LOCUS       NM_001013373            3245 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus transmembrane protease, serine 13 (Tmprss13), mRNA.
ACCESSION   NM_001013373 XM_150167
VERSION     NM_001013373.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3245)
  AUTHORS   Murray,A.S., Hyland,T.E., Sala-Hamrick,K.E., Mackinder,J.R.,
            Martin,C.E., Tanabe,L.M., Varela,F.A. and List,K.
  TITLE     The cell-surface anchored serine protease TMPRSS13 promotes breast
            cancer progression and resistance to chemotherapy
  JOURNAL   Oncogene 39 (41), 6421-6436 (2020)
   PUBMED   32868877
  REMARK    GeneRIF: The cell-surface anchored serine protease TMPRSS13
            promotes breast cancer progression and resistance to chemotherapy.
REFERENCE   2  (bases 1 to 3245)
  AUTHORS   Madsen,D.H., Szabo,R., Molinolo,A.A. and Bugge,T.H.
  TITLE     TMPRSS13 deficiency impairs stratum corneum formation and epidermal
            barrier acquisition
  JOURNAL   Biochem J 461 (3), 487-495 (2014)
   PUBMED   24832573
  REMARK    GeneRIF: Data (including data from studies in knockout mice)
            suggest Tmprss13 plays role in stratum corneum formation and
            transepidermal fluid balance; Tmprss13 expression is high in skin
            and epithelia of mouth, upper digestive tract, and urinary bladder.
REFERENCE   3  (bases 1 to 3245)
  AUTHORS   Sherwood,R.I., Jitianu,C., Cleaver,O., Shaywitz,D.A., Lamenzo,J.O.,
            Chen,A.E., Golub,T.R. and Melton,D.A.
  TITLE     Prospective isolation and global gene expression analysis of
            definitive and visceral endoderm
  JOURNAL   Dev Biol 304 (2), 541-555 (2007)
   PUBMED   17328885
REFERENCE   4  (bases 1 to 3245)
  AUTHORS   Kim,T.S., Heinlein,C., Hackman,R.C. and Nelson,P.S.
  TITLE     Phenotypic analysis of mice lacking the Tmprss2-encoded protease
  JOURNAL   Mol Cell Biol 26 (3), 965-975 (2006)
   PUBMED   16428450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166051.5 and AC162176.2.
            
            On Aug 5, 2006 this sequence version replaced NM_001013373.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC166051.5         142519-142574
            57-429              AC166051.5         151836-152208
            430-534             AC162176.2         119722-119826
            535-657             AC162176.2         122324-122446
            658-787             AC162176.2         123405-123534
            788-880             AC162176.2         125951-126043
            881-924             AC162176.2         126903-126946
            925-1087            AC162176.2         128113-128275
            1088-1260           AC162176.2         129092-129264
            1261-1359           AC162176.2         133019-133117
            1360-1502           AC162176.2         134771-134913
            1503-1655           AC162176.2         135083-135235
            1656-3245           AC162176.2         135849-137438
FEATURES             Location/Qualifiers
     source          1..3245
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..3245
                     /gene="Tmprss13"
                     /gene_synonym="Tpmrss13"
                     /note="transmembrane protease, serine 13"
                     /db_xref="GeneID:214531"
                     /db_xref="MGI:MGI:2682935"
     exon            1..56
                     /gene="Tmprss13"
                     /gene_synonym="Tpmrss13"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1682
                     /gene="Tmprss13"
                     /gene_synonym="Tpmrss13"
                     /note="membrane-type mosaic serine protease"
                     /codon_start=1
