LOCUS       NM_145561               2046 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus transmembrane protease, serine 11d (Tmprss11d), mRNA.
ACCESSION   NM_145561 XM_916524
VERSION     NM_145561.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2046)
  AUTHORS   Feng,S., Zhao,J., Yang,T. and Li,L.
  TITLE     TMPRSS11D/ALR-mediated ER stress regulates the function of
            myeloid-derived suppressor cells in the cervical cancer
            microenvironment
  JOURNAL   Int Immunopharmacol 124 (Pt A), 110869 (2023)
   PUBMED   37666068
  REMARK    GeneRIF: TMPRSS11D/ALR-mediated ER stress regulates the function of
            myeloid-derived suppressor cells in the cervical cancer
            microenvironment.
REFERENCE   2  (bases 1 to 2046)
  AUTHORS   Callies,L.K., Tadeo,D., Simper,J., Bugge,T.H. and Szabo,R.
  TITLE     Iterative, multiplexed CRISPR-mediated gene editing for functional
            analysis of complex protease gene clusters
  JOURNAL   J Biol Chem 294 (44), 15987-15996 (2019)
   PUBMED   31501243
REFERENCE   3  (bases 1 to 2046)
  AUTHORS   Zmora,P., Hoffmann,M., Kollmus,H., Moldenhauer,A.S., Danov,O.,
            Braun,A., Winkler,M., Schughart,K. and Pohlmann,S.
  TITLE     TMPRSS11A activates the influenza A virus hemagglutinin and the
            MERS coronavirus spike protein and is insensitive against blockade
            by HAI-1
  JOURNAL   J Biol Chem 293 (36), 13863-13873 (2018)
   PUBMED   29976755
REFERENCE   4  (bases 1 to 2046)
  AUTHORS   Heurich,A., Hofmann-Winkler,H., Gierer,S., Liepold,T., Jahn,O. and
            Pohlmann,S.
  TITLE     TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis
            by TMPRSS2 augments entry driven by the severe acute respiratory
            syndrome coronavirus spike protein
  JOURNAL   J Virol 88 (2), 1293-1307 (2014)
   PUBMED   24227843
REFERENCE   5  (bases 1 to 2046)
  AUTHORS   Sales,K.U., Hobson,J.P., Wagenaar-Miller,R., Szabo,R.,
            Rasmussen,A.L., Bey,A., Shah,M.F., Molinolo,A.A. and Bugge,T.H.
  TITLE     Expression and genetic loss of function analysis of the HAT/DESC
            cluster proteases TMPRSS11A and HAT
  JOURNAL   PLoS One 6 (8), e23261 (2011)
   PUBMED   21853097
  REMARK    GeneRIF: A comprehensive phenotypic analysis of mice deficient in
            two of the most widely expressed HAT/DESC proteases, TMPRSS11A and
            HAT, was performed.
REFERENCE   6  (bases 1 to 2046)
  AUTHORS   Schulte,D.M., Shapiro,I., Reincke,M. and Beuschlein,F.
  TITLE     Expression and spatio-temporal distribution of differentiation and
            proliferation markers during mouse adrenal development
  JOURNAL   Gene Expr Patterns 7 (1-2), 72-81 (2007)
   PUBMED   16920405
REFERENCE   7  (bases 1 to 2046)
  AUTHORS   Hansen,I.A., Fassnacht,M., Hahner,S., Hammer,F., Schammann,M.,
            Meyer,S.R., Bicknell,A.B. and Allolio,B.
  TITLE     The adrenal secretory serine protease AsP is a short secretory
            isoform of the transmembrane airway trypsin-like protease
  JOURNAL   Endocrinology 145 (4), 1898-1905 (2004)
   PUBMED   14691009
  REMARK    GeneRIF: Predominantly expressed in upper gastrointestinal and
            respiratory tract-but also in adrenal gland. Complex expression
            pattern. Multifunctional role beyond adrenal proliferation.
REFERENCE   8  (bases 1 to 2046)
  AUTHORS   Takahashi,M., Sano,T., Yamaoka,K., Kamimura,T., Umemoto,N.,
            Nishitani,H. and Yasuoka,S.
