LOCUS       NM_001030297            4355 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Mus musculus transmembrane protease, serine 11c (Tmprss11c), mRNA.
ACCESSION   NM_001030297 XM_487870
VERSION     NM_001030297.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4355)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4355)
  AUTHORS   Callies,L.K., Tadeo,D., Simper,J., Bugge,T.H. and Szabo,R.
  TITLE     Iterative, multiplexed CRISPR-mediated gene editing for functional
            analysis of complex protease gene clusters
  JOURNAL   J Biol Chem 294 (44), 15987-15996 (2019)
   PUBMED   31501243
REFERENCE   3  (bases 1 to 4355)
  AUTHORS   Stallmach,R. and Gloor,S.M.
  TITLE     Neurobin/TMPRSS11c, a novel type II transmembrane serine protease
            that cleaves fibroblast growth factor-2 in vitro
  JOURNAL   Biochem J 412 (1), 81-91 (2008)
   PUBMED   18215125
  REMARK    GeneRIF: Neurobin is an authentic transmembrane serine protease
            with trypsin-like activity and is able to process FGF-2 in vitro.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC100746.4.
            
            On Oct 3, 2022 this sequence version replaced NM_001030297.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM260217.1, BC147158.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN01164134
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC100746.4         117377-117480       c
            105-220             AC100746.4         110205-110320       c
            221-339             AC100746.4         99580-99698         c
            340-407             AC100746.4         88077-88144         c
            408-568             AC100746.4         84467-84627         c
            569-607             AC100746.4         71137-71175         c
            608-779             AC100746.4         67499-67670         c
            780-1039            AC100746.4         65793-66052         c
            1040-1182           AC100746.4         63604-63746         c
            1183-4355           AC100746.4         56913-60085         c
FEATURES             Location/Qualifiers
     source          1..4355
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..4355
                     /gene="Tmprss11c"
                     /gene_synonym="Tmprss13"
                     /note="transmembrane protease, serine 11c"
                     /db_xref="GeneID:435845"
                     /db_xref="MGI:MGI:3521861"
     exon            1..104
                     /gene="Tmprss11c"
                     /gene_synonym="Tmprss13"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1344
                     /gene="Tmprss11c"
                     /gene_synonym="Tmprss13"
                     /note="neurobin"
                     /codon_start=1
                     /product="transmembrane protease serine 11C"
                     /protein_id="NP_001025468.1"
                     /db_xref="CCDS:CCDS19380.1"
                     /db_xref="GeneID:435845"
                     /db_xref="MGI:MGI:3521861"
                     /translation="MARGQPRRSEEQWTALQNRTECKTKIKLTRCGKITLGILTAVLA
                     AVLIGLIAYFAACGKDSFYYHVSFKVNNIDYDSKFAKPYSQEYMDLNKRIVSLMNETF
                     HESKLRKQYVKAHTVQVSKAKGKVVIHAVLKFKACYRNNVEKYWESVETTLYQKLKGQ
                     TGLLIDSSSFKFSDIAMPIAEDLLNTCCGRRTIIHRGHKVAGGQDAEEGEWPWQASLQ
                     QNSVHRCGATLISNYWLITAAHCFIRAANPKDWKVSFGFLLSKPQAPRAVKNIIIHEN
                     YSYPAHDNDIAVVRLSSPVLYESNIRRACLPEATQKFPPNSDVVVTGWGTLKSDGDSP
                     NILQKGKVKIIDNKTCNSGKAYGGMITPGMMCAGFLKGRVDACQGDSGGPLVSEDSKG
                     IWFLAGIVSWGDECALPNKPGVYTRVTYYRDWITSKTGL"