                     /product="transmembrane protease serine 13"
                     /protein_id="NP_001013391.2"
                     /db_xref="CCDS:CCDS23132.1"
                     /db_xref="GeneID:214531"
                     /db_xref="MGI:MGI:2682935"
                     /translation="MDRGSHRNSSPARTPPQASPARTSPARAPPQASPARTPPQASPT
                     RTPPQASPARAPPPQASPARASPARASLARAPPSRSSSGRSSSARSASTTSSPTRVYL
                     VRATPVGAVPIRASPARSAPATRATRESPGLSFPKFSWQETQRQLPLIGCVILLISLV
                     ISLILLFYFWRGHTGIKYKEPLESCPIHAVRCDGVVDCKMKSDELGCVRFDWDKSLLK
                     VYSGSSGEWLPVCSSSWNDTDSKRTCQQLGFDSAYRTTEVAHRDITSSFLLSEYNTTI
                     QESLYRSQCPSRRYVSLQCSHCGLRAMTGRIVGGALTSESKWPWQVSLHFGTTHICGG
                     TLIDAQWVLTAAHCFFVTREKLLEGWKVYAGTSNLHQLPEAASISQIIINGNYTDEQD
                     DYDIALIRLSKPLTLSAHIHPACLPMHGQTFGLNETCWITGFGKTKETDEKTSPFLRE
                     VQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAG
                     VTSWGTGCGQKNKPGVYTKVTEVLPWIYRKMESEVRFRKS"
     exon            57..429
                     /gene="Tmprss13"
                     /gene_synonym="Tpmrss13"
                     /inference="alignment:Splign:2.1.0"
     exon            430..534
                     /gene="Tmprss13"
                     /gene_synonym="Tpmrss13"
                     /inference="alignment:Splign:2.1.0"
     exon            535..657
                     /gene="Tmprss13"
                     /gene_synonym="Tpmrss13"
                     /inference="alignment:Splign:2.1.0"
     exon            658..787
                     /gene="Tmprss13"
                     /gene_synonym="Tpmrss13"
                     /inference="alignment:Splign:2.1.0"
     exon            788..880
                     /gene="Tmprss13"
                     /gene_synonym="Tpmrss13"
                     /inference="alignment:Splign:2.1.0"
     exon            881..924
                     /gene="Tmprss13"
                     /gene_synonym="Tpmrss13"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1087
                     /gene="Tmprss13"
                     /gene_synonym="Tpmrss13"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1260
                     /gene="Tmprss13"
                     /gene_synonym="Tpmrss13"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1359
                     /gene="Tmprss13"
                     /gene_synonym="Tpmrss13"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1502
                     /gene="Tmprss13"
                     /gene_synonym="Tpmrss13"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1655
                     /gene="Tmprss13"
                     /gene_synonym="Tpmrss13"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..3245
                     /gene="Tmprss13"
                     /gene_synonym="Tpmrss13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3225..3230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmprss13"
                     /gene_synonym="Tpmrss13"
                     /note="hexamer: AATAAA"
     polyA_site      3245
                     /gene="Tmprss13"
                     /gene_synonym="Tpmrss13"
                     /note="major polyA site"
ORIGIN      
        1 atcagctgag cctggaagaa gcattctctt acaccatgga cagaggcagc caccggaatt
       61 cttctccagc aaggacacct ccccaggctt ccccagcaag gacatctcca gcaagggcac
      121 ctcctcaggc ctctccagca aggacacctc ctcaggcctc tccaacaagg acacctcctc
      181 aggcctctcc agcaagggca cctcctcctc aggcttcccc agcccgggca tctccagccc
      241 gggcatctct agccagggca ccaccttcca ggtcatcatc gggcagatca tcatctgcca
      301 ggtcagcctc cacgacatcc tccccaacga gagtgtacct tgttagagca acaccagtgg