  TITLE     Localization of human airway trypsin-like protease in the airway:
            an immunohistochemical study
  JOURNAL   Histochem Cell Biol 115 (3), 181-187 (2001)
   PUBMED   11326745
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC098885.3 and
            AC100746.4.
            
            On Nov 17, 2006 this sequence version replaced NM_145561.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020151.1, AB053953.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC098885.3         108898-108940
            44-165              AC098885.3         142684-142805
            166-284             AC098885.3         143386-143504
            285-352             AC098885.3         144991-145058
            353-507             AC098885.3         151060-151214
            508-546             AC100746.4         155790-155828       c
            547-724             AC100746.4         154580-154757       c
            725-984             AC100746.4         137436-137695       c
            985-1127            AC100746.4         134439-134581       c
            1128-2046           AC100746.4         131026-131944       c
FEATURES             Location/Qualifiers
     source          1..2046
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..2046
                     /gene="Tmprss11d"
                     /gene_synonym="AsP; AST"
                     /note="transmembrane protease, serine 11d"
                     /db_xref="GeneID:231382"
                     /db_xref="MGI:MGI:2385221"
     exon            1..43
                     /gene="Tmprss11d"
                     /gene_synonym="AsP; AST"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1289
                     /gene="Tmprss11d"
                     /gene_synonym="AsP; AST"
                     /note="airway trypsin-like protease; airway spesific
                     trypsin-like protease; AT; adrenal secretory serine
                     protease"
                     /codon_start=1
                     /product="transmembrane protease serine 11D"
                     /protein_id="NP_663536.1"
                     /db_xref="CCDS:CCDS39124.1"
                     /db_xref="GeneID:231382"
                     /db_xref="MGI:MGI:2385221"
                     /translation="MYRPRPMLSPSRFFTPFAVAFVVIITVGLLAMMAGLLIHFLAFD
                     KKAYFYHSSFQILNVEYTEALNSPATHEYRTLSERIEAMITDEFRGSSLKSEFIRTHV
                     VKLRKEGTGVVADVVMKFRSSKRNNRKVMKTRIQSVLRRLSSSGNLEIAPSNEITSLT
                     DQDTENVLTQECGARPDLITLSEERIIGGMQAEPGDWPWQVSLQLNNVHHCGGALISN
                     MWVLTAAHCFKSYPNPQYWTATFGVSTMSPRLRVRVRAILAHDGYSSVTRDNDIAVVQ
                     LDRSVAFSRNIHRVCLPAATQNIIPGSVAYVTGWGSLTYGGNAVTNLRQGEVRIISSE
                     ECNTPAGYSGSVLPGMLCAGMRSGAVDACQGDSGGPLVQEDSRRLWFVVGIVSWGYQC
                     GLPNKPGVYTRVTAYRNWIRQQTGI"
     exon            44..165
                     /gene="Tmprss11d"
                     /gene_synonym="AsP; AST"
                     /inference="alignment:Splign:2.1.0"
     exon            166..284
                     /gene="Tmprss11d"
                     /gene_synonym="AsP; AST"
                     /inference="alignment:Splign:2.1.0"
     exon            285..352
                     /gene="Tmprss11d"
                     /gene_synonym="AsP; AST"
                     /inference="alignment:Splign:2.1.0"
     exon            353..507
                     /gene="Tmprss11d"
                     /gene_synonym="AsP; AST"
                     /inference="alignment:Splign:2.1.0"
     exon            508..546
                     /gene="Tmprss11d"
                     /gene_synonym="AsP; AST"
