LOCUS       NM_177024               3335 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Mus musculus transmembrane protease, serine 11B (Tmprss11b), mRNA.
ACCESSION   NM_177024
VERSION     NM_177024.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3335)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3335)
  AUTHORS   Callies,L.K., Tadeo,D., Simper,J., Bugge,T.H. and Szabo,R.
  TITLE     Iterative, multiplexed CRISPR-mediated gene editing for functional
            analysis of complex protease gene clusters
  JOURNAL   J Biol Chem 294 (44), 15987-15996 (2019)
   PUBMED   31501243
REFERENCE   3  (bases 1 to 3335)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103930.10.
            
            On Oct 3, 2022 this sequence version replaced NM_177024.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137654.1, AK036858.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC103930.10        199436-199529       c
            95-210              AC103930.10        194962-195077       c
            211-329             AC103930.10        190652-190770       c
            330-397             AC103930.10        190491-190558       c
            398-558             AC103930.10        188131-188291       c
            559-597             AC103930.10        187443-187481       c
            598-772             AC103930.10        186555-186729       c
            773-1032            AC103930.10        185341-185600       c
            1033-1175           AC103930.10        184710-184852       c
            1176-3335           AC103930.10        181634-183793       c
FEATURES             Location/Qualifiers
     source          1..3335
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..3335
                     /gene="Tmprss11b"
                     /gene_synonym="9930019B18Rik; Tmprss11bnl"
                     /note="transmembrane protease, serine 11B"
                     /db_xref="GeneID:319875"
                     /db_xref="MGI:MGI:2442893"
     exon            1..94
                     /gene="Tmprss11b"
                     /gene_synonym="9930019B18Rik; Tmprss11bnl"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1337
                     /gene="Tmprss11b"
                     /gene_synonym="9930019B18Rik; Tmprss11bnl"
                     /note="airway trypsin-like protease 5; transmembrane
                     protease, serine 11b N terminal like"
                     /codon_start=1
                     /product="transmembrane protease serine 11B-like protein"
                     /protein_id="NP_795998.2"
                     /db_xref="CCDS:CCDS39126.1"
                     /db_xref="GeneID:319875"
                     /db_xref="MGI:MGI:2442893"
                     /translation="MYRPVIASRKSIPPWLIILCVLGVLAALGIIIGLLVHFLAVENK
                     IYYYQGGFKVLDIPYDRNYERETSLESNYLSKILENKMVEAFQNSNIYKQYINSQVIT
                     LVPDNNSVTAHIWLVFKDPWSNKENLRRRIESILRQMLENNPESLTTDPGSLKLTEIS
                     KVDAEKIINNRCGRRPRMSATYDRITGGSTAHKGEWPWQASLRVNGKHYCGASLIGER
                     FLLTAAHCFQGTNNPKNLTVSFGTRVTPAYMQHSVQEIIIHEDYVKGEHHDDVAVIKL
                     TEKVSFNNDVHRVCLPESTQIFPPGEGVVVTGWGSFSYNGKSPLLLQKASIKIIDTNT
                     CNSEEAYGGRIVDTMLCAGYLEGSIDACQGDSGGPLVHPNSRDIWYLVGIVSWGHECG
                     RVNKPGVYMRVTSYRNWIASKTGI"
     exon            95..210
                     /gene="Tmprss11b"
                     /gene_synonym="9930019B18Rik; Tmprss11bnl"
                     /inference="alignment:Splign:2.1.0"
     exon            211..329
                     /gene="Tmprss11b"
                     /gene_synonym="9930019B18Rik; Tmprss11bnl"
                     /inference="alignment:Splign:2.1.0"
     exon            330..397
                     /gene="Tmprss11b"
                     /gene_synonym="9930019B18Rik; Tmprss11bnl"
                     /inference="alignment:Splign:2.1.0"
     exon            398..558
                     /gene="Tmprss11b"
                     /gene_synonym="9930019B18Rik; Tmprss11bnl"
                     /inference="alignment:Splign:2.1.0"
     exon            559..597
                     /gene="Tmprss11b"
                     /gene_synonym="9930019B18Rik; Tmprss11bnl"
                     /inference="alignment:Splign:2.1.0"
     exon            598..772
                     /gene="Tmprss11b"
                     /gene_synonym="9930019B18Rik; Tmprss11bnl"
                     /inference="alignment:Splign:2.1.0"
     exon            773..1032
                     /gene="Tmprss11b"
                     /gene_synonym="9930019B18Rik; Tmprss11bnl"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1175
                     /gene="Tmprss11b"
                     /gene_synonym="9930019B18Rik; Tmprss11bnl"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..3335
