtcc tgtgaaggac ttgttctcta ccaccaatag gatgactgtg
     2161 attttcacca caaacatgga gaccagacgc aagggcttca aagcaaattt cacttccggc
     2221 tattacttgg ggattccaga gccctgccaa gatgacgaat ttcagtgcaa agatggaaac
     2281 tgcattcctc tggggaatct ctgtgatagc tacccgcact gtagagatgg ctcagatgaa
     2341 gcaagctgtg tgcgttttct taatggcaca agaagcaaca atgggttggt acagttcaat
     2401 atccatagca tatggcatat agcttgtgct gagaactgga ccacacaaat ttcaaatgaa
     2461 gtttgtcatc ttctgggact agggagtgca aactcatcaa tgccaatatc atctaccgga
     2521 ggtggaccat ttgtgagagt aaaccaagcc cctaatggaa gcttgatact aactcctagt
     2581 ctacaatgct cccaagattc cttgattcta ttgcaatgca accataaatc atgtggagaa
     2641 aaaaaggtga ctcagaaagt cagcccaaag atcgttggtg gaagtgacgc ccaggcaggg
     2701 gcctggccct gggttgtggc tttgtatcac agagacaggt ctacagaccg tctgctctgc
     2761 ggtgcatctc ttgtcagcag tgactggctg gtgtcagctg cacactgtgt gtatagaaga
     2821 aatctagatc caaccagatg gacagcagtc ctgggcctgc atatgcaatc aaatctgact
     2881 tctcctcaag tagtaagacg ggtggttgat caaattgtca taaaccctca ttatgacaga
     2941 cgcagaaagg tcaacgacat cgctatgatg caccttgagt ttaaagtaaa ttacacagat
     3001 tatatacagc ctatttgttt accagaagag aatcaaatat ttattccagg aagaacttgt
     3061 tcgattgctg gctggggata tgataaaata aatgcaggtt ctactgttga tgtgctgaaa
     3121 gaagctgatg ttcctcttat atccaatgaa aagtgccagc aacagctgcc agaatacaac
     3181 atcactgaaa gtatgatatg tgcaggatat gaagaaggag gaatagattc ttgtcagggt
     3241 gattctggag ggccattaat gtgccaagaa aacaacagat ggtttcttgt tggtgtgaca
     3301 tcatttggag tccagtgtgc actgcctaat caccctgggg tatatgtccg agtctcacag
     3361 tttatagaat ggatccatag ctttctacat taggcatttt cctgacccaa acataagtga
     3421 tggacaatta tttttccctc gtttttactc aaactagtat ggcaactgag agtttcatga
     3481 gaagaaaaaa atatatattt ttagctaaat catttaattg ctggaatggg gtagggagac
     3541 aaaacaataa attaaaatta atcttcgcaa cataaagtaa ccataaaatg tgtttctgtt
     3601 tcacagcaaa caattattct tctatagaca ttatttgtct tgaatcaatt gttatcattt
     3661 tctgttgtgt gaagggatat tattttatga cattttccac acacataagt aaaaatgggt
     3721 gcagaagtga aatgaagtag ttttttctgg agtgtatcat ttcttttgaa atcagctgtt
     3781 gtaactcatc taatttcaat ttactgttac cagcagagtc gctgttgttt tgttctccat
     3841 tcacatgaat ttctatttaa atataacatt ttcctgttca taaaagtaca tttattatga
     3901 gcccatgtcc cagacacatt tacatcataa ctatgccttt cttctagtta aataaaacat
     3961 gcaaaggtct ctctcctgac ctagcatcaa cagaaaagta aacttcttta caccctcaaa
     4021 taatctttac attgacgtca agccatcttt ttttttaacc taaaaaaaac agtttaaaat
     4081 tgtacagttt agagactatc ctgaacatgt gaaaaatttg ttcagacaca gctgaattcc
     4141 ccactaaagg caaaaaatgt gtaataaatt aatttgctcc acttc
//
