LOCUS       NM_001033233            2657 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus transmembrane protease, serine 11a (Tmprss11a), mRNA.
ACCESSION   NM_001033233 XM_110701 XM_896881 XM_917143 XM_924716
VERSION     NM_001033233.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2657)
  AUTHORS   Callies,L.K., Tadeo,D., Simper,J., Bugge,T.H. and Szabo,R.
  TITLE     Iterative, multiplexed CRISPR-mediated gene editing for functional
            analysis of complex protease gene clusters
  JOURNAL   J Biol Chem 294 (44), 15987-15996 (2019)
   PUBMED   31501243
REFERENCE   2  (bases 1 to 2657)
  AUTHORS   Zmora,P., Hoffmann,M., Kollmus,H., Moldenhauer,A.S., Danov,O.,
            Braun,A., Winkler,M., Schughart,K. and Pohlmann,S.
  TITLE     TMPRSS11A activates the influenza A virus hemagglutinin and the
            MERS coronavirus spike protein and is insensitive against blockade
            by HAI-1
  JOURNAL   J Biol Chem 293 (36), 13863-13873 (2018)
   PUBMED   29976755
  REMARK    GeneRIF: show that TMPRSS11A, another member of the TTSP family,
            cleaves and activates the influenza A virus (FLUAV) HA and the
            Middle East respiratory syndrome coronavirus spike protein
            (MERS-S).
REFERENCE   3  (bases 1 to 2657)
  AUTHORS   Sales,K.U., Hobson,J.P., Wagenaar-Miller,R., Szabo,R.,
            Rasmussen,A.L., Bey,A., Shah,M.F., Molinolo,A.A. and Bugge,T.H.
  TITLE     Expression and genetic loss of function analysis of the HAT/DESC
            cluster proteases TMPRSS11A and HAT
  JOURNAL   PLoS One 6 (8), e23261 (2011)
   PUBMED   21853097
  REMARK    GeneRIF: A comprehensive phenotypic analysis of mice deficient in
            two of the most widely expressed HAT/DESC proteases, TMPRSS11A and
            HAT, was performed.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK142820.1.
            
            On Apr 6, 2007 this sequence version replaced NM_001033233.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142820.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849387,
                                           SAMN01164133 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2657              AK142820.1         2-2658
FEATURES             Location/Qualifiers
     source          1..2657
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..2657
                     /gene="Tmprss11a"
                     /gene_synonym="Gm7"
                     /note="transmembrane protease, serine 11a"
                     /db_xref="GeneID:194597"
                     /db_xref="MGI:MGI:2684853"
     exon            1..140
                     /gene="Tmprss11a"
                     /gene_synonym="Gm7"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1305
                     /gene="Tmprss11a"
                     /gene_synonym="Gm7"
                     /note="airway trypsin-like protease 1; DESC-3; serine
                     protease DESC3"
                     /codon_start=1
                     /product="transmembrane protease serine 11A"
                     /protein_id="NP_001028405.1"
                     /db_xref="CCDS:CCDS51531.1"
                     /db_xref="GeneID:194597"
                     /db_xref="MGI:MGI:2684853"
                     /translation="MEVAGYGTHNRDLKQWMVTLLSALSLMMVVVTIGLLALFLVFDI
                     QVNSNSGQKSSNQLKDLQETNENLVDEIFIDSALNNRYIKNHVVGLTPEEDDTKADIV
                     MVFQPPATGRRTVGKKTHHSILDQKTRNARALPADVSLVQVKDCGKRAIPLIANRIVS
                     GNPAAKGAWPWQVSLQRSNIHQCGGTLIGNMWVVTAAHCFRTNSNPRQWTLSFGTTIN
                     PPLMKRDVRRIIMHERYRPPARDHDIALVQFSPRVTFSDEVRRICLPEPSASFPPNST
                     VYITGFGALYYGGESQNELREARVQIISNDICKKRHVYGNEIKRGMFCAGFLEGNYDA
                     CRGDSGGPLVIRDNKDTWYLIGIVSWGDNCGQKNKPGVYTQVTYYRHWIASKTGL"
     exon            141..262
                     /gene="Tmprss11a"
                     /gene_synonym="Gm7"
                     /inference="alignment:Splign:2.1.0"
     exon            263..339
                     /gene="Tmprss11a"
                     /gene_synonym="Gm7"
                     /inference="alignment:Splign:2.1.0"
     exon            340..407
                     /gene="Tmprss11a"
                     /gene_synonym="Gm7"
                     /inference="alignment:Splign:2.1.0"