     exon            105..220
                     /gene="Tmprss11c"
                     /gene_synonym="Tmprss13"
                     /inference="alignment:Splign:2.1.0"
     exon            221..339
                     /gene="Tmprss11c"
                     /gene_synonym="Tmprss13"
                     /inference="alignment:Splign:2.1.0"
     exon            340..407
                     /gene="Tmprss11c"
                     /gene_synonym="Tmprss13"
                     /inference="alignment:Splign:2.1.0"
     exon            408..568
                     /gene="Tmprss11c"
                     /gene_synonym="Tmprss13"
                     /inference="alignment:Splign:2.1.0"
     exon            569..607
                     /gene="Tmprss11c"
                     /gene_synonym="Tmprss13"
                     /inference="alignment:Splign:2.1.0"
     exon            608..779
                     /gene="Tmprss11c"
                     /gene_synonym="Tmprss13"
                     /inference="alignment:Splign:2.1.0"
     exon            780..1039
                     /gene="Tmprss11c"
                     /gene_synonym="Tmprss13"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1182
                     /gene="Tmprss11c"
                     /gene_synonym="Tmprss13"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..4355
                     /gene="Tmprss11c"
                     /gene_synonym="Tmprss13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4337..4342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmprss11c"
                     /gene_synonym="Tmprss13"
                     /note="hexamer: AATAAA"
     polyA_site      4355
                     /gene="Tmprss11c"
                     /gene_synonym="Tmprss13"
                     /note="major polyA site"
ORIGIN      
        1 agctaaatag gtggaggatg actgtgccac ccagcactca agggcaagat ggcaagggga
       61 cagcctcgga ggagcgaaga gcaatggaca gccttgcaga acagaacaga gtgcaaaaca
      121 aagataaaac tcacaaggtg tggcaagatt accctgggca tcttaacggc ggtgcttgcg
      181 gcagtactga ttggactcat tgcctatttt gccgcctgtg gaaaagactc tttctactac
      241 catgtcagct ttaaggttaa caacattgac tatgacagca aatttgcaaa gccatattct
      301 caggaataca tggacctaaa taaaaggata gtgtctttga tgaatgaaac atttcatgaa
      361 tcaaaactga gaaaacagta cgtcaaagct cacactgtgc aagtaagcaa agccaaaggg
      421 aaggtggtga tacatgctgt gctgaagttt aaagcctgtt atagaaataa tgtagaaaaa
      481 tactgggaaa gcgttgaaac cactttgtat cagaaactca aaggccaaac tggattactt
      541 atagactctt cctcatttaa attttcagac attgcaatgc caatagcaga agatcttctc
      601 aatacatgtt gtggacgacg cacaattatt catagaggtc acaaagtagc aggaggccag
      661 gatgctgagg aaggagaatg gccctggcaa gccagccttc aacagaacag tgtccaccga
      721 tgtggagcta ctctgatcag taactactgg cttatcactg ctgctcactg tttcatacgg
      781 gctgcaaacc ccaaagactg gaaagttagc tttgggtttc ttctaagtaa accacaagca
      841 ccacgagctg tcaagaatat tataatccac gagaactaca gttaccctgc acatgataat
      901 gacatagctg ttgtgcgtct gtcttcgcca gtattgtatg aaagcaacat ccgaagggct
      961 tgtctaccag aagctactca gaagttccca cccaactcag atgtagtggt cactgggtgg
     1021 ggaacgttaa aatcggatgg agacagtcct aatattctcc agaaaggaaa agtgaagatt
     1081 atagacaata agacctgtaa tagtggaaag gcatatggtg gcatgatcac acctggaatg
     1141 atgtgtgctg ggttcctgaa gggacgtgtt gatgcctgcc agggtgattc tggtggacca
     1201 ttggttagtg aagattctaa gggcatctgg ttcctcgctg gtattgtaag ctggggcgat
     1261 gaatgtgcac ttccaaacaa gcctggtgtc tacactcggg tgacatacta tcgagactgg
     1321 atcacatcca aaactggtct ctagtgtggt tgttctttgt agattcaagc tcagtggttg
     1381 catatctgtt aaatatgttt gtaatcccaa aaccacattt tcttagatat ttctcctctt