      361 gggctgtccc catccgggca tctcctgcca ggtcagcacc agccaccagg gccaccaggg
      421 agagcccagg tctcagtttc cccaagttct cctggcagga gacccagagg cagctgccac
      481 tcatcgggtg tgtcatcctt ctcatcagcc tggtgatctc actcatcctt ctcttctact
      541 tctggagagg ccacacaggg atcaagtaca aagagccact ggagagttgc cctatccacg
      601 cagttcgctg tgatggagtg gtggactgca aaatgaagag cgatgagctg ggctgtgtca
      661 ggttcgactg ggacaagtcc ctcctgaaag tctactctgg gtcttctggc gagtggcttc
      721 ctgtctgcag cagcagctgg aacgacactg actccaagag gacctgccag cagctgggat
      781 ttgacagcgc ttaccgaaca actgaggtag cccacaggga catcaccagc agcttcttac
      841 tctccgaata caacaccacc atccaggaaa gcctctatag gtcgcaatgt ccttcccggc
      901 ggtatgtctc cctccagtgt tcccactgtg gtttgagagc tatgaccggg cggatcgtgg
      961 gaggggctct gacctcggag agcaagtggc cctggcaagt tagcctgcac ttcggcacca
     1021 cccacatctg tgggggcaca ctcatcgatg cccagtgggt gctcaccgct gcccactgtt
     1081 tctttgtgac ccgggagaag ctgctggagg ggtggaaggt gtatgcaggc accagcaact
     1141 tgcaccagct gcccgaggct gcctctatct cccagatcat catcaacggc aactacacag
     1201 atgaacagga tgactatgac attgccctca tcaggctgtc caagcccctg accctgtcag
     1261 ctcacatcca ccctgcctgc ctccccatgc atggtcagac cttcggcctc aatgagacct
     1321 gttggatcac gggctttggc aaaaccaagg agacagatga gaagacatct cccttcctcc
     1381 gagaggttca ggtcaacctc attgacttca agaagtgcaa tgactacttg gtctatgaca
     1441 gctaccttac cccaaggatg atgtgtgccg gggatctacg aggagggagg gactcctgcc
     1501 agggagacag tggaggacct ctcgtctgtg agcagaacaa tcgctggtac ctggcaggtg
     1561 tcaccagctg gggcacaggc tgtggccaga aaaacaagcc tggtgtgtac accaaagtga
     1621 cagaagtact tccctggatt tacagaaaga tggagagtga ggtacgattc cggaaatctt
     1681 aaccatgtcc tcctcacgtt gctgactgct atgaagatcc tgggcacagg gatgggccat
     1741 ttgcagcatc tggaccagtg accaccaggc acctttgttt cttccacctc tgctgtctgc
     1801 tgtctctggg agagtgtgta tgtggtgtgt atgtgtttgc atcgtgtgtg tgtgtgtgtg
     1861 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg gtgtggtatg ttactattat aaattcttca
     1921 gaaaacagga aaactcagct cttctcagaa tcccaggctg gagatctgga gttaagagtt
     1981 tgggcaccag gtgtgttcct acgagtccat aagtgtgaag gtggagccaa aaatgagcct
     2041 gggcaggact tggaacatga caacagcagt tgtcgctctt ctgactctga cttgaaggcc
     2101 agccaggatt ggtcagacac ccaacagcca gtaacaccat tgctgtgctg ggacagcagc
     2161 aagttttgtc aggggctgtc ttgtcggtgc ccggaccatc tgtcctccgt ggaaaacctt
     2221 taccatctgt gagcaagcat ccggccctct ctgtcacttg cagctgctgt gggctccaga
     2281 gctgggctct gctgtagctg cccatctcta ggtaatgact gtgactcagg cttgctgtgc
     2341 ctttggtcac aagctgttgg gatgaatttt atttttatat ttaaaatata gaaatagatg
     2401 taactttaag gcgtctccaa aaatcctagg gaccttggga ggtttttttt tttttttttt
     2461 ttttttttac atgaattact tcatgaactc caagggaccc atgggagttg cagcatccta
     2521 taatatatta taccactgaa gcatcctgtg atatattact ggcttcatga aatcaggtga
     2581 agtgccttga tgaaatcctc aggacagaca cctccaggtc agtggagaga ctagggacct
     2641 ttgaaatact cagggaagaa aaccctcctt tgggttgaca gaaaaatcca gtgcatactg
     2701 gtctagcctc caaggactat agccagccag aagaaataaa gatgtgtgtg ctgccctggt
     2761 tcgcctcctg ggacctctga ggaagtccac acatacagca tcgtttacac ccaagggctg
     2821 acaatgaagt ctgcttctgt catccttcat cttttgactt tgtactgact taaaaggcca
     2881 tgaagagaat gcaagacctg tcctcagaac ttctaaacag cccttgtgag tggcctcagt
     2941 tggccattct cctggtcttc cctgggcctt ttctcttggt tacctgttgt tactcagctc
     3001 cactctcttc agccttcctt gggcctacca gacttctgtg atactgagtc tcggaggcaa
     3061 gttcaaggag atcagaccag ctcaggacag ctcaggcaag ctggaggtca ctggagtggt
     3121 tgggcagcat cagacagggc tgagacacaa gggaatctct tcaaggctgg gaaggaggcg
     3181 ggcagcatcc atgtgtgcag aagatcccag caatgagctt ccataataaa atcgtgtggc
     3241 acaaa
//