     exon            408..568
                     /gene="Tmprss11a"
                     /gene_synonym="Gm7"
                     /inference="alignment:Splign:2.1.0"
     exon            569..740
                     /gene="Tmprss11a"
                     /gene_synonym="Gm7"
                     /inference="alignment:Splign:2.1.0"
     exon            741..1000
                     /gene="Tmprss11a"
                     /gene_synonym="Gm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1143
                     /gene="Tmprss11a"
                     /gene_synonym="Gm7"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..2657
                     /gene="Tmprss11a"
                     /gene_synonym="Gm7"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2657
                     /gene="Tmprss11a"
                     /gene_synonym="Gm7"
                     /note="putative"
ORIGIN      
        1 ttctttgggt cctgctcctt tgaagtgtct gtctttgagg gtagactctc cacaccagag
       61 gatagctggt gaggaatctt taaggaattc aaactggatt taagattgaa gggtttctgg
      121 aattttcaca gtgggatgga agtggcagga tatggcaccc acaacagaga tctgaagcaa
      181 tggatggtta cccttctctc tgctctctcc ctgatgatgg tggtagtgac cattggactt
      241 ctggctctct tcctcgtgtt cgatattcaa gtcaatagca actcaggaca aaagagctca
      301 aatcaactga aggacttaca agagacgaat gaaaatttgg tagatgaaat atttatagat
      361 tcagccttga acaatcgcta catcaaaaac cacgtagtcg gactaacacc agaagaggat
      421 gatacaaaag cagacattgt catggtgttc cagcctcccg ctacagggcg aagaaccgta
      481 gggaaaaaga cgcaccatag catcttagat cagaagacaa ggaacgcaag agctttgcca
      541 gctgatgtct cactggttca agttaaagat tgtggcaagc gagctatccc attaattgcc
      601 aacagaatag tgtctggaaa ccctgcagct aagggtgcct ggccgtggca agtttccctt
      661 cagcgaagca acatccatca gtgtgggggc acgttgattg gtaacatgtg ggtcgtcact
      721 gcagcacact gttttagaac caattcaaac cctcgccaat ggactcttag ttttggaaca
      781 acaataaatc ctcccttaat gaaaagagac gtcagaagaa ttattatgca tgaaaggtat
      841 cgtcccccag caagagacca tgacattgct ctagtgcagt tttctcccag agtcaccttt
      901 tcggatgaag tgcgccgaat ttgtttgcca gaaccctctg catctttccc accaaattca
      961 actgtctaca tcacaggatt cggagcactt tactatggcg gggaatccca aaatgagctc
     1021 cgtgaagcca gagtacaaat cataagcaat gacatctgca agaagcgaca cgtgtatggc
     1081 aatgaaataa aacgtgggat gttctgtgct ggatttctgg aaggaaatta cgatgcctgc
     1141 aggggtgatt ctgggggacc attggttata agagacaaca aagatacctg gtatctcatt
     1201 ggaattgtga gctggggaga caactgtggt caaaagaaca agcctggggt gtacacacaa
     1261 gtgacttatt accgacactg gattgcttcg aaaacgggtc tctaactcgc tacagataga
     1321 tgttaaagaa aaccgtagcg tgtcggttat atgcatgtaa gaattcagac atccatttgg
     1381 tggcattggc acaatgaaat gagattaaat ggctggacct agcaatgtga aacacatgat
     1441 ttatttcaga atcgcatatt tgtgaaggtg taggctgatt tatcattgaa aaatgcagta
     1501 aagatccttc atctctttaa agcaagggtg catgggatgc attatgtggt tttacagatg
     1561 gcctgggaga gttttagaat gtgttttttc tgggtaccct tcaagtaaaa aacgctttga
     1621 atcttcagag acgtcaaggt gctcatacaa gtccctttga tttatctaga gttcatacac
     1681 atctttttgt cttctttaca tttcttctag attttccagt tttttccacc acaggaaata
     1741 agtttgttac ttctaaatgc atatcaggga atttagaagg gacgattata tcaaaatttg
     1801 gtggcaaaat aaagtgaagt tagtttaaac tttgctggga attttttctg tttttttttt
     1861 tatgattttt agaaacacta ccatgtatac aacactcata tcaccatccc gatggcatag
     1921 agatacataa gagaaatact gattaatggt acttgatcaa tatataattt ttatcctgaa
     1981 aaattgacag ggatgatgac tgagctgttc caggataggt gtacaagata ttttgaatgc
     2041 gcacttacat attttggtcg ccagggggag atttttgtcc agcattatct taaggtcaaa
     2101 taatggaaaa ctacagggaa tttatgtcca ggaagtaaaa acaaacagac tcatgaaggc
     2161 atcaggaaag tgaaacattg ttgcccacaa tagacctaaa gaaggcttta ttggataatt
     2221 tcttgcctgt gagatgtcta aattttcaag ttaaggtata taaaacagct taacaaagtt
     2281 atatgcaatt tgcatcctta gttgtcaaat tcacatgccc tctttccttg caaagtttgt
     2341 ttatggctgc tgtatttatt gaatcggtgt acctaggaca tttctcacta agtgctattg
     2401 gatcagtttt caaactagga aactcttact accactactc acttcaaagc aaggttcttt
     2461 cttcatatat gtaataaatt ctcacataaa ttttctgcat tacagtggtt aactatgatt
     2521 gtgtttctaa tgctaagatt cagaaagtgg tcttagagtt gtaaataatg cgctccaaac
     2581 tgtctgctgc agcatttcat tcatggttgt atgggaacaa ataatgtttt aaatctaata
     2641 aagttggtga tcagagc
//
