LOCUS       NM_178730               4277 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus transmembrane protease, serine 11f (Tmprss11f), mRNA.
ACCESSION   NM_178730 XM_916544
VERSION     NM_178730.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4277)
  AUTHORS   Callies,L.K., Tadeo,D., Simper,J., Bugge,T.H. and Szabo,R.
  TITLE     Iterative, multiplexed CRISPR-mediated gene editing for functional
            analysis of complex protease gene clusters
  JOURNAL   J Biol Chem 294 (44), 15987-15996 (2019)
   PUBMED   31501243
REFERENCE   2  (bases 1 to 4277)
  AUTHORS   Zhang,Z., Hu,Y., Yan,R., Dong,L., Jiang,Y., Zhou,Z., Liu,M.,
            Zhou,T., Dong,N. and Wu,Q.
  TITLE     The Transmembrane Serine Protease HAT-like 4 Is Important for
            Epidermal Barrier Function to Prevent Body Fluid Loss
  JOURNAL   Sci Rep 7, 45262 (2017)
   PUBMED   28338078
  REMARK    GeneRIF: Study reveals a role of HAT-L4 in the epidermal barrier
            function to prevent body fluid loss, providing another example of
            cell membrane-bound serine proteases in epidermal development and
            function.
            Erratum:[Sci Rep. 2020 Apr 10;10(1):6467. doi:
            10.1038/s41598-020-62767-5.. PMID: 32277073]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028447.1, AK037173.1, BB149675.2 and AI597076.1.
            
            On Mar 24, 2007 this sequence version replaced NM_178730.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028587.1, AK029032.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2220              AK028447.1         3-2222
            2221-3683           AK037173.1         2065-3527
            3684-4246           BB149675.2         83-645
            4247-4277           AI597076.1         1-31                c
FEATURES             Location/Qualifiers
     source          1..4277
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..4277
                     /gene="Tmprss11f"
                     /gene_synonym="4631408C20; 4732406D01Rik"
                     /note="transmembrane protease, serine 11f"
                     /db_xref="GeneID:243083"
                     /db_xref="MGI:MGI:2442348"
     exon            1..101
                     /gene="Tmprss11f"
                     /gene_synonym="4631408C20; 4732406D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            102..182
                     /gene="Tmprss11f"
                     /gene_synonym="4631408C20; 4732406D01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1491
                     /gene="Tmprss11f"
                     /gene_synonym="4631408C20; 4732406D01Rik"
                     /note="airway trypsin-like protease 4"
                     /codon_start=1
                     /product="transmembrane protease serine 11F"
                     /protein_id="NP_848845.1"
                     /db_xref="CCDS:CCDS39125.1"
                     /db_xref="GeneID:243083"
                     /db_xref="MGI:MGI:2442348"
                     /translation="MMYAPVEFSQTAYPRIEYQRRQQQFWDPIRLALFTLAIVAIVGI
                     TIGIVTHFVVEDDKSFYYLASFQVTSIKYRENYGIRSSREFIERSHQIERMMSRIFRR
                     SSGVGRFIKSHVIKISPDEQGVNILIVLMFRYPSTDSAERIKKRIERTFYQSLKIKQL
                     PLTISMPSFSLTPIDSKKMRNLLNSRCGIRMSSSNIPLPASSSTERIVQGRETAMEGE
                     WPWQASLQLIGAGHQCGATLISNTWLLTAAHCFWKNRDPTKWIVTFGTTITPPLVKRS
                     VGKIIIHEEYHRDTNENDIALAQLTTRVEFSNVVQRVCLPDSSMKLPPKTSVFVTGFG
                     SIVDDGPTQNKLRQARVETIGSDVCNRKDVYDGLITPGMLCAGFMEGKIDACKGDSGG
                     PLVYDNRDIWYIVGIVSWGQSCALPNKPGVYTRVTKYRDWIASKTGL"
     exon            183..337
                     /gene="Tmprss11f"
