LOCUS       NM_011605               3821 bp    mRNA    linear   ROD 06-FEB-2024
DEFINITION  Mus musculus thymopoietin (Tmpo), transcript variant 1, mRNA.
ACCESSION   NM_011605
VERSION     NM_011605.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3821)
  AUTHORS   Sidorenko,E., Sokolova,M., Pennanen,A.P., Kyheroinen,S., Posern,G.,
            Foisner,R. and Vartiainen,M.K.
  TITLE     Lamina-associated polypeptide 2alpha is required for intranuclear
            MRTF-A activity
  JOURNAL   Sci Rep 12 (1), 2306 (2022)
   PUBMED   35145145
  REMARK    GeneRIF: Lamina-associated polypeptide 2alpha is required for
            intranuclear MRTF-A activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3821)
  AUTHORS   Wang,F., Tan,P., Zhang,P., Ren,Y., Zhou,J., Li,Y., Hou,S., Li,S.,
            Zhang,L., Ma,Y., Wang,C., Tang,W., Wang,X., Huo,Y., Hu,Y., Cui,T.,
            Niu,C., Wang,D., Liu,B., Lan,Y. and Yu,J.
  TITLE     Single-cell architecture and functional requirement of alternative
            splicing during hematopoietic stem cell formation
  JOURNAL   Sci Adv 8 (1), eabg5369 (2022)
   PUBMED   34995116
REFERENCE   3  (bases 1 to 3821)
  AUTHORS   Chen,N.Y., Kim,P.H., Tu,Y., Yang,Y., Heizer,P.J., Young,S.G. and
            Fong,L.G.
  TITLE     Increased expression of LAP2beta eliminates nuclear membrane
            ruptures in nuclear lamin-deficient neurons and fibroblasts
  JOURNAL   Proc Natl Acad Sci U S A 118 (25) (2021)
   PUBMED   34161290
REFERENCE   4  (bases 1 to 3821)
  AUTHORS   MacPherson,M.J., Erickson,S.L., Kopp,D., Wen,P., Aghanoori,M.R.,
            Kedia,S., Burns,K.M.L., Vitobello,A., Tran Mau-Them,F., Thomas,Q.,
            Gold,N.B., Brucker,W., Amlie-Wolf,L., Gripp,K.W., Bodamer,O.,
            Faivre,L., Muona,M., Menzies,L., Baptista,J., Guegan,K., Male,A.,
            Wei,X.C., He,G., Long,Q., Innes,A.M. and Yang,G.
  TITLE     Nucleocytoplasmic transport of the RNA-binding protein CELF2
            regulates neural stem cell fates
  JOURNAL   Cell Rep 35 (10), 109226 (2021)
   PUBMED   34107259
REFERENCE   5  (bases 1 to 3821)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   6  (bases 1 to 3821)
  AUTHORS   Furukawa,K.
  TITLE     LAP2 binding protein 1 (L2BP1/BAF) is a candidate mediator of
            LAP2-chromatin interaction
  JOURNAL   J Cell Sci 112 (Pt 15), 2485-2492 (1999)
   PUBMED   10393804
REFERENCE   7  (bases 1 to 3821)
  AUTHORS   Dreger,M., Otto,H., Neubauer,G., Mann,M. and Hucho,F.
  TITLE     Identification of phosphorylation sites in native lamina-associated
            polypeptide 2 beta
  JOURNAL   Biochemistry 38 (29), 9426-9434 (1999)
   PUBMED   10413518
REFERENCE   8  (bases 1 to 3821)
  AUTHORS   Valk,P.J., Vankan,Y., Joosten,M., Jenkins,N.A., Copeland,N.G.,
            Lowenberg,B. and Delwel,R.