     1441 ctacacattt aaatataaaa tttaacagca tgaaacttta gatttaagat gtttattaaa
     1501 gtttggcata tctttagtga gattatgaac caaaatatat aattttctcc tttaccattt
     1561 tgaggataag tataattatt aaagtgaata tggtttggtt tattaataaa atactctctg
     1621 ctaccttggt gaggcagata tttgggtaat atatcacatg agcattagtt atacatgatt
     1681 caaattgtat aagccctctt ctaccgacca gttcatggat tctccagaat caatgtgttt
     1741 gaggacagag tccagaacat tatagtaaca ctgcccataa gagttactgg agaaatattt
     1801 atctattttc tttctggtct ctgtgtcaaa cctaattctt ccaatttttc ctcgtcttaa
     1861 gtgatagaaa tcaaaataat aatccacaga tgtattaata gaccacagtg tttactgact
     1921 ttcctttctc tcttgactgt gaaactgaag tcagaaggtg gttctcttgc aacagtagca
     1981 ttatccatgg gcgtattagg tttttttttt taataggtag ctttaattca taatgcaaat
     2041 aaagccacat tgtttgtatt ccaactctta aaatgtctca atattacaaa ttagcaacta
     2101 gataaacaat atgaaaaatt gttctcatgt cactctgact tcgcccatac aaaaacattc
     2161 tagtggaggg tacaggtgtc tgaaactgca cagtgatgtc aattctgctg ctcagttgac
     2221 attgctccaa aaccttatct aatccaactg ctttctcaga ctaaagttca tcactgtctc
     2281 tataggactt catatttctc tgcttcatca ctaacaatat acagctacct ccataaccat
     2341 catgacaaac attaataaca ttcgctaata tttacaggtt cttattcatg gtaggcaata
     2401 tacataatta aaatcaatgg acaactccaa gaaaatggtc tccctggtat ttcaattttg
     2461 tagatgagct tactaaagta tagagaaggc cagcagtctt ctgaagatca aagagcctct
     2521 aattgactga gatccaaatc atacagctct atttcagagc ttacaatttt aacagattgt
     2581 tatgatacag gatattgtta gggcctaaat atttcttttt ttaattaggt attttcttca
     2641 tttacatttc caatgctatc ccaaaagtcc ccccatgccc tccccccacc cactcccact
     2701 tcttggccct ggcgttcccc tgtactgagg catataaagt ttgcaagacc aatgggccta
     2761 aaataaatta acaaacataa ctaggtaaag aaaatattat tttctggtag tttaaccaga
     2821 ctaggcctct cgcatcatgt tctaaaatgt agaatttatc agaaacatta tggattaatt
     2881 gttaggtgca ttatatggat gcttttataa cattcaactc atcttgttat atatccctaa
     2941 gaattaatat ttttattatt tgtattttag aaaatagata taaacaaaat aaaagtacgt
     3001 gcacattggt taagactgac ctaacatggg ccagacatga ctctggccat ggaagaagtg
     3061 gggctttggt tgacaacccc tcaaattaaa taggggtaga ttcaaaaaat taaagagtta
     3121 tttattacct catgtaaaat ctgctatgtt ctgaatagtt agaatagtat tcagtcgtat
     3181 aatataataa agactgtatt gtgtttattg atattaactt ttaaattaca gattctatgt
     3241 gccatatgta ttttgttcta ttagaaaaaa attaatacac actaatgact taaaccacca
     3301 atactctcct tcacttaatt tctttatata tgctgaatat ggactgcctc cattagaaaa
     3361 gtataaaata cttttatttt gattcagaaa atgctttcat gtgaagacat atattgtcag
     3421 atacattcaa ataaagatga ttaaatgacc ccatctacag gttgatacac tgtataataa
     3481 taaaatccct ttcttcaatt taagtaaaaa cagtaataat ggtttctctc catctgggca
     3541 ccaaggtcat aattactggg ttttccatca gatataggta tttctcctat aaaaaaaaat
     3601 atctctcaag gtcccatgat ttgaacacat gtaaagaaat taaggtggaa ttttcacaaa
     3661 agctagctct actgtaaaga attatacatg ctatctgaaa ctgtaaaacc tctgaatttc
     3721 catacaggga taagacaaaa actccttgac acaagtttgg caatgatttt tatgagtatg
     3781 agaccaaaat ctcatacaac atggaataat aaaataaaca ttaaaactac ataaactaaa
     3841 aagtttctgc acatcagtca acaaaacgaa aacgcatcct agaagttgag agaaagcatg
     3901 ctgtaaacct tatatctgac aaacacccca aatacacaag aaaacaagct gctccacacc
     3961 agaagaaaca agaaccaaca aactgatttt aaaaatgcgt gaatgtctta aacatttttc
     4021 ccccagagaa gatatagaaa tggccaacac gtctacaaac agggtctcaa cttcaatcat
     4081 catcagagaa aggttcatta aactgcagca ctatcacctc atgcttgtta ggacaagtga
     4141 aaggaagagg actgttaata agaatctaaa cttggagctg aagagatggc tgagcggtta
     4201 agagcactga ctgctcttcc caaggtcctg agttcaattc ccagcaacaa tatagtggct
     4261 cgcaaccatc tgtaatggga tctgatgctc tcttctcgtg tgtctgaaga cagttacagt
     4321 gtactcacgt atataaaata aaaataaaaa tcttt
//