                     /gene_synonym="4631408C20; 4732406D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            338..456
                     /gene="Tmprss11f"
                     /gene_synonym="4631408C20; 4732406D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            457..524
                     /gene="Tmprss11f"
                     /gene_synonym="4631408C20; 4732406D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            525..688
                     /gene="Tmprss11f"
                     /gene_synonym="4631408C20; 4732406D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            689..727
                     /gene="Tmprss11f"
                     /gene_synonym="4631408C20; 4732406D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            728..929
                     /gene="Tmprss11f"
                     /gene_synonym="4631408C20; 4732406D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1189
                     /gene="Tmprss11f"
                     /gene_synonym="4631408C20; 4732406D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1332
                     /gene="Tmprss11f"
                     /gene_synonym="4631408C20; 4732406D01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..4277
                     /gene="Tmprss11f"
                     /gene_synonym="4631408C20; 4732406D01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3787..3792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmprss11f"
                     /gene_synonym="4631408C20; 4732406D01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3811
                     /gene="Tmprss11f"
                     /gene_synonym="4631408C20; 4732406D01Rik"
                     /note="major polyA site"
     regulatory      4251..4256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmprss11f"
                     /gene_synonym="4631408C20; 4732406D01Rik"
                     /note="hexamer: AATATA"
     polyA_site      4274
                     /gene="Tmprss11f"
                     /gene_synonym="4631408C20; 4732406D01Rik"
ORIGIN      
        1 gtctttgtct gttttggatc tcagaaaaaa gattccagtg tcattttcaa caactgcaaa
       61 ctgaagaagc acatgctatg tgaggaagga acaatttcaa gcctcccagc cctgacctgg
      121 ctgatagaga tcagatggtg actggataga aaccttccta gtcctgggtc catgatgtac
      181 gcaccagttg aattttcaca aacagcatac ccacgaatcg aatatcaaag aagacaacaa
      241 caattttggg accctatacg actagctctg ttcacattgg caattgtcgc aatcgtagga
      301 atcacaattg gcatcgtcac tcattttgtt gttgaagatg acaagtcatt ttattacctc
      361 gcctcttttc aagtcacaag catcaaatac agagaaaatt atggaatcag gtcatcaagg
      421 gagtttatag aaagaagtca tcagatcgag agaatgatgt ccaggatatt ccgacgttct
      481 tctggagtgg gtagatttat caagtcccat gttatcaaga taagtccaga tgaacaagga
      541 gtgaacattc ttatagtgct catgtttcga tacccatcta ctgatagtgc cgagcgaatc
      601 aagaaaagaa ttgaaaggac tttttatcaa agtctgaaga tcaaacagtt gcctttgact
      661 attagtatgc catcattcag cctcacaccc attgacagca aaaagatgag aaatcttctc
      721 aatagccgat gtgggataag aatgtcatct tcaaacatcc cattaccagc atcctcttct
      781 actgaacgca ttgtccaagg gagggaaaca gctatggaag gagagtggcc atggcaggct
      841 agcctccagc tcattggggc tggccatcag tgtggagcca cactcatcag caacacatgg
      901 ctgctcacag cagctcattg cttctggaaa aacagagacc caactaaatg gattgtcacc
      961 tttggtacaa ctataacacc acctttagtc aaacgaagtg ttgggaagat tatcatccat
     1021 gaagagtacc acagagatac caatgaaaac gacattgctc tagctcagct aaccacccgc
     1081 gtcgagtttt caaatgtggt tcagagagtc tgcctcccag attcatctat gaaattgcca
     1141 ccgaaaacaa gtgtttttgt cacaggattt gggtctattg tagatgatgg gcctacacaa
     1201 aataaactcc ggcaggccag ggtggaaacc ataggttctg atgtgtgcaa cagaaaggat
     1261 gtatacgatg gcttgataac tccagggatg ctgtgcgctg gattcatgga aggaaaaata