  TITLE     Retroviral insertions in Evi12, a novel common virus integration
            site upstream of Tra1/Grp94, frequently coincide with insertions in
            the gene encoding the peripheral cannabinoid receptor Cnr2
  JOURNAL   J Virol 73 (5), 3595-3602 (1999)
   PUBMED   10196250
REFERENCE   9  (bases 1 to 3821)
  AUTHORS   Theodor,L., Shoham,J., Berger,R., Gokkel,E., Trachtenbrot,L.,
            Simon,A.J., Brok-Simon,F., Nir,U., Ilan,E., Zevin-Sonkin,D.,
            Friedman,E. and Rechavi,G.
  TITLE     Ubiquitous expression of a cloned murine thymopoietin cDNA
  JOURNAL   Acta Haematol 97 (3), 153-163 (1997)
   PUBMED   9066710
REFERENCE   10 (bases 1 to 3821)
  AUTHORS   Berger,R., Theodor,L., Shoham,J., Gokkel,E., Brok-Simoni,F.,
            Avraham,K.B., Copeland,N.G., Jenkins,N.A., Rechavi,G. and
            Simon,A.J.
  TITLE     The characterization and localization of the mouse
            thymopoietin/lamina-associated polypeptide 2 gene and its
            alternatively spliced products
  JOURNAL   Genome Res 6 (5), 361-370 (1996)
   PUBMED   8743987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ071529.1, AK144642.1, BC141062.1, AK156206.1 and AV450597.1.
            
            [WARNING] On Mar 31, 2024 this sequence was replaced by
            NM_011605.4.
            
            On Sep 25, 2013 this sequence version replaced NM_011605.2.
            
            Transcript Variant: This variant (1) lacks several exons but has an
            alternate 3' terminal exon, compared to variant 3. The resulting
            isoform (alpha) is longer and has a distinct C-terminus, compared
            to isoform epsilon.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144642.1, U39078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                CJ071529.1         2-42
            42-1304             AK144642.1         2-1264
            1305-2412           BC141062.1         1023-2130
            2413-3811           AK156206.1         3044-4442
            3812-3821           AV450597.1         280-289
FEATURES             Location/Qualifiers
     source          1..3821
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 45.66 cM"
     gene            1..3821
                     /gene="Tmpo"
                     /gene_synonym="5630400D24Rik; LAP2; TP"
                     /note="thymopoietin"
                     /db_xref="GeneID:21917"
                     /db_xref="MGI:MGI:106920"
     exon            1..582
                     /gene="Tmpo"
                     /gene_synonym="5630400D24Rik; LAP2; TP"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..2388
                     /gene="Tmpo"
                     /gene_synonym="5630400D24Rik; LAP2; TP"
                     /note="isoform alpha is encoded by transcript variant 1"
                     /codon_start=1
                     /product="lamina-associated polypeptide 2 isoform alpha"
                     /protein_id="NP_035735.2"
                     /db_xref="CCDS:CCDS24122.1"
                     /db_xref="GeneID:21917"
                     /db_xref="MGI:MGI:106920"
