LOCUS       NM_183109               1333 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus transmembrane (C-terminal) protease, serine 12
            (Tmprss12), transcript variant 1, mRNA.
ACCESSION   NM_183109
VERSION     NM_183109.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1333)
  AUTHORS   Zhang,J., Zhou,X., Wan,D., Yu,L., Chen,X., Yan,T., Wu,Z., Zheng,M.,
            Zhu,F. and Zhu,H.
  TITLE     TMPRSS12 Functions in Meiosis and Spermiogenesis and Is Required
            for Male Fertility in Mice
  JOURNAL   Front Cell Dev Biol 10, 757042 (2022)
   PUBMED   35547804
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1333)
  AUTHORS   Larasati,T., Noda,T., Fujihara,Y., Shimada,K., Tobita,T., Yu,Z.,
            Matzuk,M.M. and Ikawa,M.
  TITLE     Tmprss12 is required for sperm motility and uterotubal junction
            migration in micedagger
  JOURNAL   Biol Reprod 103 (2), 254-263 (2020)
   PUBMED   32529245
  REMARK    GeneRIF: Tmprss12 is required for sperm motility and uterotubal
            junction migration in micedagger.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124479.4.
            
            On Mar 23, 2023 this sequence version replaced NM_183109.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132967.1, SRR5189685.183099.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-172               AC124479.4         61663-61834         c
            173-368             AC124479.4         60269-60464         c
            369-637             AC124479.4         57302-57570         c
            638-780             AC124479.4         53283-53425         c
            781-1333            AC124479.4         49634-50186         c
FEATURES             Location/Qualifiers
     source          1..1333
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.24 cM"
     gene            1..1333
                     /gene="Tmprss12"
                     /gene_synonym="4930478A21Rik"
                     /note="transmembrane (C-terminal) protease, serine 12"
                     /db_xref="GeneID:75002"
                     /db_xref="MGI:MGI:1922252"
     exon            1..172
                     /gene="Tmprss12"
                     /gene_synonym="4930478A21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1032
                     /gene="Tmprss12"
                     /gene_synonym="4930478A21Rik"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; transmembrane protease serine 12"
                     /codon_start=1
                     /product="transmembrane protease serine 12 isoform 1
                     precursor"
                     /protein_id="NP_898932.2"
                     /db_xref="CCDS:CCDS49732.1"
                     /db_xref="GeneID:75002"
                     /db_xref="MGI:MGI:1922252"
                     /translation="MASWALSAALLCLGGAFAYSELHSLSLREGSALGQATVPGPPEE
                     EQPVTKDCGIAPLRGAVEGSRIIGGSQADTGAWPWQVSLQVQDGDILMHVCGGALVRD
                     RWVLTAAHCTKEARDPLKWRAVMGTNDLTRSPYHSRNIRITDIIIPPDFIMETFVNDI
                     ALFRLKRAVRYNDYIQPICLPFGVFQKLDQNTACFISGWGRTREEGNGTTILQEAKVH
                     FISREVCSSDQGYSGMIPNTSFCAGHENGTFDSCRGDSGGPLMCYLPEHSRYFVMGIT
                     SYGHGCGRRHFPGVYSNPSFFQEWMTHYLSQGNINRLFNMDIVLGQVLTALGSVILLG
                     VT"
     exon            173..368
                     /gene="Tmprss12"
                     /gene_synonym="4930478A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            369..637
                     /gene="Tmprss12"
                     /gene_synonym="4930478A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            638..780
                     /gene="Tmprss12"
                     /gene_synonym="4930478A21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            781..1333
                     /gene="Tmprss12"
                     /gene_synonym="4930478A21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1306..1311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmprss12"
                     /gene_synonym="4930478A21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1333
                     /gene="Tmprss12"
                     /gene_synonym="4930478A21Rik"
                     /note="major polyA site"
ORIGIN      
        1 atcttggggc ctacagccac catggcgtca tgggcactga gcgccgcgct gctgtgcctg
       61 ggcggcgcct ttgcgtactc tgagctgcac tcactgtccc ttagggaggg ctctgcgctg
      121 ggacaggcca ctgtgccagg gccgccggaa gaggagcagc cggtcacgaa ggattgtgga
      181 atagcaccac ttagaggtgc agtggaaggg tctcggatta taggaggttc gcaagctgac
      241 actggtgcgt ggccatggca ggttagcctg caggttcaag atggcgatat tcttatgcat
      301 gtatgtggtg gcgccctagt gagagacagg tgggtcctca cagctgctca ctgcacaaaa
      361 gaggctagag atcctctgaa gtggagagca gtgatgggga ccaatgacct cacccggagc
      421 ccctaccaca gcaggaatat acgaatcaca gacatcatca taccaccaga tttcattatg
      481 gaaactttcg taaatgatat cgcactgttc cgtttaaaga gagctgtgag gtataatgac
      541 tatattcagc ccatttgtct accttttggt gttttccaaa aactggacca aaacacagcg
      601 tgttttataa gcggctgggg aagaaccaga gaagaaggca atggcacaac cattttacaa
      661 gaggcgaaag tacacttcat ctctcgggag gtttgcagct ctgaccaggg ctacagtgga
      721 atgattccca acacttcatt ctgtgcaggt cacgaaaatg ggacctttga ctcatgcagg
      781 ggtgacagcg ggggaccact aatgtgctac ctaccggaac acagcagata ctttgtcatg
      841 ggaatcacca gttacggaca tggctgtggg cggagacatt tccccggtgt ctacagcaac
      901 ccgagcttct tccaggagtg gatgacacat tatttatcac agggaaacat caaccgcctg
      961 tttaatatgg acatagtact tggccaggtc ctcacagccc taggttctgt catcctacta
     1021 ggagtaacat aaggaacctt tggggcagag ggtcaccctg cccctgctgt gtctacacca
     1081 gaacactgtg tgcatggctc actttagtgc gtccatgtca acactgggat gtttttggtt
     1141 ttgttttttt aacaaaaagg attgtgacaa gtacatagtt gtgacttttg gcaccaaacc
     1201 ccatgttttc tcactagacc ctgattcata actctgtatt tggaatactt tcctagggtt
     1261 tgtataaaat attcatttac tatatacttt atgtgtataa aggccaataa acagtttata
     1321 atttaattga aaa
//