                     /gene="Tmprss11b"
                     /gene_synonym="9930019B18Rik; Tmprss11bnl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3311..3316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tmprss11b"
                     /gene_synonym="9930019B18Rik; Tmprss11bnl"
                     /note="hexamer: AATAAA"
     polyA_site      3335
                     /gene="Tmprss11b"
                     /gene_synonym="9930019B18Rik; Tmprss11bnl"
                     /note="major polyA site"
ORIGIN      
        1 acatttaccc gagaaccaat atcaacacgt aaggagttca gaagttccct ctgcattaat
       61 atcagccacc agtgtatcag cacgttatgt acagaccagt catagcatcc cgcaaatcta
      121 tcccaccatg gctaatcatc ctctgtgtgc ttggagtgct ggcagccctt gggataatta
      181 ttggactctt agttcacttt ctggcagtag aaaacaagat ctactactat caaggtggtt
      241 ttaaagtgct ggatattcca tatgacagaa attatgaaag ggagacatca ctagaaagta
      301 actacctcag taaaatcctt gagaataaaa tggttgaagc ctttcagaat tctaacattt
      361 acaaacaata tatcaactct caggtcatca cattggttcc tgataacaac agcgtgacag
      421 cacatatatg gctggtgttt aaggatccct ggtctaacaa ggaaaaccta agaaggagaa
      481 ttgaaagcat cttacgtcag atgctggaga acaacccaga atccctgact acagatcctg
      541 ggtctctgaa gctcacggaa atcagtaagg ttgatgctga gaagattatc aacaaccgct
      601 gtgggagaag accaagaatg tctgcaacct acgacagaat cacgggaggt tccactgctc
      661 acaaaggaga gtggccatgg caagcgagtc tcagagtgaa tggtaaacac tactgtgggg
      721 catctctgat tggcgaaaga tttctgctca cagcagctca ttgctttcaa gggacaaata
      781 atccaaaaaa cttaactgtc agctttggca ctagagtaac tccagcctac atgcagcatt
      841 ctgttcaaga gattattatt catgaagatt atgtgaaggg ggaacatcat gatgacgttg
      901 cagttataaa gctcactgaa aaagtttcat tcaataatga tgtgcatcgg gtttgtcttc
      961 cggaatccac ccagattttt ccaccaggtg aaggagtcgt tgttacagga tggggatcat
     1021 tttcttacaa tggtaaatcc ccactgttac ttcagaaagc atccattaaa atcattgaca
     1081 caaatacttg caattcagaa gaagcttatg gaggcaggat agtggacaca atgctctgtg
     1141 ctggctactt ggaaggcagt atcgatgctt gccagggtga ctctggagga ccactagttc
     1201 atcccaattc tcgagatatt tggtaccttg ttgggatagt gagctggggg catgaatgtg
     1261 gcagagtcaa caagccaggg gtctatatga gagtaacttc ctaccgtaac tggattgcct
     1321 ccaagactgg tatctagtag aaaatcatct tttaataatg aatgcagatc atatcgcctg
     1381 gtacgatatc actgaacatc caattcttta ttctttcccg ttgtatatgt gtgtgtctct
     1441 gtgtgttttt gcatgtgtgt gggtaaatgt gtgtttgtgc ttatatatgt aagtgtgcct
     1501 gtaagtagat gcataagctg ttgttaagaa tcatcctcaa caatttcact gagacagggt
     1561 aatggtcaaa ccaagagctc tcagaaatat actgtcttac aactcatgct gctgttagaa
     1621 ccggctattt ctgtcttcta aggatggaag tatagacagg cttgtatgcc catcagccca
     1681 tcaggtattt atgagtatcc cggggattcc atttgcagtc cttaggcttt catgcttaat
     1741 cactgagcaa gccctcagct tgttttaaac attactattt ggggtgaatg ggcgtttttt
     1801 cctgtaccac ataaatgcct aggggtcaga agagggagct gtattctctt ggactggagt
     1861 tacagaccat atgagccacc ctataggtgc tgggaattga accccagtct attgaaagaa
     1921 catccaggcc tcttaacctt agccattccc actcaatact ttacatgctt tttaaatgta
     1981 tataatggtt attttgagag aattattgcc ctaagggaat atttgtaagc ttttaatcaa
     2041 actaaacaag acaaaattag agaccttgag tttcttagtt caggaagccc ttagccaaga
     2101 aagtactccc accaaaatac tggtaaaatg ctatttgtgc cctggcttat cagtctacat
     2161 tactgctatt tcggtactta aggttcttat gttttatcat atagactttg taactgtgga
     2221 aacatggtgt tgactgtagt gatttaccag gctgtatgag gggacagtag tgcctcccca
     2281 aggttgggtt ggaacatgag ggatctattt tcatgtcaga gctttgtgga aggttgtgac
     2341 tgtgacctga cctactctga aaacaggtat tgaatcacaa cctcttgtta tggatgcatt
     2401 caccaggtct gcagtcattc tgagtttctc accaccatta atttagatat gttttaagtt
     2461 atagagaata agtacagtaa ttcttcatca tagatacaga tttctgtgga aattctctat
     2521 atgtaatata tttaaaacat ttttctcttc aggatttttt tccctgtgct catatctttg
     2581 aggctcttcc ccactttccc cttgataagt ttcaatgtct ttggttttat gtggagttcc
     2641 ttgatccact tggacttgag ctttgtacca ggagataaga atggatcaat tagcattctt
     2701 ctacatgata accaccagtt gagccaacac catttgttga aaatgctgtc ttttttccaa
     2761 aggatggttt tagctccttt gtcaaaaatc aagtgatcat aagtgtgtgg gttaatttct
     2821 gggtcttcaa ttctattcca ttgatctacc tgtctgtcgc tgtatcagtg ccatgcagtt
     2881 tttatcacaa ttgttctgta gtacagcttt aggtcaggat ggtgattcca ccagaagatg
     2941 gcctagtcag ccatcaatgg gaggagaggc ctttggtctt gtgaaggttc tatgccccag
     3001 tataggggat tgccagggcc aggaagtggg agggggtggg ttgaggagaa gggggaagag
     3061 tgagaggggt agggagtttt tggagaggaa actaggaaag gggataacat tttaaatgta
     3121 aataaagaaa atatctaatt aaaaaataaa aacataaaga aaaaacatgc attcagttaa
     3181 cttgaggaaa gtagaaaatg agaaaatgca aagtaaaatt taaatgtcac atgatactat
     3241 aaatgtattt ttgcacacca ataagtgacc tttctttgtt tttgccctct aaaaaaattt
     3301 atctgaactc aataaaaatg tatggtttat actaa
//