                     /translation="MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQH
                     LTARNRPPLAAGANSKGPPDFSSDEEREPTPVLGSGASVGRGRGAVGRKATKKTDKPR
                     LEDKDDLDVTELSNEELLDQLVRYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSSTP
                     LPTVSSSAENTRQNGSNDSDRYSDNDEGKKKEHKKVKSARDCVPFSELASTPSGAFFQ
                     GISFPEISTRPPLGRTELQAAKKVQTTKRDPPRETCTDTALPGKGQTHKLAPGRSLFI
                     PSESSYDRCVEKSSSPSSQREFAARLVSAAASPSLIRETTTTYSKDIVENICRGGKSR
                     AQPLRAEEPGVSDQSVFSSEREVLQESERSQVISPPLAQAIRDYVNSLLVQGGVGSLP
                     GTSDSVPTLDVENICKRLSQSSYQDSESLSPPRKVPRLSEKPARGGDSGSCVAFQNTP
                     GSEHRSSFAKSVVSHSLTTLGVEVSKPPPQHDKIEASEPSFPLHESILKVVEEEWQQI
                     DRQLPSVACRYPVSSIEAARILSVPKVDDEILGFISEATPRAATQASSTESCDKHLDL
                     ALCRSYEAAASALQIAAHTAFVAKSLQADISQAAQIINSDPSDAQQALRILNRTYDAA
                     SYLCDAAFDEVRMSACAMGSSTMGRRYLWLKDCKISPASKNKLTVAPFKGGTLFGGEV
                     HKVIKKRGNKQ"
     exon            583..709
                     /gene="Tmpo"
                     /gene_synonym="5630400D24Rik; LAP2; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            710..868
                     /gene="Tmpo"
                     /gene_synonym="5630400D24Rik; LAP2; TP"
                     /inference="alignment:Splign:2.1.0"
     exon            869..3813
                     /gene="Tmpo"
                     /gene_synonym="5630400D24Rik; LAP2; TP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcgtgcg cgagccaggc tccccccacc ccaccccacg cactagcttg tgtatgggct
       61 cggctcgctg cgggctccgg gttcggctgc acttgctccc cagtcgtgcg ccaggggctt
      121 tttgtggcgg gggccggacc tgggttttgt gtcccgagtt ctgtgccgtg cccgcggcgc
      181 cgctccgggg cagggatctc ccgaggcggc gggcgcagcc cccgggacca gcgagcgagc
      241 gcgccggcgt gagcagcggc ggcggcgact gtgaggggcc ggggaggaga gaaggagggg
      301 gacgagatgc cggagttcct agaggaccct tcggtcctga ccaaagacaa gttgaagagc
      361 gagttggtcg ccaacaacgt gacgctcccg gccggcgagc agcgcaagga cgtgtacgtg
      421 cagctctacc tgcagcacct cacggcgcgc aaccggccgc cgctcgccgc gggagccaac
      481 agcaaagggc cgcccgactt ctcgagcgac gaggagcgcg agcccacgcc ggtgctcggc
      541 tccggggcct ccgtgggtcg cggccgcggc gccgtcggca ggaaagccac aaagaaaact
      601 gataagccca ggctagaaga taaagatgat ctggatgtga cagagctctc taatgaagaa
      661 cttctggatc agcttgtaag atatggagtg aatcctggtc ccattgtggg aacaaccagg
      721 aagctatatg agaagaagct gttgaagctg agggagcagg gaactgaatc gagatcctct
      781 actcctcttc caacagtctc ttcctctgca gaaaacacaa ggcagaatgg aagtaacgac
      841 tctgacagat acagcgacaa tgatgaagga aagaagaaag aacacaagaa agtgaagtcc
      901 gctagggatt gtgttccttt ttctgaactt gcatctactc cctctggtgc attttttcag
      961 ggtatttctt tccctgaaat ctccacccgt cctcctttgg gcaggactga actgcaggca
     1021 gctaagaaag tacaaaccac taagagagac ccacctaggg agacttgtac tgatacggcc
     1081 ttgcccggga aggggcagac gcacaagtta gcccctggac ggagtttatt tattccttca
     1141 gagtctagct atgatagatg tgtagagaaa agttcttcac catcttctca gcgtgaattt
     1201 gctgccaggt tggtctctgc tgcagcttct ccttcactga taagagaaac cactactact
     1261 tactctaagg acatagtgga aaatatttgc cgtggaggga agagtagagc tcagccattg