                     /inference="alignment:Splign:2.1.0"
     exon            547..724
                     /gene="Tmprss11d"
                     /gene_synonym="AsP; AST"
                     /inference="alignment:Splign:2.1.0"
     exon            725..984
                     /gene="Tmprss11d"
                     /gene_synonym="AsP; AST"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1127
                     /gene="Tmprss11d"
                     /gene_synonym="AsP; AST"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..2046
                     /gene="Tmprss11d"
                     /gene_synonym="AsP; AST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1411..1416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmprss11d"
                     /gene_synonym="AsP; AST"
                     /note="hexamer: CATAAA"
     polyA_site      1436
                     /gene="Tmprss11d"
                     /gene_synonym="AsP; AST"
                     /note="major polyA site"
ORIGIN      
        1 cagaaacaag gacctcttca ttattcaaga gtaaaatgta taggccaaga ccaatgctat
       61 caccgtcaag attcttcact ccctttgcag tagctttcgt tgtcataata acggtagggc
      121 tcctggccat gatggcaggt ctacttattc actttttagc ttttgacaag aaagcttact
      181 tttatcatag cagctttcaa atcctaaacg ttgaatacac tgaggcttta aactcaccag
      241 ctacacacga atacagaacc ttgagtgaaa gaattgaggc tatgattact gatgaatttc
      301 gaggatcaag tctaaaaagt gagtttatca ggacacatgt tgtcaaacta agaaaagaag
      361 ggactggtgt ggttgcggat gttgtcatga aatttcgatc tagtaaacgt aacaacagaa
      421 aggtaatgaa aaccagaatt caatctgtgc tacgaagact cagcagctct ggaaacttgg
      481 aaatagcccc ttcgaatgag ataacatcac tcactgacca ggatacagaa aatgttttga
      541 ctcaagaatg tggagcacgt ccagacctta taacactgtc agaagagaga atcattggag
      601 gcatgcaagc tgagcccggt gactggccct ggcaagtcag tctacagctc aataatgtcc
      661 accactgtgg aggtgccctg atcagtaaca tgtgggtcct gacagcagct cattgcttca
      721 aaagctatcc taatcctcaa tattggacag ccacctttgg ggtttctaca atgagcccta
      781 ggctgagagt gagagtaagg gctattttag cccacgacgg gtacagctcc gtaactcgtg
      841 acaatgacat cgcagttgta caacttgaca gatctgtcgc cttttccaga aatatccata
      901 gggtatgtct cccagcagca acccaaaata tcatccctgg ttctgtcgca tatgttacag
      961 gatggggatc tctcacatat ggaggcaacg cagtcacaaa tctacggcaa ggagaggtca
     1021 gaataataag ttcagaggaa tgcaatacgc cagctggtta cagtggaagt gtcttgccag
     1081 gaatgctgtg tgctggaatg cgttcagggg ccgtggatgc atgccagggt gattcaggtg
     1141 gcccgctagt acaagaagac tcaaggcggc tttggtttgt tgtgggcatt gtgagctggg
     1201 gatatcagtg tggcctccca aataagccag gcgtgtatac tcgagtgaca gcctaccgca
     1261 actggatcag acagcagacg ggaatctagt gcaaccgagg aaaaaacgtg ccatgaggtc
     1321 tctgtatcca agtgtgactg actcggatgc catggcttca catttcaact gcaaaggaga
     1381 ctggaaatgc cccttctgaa cgtcccatta cataaatatg gtttaactgt ttagtatttc
     1441 tttgtcggta cagattttta ctttcttgag gaaaaaaaaa acatgaacat ggctaagtaa
     1501 gaattatgtt aggctagtaa caggaagaca tttattacat gggtggtcag gtgtagtagt
     1561 gagaagtcag gtaagttaag tcaataattt acagaaaata atgtcaggta gtcctaacgt
     1621 taaatatgtg aggccacaga acaaatagtg ttagaactga agccatccca agtatttaac
     1681 atttgttttc aagtgaaact aagaaacaga cttacatata gttttaatgg tgaattttca
     1741 ttttaaatat tttatctaca tagaaaagac atatctcctt catgaagaag ctgaggtgat
     1801 gaatcaacac agcctcttca gctatgtttg caaccacaag atttgtggga aagaaatccc
     1861 tactaccaac ttcctactgt tggcattatt ttttagagta acacgacgca caatagcaaa
     1921 atttaagtaa caaattaaaa gttaatgatg aagaagaagt aaagagtttg tttgcaaaga
     1981 caaaaattaa acagattaat atcaataaat ctggagacag aagggtctca gattcatatt
     2041 ctctct
//