     1321 gatgcatgta agggtgattc tggtggacct ttggtttatg acaatcggga catctggtac
     1381 attgtgggca tagtaagttg gggacaatct tgtgctcttc caaacaagcc tggagtctac
     1441 acaagagtga ctaagtatcg agactggata gcctccaaga ctggcctcta aagtatactg
     1501 ttgtgagtga tggccatagc ccacgaagca ggatacctgc agattgtaca gtattactta
     1561 gagagttgtg agctacagtc acagcccatg gaacaggatg cctgcagata gtacattatg
     1621 cgcattgtta cttagagtca ttgggggtaa atgagtgctt ctgccagatg tgaaggactc
     1681 ttcagatgga gaccaattta ataacatgag gtgacttttt gtgcataaac tttaccaaga
     1741 aggaagaaaa cttagcaaat gacaggcagc accagcatct cactcgtaaa ggtgactcct
     1801 taatgtgaca aacataaata gcttccctca ggatataaag agctgccaag ctgctatgat
     1861 cttacctcat ataatgcata gagctccagg actcatctta caaatgtcag ctagcatctt
     1921 ccttaaggat tcaagacaca agcattttag aactcataac tggacattca actgctacaa
     1981 tgaaggagtg tgtaacctgc agtaaaactt gaactctaac ctgcatttgc agctgaccga
     2041 gcagagcttt attctcaacc acaggaactg tcattattta aatgcatatg aacttgccat
     2101 tatactatat aatgtcctaa aacagtagcc ttaggaagca tattgagttg ataagaatca
     2161 tttctggctt actccttagc agtgtcttgc catccacata taaatcatat ttagcccatc
     2221 aaagagaaaa ataaaattat tacaagtatt tttccactag tataggaaga attaaaggaa
     2281 gctgatgaaa gcagaataat ctgaaatata gttagtgaca cggcactcac aacttttgat
     2341 ggaacgtgtt ttccaaatat ttatttagaa atgtttagac ataagcaaat ggtagctctt
     2401 gctatcatac gttaccagct cattgccaag ttatatgtct atcaaaatgt caggcgggaa
     2461 gggccttact gaaaacactt agtacagtgc ttactatata ctaagtacta agtaatagtg
     2521 agtgtcccag caaagcctgg tggtgggcat agtgttagtg agcccatatt gtctgagcaa
     2581 ggccagtggc tcacgagttt tgtctctgcc atatgcaaag tatatgcttt tatgcaaatg
     2641 acccaatatc tctctgttag ttagctcttt catctggatg gtgtgaatta aaatactacc
     2701 tcactgtggt tgtttttttt ttttttgagg gttacatgta ttaatacatg taaagtattt
     2761 gcaatagcat ccgcacacag taagttctta ggatgaataa gctactatca atattaatat
     2821 taatgttcct tggactttaa aagcacattg tatttttaaa tgtcctactt attccaaaga
     2881 tgcaaataat ttcaaaggac cttaaattac attgttgaaa agcagatgga gtattcaggt
     2941 tttcaaaatc acttttatgt ttcctggatt taattttgat ctgtgtctac tgtagatgat
     3001 ctgtgtctac aggatgatgg ccgccatgct tggaactaaa ctatagccga gtgtcagtat
     3061 tcaccctctg ccctcagctg tgaggtttgc aagttacttt gacttagcag acaaaaactg
     3121 tggcatagcc atcgttgaat ggctaaaagt tttgttttct tttgagttta catgtaattg
     3181 gttttatatg tagcatttgt aaccgagatt aatataacct tttcaaagtc tctgaggtgc
     3241 tctacgttgc atctcaatga actacgagca cacagaggtc atgtctggtc acttaaaaaa
     3301 ttaaagctgg gcatgactga tgttggattt tttttctttt aatttaaata aatgactgct
     3361 tttggtagat atgggaaagc aaatctgtct accaaaagga cccttattct ttcctttgta
     3421 agtctctaac aatagataca tgcttgtgtc taattttatt tatagttcat caaactgtga
     3481 taactttttt taagtattca tgaaactctg tattctgatt taaatcttcc atgcttagtt
     3541 agattgaatt agatgataat ttaacaggaa taagaaaaat aaatataaaa agtcatatga
     3601 atcctaaaag aaaaagaaaa gtgtattttt tataacagtg tttgtatgtc ttagttcatg
     3661 tttggtattt gacttattga tcgaatgtca tagaagtcaa gtaatactgt actccatgtt
     3721 ttccacctga tatatgggtt actaagctgt ctacctcata gcattcctgt gaggattctt
     3781 gtaaataata aagttgaaaa gttgaagaac atttaaagat ctcaaaaaat gcagagtaca
     3841 ttattgttaa tagataccaa tatagatgat acagaaaatg catttagatt atgaagattg
     3901 aggcattttg ctctgcaatg ttgtggtttt attgctttgt acatttggca aacataaaaa
     3961 tggttaacaa cacacaagaa aatgatcttg cctcctctgt attgacacta tagtaatttt
     4021 agtactcttt taatcaaaag ccggatatag gcttaaaaga accaaaaaat caattagatg
     4081 tatagaaaat gtaataatcc ctacaaaaca gaatctcttg aaaccttggg ttctgactaa
     4141 aggttattta tttatttatt ttttggtgga gaaagactaa gccaaaactt ttggtagtaa
     4201 taaaccatga ctctgacatc tttataattc accaacaata agagcaataa aatatatcta
     4261 tcctttcaac taaatac
//