     1321 cgtgctgagg agcctggcgt gtcagatcag tcagttttct ctagtgaaag agaagtactg
     1381 caggagtcgg agaggtcgca ggtcatttct ccaccacttg ctcaggcaat tcgagattat
     1441 gtcaattctc tgttagtcca gggtggggtc ggcagtttgc ctgggacttc tgattctgtg
     1501 cccacactgg atgtagaaaa catatgtaag agacttagcc agtccagcta tcaagattct
     1561 gaatccctgt cccctccccg aaaagtccca agactcagtg agaagccagc aaggggcggg
     1621 gactcaggct cctgtgtggc atttcagaat acacctggat ccgaacatag gtcttctttt
     1681 gccaaaagtg ttgtctctca ttctctgact actttaggag tagaagtgtc taagccacca
     1741 ccacagcatg ataaaataga agcctcagag ccgtcttttc ctctccacga atctatccta
     1801 aaagtggtgg aagaggagtg gcagcaaatt gataggcagc tgccctcggt ggcgtgcaga
     1861 tatccagttt cctccatcga ggcagcacgg atattatcag taccaaaagt ggatgatgaa
     1921 atcctggggt ttatttctga agccacccca cgagcagcta ctcaggcgtc ctccactgag
     1981 tcttgtgata aacatttgga cttagctctc tgtagatctt acgaagctgc agcatcagca
     2041 ttgcagattg cagcccacac ggccttcgta gctaagtctc tgcaagctga cataagtcag
     2101 gctgcacaga ttattaattc agatcctagt gatgcacagc aggcactcag gattctgaac
     2161 agaacctatg atgcagcttc atatctttgt gatgctgcat ttgatgaagt gaggatgtct
     2221 gcctgtgcca tggggtcttc taccatgggt cggcgttatc tgtggttgaa ggattgtaag
     2281 attagtccag cttctaagaa taaattgact gttgccccct ttaaaggtgg aacattattt
     2341 ggaggggaag tacacaaagt tattaaaaag cgtggaaata agcagtaatg aggttaagaa
     2401 caaaggcaga aactttgact tagagaattt gtgaaccttt ctaagacttt agtctcctaa
     2461 tagagctaat ttcaaggtgt tacgctacca ctcatccagt tacagtataa ttgcatatgt
     2521 agaggcctag tacagttgaa gctccgtagg tcacatctgt cttacatgat cgtacagctt
     2581 cctgtttcat ttaacatttt agatatacaa ggaattcagc aactagaata tcagtggaac
     2641 cctcgcttcc tttagtttgc cattcgagta cttcctgatg cataggtcgg agttaaacat
     2701 tgttagtcac ttgaaacact gatttttttt ttccccccct gctcagagga gtttaacttt
     2761 gagaagtctc gtgtgtagta tgtcgagtct cacagctcct gtgattccag tctgctctgc
     2821 cttctgctgc ttgctttcat tatataaata atattttgcc atgagtcctt ttgttgtcca
     2881 ctcattacat tgcaggccat ctcacaagtg acctttgtac tgcaacaaac ctcataataa
     2941 ttctagatca gtgtaactct tttaagtgcc agtgcacaaa cttgctgctt ggctcgcaga
     3001 caagcgtgtg catgtataga agggaaagac cctgctgctc tgtgtgtggg aggatgcatg
     3061 cacttggcgt gcacgtgact gagttcagag ccacttaaga aagtgtaata agagtttaaa
     3121 tctagagata ctttgtaaac aaataagagg taaattgtat acctgtatgt atgtataaac
     3181 acaaacacat ttatgcacat ttttaataat cgaatagaca aggcagtgta cagttttatg
     3241 tctgatagag gaggtagcca acaaacaatt cctagttata caagtacatg gaccacactt
     3301 gaggaacaca gcaagggatg gtaagtggag ttctggtata cctcatcttc actcaacatg
     3361 gctattttgt tagataaaca agacactaca aaggtggggc ttttttattt tctacatgta
     3421 tttaaaggta ttttatatgt cctacataga tctggatgct aaaaccaaca agatgttttc
     3481 taaaaacctt aagaattttt actataccct aatgtctgtg tctgtatgaa gcaatgtatc
     3541 accctgtttt catttgtatg gttgtaaggt aaggaatcct agctgtcgag atgctgtgga
     3601 aaacagtctc aggcacaatc aaatacggtc tcggtgtcca tgtctaccac taccatgttc
     3661 ttaggctgca cagtccatcg ctacagccct gttacttgtc tttaaaatgt acatgtatac
     3721 atgtacctgt gaagtgctgt gtgatttttt tttttaaagc aatgtatgcc tgtagaatgc
     3781 ttctacaaat tcaataaagt tgttaaattt gaaaaaaaaa a
//
